AMPKα1/2 siRNA (m) from Santa Cruz Biotechnology, Inc.

Product Specs
ItemAMPKα1/2 siRNA (m)
CompanySanta Cruz Biotechnology, Inc.
Price $293.00Supplier Page View Company Product Page
Catalog Numbersc-45313
Gene Nameprotein kinase, AMP-activated, alpha 2 catalytic subunit
Quantity10 µM
Speciesmouse
NCBI Full Gene Nameprotein kinase, AMP-activated, alpha 1 catalytic subunit, protein kinase, AMP-activated, alpha 2 catalytic subunit
NCBI Gene Aliases2310008I11Rik, C130083N04Rik, AMPKalpha1, A830082D05, AMPKalpha2
TypesiRNA/dsRNA

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Santa Cruz Biotechnology, Inc.

10410 Finnell Street

Dallas, Texas 75220

United States

Phone: 1-800-457-3801
831-457-3801

Company Profile

Website: http://www.scbt.com/

(1) FGF4-FGFR1 signaling promotes podocyte survival and glomerular function to ameliorate diabetic kidney disease in male miceNature CommunicationsNovember 25, 2025Jie Zhou, Shuxin Wang, Jiaxin Lou, Beibin Pan, Min Zhao, Qian Li, Jing Zhou, Yali Du, Shuodan Ding, Meiling Yu, et al.with mouse Fgf4 siRNA (siFgf4; Cat. No. sc-39451; Santa Cruz), mouse Ampkα1/2 siRNA (siAmpk; Cat. No. sc-45313; Santa Cruz) and mouse Fgfr1 siRNA (siFgfr1; Cat. No. sc-29317; Santa Cruz) respectively. For control

(2) Tomatine Improves Glucose Metabolism and Mitochondrial Respiration in Insulin-Resistant Hepatocyte Cell Lines AML12 and HepG2 via an AMP-Activated Protein Kinase-Dependent PathwayCellsFebruary 23, 2025Yu Geon Lee, Donghwan KimSanta Cruz Biotechnology), human AMPK1/2-targeting siRNA (siAMPK, #sc-45312, Santa Cruz Biotechnology), or mouse siAMPK (#sc-45313, Santa Cruz Biotechnology) to knock down AMPK expression. siRNAs were transfected at a final concentration

(3) Unexpected roles for AMPK in the suppression of autophagy and the reactivation of MTORC1 signaling during prolonged amino acid deprivationAutophagySeptember 1, 2024Dubek Kazyken, Sydney G. Dame, Claudia Wang, Maxwell Wadley, Diane C. FingarBiotechnology, sc -37,007) or Prkaa1/AMPKα1- and Prkaa2/AMPKα2-specific siRNAs (Santa Cruz Biotechnology; sc45313) (10 nM). C2C12 cells on 6-well plates were transiently transfected with RNAiMAX (Invitrogen; 13778–150)

(4) Extracellular macrophage migration inhibitory factor (MIF) downregulates adipose hormone-sensitive lipase (HSL) and contributes to obesityMolecular MetabolismJanuary 1, 2024Liujun Chen, Lisha Li, Donghong Cui, Yiheng Huang, Haibin Tong, Haleh Zabihi, Shuxia Wang, Yadan Qi, Ted Lakowski, Lin Leng, et al.(cultured in 12-well plates), 1 nM of Mif siRNA (Mif siRNA, N405895, ThermoFisher) or AMPK Alpha 1/2 siRNA (sc-45313, Santa Cruz) or non-silencing control siRNA (AM4611, ThermoFisher) was transfected into the cells by

(5) A pref-1-controlled non-inflammatory mechanism of insulin resistanceiScienceJune 16, 2023Huang Y, Cui D, Chen L, Tong H, Wu H, Muller GK, Qi Y, Wang S, Xu J, Gao X, et al.Silencer™ Negative Control No. 1 siRNA,Invitrogen,AM4611 Par2 siRNA,Invitrogen,s65793 AMPK alpha 1/2 siRNA (m),Santa Cruz Biotechnology,sc-45313 See Tables S1 and S2 for primer sequences,This paper,N/A ,, Software and algorithms,Software and

(6) Sulforaphane induces lipophagy through the activation of AMPK-mTOR-ULK1 pathway signaling in adipocytesThe Journal of nutritional biochemistryAugust 1, 2022Masuda M, Yoshida-Shimizu R, Mori Y, Ohnishi K, Adachi Y, Sakai M, Kabutoya S, Ohminami H, Yamanaka-Okumura H, Yamamoto H, et al.SASI_Mm01_00089197; Sigma-Aldrich) and negative control (SIC001; Sigma-Aldrich) or against AMPKα1/2 (sc-45313; Santa Cruz Biotechnology) and negative control (sc-37007; Santa Cruz Biotechnology) using Lipofectamine

(7) ∆nFGF1 Protects β-Cells against High Glucose-Induced Apoptosis via the AMPK/SIRT1/PGC-1α AxisOxidative medicine and cellular longevityJanuary 1, 2022Chen Q, Chen X, Jia Z, Du Y, Zhang S, Xu W, Pan B, Lou J, Zhou J, Zhou J, et al.with the manufacturer's instructions. A 24 h transfection of AMPK siRNA (Santa Cruz Biotechnology, sc45313) was followed by starvation and treatment as described above. 2.2. Cell Counting Kit-8 Assay MIN6

(8) GDF15 mediates the metabolic effects of PPARβ/δ by activating AMPKCell reportsAugust 10, 2021Aguilar-Recarte D, Barroso E, Gumà A, Pizarro-Delgado J, Peña L, Ruart M, Palomer X, Wahli W, Vázquez-Carrera M.

