HSP 90α/β siRNA (h) from Santa Cruz Biotechnology, Inc.

Product Specs
ItemHSP 90α/β siRNA (h)
CompanySanta Cruz Biotechnology, Inc.
Price $293.00Supplier Page View Company Product Page
Catalog Numbersc-35608
Gene Nameheat shock protein 90kDa alpha (cytosolic), class A member 1
Quantity10 µM
Specieshuman
NCBI Full Gene Nameheat shock protein 90 alpha family class B member 1, heat shock protein 90 beta family member 1, heat shock protein 90 alpha family class A member 1
NCBI Gene AliasesEL52, HSPC1, LAP-2, D6S182, LAP2, GP96, GRP94, TRA1, HSP90B, HEL35, HSPN, HSPC2, HSP84, HSP86, Hsp89, Hsp90, HSPCB, HEL-S-65p, HEL-S-125m, HSP90N, HSPCAL1, HSP90A, HSPCAL4, HSP89A, HSPCA, Hsp103, ECGP
TypesiRNA/dsRNA

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Santa Cruz Biotechnology, Inc.

10410 Finnell Street

Dallas, Texas 75220

United States

Phone: 1-800-457-3801
831-457-3801

Company Profile

Website: http://www.scbt.com/

(1) HER2-Driven Breast Cancer: Role of the Chaperonin HSP90 in Modulating Response to Trastuzumab-Based Therapeutic CombinationsInt J Mol SciJuly 9, 2025Italia Falcone, Elena Giontella, Stefano Giuliani, Giulia Borghesani, Alessandro Valenti, Valentina Zambonin, Sara Monteverdi, Luisa Carbognin, Emilio Bria, Ludovica Ciuffreda, et al.Transfection Cells were transfected with a short interfering RNA (siRNA) targeting human HSP90α/β (sc-35608, Santa Cruz Biotechnology, Dallas, TX, USA). RNA was transfected with RNAiMax reagent (Invitrogen, Carlsbad,

(2) DNA damage response regulator ATR licenses PINK1-mediated mitophagyNucleic Acids ResMarch 19, 2025Christian Marx, Xiaobing Qing, Yamin Gong, Joanna Kirkpatrick, Kanstantsin Siniuk, Galina V Beznoussenko, Gururaj Rao Kidiyoor, Murat Kirtay, Katrin Buder, Philipp Koch, et al.ATR (siATR#1: sc-29763), PINK1 (siPINK1#1: sc-44598), TIM23 (sc-44155), TOM7 (sc-89537), and HSP90 (sc-35608) were purchased from Santa Cruz Biotechnologies, and (siATR#2: EHU040341-50UG) (siATR mix: equal mixture

(3) Inhibiting HSP90 changes the expression pattern of PINK1 and BNIP3 and induces oxidative stress in colon cancer cellsMol Biol RepFebruary 8, 2025Ejlal Abu-El-Rub, Ayman Alzu'bi, Fatimah A. Almahasneh, Ramada R. Khaswaneh, Rawan Almazari, Amani Kasasbeh, Ala A. Aldamen, Heba F. Ai-Jariri, Amal Alomari, Tuqa Yousef, et al.employed siRNA to knockdown HSP90 in RKO cells. We used HSP90 siRNA from Santa Cruz Biotechnology (sc-35608) and as a control (sc-37007). The siRNA used is a pool of 4 target-specific 19–25 nt siRNAs designed

(4) SU086, an inhibitor of HSP90, impairs glycolysis and represents a treatment strategy for advanced prostate cancerCell reports. MedicineFebruary 15, 2022Rice MA, Kumar V, Tailor D, Garcia-Marques FJ, Hsu EC, Liu S, Bermudez A, Kanchustambham V, Shankar V, Inde Z, et al.

(5) C0818, a novel curcumin derivative, induces ROS-dependent cytotoxicity in human hepatocellular carcinoma cells in vitro via disruption of Hsp90 functionActa pharmacologica SinicaFebruary 1, 2022Abdelmoaty AAA, Zhang P, Lin W, Fan YJ, Ye SN, Xu JH.

(6) Mitochondrial Targeting of the Ammonia-Sensitive Uncoupler SLC4A11 by the Chaperone-Mediated Carrier Pathway in Corneal EndotheliumInvestigative ophthalmology & visual scienceSeptember 2, 2021Choi M, Bonanno JA.Negative Control #1 (#SIC001-10NMOL) were purchased from Sigma-Aldrich. siRNAs targeting human HSP90 (#sc-35608) and mouse HSP90 (#sc-35610) were obtained from Santa Cruz. Cells were transfected using Lipofectamine RNAiMAX Transfection reagent

(7) Tubocapsenolide A targets C-terminal cysteine residues of HSP90 to exert the anti-tumor effectPharmacological researchApril 1, 2021Zhu D, Li S, Chen C, Wang S, Zhu J, Kong L, Luo J.

(8) p53 Protects Cells from Death at the Heatstroke Threshold TemperatureCell reportsDecember 10, 2019Gong L, Zhang Q, Pan X, Chen S, Yang L, Liu B, Yang W, Yu L, Xiao ZX, Feng XH, et al.

