SIRT1 siRNA (m) from Santa Cruz Biotechnology, Inc.

Product Specs
ItemSIRT1 siRNA (m)
CompanySanta Cruz Biotechnology, Inc.
Price $293.00Supplier Page View Company Product Page
Catalog Numbersc-40987
Gene Namesirtuin 1
Quantity10 µM
Speciesmouse
NCBI Full Gene Namesirtuin 1
NCBI Gene AliasesSIR2L1, Sir2, Sir2a, Sir2alpha
TypesiRNA/dsRNA

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Santa Cruz Biotechnology, Inc.

10410 Finnell Street

Dallas, Texas 75220

United States

Phone: 1-800-457-3801
831-457-3801

Company Profile

Website: http://www.scbt.com/

(1) Energy-sensing molecule RORγ regulates cholesterol metabolism and immune signaling in diabetic kidney disease and agingNature CommunicationsFebruary 18, 2026Zhen Liang, Jiaqing Xiang, Guangyan Yang, Xiaomai Liu, Lixing Li, Yanchun Li, Yan Lu, Lin Kang, Yuanli Chen, Chuanrui Ma, et al.purchased from Santa Cruz Biotechnology (Dallas, TX, USA), including mouse Sirt1 siRNA (catalog number: sc-40987), mouse Prkaa1 siRNA (catalog number: sc-29674), mouse Ctcf siRNA (catalog number: sc-35125), and mouse

(2) SIRT1 activation by SRT2104 enhances mitophagy and reduces senescence in auditory cellsScientific ReportsJanuary 27, 2026Sung Il Cho, Eu-Ri Jo, Hee Sun JangGermany). Transfection SIRT1 expression was silenced using SIRT1-specific siRNA (m) (Santa Cruz, CA, USA, Cat. # sc-40987, Lot # L1024) and control siRNA-A (Santa Cruz, Cat. # sc-37007, Lot # L1824) was used as a negative

(3) The dual functions of the pentacyclic triterpenoid madecassic acid in ameliorating doxorubicin-induced cardiotoxicity and enhancing the antitumor efficacy of doxorubicinInternational Journal of Biological SciencesOctober 7, 2024Wenlin Li, Kun Xu, Ming Lan, Junpeng Gao, Lin Dou, Yao Yang, Que Wang, Mingjing Yan, Sainan Li, Qinan Ma, et al.Mouse siRNA Negative control (Nci, Cat. No. sc-37007, Santa Cruz, USA) and mouse SIRT1 siRNA (Cat. No. sc-40987, Santa Cruz, USA) were purchased from Santa Cruz Co. When the cell density was cultured to 70%, Nci

(4) β-Nicotinamide mononucleotide activates NAD+/SIRT1 pathway and attenuates inflammatory and oxidative responses in the hippocampus regions of septic miceRedox biologyJuly 1, 2023Li HR, Liu Q, Zhu CL, Sun XY, Sun CY, Yu CM, Li P, Deng XM, Wang JF.transfection According to the manufacturer's instructions, BV-2 cells were transiently transfected with SIRT1 siRNA (sc-40987) or non-targeting siRNA (sc-37007) as a control siRNA (Santa Cruz Inc, CA, USA). Briefly, 2 × 105 BV-2

(5) Metformin-induced TTP mediates communication between Kupffer cells and hepatocytes to alleviate hepatic steatosis by regulating lipophagy and necroptosisMetabolism: clinical and experimentalApril 1, 2023Park J, Rah SY, An HS, Lee JY, Roh GS, Ryter SW, Park JW, Yang CH, Surh YJ, Kim UH, et al.

(6) LncRNA GAS5 suppresses inflammatory responses by inhibiting HMGB1 release via miR-155-5p/SIRT1 axis in sepsisEuropean journal of pharmacologyMarch 5, 2023Zeng Z, Lan Y, Chen Y, Zuo F, Gong Y, Luo G, Peng Y, Yuan Z.

(7) Placental Mesenchymal Stem Cells Alleviate Podocyte Injury in Diabetic Kidney Disease by Modulating Mitophagy via the SIRT1-PGC-1alpha-TFAM PathwayInternational journal of molecular sciencesFebruary 28, 2023Han X, Wang J, Li R, Huang M, Yue G, Guan L, Deng Y, Cai W, Xu J.

(8) Screening of an FDA-approved compound library identifies apigenin for the treatment of myocardial injuryInternational journal of biological sciencesJanuary 1, 2023Li H, Chen D, Zhang X, Chen M, Zhi Y, Cui W, Li S, Xu F, Tan Y, Zhou H, et al.isopropanol 61. Cellular transfections Cells were transfected with control siRNA (sc-37007), Sirt1 siRNA (sc-40987), or Atf5 siRNA (sc-60222) purchased from Santa Cruz Biotechnology, in combination with Lipofectamine

(9) Puerarin prevents cadmium-induced mitochondrial fission in AML-12 cells via Sirt1-dependent pathwayEcotoxicology and environmental safetyDecember 15, 2022Wan XM, Zheng C, Zhou XL.