(9) Gut-liver axis modulation of Panax notoginseng saponins in nonalcoholic fatty liver diseaseHepatology internationalApril 1, 2021Xu Y, Wang N, Tan HY, Li S, Zhang C, Feng Y.

(10) Dictyostelium Differentiation-Inducing Factor-1 Promotes Glucose Uptake, at Least in Part, via an AMPK-Dependent Pathway in Mouse 3T3-L1 CellsInternational journal of molecular sciencesFebruary 25, 2021Kubohara Y, Homma Y, Shibata H, Oshima Y, Kikuchi H.(BCIP) were purchased from Promega (Madison, WI, USA). The small interfering RNA (siRNA) for AMPKα1/2 (sc-45313) was obtained from Santa Cruz Biotechnology Inc. (Dallas, TX, USA). Int. J. Mol. Sci. 2021, 22,

(11) Lipid Extract From a Vegetable (Sonchus Oleraceus) Attenuates Adipogenesis and High Fat Diet-Induced Obesity Associated With AMPK ActivationFrontiers in nutritionJanuary 1, 2021Chen CY, Su CW, Li X, Liu Y, Pan Q, Cao T, Kang JX.

(12) Elevation of JAML Promotes Diabetic Kidney Disease by Modulating Podocyte Lipid MetabolismCell metabolismDecember 1, 2020Fu Y, Sun Y, Wang M, Hou Y, Huang W, Zhou D, Wang Z, Yang S, Tang W, Zhen J, et al.

(13) AMP-activated protein kinase contributes to cisplatin-induced renal epithelial cell apoptosis and acute kidney injuryAmerican journal of physiology. Renal physiologyDecember 1, 2020Jin X, An C, Jiao B, Safirstein RL, Wang Y.

(14) Interleukin-6 confers radio-resistance by inducing Akt-mediated glycolysis and reducing mitochondrial damage in cellsJournal of biochemistryMarch 1, 2020Kumari N, Das A, Bhatt AN.

(15) Astaxanthin stimulates mitochondrial biogenesis in insulin resistant muscle via activation of AMPK pathwayJournal of cachexia, sarcopenia and muscleFebruary 1, 2020Nishida Y, Nawaz A, Kado T, Takikawa A, Igarashi Y, Onogi Y, Wada T, Sasaoka T, Yamamoto S, Sasahara M, et al.C2C12 cells were cultured with small interfering RNA (siRNA) duplexes specific for mouse AMPKα1/2 (sc‐45313, Santa Cruz Biotechnology) or non‐target control (NTC) siRNA (sc‐36869, Santa Cruz Biotechnology) using

(16) Inhibition of Mitochondrial Calcium Overload by SIRT3 Prevents Obesity- or Age-Related Whitening of Brown Adipose TissueDiabetesFebruary 1, 2020Gao P, Jiang Y, Wu H, Sun F, Li Y, He H, Wang B, Lu Z, Hu Y, Wei X, et al.of Lipofectamine 3000 was 3.75 mL. Mouse siRNAs against Sirt3 (sc-61556), Mcu (sc-142052), AMPKa1/2 (sc45313), Pgc-1a (sc-38885), and negative control siRNA were purchased from Santa Cruz Biotechnology. The fulllength

(17) Panax notoginseng saponins modulate the gut microbiota to promote thermogenesis and beige adipocyte reconstruction via leptin-mediated AMPKα/STAT3 signaling in diet-induced obesityTheranosticsJanuary 1, 2020Xu Y, Wang N, Tan HY, Li S, Zhang C, Zhang Z, Feng Y.beige differentiation) were transfected with a mouse siRNA targeting STAT 3 (SC-29494) or AMPKα1/2 (sc-45313) or control siRNA (sc-37007) purchased from Santa Cruz Biotechnology (Reston, VA, USA) according to

(18) Suppression of AMP-activated protein kinase reverses osteoprotegerin-induced inhibition of osteoclast differentiation by reducing autophagyCell proliferationJanuary 1, 2020Tong X, Zhang C, Wang D, Song R, Ma Y, Cao Y, Zhao H, Bian J, Gu J, Liu Z.monoclonal anti‐NFATc1 (sc‐7294) and CTSK (sc‐7294) antibodies, control siRNA (sc‐37007) and AMPKα1/2 siRNA (sc‐45313) were obtained from Santa Cruz Biotechnology. Com C (P5499), AICAR (Acadesine/AICA riboside, ab120358)

(19) Treatment with a Combination of Metformin and 2-Deoxyglucose Upregulates Thrombospondin-1 in Microvascular Endothelial Cells: Implications in Anti-Angiogenic Cancer TherapyCancersNovember 6, 2019Mathews Samuel S, Satheesh NJ, Ghosh S, Büsselberg D, Majeed Y, Ding H, Triggle CR.attain 40–50% confluency at the time of transfection. AMPK gene silencing using AMPKα1/2 siRNA (Cat # sc45313; Santa Cruz Biotechnology, Inc., Dallas, TX, USA) was performed as previously described [16]. Scrambled siRNA

(20) Myricanol modulates skeletal muscle-adipose tissue crosstalk to alleviate high-fat diet-induced obesity and insulin resistanceBritish journal of pharmacologyOctober 1, 2019Shen S, Liao Q, Zhang T, Pan R, Lin L.

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AMPKα1/2 siRNA (m)

AMPKα1/2 siRNA (m) from Santa Cruz Biotechnology, Inc.

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Santa Cruz Biotechnology, Inc.

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AMPKα1/2 siRNA (m) from Santa Cruz Biotechnology, Inc.

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