Cryopyrin siRNA (m) from Santa Cruz Biotechnology, Inc.

Product Specs
ItemCryopyrin siRNA (m)
CompanySanta Cruz Biotechnology, Inc.
Price $293.00Supplier Page View Company Product Page
Catalog Numbersc-45470
Gene NameNLR family, pyrin domain containing 3
Quantity10 µM
Speciesmouse
NCBI Full Gene NameNLR family, pyrin domain containing 3
NCBI Gene AliasesAGTAVPRL, AII/AVP, Cias1, FCAS, FCU, MWS, Mmig1, NALP3, Pypaf1
TypesiRNA/dsRNA

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Santa Cruz Biotechnology, Inc.

10410 Finnell Street

Dallas, Texas 75220

United States

Phone: 1-800-457-3801
831-457-3801

Company Profile

Website: http://www.scbt.com/

(1) GLUT9b- and ABCG2-mediated collecting duct urate transport uncovers a vasopressin-independent mechanism of renal water reabsorptionJ Clin InvestJune 16, 2026Mohamad Hadla, Jean Marc Mardirossian, Daniel G. Bichet, Abdul Hamid Borghol, Georges Abboud, Ahmad Ghanem, Eduardo Chini, Peter Harris, Vicente E. Torres, Seth L. Alper, et al.targeting mouse V2r (sc-40276), Slc2a9/Glut9 (sc-145451), Abcg2 (sc-37054), Panx1 (sc-61288), Nlrp3 (sc-45470), Slc14a2/UT-A (sc-45313), Prkaa1/Prkaa2 (sc-154952), or scrambled control (sc-37007) was performed

(2) Role of Dysregulated Autophagy in HIV Tat, Cocaine, and cART Mediated NLRP3 Activation in MicrogliaJournal of Neuroimmune PharmacologySeptember 1, 2023Seema Singh, Annadurai Thangaraj, Ernest T. Chivero, Ming-Lei Guo, Palsamy Periyasamy, Shilpa Buchpurchased from Life Technologies. Control siRNA (sc-37007), BECN1 siRNA (sc-29798), and NLRP3 siRNA (sc-45470) were purchased from Santa Cruz Biotechnology. Animals Doxycycline (Dox)-inducible HIV Tat transgenic

(3) miR-223 in exosomes from bone marrow mesenchymal stem cells ameliorates rheumatoid arthritis via downregulation of NLRP3 expression in macrophagesMolecular immunologyMarch 1, 2022Huang Y, Lu D, Ma W, Liu J, Ning Q, Tang F, Li L.

(4) Idebenone Regulates Aβ and LPS-Induced Neurogliosis and Cognitive Function Through Inhibition of NLRP3 Inflammasome/IL-1β Axis ActivationFrontiers in immunologyJanuary 1, 2022Lee HJ, Park JH, Hoe HS.

(5) Effects of the Cytoplasm and Mitochondrial Specific Hydroxyl Radical Scavengers TA293 and mitoTA293 in Bleomycin-Induced Pulmonary Fibrosis Model MiceAntioxidants (Basel, Switzerland)August 31, 2021Sakai T, Takagaki H, Yamagiwa N, Ui M, Hatta S, Imai J.

(6) Clinical severity of serum S100A12 levels in patients with osteoarthritis and S100A12 open inflammation of osteoarthritis model by NLRP3European Journal of InflammationJanuary 1, 2021Zhi Li, Weitao Zhai, Qinggang Sun, Shipeng Hu, Yinghui Ma, Bin Zhang5′-AGGGCT AAGATGAAGCCTGA-3′), siS100A12 (sc-43346, 3 Santa Cruz Biotechnology), S100A12+siNLRP3 (sc-45470, Santa Cruz Biotechnology), siS100A12 +NLRP3 (5′-GGCTTCGAATGTTGAGGTAAT G-3′), and negative mimics (5′-TTCTCCGAACGT GTCACGT-3′)

(7) Anthocyanins from Hibiscus syriacus L. Inhibit NLRP3 Inflammasome in BV2 Microglia Cells by Alleviating NF-κB- and ER Stress-Induced Ca²⁺ Accumulation and Mitochondrial ROS ProductionOxidative medicine and cellular longevityJanuary 1, 2021Molagoda IMN, Lee KT, Choi YH, Jayasingha JACC, Kim GY.small interfering RNA (siRNA) of CHOP (siCHOP, sc-35438, Santa Cruz Biotechnology) and NLRP3 (siNLRP3, sc-45470, Santa Cruz Biotechnology) using G-Fectin (Genolution Pharmaceuticals Inc., Seoul, Republic of Korea)

(8) PCSK9 regulates pyroptosis via mtDNA damage in chronic myocardial ischemiaBasic research in cardiologyNovember 12, 2020Wang X, Li X, Liu S, Brickell AN, Zhang J, Wu Z, Zhou S, Ding Z.

