ATR siRNA (h) from Santa Cruz Biotechnology, Inc.

Product Specs
ItemATR siRNA (h)
CompanySanta Cruz Biotechnology, Inc.
Price $293.00Supplier Page View Company Product Page
Catalog Numbersc-29763
Gene Nameataxia telangiectasia and Rad3 related
Quantity10 µM
Specieshuman
NCBI Full Gene NameATR serine/threonine kinase
NCBI Gene AliasesFCTCS, FRP1, MEC1, SCKL, SCKL1
TypesiRNA/dsRNA

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Santa Cruz Biotechnology, Inc.

10410 Finnell Street

Dallas, Texas 75220

United States

Phone: 1-800-457-3801
831-457-3801

Company Profile

Website: http://www.scbt.com/

(1) DNA damage response regulator ATR licenses PINK1-mediated mitophagyNucleic Acids ResMarch 19, 2025Christian Marx, Xiaobing Qing, Yamin Gong, Joanna Kirkpatrick, Kanstantsin Siniuk, Galina V Beznoussenko, Gururaj Rao Kidiyoor, Murat Kirtay, Katrin Buder, Philipp Koch, et al.(siCtl: equal mixture of sc-37007, sc-44230, and sc-44231) and targeted siRNAs against ATR (siATR#1: sc-29763), PINK1 (siPINK1#1: sc-44598), TIM23 (sc-44155), TOM7 (sc-89537), and HSP90 (sc-35608) were purchased

(2) ATR-hippo drives force signaling to nuclear F-actin and links mechanotransduction to neurological disordersSci AdvFebruary 14, 2025Maria Chatzifrangkeskou, Tess Stanly, Delia Koennig, Luana Campos-Soares, Michael Eyres, Alexander Hasson, Alexandra Perdiou, Iolanda Vendrell, Roman Fischer, Sayoni Das, et al.GCCAUUCUAUCCUCUAGAGGAUG was used as control. siRNA against RASSF1A was previously used (16). siRNA against ATR (sc-29763) was purchased from Santa Cruz Biotechnology. siRNA against Filamin-A was purchased from Origene (#SR301624).

(3) Treacle and TOPBP1 control replication stress response in the nucleolusThe Journal of cell biologyAugust 2, 2021Velichko AK, Ovsyannikova N, Petrova NV, Luzhin AV, Vorobjeva M, Gavrikov AS, Mishin AS, Kireev II, Razin SV, Kantidze OL.Scientific) following the manufacturer’s instructions. The cells were transfected with 50 nM ATR siRNA (#sc-29763; Santa Cruz Biotechnology), 50 nM Treacle/TCOF1 (#sc-61707; Santa Cruz Biotechnology), 50 nM TOPBP1

(4) PB01 suppresses radio-resistance by regulating ATR signaling in human non-small-cell lung cancer cellsScientific reportsJune 8, 2021Kim TW, Hong DW, Hong SH.

(5) EB virus-induced ATR activation accelerates nasopharyngeal carcinoma growth via M2-type macrophages polarizationCell death & diseaseSeptember 11, 2020Zhang B, Miao T, Shen X, Bao L, Zhang C, Yan C, Wei W, Chen J, Xiao L, Sun C, et al.

(6) ATR signalling mediates the prosurvival function of phospho-NPM against PIDDosome mediated cell deathCellular signallingJuly 1, 2020Hiregange D, Naick H, Rao BJ.

(7) Ubiquitination of the DNA-damage checkpoint kinase CHK1 by TRAF4 is required for CHK1 activationJournal of hematology & oncologyMay 1, 2020Yu X, Li W, Liu H, Deng Q, Wang X, Hu H, Xu-Monette ZY, Xiong W, Lu Z, Young KH, et al.siRNA (cat. #sc-93314), UbcH6 siRNA (cat. #sc-61744), BTG3 siRNA (cat. #sc-43644), and ATR siRNA (cat. #sc-29763) were purchased from Santa Cruz Biotechnology (Dallas, TX, USA). Three independent experiments were

(8) Hypoosmotic stress induces R loop formation in nucleoli and ATR/ATM-dependent silencing of nucleolar transcriptionNucleic acids researchJuly 26, 2019Velichko AK, Petrova NV, Luzhin AV, Strelkova OS, Ovsyannikova N, Kireev II, Petrova NV, Razin SV, Kantidze OL.200 nM ATM siRNA (Santa Cruz Biotechnology, #sc-29761), 50 nM ATR siRNA (Santa Cruz Biotechnology, # sc-29763), 100 nM DNA-PKcs (PRKDC; Santa Cruz Biotechnology, #sc-35200), 50 nM Nbs1 siRNA (Santa Cruz Biotechnology,

(9) High-risk human papillomavirus oncogenes disrupt the Fanconi anemia DNA repair pathway by impairing localization and de-ubiquitination of FancD2PLoS pathogensFebruary 1, 2019Khanal S, Galloway DA.AACAGCCAUGGAUACACUUGA-3’; si-Palb2 (Santa Cruz Biotechnology, sc-93396), siATR (Santa Cruz Biotechnology, sc-29763), siPCNA (Santa Cruz Biotechnology, sc-29440), siUHRF1 (Santa Cruz Biotechnology, sc-7680) and siRNA

(10) ATR activated by EB virus facilitates chemotherapy resistance to cisplatin or 5-fluorouracil in human nasopharyngeal carcinomaCancer management and researchJanuary 1, 2019Zhang B, Cui B, Du J, Shen X, Wang K, Chen J, Xiao L, Sun C, Li Y.

