Stat3 siRNA (h) from Santa Cruz Biotechnology, Inc.

Product Specs
ItemStat3 siRNA (h)
CompanySanta Cruz Biotechnology, Inc.
Price $293.00Supplier Page View Company Product Page
Catalog Numbersc-29493
Gene Namesignal transducer and activator of transcription 3 (acute-phase response factor)
Quantity10 µM
Specieshuman
NCBI Full Gene Namesignal transducer and activator of transcription 3
NCBI Gene AliasesADMIO, ADMIO1, APRF, HIES
TypesiRNA/dsRNA

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Santa Cruz Biotechnology, Inc.

10410 Finnell Street

Dallas, Texas 75220

United States

Phone: 1-800-457-3801
831-457-3801

Company Profile

Website: http://www.scbt.com/

(1) The Mitigating Effect and Mechanism of Polydeoxyribonucleotide Against Zoledronic Acid-Induced Growth Suppression of Human Gingival FibroblastsInternational Journal of Molecular SciencesNovember 24, 2025Shailashree Pachhapure, Young-Min Shin, Duk Gyu Kim, Dong-Rak Choi, Jong-IL Yun, Jae-Hong Kim, Byeong-Churl JangNJ, USA). Control siRNA (cat. no. sc-37007), TBK1 siRNA (cat. no. sc-39058), STAT-3 siRNA (cat. no. sc-29493), PKB siRNA (cat. no. sc-29195) were obtained from Santa Cruz Biotechnology (Dallas, TX, USA). N-acetyl-L-cysteine

(2) STAT3 regulates basal cell identity and morphogenesis during early esophageal developmentbioRxiv : the preprint server for biologyAugust 1, 2025Kariuki SW, Mitani Y, Bailey DD, Efe G, Tripathi VV, Tekin H, Suzuki K, Que J, Gabre J, Cruz-Acuña R.days and cultured at normoxic conditions (21% O2; 5% CO2). STAT3 inhibition STAT3 siRNA (Santa Cruz, sc-29493) or control siRNA (MilliporeSigma, SIC003) was delivered at 10 μM using Lipofectamine RNAiMAX (Invitrogen,

(3) Apelin facilitates integrin αvβ3 production and enhances metastasis in prostate cancer by activating STAT3 and inhibiting miR-8070International Journal of Biological SciencesJune 12, 2025Tien-Huang Lin, Shan-Chi Liu, Yuan-Li Huang, Chao-Yang Lai, Xiu-Yuan He, Chun-Hao Tsai, Yi-Chin Fong, Hsi-Chin Wu, An-Chen Chang, Yen-You Lin, et al.(SC-7383) and integrin αvβ3 (SC-7312) antibodies as well as JNK (sc-29380), p38 (sc-29433), STAT3 (sc-29493), integrin αv (sc-29373), integrin β3 (sc-29375) and apelin (sc-44741) siRNA were purchased from Santa Cruz Biotechnology

(4) Defining Mechanistic Links Between the Non-Coding Variant rs17673553 in CLEC16A and Lupus SusceptibilityInt J Mol SciJanuary 1, 2025Harikrishna Reddy Rallabandi, Manish Kumar Singh, Loren L. Looger, Swapan K. Nathgenes, siRNA was used. Briefly, 10 µM working concentrations were prepared of siRNAs targeting STAT3 (sc-29493) and GATA3 (sc-29331; Santa Cruz Biotechnology: Dallas, TX, USA) per manufacturer instructions. siRNA

(5) NFE2L2 and STAT3 Converge on Common Targets to Promote Survival of Primary Lymphoma CellsInternational journal of molecular sciencesJuly 18, 2023Arena A, Di Crosta M, Gonnella R, Zarrella R, Romeo MA, Benedetti R, Gilardini Montani MS, Santarelli R, D'Orazi G, Cirone M.Santa Cruz Biotechnology Inc., Dallas, TX, USA, sc-29226), STAT3-siRNA (siSTAT3, Santa Cruz Biotechnology Inc., Dallas, TX, USA, sc-29493), and p62/SQSTM1-siRNA (sip62/SQSTM1, Santa Cruz Biotechnology Inc., Dallas, TX, USA, sc-29679). Control siRNA-A

