AMPKα2 siRNA (h) from Santa Cruz Biotechnology, Inc.

Product Specs
ItemAMPKα2 siRNA (h)
CompanySanta Cruz Biotechnology, Inc.
Price $293.00Supplier Page View Company Product Page
Catalog Numbersc-38923
Quantity10 µM
TypesiRNA/dsRNA
NCBI Gene AliasesAMPK, AMPK2, AMPKa2, PRKAA
NCBI Full Gene Nameprotein kinase AMP-activated catalytic subunit alpha 2
Specieshuman
Gene Nameprotein kinase, AMP-activated, alpha 2 catalytic subunit

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Santa Cruz Biotechnology, Inc.

10410 Finnell Street

Dallas, Texas 75220

United States

Phone: 1-800-457-3801
831-457-3801

Company Profile

Website: http://www.scbt.com/

(1) AMPKα2 regulates fasting-induced hyperketonemia by suppressing SCOT ubiquitination and degradationScientific reportsJanuary 19, 2024Zhang L, Lu Y, An J, Wu Y, Liu Z, Zou MH.Opti-MEM I reduced serum (#31985-088) were from Fisher Scientific (Waltham, MA). AMPKα2 siRNA (h) (sc-38923), anti- AMPKα2 (sc-19129), anti-MCT1 (sc-50325), anti-actin (sc-47778), anti-BDH1 (sc-514413), anti-GAPDH

(2) AMPK inhibition induces MCL1 mRNA destabilization via the p38 MAPK/miR-22/HuR axis in chronic myeloid leukemia cellsBiochemical pharmacologyMarch 1, 2023Lee YC, Chiou JT, Chang LS.

(3) Translation initiation factor eIF3a regulates glucose metabolism and cell proliferation via promoting small GTPase Rheb synthesis and AMPK activationThe Journal of biological chemistryJuly 1, 2022Ma S, Dong Z, Huang Y, Liu JY, Zhang JT.

(4) Ginkgolide B Protects Against Ischemic Stroke via Targeting AMPK/PINK1Frontiers in pharmacologyJanuary 1, 2022Cao Y, Yang L, Cheng H.cells were subjected to transient transfection with 100 nM siRNAs targeting AMPKα1/α2 (sc-29673 and sc-38923) or non-silencing control siRNA (scram) (sc-37007) (Santa Cruz Biotechnology, Santa Cruz, CA, United

(5) Hesperetin inhibits foam cell formation and promotes cholesterol efflux in THP-1-derived macrophages by activating LXRα signal in an AMPK-dependent mannerJournal of physiology and biochemistryAugust 1, 2021Chen X, Zou D, Chen X, Wu H, Xu D.(Billerica, MA, USA). The control siRNA (sc-37007), AMPK alpha 1 siRNA (sc-29673), and AMPK alpha 2 siRNA (sc-38923) were purchased from Santa Cruz Biotechnology (Dallas, TX, USA). The Total RNA Extraction Reagent (R401-01),

(6) Targeting PI3K and AMPKα Signaling Alone or in Combination to Enhance Radiosensitivity of Triple Negative Breast CancerCellsMay 19, 2020Johnson J, Chow Z, Napier D, Lee E, Weiss HL, Evers BM, Rychahou P.

(7) 6-Phosphofructo-2-kinase/fructose-2,6-bisphosphatase isoform 3 spatially mediates autophagy through the AMPK signaling pathwayOncotargetOctober 6, 2017Yan S, Wei X, Xu S, Sun H, Wang W, Liu L, Jiang X, Zhang Y, Che Y.constructed in our lab. The siRNA specific for human PFKFB3 (sc-44011), and AMPKα1/2 (sc-29673 and sc-38923) were purchased from Santa Cruz Biotechnology, along with the control siRNA (sc-37007). Cell culture

(8) AMPK negatively regulates tensin-dependent integrin activityThe Journal of cell biologyApril 3, 2017Georgiadou M, Lilja J, Jacquemet G, Guzmán C, Rafaeva M, Alibert C, Yan Y, Sahgal P, Lerche M, Manneville JB, et al.for 3 d. The siRNAs used for simultaneous AMPKα1 and AMPKα2 silencing were PRKAA1 (sc-29673), PRKAA2 (sc-38923), and control (sc-37007; Santa Cruz Biotechnology, Inc.; Wang et al., 2012). The additional siRNAs against

(9) Deletion of PRKAA triggers mitochondrial fission by inhibiting the autophagy-dependent degradation of DNM1LAutophagyFebruary 1, 2017Wang Q, Wu S, Zhu H, Ding Y, Dai X, Ouyang C, Han YM, Xie Z, Zou MH.