(10) Notch-activated mesenchymal stromal/stem cells enhance the protective effect against acetaminophen-induced acute liver injury by activating AMPK/SIRT1 pathwayStem cell research & therapyJuly 16, 2022Yu M, Zhou M, Li J, Zong R, Yan Y, Kong L, Zhu Q, Li C.

(11) Laminaria japonica Polysaccharide Suppresses Atherosclerosis via Regulating Autophagy-Mediated Macrophage PolarizationJournal of agricultural and food chemistryMarch 30, 2022Li XY, Wang YJ, Chen S, Pan LH, Li QM, Luo JP, Zha XQ.

(12) Metformin Alleviates LPS-Induced Acute Lung Injury by Regulating the SIRT1/NF-κB/NLRP3 Pathway and Inhibiting Endothelial Cell PyroptosisFrontiers in pharmacologyJanuary 1, 2022Zhang Y, Zhang H, Li S, Huang K, Jiang L, Wang Y.μg/ml LPS with/without pretreatment with metformin (10 mM), MCC950 (10 μM), NAM (1 mM), or SIRT1 siRNA (sc-40987, Santa Cruz). The supernatants were collected and stored at −80°C until assayed. Monocyte–ECs Adhesion For

(13) Patchouli alcohol ameliorates skeletal muscle insulin resistance and NAFLD via AMPK/SIRT1-mediated suppression of inflammationMolecular and cellular endocrinologyDecember 1, 2021Pyun DH, Kim TJ, Park SY, Lee HJ, Abd El-Aty AM, Jeong JH, Jung TW.

(14) Luteolin inhibits H(2)O(2)-induced cellular senescence via modulation of SIRT1 and p53The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of PharmacologyJuly 1, 2021Zhu RZ, Li BS, Gao SS, Seo JH, Choi BM.phospho-p38 (p-p38, Cell Signaling Technology, 9211). The specific siRNA for p53 (sc-29436) and SIRT1 (sc-40987) was purchased from Santa Cruz Biotechonology (Santa Cruz, CA, USA). Unless indicated otherwise, all

(15) E17241 as a Novel ABCA1 (ATP-Binding Cassette Transporter A1) Upregulator Ameliorates Atherosclerosis in MiceArteriosclerosis, thrombosis, and vascular biologyJune 1, 2021Xu (许艳妮) Y, Liu (刘畅) C, Han (韩小婉) X, Jia (贾晓健) X, Li (李永臻) Y, Liu (刘超) C, Li (李霓) N, Liu (刘伦铭) L, Liu (刘鹏) P, Jiang (姜新海) X, et al.Guangzhou GenePharma, Co, Ltd, China), PKCζ siRNA (20 nmol/L, sc-36254), or SIRT1 siRNA (20 nmol/L, sc-40987, Santa Cruz) using RNAMAX (Thermo Fisher Scientific). Six hours later, the medium was exchanged with

(16) Sodium hydrosulfide alleviates dexamethasone-induced cell senescence and dysfunction through targeting the miR-22/sirt1 pathway in osteoblastic MC3T3-E1 cellsExperimental and therapeutic medicineMarch 1, 2021Li P, Mao WW, Zhang S, Zhang L, Chen ZR, Lu ZD.Biotechnology Co., Ltd.) was used to perform sirtuin 1 (sirt1) siRNA transfections (200 nM; cat. no. sc‑40987; Santa Cruz Biotechnology, Inc.) into osteoblastic MC3T3‑E1 cells, with a non‑targeting siRNA (Santa

(17) Activation of AMP-Activated Protein Kinase-Sirtuin 1 Pathway Contributes to Salvianolic Acid A-Induced Browning of White Adipose Tissue in High-Fat Diet Fed Male MiceFrontiers in pharmacologyJanuary 1, 2021Lai J, Qian Q, Ding Q, Zhou L, Fu A, Du Z, Wang C, Song Z, Li S, Dou X.

(18) Ubiquitin-Specific Protease 29 Exacerbates Cerebral Ischemia-Reperfusion Injury in MiceOxidative medicine and cellular longevityJanuary 1, 2021Hou JB, Shen QN, Wan X, Liu XK, Yu Y, Li M, Gao WW, Zhao B.generated by Hanbio Biotechnology Co., Ltd. (Shanghai, China). Small interfering RNA against mouse SIRT1 (sc-40987) or BMAL1 (sc-38166) were purchased from Santa Cruz Biotechnology (Dallas, Texas, USA). The primary

(19) Apigenin Alleviates Oxidative Stress-Induced Cellular Senescence via Modulation of the SIRT1-NAD[Formula: see text]-CD38 AxisThe American journal of Chinese medicineJanuary 1, 2021Li BS, Zhu RZ, Lim SH, Seo JH, Choi BM.

(20) Sirt1 is regulated by miR-135a and involved in DNA damage repair during mouse cellular reprogrammingAgingApril 26, 2020Chen ACH, Peng Q, Fong SW, Yeung WSB, Lee YL.

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SIRT1 siRNA (m)

SIRT1 siRNA (m) from Santa Cruz Biotechnology, Inc.

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Santa Cruz Biotechnology, Inc.

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SIRT1 siRNA (m) from Santa Cruz Biotechnology, Inc.

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