Thrombin R siRNA (h) from Santa Cruz Biotechnology, Inc.

Product Specs
ItemThrombin R siRNA (h)
CompanySanta Cruz Biotechnology, Inc.
Price $293.00Supplier Page View Company Product Page
Catalog Numbersc-36663
Gene Namecoagulation factor II (thrombin) receptor
Quantity10 µM
Specieshuman
NCBI Full Gene Namecoagulation factor II thrombin receptor
NCBI Gene AliasesCF2R, HTR, PAR-1, PAR1, TR
TypesiRNA/dsRNA

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Santa Cruz Biotechnology, Inc.

10410 Finnell Street

Dallas, Texas 75220

United States

Phone: 1-800-457-3801
831-457-3801

Company Profile

Website: http://www.scbt.com/

(1) Organic dust induces inflammatory gene expression in lung epithelial cells via ROS-dependent STAT-3 activationAmerican journal of physiology. Lung cellular and molecular physiologyJuly 1, 2019Natarajan K, Meganathan V, Mitchell C, Boggaram V.for human STAT-3 (sc-29493), EGFR (sc-29301), TYK2 (sc-36764), protease-activated receptor 1 (PAR-1; sc-36663), and PAR-2 (sc-36188) were obtained from Santa Cruz Biotechnology and dissolved in autoclaved water. Dust

(2) PAR-1 is a novel mechano-sensor transducing laminar flow-mediated endothelial signalingScientific reportsOctober 11, 2018Kim S, Han JH, Nam DH, Kim GY, Lim JH, Kim JR, Woo CH.from Gibco. Small interfering RNA against human PAR-1 was purchased from Santa Cruz Biotechnology (sc-36663, Santa Cruz, CA, USA). For PAR-1 silencing, HUVECs were transiently transfected with 100 pmol/L of control

(3) Proteases and oxidant stress control organic dust induction of inflammatory gene expression in lung epithelial cellsRespiratory researchOctober 22, 2016Natarajan K, Gottipati KR, Berhane K, Samten B, Pendurthi U, Boggaram V.

(4) Trefoil factor 3 (TFF3) from human breast milk activates PAR-2 receptors, of the intestinal epithelial cells HT-29, regulating cytokines and defensinsBratislava Medical JournalAugust 23, 2016G. J. Barrera, G. Sanchez TortoleroAssay siRNAs targeting PAR-2 and PAR-1 were from Santa Cruz Biotechnology (cat. No. sc-36188, and cat. No. sc-36663). HT29 cells were cultured at 250,000 cells/ml in DMEM with 10 % FBS in 25 cm2 Falcon culture flask,

(5) Silencing of protease-activated receptors attenuates synovitis and cartilage damage following a joint bleed in haemophilic miceHaemophilia : the official journal of the World Federation of HemophiliaJanuary 1, 2016Nieuwenhuizen L, Schutgens RE, Coeleveld K, Mastbergen SC, Schiffelers RM, Roosendaal G, Biesma DH, Lafeber FP.

(6) Proteases in agricultural dust induce lung inflammation through PAR-1 and PAR-2 activationAmerican journal of physiology. Lung cellular and molecular physiologyAugust 15, 2015Romberger DJ, Heires AJ, Nordgren TM, Souder CP, West W, Liu XD, Poole JA, Toews ML, Wyatt TA.

(7) Thrombin receptor PAR-1 activation on endothelial progenitor cells enhances chemotaxis-associated genes expression and leukocyte recruitment by a COX-2-dependent mechanismAngiogenesisJuly 1, 2015d'Audigier C, Cochain C, Rossi E, Guérin CL, Bièche I, Blandinières A, Marsac B, Silvestre JS, Gaussem P, Smadja DM.

(8) Neutrophil proteinase 3 acts on protease-activated receptor-2 to enhance vascular endothelial cell barrier functionArteriosclerosis, thrombosis, and vascular biologyFebruary 1, 2013Kuckleburg CJ, Newman PJ.of siRNA Human umbilical vein endothelial cells were transfected with siRNA for PAR-1 (100 nmol/L, sc-36663), PAR-2 (100 nmol/L, sc-36188), or control siRNA (Santa Cruz Biotechnologies, Santa Cruz, CA) using

(9) Matrix metalloproteinase-1-mediated up-regulation of vascular endothelial growth factor-2 in endothelial cellsThe Journal of biological chemistryJanuary 4, 2013Mazor R, Alsaigh T, Shaked H, Altshuler AE, Pocock ES, Kistler EB, Karin M, Schmid-Schönbein GW.

(10) Thrombin induces heme oxygenase-1 expression in human synovial fibroblasts through protease-activated receptor signaling pathwaysArthritis research & therapyApril 27, 2012Liu JF, Hou SM, Tsai CH, Huang CY, Yang WH, Tang CH.

(11) Interleukin 8 is differently expressed and modulated by PAR-1 activation in early and late endothelial progenitor cellsJournal of cellular and molecular medicineAugust 1, 2009Smadja DM, Bièche I, Susen S, Mauge L, Laurendeau I, d'Audigier C, Grelac F, Emmerich J, Aiach M, Gaussem P.

(12) Modulation of tissue factor and tissue factor pathway inhibitor-1 by neutrophil proteasesThrombosis and haemostasisDecember 1, 2008Steppich BA, Seitz I, Busch G, Stein A, Ott I.

(13) Dual regulation of interleukin-8 production in human oral epithelial cells upon stimulation with gingipains from Porphyromonas gingivalisJournal of medical microbiologyApril 1, 2008Uehara A, Naito M, Imamura T, Potempa J, Travis J, Nakayama K, Takada H.

(14) Double transfection improves small interfering RNA-induced thrombin receptor (PAR-1) gene silencing in DU 145 prostate cancer cellsFEBS lettersNovember 5, 2004Liu J, Schuff-Werner P, Steiner M.

(15) Hyaluronic Acid binding protein 2 is a novel regulator of vascular integrity"Arteriosclerosis, thrombosis, and vascular biology"January 1, 0001"Mambetsariev N, Mirzapoiazova T, Mambetsariev B, Sammani S, Lennon FE, Garcia JG, Singleton PA."

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