(11) ATM-activated autotaxin (ATX) propagates inflammation and DNA damage in lung epithelial cells: a new mode of action for silica-induced DNA damage?CarcinogenesisDecember 7, 2017Zheng H, Högberg J, Stenius U.

(12) Mechanism of heat stress-induced cellular senescence elucidates the exclusive vulnerability of early S-phase cells to mild genotoxic stressNucleic acids researchJuly 27, 2015Velichko AK, Petrova NV, Razin SV, Kantidze OL.

(13) Cytochrome P450 2A13 mediates the neoplastic transformation of human bronchial epithelial cells at a low concentration of aflatoxin B1International journal of cancerApril 1, 2014Zhang Z, Lu H, Huan F, Meghan C, Yang X, Wang Y, Wang X, Wang X, Wang SL.

(14) ATR suppresses endogenous DNA damage and allows completion of homologous recombination repairPloS oneJanuary 1, 2014Brown AD, Sager BW, Gorthi A, Tonapi SS, Brown EJ, Bishop AJ.transfect 75 picomoles of either scramble control siRNA (Santa Cruz sc-37007) or ATR siRNA (Santa Cruz sc-29763) into 1×105 DR-GFP U2OS cells using the reverse transfection method according to the manufacturer’s

(15) Kaposi sarcoma herpes virus latency associated nuclear antigen protein release the G2/M cell cycle blocks by modulating ATM/ATR mediated checkpoint pathwayPloS oneJanuary 1, 2014Kumar A, Sahu SK, Mohanty S, Chakrabarti S, Maji S, Reddy RR, Jha AK, Goswami C, Kundu CN, Rajasubramaniam S, et al.

(16) Chemotherapy-mediated p53-dependent DNA damage response in clear cell renal cell carcinoma: role of the mTORC1/2 and hypoxia-inducible factor pathwaysCell death & diseaseOctober 17, 2013Selvarajah J, Nathawat K, Moumen A, Ashcroft M, Carroll VA.non-silencing control (NSC) duplex were obtained from QIAGEN and have been described previously.9,57 ATR siRNA (sc-29763) was purchased from Santa Cruz. AllStars negative control siRNA duplex was purchased from QIAGEN. Real-time

(17) Overexpressed DNA polymerase iota regulated by JNK/c-Jun contributes to hypermutagenesis in bladder cancerPloS oneJanuary 1, 2013Yuan F, Xu Z, Yang M, Wei Q, Zhang Y, Yu J, Zhi Y, Liu Y, Chen Z, Yang J.experiments c-Jun siRNA (sc-29223; Santa Cruz) which is a pool of 4 target-special 19–25 nt siRNAs, ATR siRNA (sc-29763; Santa Cruz) which is a pool of 3 target-special 19–25 nt siRNAs or control siRNA-A (sc-37007; Santa Cruz

(18) Human MutY homolog induces apoptosis in etoposide-treated HEK293 cellsOncology lettersDecember 1, 2012Hahm SH, Chung JH, Agustina L, Han SH, Yoon IS, Park JH, Kang LW, Park JW, Na JJ, Han YS.and siGFP sequences and transfection method were conducted as previously described (14). ATR siRNA (sc‑29763) and TopBP1 siRNA were purchased from Santa Cruz Biotechnology, Inc. (sc‑41068; Santa Cruz, CA, USA).

(19) Low concentrations of diindolylmethane, a metabolite of indole-3-carbinol, protect against oxidative stress in a BRCA1-dependent mannerCancer researchAugust 1, 2009Fan S, Meng Q, Saha T, Sarkar FH, Rosen EM.(Santa Cruz Biotechnology, Santa Cruz, CA). BRCA1-siRNA (sc-29219), ATM-siRNA (sc-29761), ATR-siRNA (sc-29763), beclin 1-siRNA (sc-29797), and control-siRNA (sc-37007) were purchased from Santa Cruz. The cells

(20) ATR kinase is required for global genomic nucleotide excision repair exclusively during S phase in human cellsProceedings of the National Academy of Sciences of the United States of AmericaNovember 18, 2008Auclair Y, Rouget R, Affar el B, Drobetsky EA.

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ATR siRNA (h)

ATR siRNA (h) from Santa Cruz Biotechnology, Inc.

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Santa Cruz Biotechnology, Inc.

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ATR siRNA (h) from Santa Cruz Biotechnology, Inc.

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