(6) Matrix Metalloproteinase 9 Induced in Esophageal Squamous Cell Carcinoma Cells via Close Contact with Tumor-Associated Macrophages Contributes to Cancer Progression and Poor PrognosisCancersMay 30, 2023Tsukamoto S, Koma YI, Kitamura Y, Tanigawa K, Azumi Y, Miyako S, Urakami S, Hosono M, Kodama T, Nishio M, et al.experiment, siRNA was used to knock down the expression of STAT3 mRNA in ESCC cells. Specifically, si-STAT3 (sc-29493, Santa Cruz Biotechnology, Dallas, TX, USA) was used as the specific siRNA targeting STAT3 mRNA, while

(7) STAT3 is Activated by CTGF-mediated Tumor-stroma Cross Talk to Promote HCC ProgressionCellular and molecular gastroenterology and hepatologyJanuary 1, 2023Makino Y, Hikita H, Kato S, Sugiyama M, Shigekawa M, Sakamoto T, Sasaki Y, Murai K, Sakane S, Kodama T, et al.

(8) Advanced Glycation End Products-Induced Activation of Keratinocytes: A Mechanism Underlying Cutaneous Immune Response in PsoriasisJournal of innate immunityJanuary 1, 2023Kang P, Chen J, Wang S, Zhang S, Li S, Guo S, Song P, Liu L, Wang G, Gao T, et al.(siRNA) targeting STAT1 (STAT1 siRNA) (sc-44123, Santa Cruz Biotechnology, USA), STAT3 (STAT3 siRNA) (sc-29493, Santa Cruz Biotechnology, USA), or RAGE (RAGE siRNA) (sc-36374, Santa Cruz Biotechnology, USA) were

(9) EGFR ligand shifts the role of EGFR from oncogene to tumour suppressor in EGFR-amplified glioblastoma by suppressing invasion through BIN3 upregulationNature cell biologyAugust 1, 2022Guo G, Gong K, Beckley N, Zhang Y, Yang X, Chkheidze R, Hatanpaa KJ, Garzon-Muvdi T, Koduru P, Nayab A, et al.(sc-77692), HB-EGF (sc-39420), EGFR (sc-29301), DOCK7 (sc-105312), RhoA (sc-29471), Cdc42 (sc-29256), STAT3 (sc-29493), Shc (sc-29480), ERK1(sc-29307), ERK2 (sc-35335), Sp1 (sc-29487), TAB1(sc-61851), TAK1(sc-36606) and

(10) Alcohol and HIV-Derived Hepatocyte Apoptotic Bodies Induce Hepatic Stellate Cell ActivationBiologyJuly 14, 2022New-Aaron M, Dagur RS, Koganti SS, Ganesan M, Wang W, Makarov E, Ogunnaike M, Kharbanda KK, Poluektova LY, Osna NA.Transfection of LX2 Cells Inhibition of STAT3 expression in LX2 cells was achieved by STAT3 siRNA (sc-29493, Santa Cruz, Dallas, TX, USA) transfection according to the manufacturer’s instructions. The siRNA transfection efficiency

(11) Growth-Suppressive and Apoptosis-Inducing Effects of Tetrandrine in SW872 Human Malignant Liposarcoma Cells via Activation of Caspase-9, Down-Regulation of XIAP and STAT-3, and ER StressBiomoleculesJune 17, 2022Samsuzzaman M, Jang BC.

(12) Anti-Growth, Anti-Angiogenic, and Pro-Apoptotic Effects by CX-4945, an Inhibitor of Casein Kinase 2, on HuCCT-1 Human Cholangiocarcinoma Cells via Control of Caspase-9/3, DR-4, STAT-3/STAT-5, Mcl-1, eIF-2α, and HIF-1αInternational journal of molecular sciencesJune 6, 2022Wang S, Yadav AK, Han JY, Ahn KS, Jang BC.sc-37007), CK2α siRNA (cat. no. sc-29918), HIF-1α siRNA (cat. no. sc-35561), STAT-3 siRNA (cat. no. sc-29493), and STAT-5 siRNA (cat. no. sc-29495) were purchased from Santa Cruz Biotechnology (Delaware, CA, USA).