(10) Compound 13, an α1-selective small molecule activator of AMPK, potently inhibits melanoma cell proliferationTumour biology : the journal of the International Society for Oncodevelopmental Biology and MedicineJanuary 1, 2016Hu X, Jiang F, Bao Q, Qian H, Fang Q, Shao Z.

(11) Compound 13, an α1-selective small molecule activator of AMPK, inhibits Helicobacter pylori-induced oxidative stresses and gastric epithelial cell apoptosisBiochemical and biophysical research communicationsAugust 7, 2015Zhao H, Zhu H, Lin Z, Lin G, Lv G.

(12) Activation of AMP-activated protein kinase prevents TGF-β1-induced epithelial-mesenchymal transition and myofibroblast activationThe American journal of pathologyAugust 1, 2015Thakur S, Viswanadhapalli S, Kopp JB, Shi Q, Barnes JL, Block K, Gorin Y, Abboud HE.

(13) The dipeptidyl peptidase-IV inhibitor inhibits the expression of vascular adhesion molecules and inflammatory cytokines in HUVECs via Akt- and AMPK-dependent mechanismsMolecular and cellular endocrinologyApril 15, 2015Hwang HJ, Chung HS, Jung TW, Ryu JY, Hong HC, Seo JA, Kim SG, Kim NH, Choi KM, Choi DS, et al.

(14) Pharmacological activation of AMPK suppresses inflammatory response evoked by IL-6 signalling in mouse liver and in human hepatocytesMolecular and cellular endocrinologyAugust 15, 2013Nerstedt A, Cansby E, Amrutkar M, Smith U, Mahlapuu M.

(15) Adiponectin increases MMP-3 expression in human chondrocytes through AdipoR1 signaling pathwayJournal of cellular biochemistryMay 1, 2011Tong KM, Chen CP, Huang KC, Shieh DC, Cheng HC, Tzeng CY, Chen KH, Chiu YC, Tang CH.

(16) Adenosine activates AMPK to phosphorylate Bcl-XL responsible for mitochondrial damage and DIABLO release in HuH-7 cellsCellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacologyJanuary 1, 2011Yang D, Yaguchi T, Nakano T, Nishizaki T.

(17) AMP-activated protein kinase inhibits IL-6-stimulated inflammatory response in human liver cells by suppressing phosphorylation of signal transducer and activator of transcription 3 (STAT3)DiabetologiaNovember 1, 2010Nerstedt A, Johansson A, Andersson CX, Cansby E, Smith U, Mahlapuu M.transfected with siRNA directed against AMPKα1 (PRKKA1, #AM51334; Ambion, Austin, TX, USA) and AMPKα2 (sc-38923; Santa Cruz Biotechnology, Santa Cruz, CA, USA) subunits, LKB1 (s13581, Ambion) or scrambled siRNA (#AM4635, Ambion)

(18) Adiponectin increases BMP-2 expression in osteoblasts via AdipoR receptor signaling pathwayJournal of cellular physiologyAugust 1, 2010Huang CY, Lee CY, Chen MY, Tsai HC, Hsu HC, Tang CH.

(19) Adiponectin increases motility of human prostate cancer cells via adipoR, p38, AMPK, and NF-kappaB pathwaysThe ProstateDecember 1, 2009Tang CH, Lu ME.

(20) Involvement of AdipoR receptor in adiponectin-induced motility and alpha2beta1 integrin upregulation in human chondrosarcoma cellsCarcinogenesisOctober 1, 2009Chiu YC, Shieh DC, Tong KM, Chen CP, Huang KC, Chen PC, Fong YC, Hsu HC, Tang CH.