(9) C1206, a novel curcumin derivative, potently inhibits Hsp90 and human chronic myeloid leukemia cells in vitroActa pharmacologica SinicaApril 1, 2018Fan YJ, Zhou YX, Zhang LR, Lin QF, Gao PZ, Cai F, Zhu LP, Liu B, Xu JH.supplemented with fetal bovine serum. Single-strand siRNA oligonucleotides targeting human Hsp90α/β (sc-35608, Santa Cruz Biotechnology, Dallas, TX, USA) and control siRNA (sc-37007) were diluted in siRNA transfection medium

(10) HSP90 promotes cell glycolysis, proliferation and inhibits apoptosis by regulating PKM2 abundance via Thr-328 phosphorylation in hepatocellular carcinomaMolecular cancerDecember 20, 2017Xu Q, Tu J, Dou C, Zhang J, Yang L, Liu X, Lei K, Liu Z, Wang Y, Li L, et al.

(11) Mass Spectrometric Analysis of SOX11-Binding Proteins in Head and Neck Cancer Cells Demonstrates the Interaction of SOX11 and HSP90αJournal of proteome researchNovember 3, 2017Elzakra N, Cui L, Liu T, Li H, Huang J, Hu S.

(12) FM807, a curcumin analogue, shows potent antitumor effects in nasopharyngeal carcinoma cells by heat shock protein 90 inhibitionOncotargetFebruary 28, 2017Ye M, Huang W, Wu WW, Liu Y, Ye SN, Xu JH.FBS. Single siRNA oligonucleotides (obtained from Santa Cruz Biotechnology) targeting human Hsp90α/β (sc-35608) and control siRNA (sc-37007) were diluted in siRNA Transfection Medium (sc-36868) and mixed with siRNA Transfection Reagent

(13) Heat Shock Protein 90 Modulates Lipid Homeostasis by Regulating the Stability and Function of Sterol Regulatory Element-binding Protein (SREBP) and SREBP Cleavage-activating ProteinThe Journal of biological chemistryFebruary 17, 2017Kuan YC, Hashidume T, Shibata T, Uchida K, Shimizu M, Inoue J, Sato R.

(14) Inhibition of hepatitis C virus using siRNA targeted to the virus and Hsp90Cell stress & chaperonesJanuary 1, 2017Braga AC, Carneiro BM, Batista MN, Akinaga MM, Rahal P.plate. RNAi molecules and transfection For knocking down Hsp90 mRNA, a commercial siRNA was obtained (SC-35608, Santa Cruz Biotechnology, Dallas, TX, USA). This siRNA product consists of a pool of three to five target-specific

(15) Key role of heat shock protein 90 in leptin-induced STAT3 activation and feeding regulationBritish journal of pharmacologyAugust 1, 2016Hosoi T, Kohda T, Matsuzaki S, Ishiguchi M, Kuwamura A, Akita T, Tanaka J, Ozawa K.

(16) HSP90 Chaperoning in Addition to Phosphoprotein Required for Folding but Not for Supporting Enzymatic Activities of Measles and Nipah Virus L PolymerasesJournal of virologyAugust 1, 2016Bloyet LM, Welsch J, Enchery F, Mathieu C, de Breyne S, Horvat B, Grigorov B, Gerlier D.water (the latter three). Small interfering RNAs (siRNAs) targeting human HSP90␣/␤ and a control siRNA (sc-35608) from Santa Cruz Biotech were transfected 1 day before MeV infection with Oligofectamine transfection reagent

(17) PMCA2 regulates HER2 protein kinase localization and signaling and promotes HER2-mediated breast cancerProceedings of the National Academy of Sciences of the United States of AmericaJanuary 19, 2016Jeong J, VanHouten JN, Dann P, Kim W, Sullivan C, Yu H, Liotta L, Espina V, Stern DF, Friedman PA, et al.

(18) Baculovirus IE2 Stimulates the Expression of Heat Shock Proteins in Insect and Mammalian Cells to Facilitate Its Proper FunctioningPloS oneJanuary 1, 2016Tung H, Wei SC, Lo HR, Chao YC.

(19) Targeting KRAS Oncogene in Colon Cancer Cells with 7-Carboxylate Indolo[3,2-b]quinoline Tri-Alkylamine DerivativesPloS oneJanuary 1, 2015Brito H, Martins AC, Lavrado J, Mendes E, Francisco AP, Santos SA, Ohnmacht SA, Kim NS, Rodrigues CM, Moreira R, et al.cells were transfected with 50 or 100 nM siRNA KRAS, siRNA control, siRNA HSP90 (HSP90α/β siRNA (h) (sc-35608 Santa Cruz Biotechnology Inc., Santa Cruz, CA, USA), and co-transfected with 50 nM siRNA KRAS plus 50

(20) Exosomes from hepatitis C infected patients transmit HCV infection and contain replication competent viral RNA in complex with Ago2-miR122-HSP90PLoS pathogensOctober 1, 2014Bukong TN, Momen-Heravi F, Kodys K, Bala S, Szabo G.transfections The following siRNA and miRNA inhibitors were used: human HSP90 siRNA (Santa Cruz cat. #sc-35608); control siRNA (Santa Cruz cat. #sc-44236), hsa-miR-122 anti-miR miRNA Inhibitor (Ambion, Austin, Tx

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