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RNAi Technology
RNAi
SIRT3 siRNA (m)
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SIRT3 siRNA (m)
SIRT3 siRNA (m) from Santa Cruz Biotechnology, Inc.
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Citations:
(39)
Figures:
(51)
Supplier Page
Supplier Page from
Santa Cruz Biotechnology, Inc. for
SIRT3 siRNA (m)
Description
SIRT3 siRNA (m)
Product Specs
Company Info
Citations
Reviews
Product Specs
Item
SIRT3 siRNA (m)
Company
Santa Cruz Biotechnology, Inc.
Price
$293.00
Supplier Page
View Company Product Page
Catalog Number
sc-61556
Gene Name
sirtuin 3 (silent mating type information regulation 2, homolog) 3 (S. cerevisiae)
Quantity
10 µM
Species
mouse
NCBI Full Gene Name
sirtuin 3
NCBI Gene Aliases
2310003L23Rik, Sir2l3
Type
siRNA/dsRNA
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Santa Cruz Biotechnology, Inc.
10410 Finnell Street
Dallas
,
Texas
75220
United States
Phone
: 1-800-457-3801
831-457-3801
Company Profile
Website:
http://www.scbt.com/
Citations (39)
(1)
Icariin attenuates diabetic cardiomyopathy by inhibiting NLRP3 inflammasome through SIRT3-mediated TFAM deacetylation
Frontiers in Pharmacology
May 29, 2026
Min Sun, Hui Huang, Chao Wei, Yuan Xing, Bing Wu
cell density
reached 60% confluence. The siRNA was purchased from
Santa Cruz Biotechnology
(
SIRT3
:
sc-61556
; Control siRNA:
sc-365175
).
Transfection
was performed using Lipofectamine RNAiMAX reagent (Thermo Fisher
(2)
Activation of Sirtuin3 by 6,4'-Dihydroxy-7-methoxyflavanone Against Myoblasts Senescence by Attenuating D-Galactose-Induced Oxidative Stress and Inflammation
Nutrients
October 20, 2025
Bingsi Li, Yuxuan Gu, Libing Zhou, Rui Chen, Yiwei Liu, Zexuan Wan, Ziyi Liang, Yukang Wang, Renlei Ji, Zhian Liu
RNA Interference
Myoblasts
were
transfected
with 16 pmol of either
SIRT3
small interfering RNAs (SIRT3 siRNA,
sc-61556
,
Santa Cruz Biotechnology
) or a fluorescently labeled control siRNA (
sc-36869
,
Santa Cruz Biotechnology
)
(3)
Sirt3 deficiency induced down regulation of insulin degrading enzyme in comorbid Alzheimer's disease with metabolic syndrome
Scientific reports
November 17, 2022
Tyagi A, Musa M, Labeikovsky W, Pugazhenthi S.
(4)
SIRT3 expression alleviates microglia activation‑induced dopaminergic neuron injury through the mitochondrial pathway
Experimental and therapeutic medicine
November 1, 2022
Jiang DQ, Zang QM, Jiang LL, Lu CS, Zhao SH, Xu LC.
adenoviral vector (Ad-GFP) were purchased premade from Vigene Biosciences, Inc. SIRT3 siRNA (cat. no.
sc-61556
) and negative control siRNA (cat. no.
sc-37007
) were purchased from
Santa Cruz Biotechnology, Inc
. For
(5)
Berberine remodels adipose tissue to attenuate metabolic disorders by activating sirtuin 3
Acta pharmacologica Sinica
May 1, 2022
Li D, Yang C, Zhu JZ, Lopez E, Zhang T, Tong Q, Peng C, Lin LG.
(6)
The portrait of liver cancer is shaped by mitochondrial genetics
Cell reports
January 18, 2022
Chattopadhyay M, Jenkins EC, Lechuga-Vieco AV, Nie K, Fiel MI, Rialdi A, Guccione E, Enriquez JA, Sia D, Lujambio A,
et al
.
(7)
Role of Carbon Monoxide in Oxidative Stress-Induced Senescence in Human Bronchial Epithelium
Oxidative medicine and cellular longevity
January 1, 2022
Cai MY, Yip CY, Pan K, Zhang Y, Chan RW, Chan WY, Ko WH.
increase over control. 2.8.
Transfection
BEAS-2B were
transfected
with
SIRT3
small interfering RNAs (#
sc-61556
, siRNAs,
Santa Cruz Biotechnologies
, South San Francisco, CA) or overexpression plasmid using Lipofectamine
(8)
Honokiol attenuates lipotoxicity in hepatocytes via activating SIRT3-AMPK mediated lipophagy
Chinese medicine
November 10, 2021
Liu J, Zhang T, Zhu J, Ruan S, Li R, Guo B, Lin L.
membranes
were supplied by Bio-Rad laboratories (Hercules, CA, USA). The
shRNA
targeting
SIRT3
(
mouse
,
sc-61556
), scrambled
shRNA
(
mouse
, sc-1080600), and
shRNA
transfection reagent
(
mouse
,
sc-108061
) were provided
(9)
Overexpression of SIRT3 Suppresses Oxidative Stress-induced Neurotoxicity and Mitochondrial Dysfunction in Dopaminergic Neuronal Cells
Experimental neurobiology
October 31, 2021
Lee S, Jeon YM, Jo M, Kim HJ.
