Smad2/3 siRNA (h) from Santa Cruz Biotechnology, Inc.

Product Specs
ItemSmad2/3 siRNA (h)
CompanySanta Cruz Biotechnology, Inc.
Price $293.00Supplier Page View Company Product Page
Catalog Numbersc-37238
Gene NameSMAD family member 2
Quantity10 µM
Specieshuman
NCBI Full Gene NameSMAD family member 3, SMAD family member 2
NCBI Gene AliasesJV15-2, hMAD-2, JV18, MADH3, MADH2, LDS6, LDS3, HsT17436, MADR2, hSMAD3, mad3, CHTD8, HSPC193, JV18-1, hMAD-3, LDS1C, hSMAD2
TypesiRNA/dsRNA

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Santa Cruz Biotechnology, Inc.

10410 Finnell Street

Dallas, Texas 75220

United States

Phone: 1-800-457-3801
831-457-3801

Company Profile

Website: http://www.scbt.com/

(1) TGF-β1/SMAD signaling downregulates KLF4 expression via direct transcriptional suppression and FAT10-mediated proteasomal degradation in hepatocellular carcinomaCell & BioscienceJanuary 6, 2026Zeping Chen, Senlin Zhao, Desheng Chen, Yichao Lou, Hanhao Lu, Qihang Yao, Jie Lu, Hongcheng SunVerified SMAD2 siRNA (sc-38374, Santa Cruz), SMAD3 siRNA (sc-38376, Santa Cruz), and SMAD2/3 siRNA (sc-37238, Santa Cruz) duplexes were used to knock down the target gene. Transient transfection Plasmids and

(2) Targeting TGF-β–Smad2/3–JNK1-mediated SIRT1 activity overcomes the chemoresistance of KRAS mutation lung cancerExperimental & Molecular MedicineSeptember 12, 2025Dong Hoon Shin, Minyoung Choi, Chungyong Han, Sang Soo Kiminterfering RNAs (siRNAs), including siKRAS (sc-35731 and sc-43874), siSIRT1 (sc-40986) and siSmad2/3 (sc-37238) and antibodies including SIRT1 (sc-15454), KRAS (F234, sc-30), PARP (sc-8007) and cleaved PARP (sc-56196)

(3) FXR1 promotes proliferation, invasion and migration of hepatocellular carcinoma in vitro and in vivoOncology lettersJanuary 1, 2023Zhao K, Gao J, Shi J, Shi C, Pang C, Li J, Guo W, Zhang S.in immunohistochemistry assays. SMAD2/3 siRNA was purchased from Santa Cruz Biotechnology, Inc. (cat. no. sc-37238). shRNA was purchased from Public Protein/Plasmid Library. The sequences of the FXR1 knockdown shRNAs

(4) Ochratoxin a induces hepatic fibrosis through TGF-β receptor I/Smad2/3 signaling pathwayEnvironmental toxicologyAugust 1, 2022Chae SA, Pyo MC, Yoo HJ, Lee KW.

(5) TGF-β isoforms inhibit hepatitis C virus propagation in transforming growth factor beta/SMAD protein signalling pathway dependent and independent mannersJournal of cellular and molecular medicineApril 1, 2021Zou LL, Li JR, Li H, Tan JL, Wang MX, Liu NN, Gao RM, Yan HY, Wang XK, Dong B, et al.and corresponding secondary antibodies (ZSGB‐BIO). The siRNAs for TβRI (sc‐40222) and for SMAD2/3 (sc‐37238) and the negative control siRNA‐A (sc‐37007) were purchased from Santa Cruz Biotechnology. 2.3 Plasmids The

(6) Transcriptome Analysis Reveals the AhR, Smad2/3, and HIF-1α Pathways as the Mechanism of Ochratoxin A Toxicity in Kidney CellsToxinsMarch 6, 2021Pyo MC, Choi IG, Lee KW.

(7) Ochratoxin A induces epithelial-to-mesenchymal transition and renal fibrosis through TGF-β/Smad2/3 and Wnt1/β-catenin signaling pathways in vitro and in vivoArchives of toxicologySeptember 1, 2020Pyo MC, Chae SA, Yoo HJ, Lee KW.

(8) Transforming growth factor beta induces fibroblasts to express and release the immunomodulatory protein PD-L1 into extracellular vesiclesFASEB journal : official publication of the Federation of American Societies for Experimental BiologyFebruary 1, 2020Kang JH, Jung MY, Choudhury M, Leof EB.

(9) CXCR7 promotes migration and invasion in head and neck squamous cell carcinoma by upregulating TGF-β1/Smad2/3 signalingScientific reportsDecember 2, 2019Kim N, Ryu H, Kim S, Joo M, Jeon HJ, Lee MW, Song IC, Kim MN, Kim JM, Lee HJ.

