karyopherin β1 siRNA (h) from Santa Cruz Biotechnology, Inc.

Product Specs
Itemkaryopherin β1 siRNA (h)
CompanySanta Cruz Biotechnology, Inc.
Price $293.00Supplier Page View Company Product Page
Catalog Numbersc-35736
Gene Namekaryopherin (importin) beta 1
Quantity10 µM
Specieshuman
NCBI Full Gene Namekaryopherin subunit beta 1
NCBI Gene AliasesIMB1, IPO1, IPOB, Impnb, NTF97
TypesiRNA/dsRNA

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Santa Cruz Biotechnology, Inc.

10410 Finnell Street

Dallas, Texas 75220

United States

Phone: 1-800-457-3801
831-457-3801

Company Profile

Website: http://www.scbt.com/

(1) Inhibition of Karyopherin β1-Mediated Nuclear Import Disrupts Oncogenic Lineage-Defining Transcription Factor Activity in Small Cell Lung CancerCancer researchSeptember 2, 2022Kelenis DP, Rodarte KE, Kollipara RK, Pozo K, Choudhuri SP, Spainhower KB, Wait SJ, Stastny V, Oliver TG, Johnson JE.#31985062). siRNAs used were: Control siRNA-A (Santa Cruz #sc-37007), Karyopherin β1 siRNA(h) (Santa Cruz #sc-35736), and ASCL1 siRNA (ThermoFisher #HSS100744). For rescue experiments, ResKPNB1 vs. Vector Control expression

(2) Inhibition of Kpnβ1 mediated nuclear import enhances cisplatin chemosensitivity in cervical cancerBMC cancerFebruary 2, 2021Chi RA, van der Watt P, Wei W, Birrer MJ, Leaner VD.

(3) A new transcription factor ATG10S activates IFNL2 transcription by binding at an IRF1 site in HepG2 cellsAutophagyDecember 1, 2020Zhang MQ, Zhao Q, Zhang JP.

(4) Characterization of the nuclear import pathway for BLM proteinArchives of biochemistry and biophysicsNovember 15, 2017Duan Z, Zhao J, Xu H, Xu H, Ji X, Chen X, Xiong J.

(5) KPNB1-mediated nuclear import is required for motility and inflammatory transcription factor activity in cervical cancer cellsOncotargetMay 16, 2017Stelma T, Leaner VD.RNA interference & drug treatment Short-interfering RNA (siRNA) was used to inhibit KPNB1 gene expression (sc-35736, Santa Cruz Biotechnology, USA). Control siRNA (SIC001, Sigma-Aldrich, USA) consisting of a scrambled

(6) Targeting the Nuclear Import Receptor Kpnβ1 as an Anticancer TherapeuticMolecular cancer therapeuticsApril 1, 2016van der Watt PJ, Chi A, Stelma T, Stowell C, Strydom E, Carden S, Angus L, Hadley K, Lang D, Wei W, et al.

(7) Inhibition of the nuclear transporter, Kpnβ1, results in prolonged mitotic arrest and activation of the intrinsic apoptotic pathway in cervical cancer cellsCarcinogenesisMay 1, 2014Angus L, van der Watt PJ, Leaner VD.

(8) Down-modulation of nucleoporin RanBP2/Nup358 impaired chromosomal alignment and induced mitotic catastropheCell death & diseaseOctober 10, 2013Hashizume C, Kobayashi A, Wong RW.5′-CCGUUUUGGUGAGUCAACAtt-3′, siRNA ID s11773, cat no. 4390824) were purchased from Life Technologies Corporation. Importin β1 (sc-35736) and control siRNAs (sc-37007) were purchased from Santa Cruz Biotechnology (Dallas, TX, USA). Another

(9) Proteomic and functional analyses of protein-DNA complexes during gene transferMolecular therapy : the journal of the American Society of Gene TherapyApril 1, 2013Badding MA, Lapek JD, Friedman AE, Dean DA.

(10) Stress-induced nuclear import of apoptosis signal-regulating kinase 1 is mediated by karyopherin α2/β1 heterodimerBiochimica et biophysica actaMarch 1, 2013Sturchler E, Feurstein D, Chen W, McDonald P, Duckett D.

(11) Importin β1 protein-mediated nuclear localization of death receptor 5 (DR5) limits DR5/tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL)-induced cell death of human tumor cellsThe Journal of biological chemistryDecember 16, 2011Kojima Y, Nakayama M, Nishina T, Nakano H, Koyanagi M, Takeda K, Okumura K, Yagita H.

(12) Regulation of cell proliferation by the opioid growth factor receptor is dependent on karyopherin beta and Ran for nucleocytoplasmic traffickingExperimental biology and medicine (Maywood, N.J.)September 1, 2010Cheng F, McLaughlin PJ, Zagon IS.

(13) The Karyopherin proteins, Crm1 and Karyopherin beta1, are overexpressed in cervical cancer and are critical for cancer cell survival and proliferationInternational journal of cancerApril 15, 2009van der Watt PJ, Maske CP, Hendricks DT, Parker MI, Denny L, Govender D, Birrer MJ, Leaner VD.inhibition of gene expression, short-interfering RNA (siRNA) was used [Crm1 siRNA (sc-35116), Kpnβ1 siRNA (sc-35736) and Kpnα2 siRNA (sc-35741), Santa Cruz Biotechnology]. siRNA consisting of a scrambled sequence (sc-37007,

(14) Heterodimerization with Jun family members regulates c-Fos nucleocytoplasmic trafficThe Journal of biological chemistryOctober 19, 2007Malnou CE, Salem T, Brockly F, Wodrich H, Piechaczyk M, Jariel-Encontre I.

(15) Importin-mediated nuclear translocation of galectin-3The Journal of biological chemistryDecember 22, 2006Nakahara S, Hogan V, Inohara H, Raz A.

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