HIF-1α siRNA (r) from Santa Cruz Biotechnology, Inc.

Product Specs
ItemHIF-1α siRNA (r)
CompanySanta Cruz Biotechnology, Inc.
Price $293.00Supplier Page View Company Product Page
Catalog Numbersc-45919
Gene Namehypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)
Quantity10 µM
Speciesrat
NCBI Full Gene Namehypoxia inducible factor 1 subunit alpha, hypoxia inducible factor 1, alpha subunit
NCBI Gene AliasesHIF1-alpha, HIF1, MOP1, HIF-1-alpha, PASD8, HIF-1A, HIF1-ALPHA, HIF1alpha, bHLHe78, HIF-1alpha
TypesiRNA/dsRNA

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Santa Cruz Biotechnology, Inc.

10410 Finnell Street

Dallas, Texas 75220

United States

Phone: 1-800-457-3801
831-457-3801

Company Profile

Website: http://www.scbt.com/

(1) Cav3.2 T-Type calcium channels downregulation attenuates bone cancer pain induced by inhibiting IGF-1/HIF-1α signaling pathway in the rat spinal cordJournal of Bone OncologyOctober 1, 2023Qingying Liu, Zhongyuan Lu, Huan Ren, Lijun Fu, Yueliang Wang, Huilian Bu, Minyu Ma, Letian Ma, Chen Huang, Jian Wang, et al.administration Selective Cav3.2 siRNA (sc-61870, Santa Cruz Biotechnology), selective HIF-1α siRNA (sc-45919, Santa Cruz Biotechnology) and control siRNA (sc-37007, Santa Cruz Biotechnology) were purchased. These

(2) An Original Aspirin-Containing Carbonic Anhydrase 9 Inhibitor Overcomes Hypoxia-Induced Drug Resistance to Enhance the Efficacy of Myocardial ProtectionCardiovascular drugs and therapyAugust 1, 2022Zhou W, Zhang B, Fan K, Yin X, Liu J, Gou S.(Image-Pro Plus 6.0). 4.3 HIF-1α siRNA Transfection H9c2 cells were transfected with HIF-1α siRNA (sc-45919) (Santa Cruz, CA, USA) in 6-well plates using siRNA transfection reagent (sc-29528) (Santa Cruz). 1

(3) Insulin-like growth factor binding protein-1 regulates HIF-1α degradation to inhibit apoptosis in hypoxic cardiomyocytesCell death discoverySeptember 16, 2021Tang X, Jiang H, Lin P, Zhang Z, Chen M, Zhang Y, Mo J, Zhu Y, Liu N, Chen X.Anti-Bax antibodies for immunohistochemistry (Cell signaling) were utilized at 1:50. The HIF-1α siRNA (sc-45919) was obtained from Santa Cruz Biotechnology (Santa Cruz, CA, USA). The adenovirus and plasmids were

(4) miR-20b-5p attenuates hypoxia-induced apoptosis in cardiomyocytes via the HIF-1α/NF-κB pathwayActa biochimica et biophysica SinicaSeptember 8, 2020Zhou Z, Chen S, Tian Z, Deng S, Yi X, Yang S, Yang X, Jin L, Shi W.

(5) VASH-1 Regulates Oxidative Stress and Fibrosis in Diabetic Kidney Disease via SIRT1/HIF1α and TGFβ1/Smad3 Signaling PathwaysFrontiers in molecular biosciencesJanuary 1, 2020Ren H, Shao Y, Wu C, Lv C, Zhou Y, Wang Q.

(6) Oroxylin A increases the sensitivity of temozolomide on glioma cells by hypoxia-inducible factor 1α/hedgehog pathway under hypoxiaJournal of cellular physiologyAugust 1, 2019Wei M, Ma R, Huang S, Liao Y, Ding Y, Li Z, Guo Q, Tan R, Zhang L, Zhao L.

(7) Systems pharmacology dissection of the anti-stroke mechanism for the Chinese traditional medicine Xing-Nao-JingJournal of pharmacological sciencesJanuary 1, 2018Chen Y, Sun Y, Li W, Wei H, Long T, Li H, Xu Q, Liu W.

(8) Succinate accumulation impairs cardiac pyruvate dehydrogenase activity through GRP91-dependent and independent signaling pathways: Therapeutic effects of ginsenoside Rb1Biochimica et biophysica acta. Molecular basis of diseaseNovember 1, 2017Li J, Yang YL, Li LZ, Zhang L, Liu Q, Liu K, Li P, Liu B, Qi LW.

