Description
Building block is a term in chemistry which is used to describe a virtual molecular fragment or a real chemical compound the molecules of which possess reactive functional groups. As for chiral building blocks, they are valuable intermediates in the syntheses of natural products and pharmaceuticals. With the development of new drugs, it increasingly requires the use of chiral building blocks for lead optimization, and even on early stages-in search for efficient compounds. This is mainly because of the fact that at almost all the biological targets are chiral, and the drug-receptor interaction requires strict match of chirality.