(10) Transcriptome analysis reveals autophagy as regulator of TGFβ/Smad-induced fibrogenesis in trabecular meshwork cellsScientific reportsNovember 6, 2019Nettesheim A, Shim MS, Hirt J, Liton PB.

(11) Transforming growth factor β1 promotes fibroblast-like synoviocytes migration and invasion via TGF-β1/Smad signaling in rheumatoid arthritisMolecular and cellular biochemistrySeptember 1, 2019Zhu D, Zhao J, Lou A, Huang Q, OuYang Q, Zhu J, Fan M, He Y, Ren H, Yang M.

(12) Targeting of dermal myofibroblasts through death receptor 5 arrests fibrosis in mouse models of sclerodermaNature communicationsMarch 8, 2019Park JS, Oh Y, Park YJ, Park O, Yang H, Slania S, Hummers LK, Shah AA, An HT, Jang J, et al.

(13) SMYD3 promotes the epithelial-mesenchymal transition in breast cancerNucleic acids researchFebruary 20, 2019Fenizia C, Bottino C, Corbetta S, Fittipaldi R, Floris P, Gaudenzi G, Carra S, Cotelli F, Vitale G, Caretti G.synthetized by Eurofins Genomics, and SMAD2/3 siRNAs were purchased from Santa Cruz Biotechnology (sc-37238). siRNAs were transfected (150nM) with Lipofectamine 2000 according to the manufacturer's instructions.

(14) B7-1 drives TGF-β stimulated pancreatic carcinoma cell migration and expression of EMT target genesPloS oneJanuary 1, 2019Kang JH, Jung MY, Leof EB.by siRNA Cells were transiently transfected with 60 nmol/L B7-1 siRNAs (sc-39699), Smad2/3 siRNAs (sc-37238 and sc-37239) or non-targeting siRNAs (sc-37007) as control siRNA according to the manufacturer’s instructions

(15) Growth and differentiation factor 15 regulates PD-L1 expression in glioblastomaCancer management and researchJanuary 1, 2019Peng H, Li Z, Fu J, Zhou R.

(16) Effect of phlorotannins on myofibroblast differentiation and ECM protein expression in transforming growth factor β1‑induced nasal polyp‑derived fibroblastsInternational journal of molecular medicineOctober 1, 2018Park J, Choi G, Yim MJ, Lee JM, Yoo JS, Park WS, Park SK, Park S, Seo SK, Kim TG, et al.Cell Signaling Technology, Inc. (Danvers, MA, USA). Smad2/3‑specific small interfering (si)RNAs (cat. no. sc‑37238) were purchased from Santa Cruz Biotechnology, Inc. (Santa Cruz, CA, USA). Rat tail type‑1 collagen

(17) Fucoxanthin Inhibits Myofibroblast Differentiation and Extracellular Matrix Production in Nasal Polyp-Derived Fibroblasts via Modulation of Smad-Dependent and Smad-Independent Signaling PathwaysMarine drugsSeptember 10, 2018Jung H, Lee DS, Park SK, Choi JS, Jung WK, Park WS, Choi IW.Cell Signaling Technology, Inc. (Danvers, MA, USA). We purchased Smad 2/3-specific small interfering RNAs (siRNAs, cat. no. sc-37238) and control siRNA (cat. no. sc-37007) from Santa Cruz Biotechnology Inc. (Santa Cruz, CA, USA). Rat

(18) MicroRNA-942 mediates hepatic stellate cell activation by regulating BAMBI expression in human liver fibrosisArchives of toxicologySeptember 1, 2018Tao L, Xue D, Shen D, Ma W, Zhang J, Wang X, Zhang W, Wu L, Pan K, Yang Y, et al.

(19) Fatty acid synthase is required for profibrotic TGF-β signalingFASEB journal : official publication of the Federation of American Societies for Experimental BiologyJuly 1, 2018Jung MY, Kang JH, Hernandez DM, Yin X, Andrianifahanana M, Wang Y, Gonzalez-Guerrico A, Limper AH, Lupu R, Leof EB.

(20) Metformin ameliorates TGF-β1-induced osteoblastic differentiation of human aortic valve interstitial cells by inhibiting β-catenin signalingBiochemical and biophysical research communicationsJune 7, 2018Liu F, Chu C, Wei Q, Shi J, Li H, Dong N.

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Smad2/3 siRNA (h)

Smad2/3 siRNA (h) from Santa Cruz Biotechnology, Inc.

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Santa Cruz Biotechnology, Inc.

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Smad2/3 siRNA (h) from Santa Cruz Biotechnology, Inc.

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