(9) Hypoxia-Inducible Factor-1α Mediates Increased Sympathoexcitation via Glutamatergic N-Methyl-d-Aspartate Receptors in the Paraventricular Nucleus of Rats With Chronic Heart FailureCirculation. Heart failureNovember 1, 2016Sharma NM, Cunningham CJ, Zheng H, Liu X, Patel KP.META confocal microscope (see Data Supplement for details). siRNA Knockdown of HIF-1α siRNA targeting HIF-1α (sc-45919), a negative control siRNA (sc-37007), was purchased from Santa Cruz Biotechnology, Inc. Transient transfection

(10) Mir-217 promotes inflammation and fibrosis in high glucose cultured rat glomerular mesangial cells via Sirt1/HIF-1α signaling pathwayDiabetes/metabolism research and reviewsSeptember 1, 2016Shao Y, Lv C, Wu C, Zhou Y, Wang Q.

(11) Nitric oxide from brain microvascular endothelial cells may initiate the compensatory response to mild hypoxia of astrocytes in a hypoxia-inducible factor-1α dependent mannerAmerican journal of translational researchJanuary 1, 2016Shi Q, Liu X, Wang N, Zheng X, Fu J, Zheng J.

(12) Brain protection against ischemic stroke using choline as a new molecular bypass treatmentActa pharmacologica SinicaDecember 1, 2015Jin X, Wang RH, Wang H, Long CL, Wang H.small-interfering-RNA (siRNA) targeting HIF-1α or an HIF-1α scrambled control and a transfection reagent (sc-45919, sc-37007 and sc-29528, Santa Cruz) according to the manufacturer’s instructions. The transfection efficiency

(13) Tetramethylpyrazine inhibits CoCl2 -induced neurotoxicity through enhancement of Nrf2/GCLc/GSH and suppression of HIF1α/NOX2/ROS pathwaysJournal of neurochemistryAugust 1, 2015Guan D, Su Y, Li Y, Wu C, Meng Y, Peng X, Cui Y.

(14) Energy Metabolism Disorder as a Contributing Factor of Rheumatoid Arthritis: A Comparative Proteomic and Metabolomic StudyPloS oneJanuary 1, 2015Yang XY, Zheng KD, Lin K, Zheng G, Zou H, Wang JM, Lin YY, Chuka CM, Ge RS, Zhai W, et al.the experiment. HIF-1α knock-down experiments were performed by transfecting HIF-1α specific siRNA (sc-45919, Santa-Cruz, USA) or nonspecific (NS) siRNA into FLS cells using Lipofectamine 2000 (Invitrogen, USA)

(15) HIF-1α signaling activation by post-ischemia treatment with astragaloside IV attenuates myocardial ischemia-reperfusion injuryPloS oneJanuary 1, 2014Si J, Wang N, Wang H, Xie J, Yang J, Yi H, Shi Z, Ma J, Wang W, Yang L, et al.

(16) Hypoxia-inducible factor-1alpha and MAPK co-regulate activation of hepatic stellate cells upon hypoxia stimulationPloS oneJanuary 1, 2013Wang Y, Huang Y, Guan F, Xiao Y, Deng J, Chen H, Chen X, Li J, Huang H, Shi C.6-well plates. Eighteen hours post-seeding, cells were transfected with 100nM siRNA specific to Hif-1α (sc-45919, Santa-Cruz, USA) or nonspecific (NS) siRNA using Lipofectamine 2000 (Invitrogen, USA) following manual

(17) N-acetylcysteine and allopurinol confer synergy in attenuating myocardial ischemia injury via restoring HIF-1α/HO-1 signaling in diabetic ratsPloS oneJanuary 1, 2013Mao X, Wang T, Liu Y, Irwin MG, Ou JS, Liao XL, Gao X, Xu Y, Ng KF, Vanhoutte PM, et al.

(18) Mipu1, a novel direct target gene, is involved in hypoxia inducible factor 1-mediated cytoprotectionPloS oneJanuary 1, 2013Wang K, Lei J, Zou J, Xiao H, Chen A, Liu X, Liu Y, Jiang L, Xiao Z, Xiao X.unique KpnⅠand EcoRⅠ of pcDNA3.1(+) vector as previously described [20]. The siRNA against to HIF-1α (sc-45919) and control siRNA (sc-37007) were purchased from Santa Cruz. Lipofectamine® 2000 and Lipofectamine®

(19) Regulation of S100A4 expression via the JAK2-STAT3 pathway in rhomboid-phenotype pulmonary arterial smooth muscle cells exposure to hypoxiaThe international journal of biochemistry & cell biologyAugust 1, 2012Liu T, Li Y, Lin K, Yin H, He B, Zheng M, Wang G.

(20) Pyruvate protects the brain against ischemia-reperfusion injury by activating the erythropoietin signaling pathwayStrokeApril 1, 2012Ryou MG, Liu R, Ren M, Sun J, Mallet RT, Yang SH.

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HIF-1α siRNA (r)

HIF-1α siRNA (r) from Santa Cruz Biotechnology, Inc.

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Santa Cruz Biotechnology, Inc.

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HIF-1α siRNA (r) from Santa Cruz Biotechnology, Inc.

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