cells/well) were
transfected
with control siRNA (
Santa Cruz
;
sc-37007
), human SIRT3 siRNA (
Santa Cruz
;
sc-61556
), or mouse Sirt3 siRNA (Santa Cruz;
sc-61556
), using Lipofectamine RNAiMAX reagent (Invitrogen), and
(10)
Inhibition of miR-134-5p protects against kainic acid-induced excitotoxicity through Sirt3-mediated preservation of mitochondrial function
Epilepsy research
October 1, 2021
Lin W, Qian X, Yang LK, Zhu J, Wang D, Hang CH, Wang Y, Chen T.
(11)
Effects of Lipotoxicity in Brain Microvascular Endothelial Cells During Sirt3 Deficiency-Potential Role in Comorbid Alzheimer's Disease
Frontiers in aging neuroscience
January 1, 2021
Tyagi A, Mirita C, Shah I, Reddy PH, Pugazhenthi S.
(12)
Sirtuin 3 is required for the protective effect of Resveratrol on Manganese-induced disruption of mitochondrial biogenesis in primary cultured neurons
Journal of neurochemistry
January 1, 2021
Sun Q, Kang RR, Chen KG, Liu K, Ma Z, Liu C, Deng Y, Liu W, Xu B.
(13)
The AMPAR antagonist perampanel protects the neurovascular unit against traumatic injury via regulating Sirt3
CNS neuroscience & therapeutics
January 1, 2021
Chen T, Liu WB, Qian X, Xie KL, Wang YH.
protocols. 2.10 Short interfering RNA (siRNA)
and transfection
The specific siRNA targeted
Sirt3
(Si‐
Sirt3
,
sc‐61556
) and control siRNA (Si‐control,
sc‐37007
) were purchased from
Santa Cruz
. For
in vitro
experiments,
(14)
TGR5 deficiency aggravates hepatic ischemic/reperfusion injury via inhibiting SIRT3/FOXO3/HIF-1ɑ pathway
Cell death discovery
November 1, 2020
Wang Q, Wei S, Li L, Qiu J, Zhou S, Shi C, Shi Y, Zhou H, Lu L.
with 10% fetal calf serum. The negative control (
sc-37007
) and specific siRNAs including SIRT3 siRNA (
sc-61556
), and HIF-1α siRNA (
sc-35562
) were purchased (
Santa Cruz Biotechnology
, CA, USA). BMDMs
transfection
(15)
SIRT3 Acts as a Positive Autophagy Regulator to Promote Lipid Mobilization in Adipocytes via Activating AMPK
International journal of molecular sciences
January 7, 2020
Zhang T, Liu J, Tong Q, Lin L.
weeks.
3T3-L1 cells
at 50% confluence were
transfected
with 4 µg
shRNA
(
shRNA
targeting
SIRT3
(
mouse
,
sc-61556
) or scrambled
shRNA
(
mouse
,
sc-108060
,
Santa Cruz Biotechnology
, Santa Cruz, CA, USA) for 6 h according
(16)
SIRT3 promotes lipophagy and chaperon-mediated autophagy to protect hepatocytes against lipotoxicity
Cell death and differentiation
January 1, 2020
Zhang T, Liu J, Shen S, Tong Q, Ma X, Lin L.
for 12 days. Medium was changed every other day.
RNA interference
The
shRNA
targeting
SIRT3
(
mouse
,
sc-61556
) and scrambled RNA (
mouse
,
sc-108060
), and
shRNA
transfection reagent
(
mouse
,
sc-108061
) were purchased
(17)
α-Mangostin remodels visceral adipose tissue inflammation to ameliorate age-related metabolic disorders in mice
Aging
December 6, 2019
Li D, Liu Q, Lu X, Li Z, Wang C, Leung CH, Wang Y, Peng C, Lin L.
(18)
Nicotinic ACh receptor α7 inhibits PDGF-induced migration of vascular smooth muscle cells by activating mitochondrial deacetylase sirtuin 3
British journal of pharmacology
November 1, 2019
Li DJ, Tong J, Zeng FY, Guo M, Li YH, Wang H, Wang P.
(19)
SIRT3 mediates hippocampal synaptic adaptations to intermittent fasting and ameliorates deficits in APP mutant mice
Nature communications
April 23, 2019
Liu Y, Cheng A, Li YJ, Yang Y, Kishimoto Y, Zhang S, Wang Y, Wan R, Raefsky SM, Lu D,
et al
.
(20)
Honokiol protects hepatocytes from oxidative injury through mitochondrial deacetylase SIRT3
European journal of pharmacology
September 5, 2018
Liu JX, Shen SN, Tong Q, Wang YT, Lin LG.
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SIRT3 siRNA (m) from Santa Cruz Biotechnology, Inc.
Supplier Page
View Company Product Page
$293.00
Product Specs
Company Info
Citations
Reviews
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