(9) NLRP3 inflammasome activation by Foot-and-mouth disease virus infection mainly induced by viral RNA and non-structural protein 2BRNA biologyMarch 1, 2020Zhi X, Zhang Y, Sun S, Zhang Z, Dong H, Luo X, Wei Y, Lu Z, Dou Y, Wu R, et al.

(10) Ventilator-induced lung injury is alleviated by inhibiting NLRP3 inflammasome activationMolecular immunologyJuly 1, 2019Liu H, Gu C, Liu M, Liu G, Wang D, Liu X, Wang Y.

(11) Deoxynivalenol enhances IL-1ß expression in BV2 microglial cells through activation of the NF-?B pathway and the ASC/NLRP3 inflammasomeEXCLI journalJanuary 1, 2019Molagoda IMN, Lee S, Jayasooriya RGPT, Jin CY, Choi YH, Kim GY.

(12) NLRP3 deficiency accelerates pressure overload-induced cardiac remodeling via increased TLR4 expressionJournal of molecular medicine (Berlin, Germany)November 1, 2018Li F, Zhang H, Yang L, Yong H, Qin Q, Tan M, Xu L, Liang K, Zong J, Qian W.

(13) A high concentration of DMSO activates caspase-1 by increasing the cell membrane permeability of potassiumCytotechnologyFebruary 1, 2018Xiang Y, Zhao MM, Sun S, Guo XL, Wang Q, Li SA, Lee WH, Zhang Y.manufacturer’s instructions (Peeters et al. 2013; Joshi et al. 2002). RNA interference siRNA targeting NLRP3 (sc-45470), NLRC4 (sc60329), ASC (sc-37282) and caspase-1 (sc-29922) were purchased from Santa Cruz Biotechnology

(14) The SGK1 inhibitor EMD638683, prevents Angiotensin II-induced cardiac inflammation and fibrosis by blocking NLRP3 inflammasome activationBiochimica et biophysica acta. Molecular basis of diseaseJanuary 1, 2018Gan W, Ren J, Li T, Lv S, Li C, Liu Z, Yang M.

(15) HIV-1 Tat Primes and Activates Microglial NLRP3 Inflammasome-Mediated NeuroinflammationThe Journal of NeuroscienceMarch 29, 2017Ernest T. Chivero, Ming-Lei Guo, Palsamy Periyasamy, Ke Liao, Shannon E. Callen, Shilpa Buch#A1978 known to activate NF-kB (signal 1) (Demarchi et al., 1996; DanRRID:AB_476692). Cryopyrin/NLRP3 siRNA (sc-45470) was from dekar et al., 2004; Fiume et al., 2012), we hypothesized that Tat Santa Cruz Biotechnology.

(16) Exposure to nickel oxide nanoparticles induces pulmonary inflammation through NLRP3 inflammasome activation in ratsInternational journal of nanomedicineJanuary 1, 2016Cao Z, Fang Y, Lu Y, Qian F, Ma Q, He M, Pi H, Yu Z, Zhou Z.in DMEM without penicillin/streptomycin. The cells were then transfected with 100 nmol/L Nlrp3 siRNA (sc-45470; Santa Cruz Biotechnology Inc., Dallas, TX, USA) or control nonspecific siRNA (sc-37007; Santa Cruz Biotechnology Inc

(17) TXNIP mediates NLRP3 inflammasome activation in cardiac microvascular endothelial cells as a novel mechanism in myocardial ischemia/reperfusion injuryBasic research in cardiologyJanuary 1, 2014Liu Y, Lian K, Zhang L, Wang R, Yi F, Gao C, Xin C, Zhu D, Li Y, Yan W, et al.

(18) Low-Salt Diet Reduces Anti-CTLA4 Mediated Systemic Immune-Related Adverse Events while Retaining Therapeutic Efficacy against Breast CancerBiologyJanuary 1, 0001"Khandekar D, Dahunsi DO, Manzanera Esteve IV, Reid S, Rathmell JC, Titze J, Tiriveedhi V."siRNA with a pool of 3 target-specific 19–25 nt siRNAs designed to knock down gene expression (Cat# sc-45470, final concentration, 25 nM, Santa Cruz Biotech, Dallas, TX, USA), or scrambled control siRNA (sc-37007)

(19) NET-Triggered NLRP3 Activation and IL18 Release Drive Oxaliplatin-Induced Peripheral NeuropathyCancer immunology researchJanuary 1, 0001"Lin T, Hu L, Hu F, Li K, Wang CY, Zong LJ, Zhao YQ, Zhang X, Li Y, Yang Y, et al."

(20) NLRP3 Inflammasome Blockade Reduces Cocaine-Induced Microglial Activation and NeuroinflammationMolecular neurobiologyJanuary 1, 0001"Chivero ET, Thangaraj A, Tripathi A, Periyasamy P, Guo ML, Buch S."(Santa Cruz Biotechnology; sc-2004); IL-1 beta (Abcam; ab9722); actin (Sigma-Aldrich; A1978). Cryopyrin/NLRP3 siRNA (sc-45470) was from Santa Cruz Biotechnology. MCC950/CP-456773 (Sigma; pz0280) was from Sigma-Aldrich. Cocaine

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