p21 Waf1/Cip1 siRNA (h) from Santa Cruz Biotechnology, Inc.

Product Specs
Itemp21 Waf1/Cip1 siRNA (h)
CompanySanta Cruz Biotechnology, Inc.
Price $293.00Supplier Page View Company Product Page
Catalog Numbersc-29427
Gene Namecyclin-dependent kinase inhibitor 1A (p21, Cip1)
Quantity10 µM
Specieshuman
NCBI Full Gene Namecyclin dependent kinase inhibitor 1A
NCBI Gene AliasesCAP20, CDKN1, CIP1, MDA-6, P21, SDI1, WAF1, p21CIP1
TypesiRNA/dsRNA

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Santa Cruz Biotechnology, Inc.

10410 Finnell Street

Dallas, Texas 75220

United States

Phone: 1-800-457-3801
831-457-3801

Company Profile

Website: http://www.scbt.com/

(1) Myc and Skp2 overexpression promotes p27 ubiquitination and degradation in Ewing SarcomaPLoS OneMarch 9, 2026Yuta Kubota, Masanori Kawano, Ichiro Itonaga, Nobuhiro Kaku, Kazuhiro Tanaka(Invitrogen; Thermo Fisher Scientific) at 10–160 nM. AP4-siRNA (Cat. #sc-37690) and p21-siRNA (Cat. #sc-29427), purchased from Santa Cruz Biotechnology (Dallas, TX, USA). Expression vectors: AP4 (12101), Skp2 (89142),

(2) Therapy-induced senescence of glioblastoma cells is determined by the p21CIP1-CDK1/2 axis and does not require activation of DREAMCell Death DisMay 3, 2025Christian Schwarzenbach, Justus Rinke, Juliana B. Vilar, Jason Sallbach, Larissa Tatsch, Ariane Schmidt, Anna Schöneis, Birgit Rasenberger, Bernd Kaina, Maja T. Tomicic, et al.University Medical Center Mainz, Germany. For gene silencing, predesigned siRNAs specific for p21CIP1 (sc-29427, Santa Cruz Biotechnology) were used; control human non-silencing siRNA (Silencer Select Predesigned

(3) The p21CIP1-CDK4-DREAM axis is a master regulator of genotoxic stress-induced cellular senescenceNucleic Acids ResearchJuly 8, 2024Ariane Schmidt, Sebastian Allmann, Christian Schwarzenbach, Petra Snyder, Jia-Xuan Chen, Georg Nagel, Anna Schöneis, Birgit Rasenberger, Petra Beli, Alexander Loewer, et al.silencing, predesigned siRNAs specific for p16INK4A (sc-37622, Santa Cruz Biotechnology), p21CIP1 (sc-29427, Santa Cruz Biotechnology), E2F4 (sc-29300, Santa Cruz Biotechnology) and E2F5 (sc-35250, Santa Cruz Biotechnology

(4) The impact of senescence on muscle wasting in chronic kidney diseaseJournal of Cachexia, Sarcopenia and MuscleFebruary 1, 2023Ying Huang, Bin Wang, Faten Hassounah, S. Russ Price, Janet Klein, Tamer M.A. Mohamed, Yanhua Wang, Jeanie Park, Hui Cai, Xuemei Zhang, et al.MA) 20 ; a p16INK4a plasmid (SR403922) was from OriGene Technologies (Rockville, MD); p21Waf1/Cip1(sc‐29427) siRNA was from Santa Cruz, (Dallas, TX). Effectene transfection reagent (Qiagen, Germantown, MD) was

(5) Estrogen Receptor Subtypes Elicit a Distinct Gene Expression Profile of Endothelial-Derived Factors Implicated in Atherosclerotic Plaque VulnerabilityInternational journal of molecular sciencesSeptember 19, 2022Nasiri-Ansari N, Spilioti E, Kyrou I, Kalotychou V, Chatzigeorgiou A, Sanoudou D, Dahlman-Wright K, Randeva HS, Papavassiliou AG, Moutsatsou P, et al.transfected at a 70% confluence for 24 h with 20 nM small interfering (si) RNAs targeting human p21 (sc-29427, Santa Cruz Technology, Dallas, TX, USA) using Lipofectamine 2000 reagent (Invitrogen) according to

(6) A RUNX-targeted gene switch-off approach modulates the BIRC5/PIF1-p21 pathway and reduces glioblastoma growth in miceCommunications biologySeptember 9, 2022Hattori EY, Masuda T, Mineharu Y, Mikami M, Terada Y, Matsui Y, Kubota H, Matsuo H, Hirata M, Kataoka TR, et al.siRNAs targeting p21 or PIF1 were purchased from Santa Cruz Biotechnology (Dallas, TX) (si p21(h): sc-29427; si PIF1(h): sc-76134; si control: sc-37007) and transfected using lipofectamine RNAiMAX (Invitrogen,

(7) DNA damage triggers an interplay between wtp53 and c-Myc affecting lymphoma cell proliferation and Kaposi sarcoma herpesvirus replicationBiochimica et biophysica acta. Molecular cell researchJanuary 1, 2022Arena A, Gilardini Montani MS, Romeo MA, Benedetti R, Gaeta A, Cirone M.