(13) p52 signaling promotes cellular senescenceCell & bioscienceApril 4, 2022Bernal GM, Wu L, Voce DJ, Weichselbaum RR, Yamini B.

(14) STAT3 is required for Smo-dependent signaling and mediates Smo-targeted treatment resistance and tumorigenesis in Shh medulloblastomaMolecular oncologyFebruary 1, 2022Yuan L, Zhang H, Liu J, Malhotra A, Dey A, Yu B, Jella KK, McSwain LF, Schniederjan MJ, MacDonald TJ.Frozen the stable cells for further experiments. 2.8.2 STAT3 knockdown cells STAT3 shRNA plasmid (h) (#sc‐29493) and control shRNA(#sc‐108080) were purchased from Santa Cruz Biotechnology. Puromycin was used to select

(15) Formononetin represses cervical tumorigenesis by interfering with the activation of PD-L1 through MYC and STAT3 downregulationThe Journal of nutritional biochemistryFebruary 1, 2022Wang JY, Jiang MW, Li MY, Zhang ZH, Xing Y, Ri M, Jin CH, Xu GH, Piao LX, Jin HL, et al.

(16) Digitoxin promotes apoptosis and inhibits proliferation and migration by reducing HIF-1α and STAT3 in KRAS mutant human colon cancer cellsChemico-biological interactionsJanuary 5, 2022Mi C, Cao X, Ma K, Wei M, Xu W, Lin Y, Zhang J, Wang TY.

(17) Targeting STAT3 prevents bile reflux-induced oncogenic molecular events linked to hypopharyngeal carcinogenesisJournal of cellular and molecular medicineJanuary 1, 2022Vageli DP, Doukas PG, Siametis A, Judson BL.0.05% trypsin‐EDTA (Gibco®). 2.2 STAT3 knockdown To knockdown STAT3, STAT3 siRNA (STAT3 siRNA(h); sc‐29493, Santa Cruz Biotechnology Inc.) and Control siRNA, as a negative control (Control siRNA‐A; sc‐37007,

(18) Sphingosine kinase 1 regulates lysyl oxidase through STAT3 in hyperoxia-mediated neonatal lung injuryThoraxJanuary 1, 2022Ha AW, Bai T, Ebenezer DL, Sethi T, Sudhadevi T, Mangio LA, Garzon S, Pryhuber GS, Natarajan V, Harijith A.Santa Cruz Biotechnology). The following siRNAs from Santa Cruz Biotechnology were used: STAT3 siRNA (sc-29493), SPNS2 siRNA (sc-106749), S1P1 siRNA (sc-37086), Control siRNA (sc-37007) and SPHK1 siRNA (sc-36494).

(19) Salvianolic acid B targets mortalin and inhibits the migration and invasion of hepatocellular carcinoma via the RECK/STAT3 pathwayCancer cell internationalDecember 7, 2021Teng M, Hu C, Yang B, Xiao W, Zhou Q, Li Y, Li Z.

(20) PERK signaling through C/EBPδ contributes to ER stress-induced expression of immunomodulatory and tumor promoting chemokines by cancer cellsCell death & diseaseNovember 1, 2021Sheshadri N, Poria DK, Sharan S, Hu Y, Yan C, Koparde VN, Balamurugan K, Sterneck E.ATF6A/ATF6α (sc-37699), ERN1/IRE1α (sc-40705), EIF2AK3/PERK (sc-36213), NRF2 (sc-37030) and STAT3 (sc-29493) were purchased from Santa Cruz Biotechnology. RNA isolation and qRT-PCR RNA was isolated using GeneJET RNA purification kit

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Stat3 siRNA (h)

Stat3 siRNA (h) from Santa Cruz Biotechnology, Inc.

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Santa Cruz Biotechnology, Inc.

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Stat3 siRNA (h) from Santa Cruz Biotechnology, Inc.

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