(8) Stimulation of Cardiomyocyte Proliferation Is Dependent on Species and Level of MaturationFrontiers in cell and developmental biologyJanuary 1, 2022Yücel D, Garay BI, Perlingeiro RCR, van Berlo JH.used according to manufacturer’s instructions to deliver p21 (human siRNA, Santa Cruz Biotechnology; sc-29427 and mouse siRNA, Dharmacon, L-058636-00-0005) or scrambled siRNAs (Dharmacon, D-001810-10-20). To measure

(9) Transient Receptor Potential Melastatin 8, a sensor of cold temperatures mediates expression of cyclin-dependent kinase inhibitor, p21/Cip1, a regulator of epidermal cell proliferationThe Journal of toxicological sciencesJanuary 1, 2022Fujino T.

(10) ACTL6A suppresses p21(Cip1) tumor suppressor expression to maintain an aggressive mesothelioma cancer cell phenotypeOncogenesisOctober 23, 2021Shrestha S, Adhikary G, Naselsky W, Xu W, Friedberg JS, Eckert RL.were purchased from Millipore/Sigma (St. Louis, MO). Control (sc-37007), p53 (sc-44218) and p21Cip1 (sc-29427) siRNA were obtained from Santa Cruz Biotechnology (Dallas, TX). ACTL6A-siRNA (AM16708) was obtained

(11) Functional Analysis of p21^Cip1/CDKN1A and Its Family Members in Trophoblastic Cells of the Placenta and Its Roles in PreeclampsiaCellsAugust 27, 2021Kreis NN, Friemel A, Jennewein L, Hoock SC, Hentrich AE, Nowak T, Louwen F, Yuan J.as sip21 #2), containing a mixed pool of siRNAs, was obtained from Santa Cruz (Heidelberg, Germany; sc-29427). Control siRNA was obtained from Qiagen (Hilden, Germany; #1027281). siRNAs (30 nM). Cells were transiently

(12) PAX8 plays an essential antiapoptotic role in uterine serous papillary cancerOncogeneAugust 1, 2021Fares B, Berger L, Bangiev-Girsh E, Kakun RR, Ghannam-Shahbari D, Tabach Y, Zohar Y, Gottlieb E, Perets R.

(13) Implication of integrin α2β1 in senescence of SK-Mel-147 human melanoma cellsAgingJuly 13, 2021Kozlova NI, Morozevich GE, Berman AE.

(14) Aurora kinase inhibition sensitizes melanoma cells to T-cell-mediated cytotoxicityCancer immunology, immunotherapy : CIIApril 1, 2021Punt S, Malu S, McKenzie JA, Manrique SZ, Doorduijn EM, Mbofung RM, Williams L, Silverman DA, Ashkin EL, Dominguez AL, et al.

(15) p21(WAF1/CIP1) promotes p53 protein degradation by facilitating p53-Wip1 and p53-Mdm2 interactionBiochemical and biophysical research communicationsMarch 5, 2021Lee J, Kim J, Kim EM, Kim U, Kang AR, Park JK, Um HD.

(16) MBNL2 Regulates DNA Damage Response via Stabilizing p21International journal of molecular sciencesJanuary 14, 2021Cai J, Wang N, Lin G, Zhang H, Xie W, Zhang Y, Xu N.transfected with 50 nM siRNA oligonucleotides (Santa Cruz Biotechnology, siMBNL2, sc-60990; sip21, sc-29427) or 1 µg/mL overexpression plasmids (synthetized from YouBio, Changsha, China) as indicated. All the

(17) Silencing of TLR7 protects against lipopolysaccharide-induced chondrocyte apoptosis and injury by blocking the p21-mediated JAK2/STAT3 pathwayAmerican journal of translational researchJanuary 1, 2021Liu D, Liu W, Jiang L, Dong S, Ma W, Wang S, Wan C.

(18) Benzo[a]pyrene represses DNA repair through altered E2F1/E2F4 function marking an early event in DNA damage-induced cellular senescenceNucleic acids researchDecember 2, 2020Allmann S, Mayer L, Olma J, Kaina B, Hofmann TG, Tomicic MT, Christmann M.2000 (Cs-137 source, Molsgaard Medical, Denmark). For silencing, predesigned siRNAs specific for p21 (sc-29427, Santa Cruz Biotechnology), E2F1 (L-003259-00-0005, Dharmacon) and E2F4 (sc-29300) were used; control

(19) ACTL6A suppresses p21^Cip1 expression to enhance the epidermal squamous cell carcinoma phenotypeOncogeneSeptember 1, 2020Shrestha S, Adhikary G, Xu W, Kandasamy S, Eckert RL.was obtained from Millipore/Sigma (St. Louis, MO). Control (sc-37007), p53 (sc-44218) and p21Cip1 (sc-29427) siRNA were obtained from Santa Cruz Biotechnology (Dallas, TX). ACTL6A-siRNA (AM16708) was obtained

(20) Mitochondrial nucleoid remodeling and biogenesis are regulated by the p53-p21(WAF1)-PKCζ pathway in p16(INK4a)-silenced cellsAgingApril 24, 2020Lee YY, Choi YS, Kim DW, Cheong JY, Song KY, Ryu MS, Lim IK.Cells on coverslips were transfected with control siRNAs (sc-37007), siPKCζ (sc44270), si-p21WAF1 (sc-29427) and si-p16INK4a (sc-37622) using Lipofectamine RNAiMAX (Invitrogen). After 48 h, the cells were subjected

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