ATF-4 siRNA (m) from Santa Cruz Biotechnology, Inc.

Product Specs
ItemATF-4 siRNA (m)
CompanySanta Cruz Biotechnology, Inc.
Price $293.00Supplier Page View Company Product Page
Catalog Numbersc-35113
Gene Nameactivating transcription factor 4
Quantity10 µM
Speciesmouse
NCBI Full Gene Nameactivating transcription factor 4
NCBI Gene AliasesAtf-4, C/ATF, CREB-2, CREB2, TAXREB67
TypesiRNA/dsRNA

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Santa Cruz Biotechnology, Inc.

10410 Finnell Street

Dallas, Texas 75220

United States

Phone: 1-800-457-3801
831-457-3801

Company Profile

Website: http://www.scbt.com/

(1) CREB2 Functions as a Central Mediator of Oxidative Neuronal Death Triggered by Microglial Glutamate Release Under Neuroinflammatory ConditionsCellular and Molecular NeurobiologyFebruary 13, 2026Uk Yeol Moon, Young Eun Kim, Huu Dat Nguyen, Hye Joung Choioxidative cytotoxicity were examined using mouse-specific siRNAs targeting GADD45α (sc-35439), CREB2/ATF4 (sc-35113), and p53 (sc-29436), along with a control siRNA (sc-37007) (Santa Cruz Biotechnology). HT22 cells were

(2) Saturated phosphatidic acids induce mTORC1-driven integrated stress response contributing to glucolipotoxicity in hepatocytesAmerican Journal of Physiology-Gastrointestinal and Liver PhysiologyJune 1, 2025Rui Guo, Yanhui Li, Yuwei Jiang, Md. Wasim Khan, Brian T. Layden, Zhenyuan Songinterventions. RNA interference Cultured cells were transfected with ATF4 siRNA (Santa Cruz Biotechnology, sc-35113), Agpat1 siRNA (Invitrogen, ASO2NJUL), Agpat3 siRNA (Invitrogen, ASO2NJUM), Gpam siRNA (Santa Cruz Biotechnology,

(3) Wogonin, a Compound in Scutellaria baicalensis, Activates ATF4-FGF21 Signaling in Mouse Hepatocyte AML12 CellsNutrientsSeptember 21, 2022Yamada Y, Saito H, Araki M, Tsuchimoto Y, Muroi SI, Suzuki K, Toume K, Kim JD, Matsuzaka T, Sone H, et al.luciferase (siLuc) (Invitrogen, Waltham, MA, USA, 12935-146) and ATF4 (Santa Cruz, Dallas, TX, USA, sc-35113) were purchased. These plasmids and siRNAs were transfected into AML12 cells with Lipofectamine 3000

(4) Up-regulation of thioredoxin system by puerarin inhibits lipid uptake in macrophagesFree radical biology & medicineJanuary 1, 2021Li W, Xu X, Dong D, Lei T, Ou H.

(5) Heme Induces BECN1/ATG5-Mediated Autophagic Cell Death via ER Stress in NeuronsNeurotoxicity researchDecember 1, 2020Yang Z, Zhou C, Shi H, Zhang N, Tang B, Ji N.

(6) PRMT1 suppresses ATF4-mediated endoplasmic reticulum response in cardiomyocytesCell death & diseaseDecember 2, 2019Jeong MH, Jeong HJ, Ahn BY, Pyun JH, Kwon I, Cho H, Kang JS.ATF4 knockdown, NRVM and H9C2 cells were transfected with control scrambled siRNA or siATF4 (CREB-2: sc-35113, Santa Cruz) using Lipofectamine RNAiMAX according to manufacturer’s instruction. For overexpression

(7) Old age-associated phenotypic screening for Alzheimer's disease drug candidates identifies sterubin as a potent neuroprotective compound from Yerba santaRedox biologyFebruary 1, 2019Fischer W, Currais A, Liang Z, Pinto A, Maher P.transfection, HT22 cells were plated in 60 mm dishes at 5 × 105 cells/dish and 20 pmol ATF4 siRNA (#sc-35113), Nrf2 siRNA (#sc-37049) or control siRNA (#sc-37007), all from Santa Cruz Biotechnology were used along

(8) Down-regulation of miR-193a-3p promotes osteoblast differentiation through up-regulation of LGR4/ATF4 signalingBiochemical and biophysical research communicationsSeptember 10, 2018Wang W, Chen J, Hui Y, Huang M, Yuan P.

(9) Hepatic regulation of VLDL receptor by PPARβ/δ and FGF21 modulates non-alcoholic fatty liver diseaseMolecular metabolismFebruary 1, 2018Zarei M, Barroso E, Palomer X, Dai J, Rada P, Quesada-López T, Escolà-Gil JC, Cedó L, Zali MR, Molaei M, et al.

(10) The role of unfolded protein response in differentiation of mammary epithelial cellsBiochemical and biophysical research communicationsMarch 18, 2017Tsuchiya M, Koizumi Y, Hayashi S, Hanaoka M, Tokutake Y, Yonekura S.

(11) RAGE deficiency alleviates aortic valve calcification in ApoE(-/-) mice via the inhibition of endoplasmic reticulum stressBiochimica et biophysica acta. Molecular basis of diseaseMarch 1, 2017Wang B, Cai Z, Liu B, Liu Z, Zhou X, Dong N, Li F.

(12) The p-eIF2α/ATF4 pathway links endoplasmic reticulum stress to autophagy following the production of reactive oxygen species in mouse spermatocyte-derived cells exposed to dibutyl phthalateFree radical researchJuly 1, 2016Zhang G, Ling X, Liu K, Wang Z, Zou P, Gao J, Cao J, Ao L.

(13) Rottlerin induces cyclooxygenase-2 upregulation through an ATF4 and reactive oxygen species-independent pathway in HEI-OC1 cellsMolecular medicine reportsJuly 1, 2016Woo SM, Lee WK, Min KJ, Kim DE, Park SH, Nam SI, Kwon TK.

(14) Impact of ER stress-regulated ATF4/p16 signaling on the premature senescence of renal tubular epithelial cells in diabetic nephropathyAmerican journal of physiology. Cell physiologyApril 15, 2015Liu J, Yang JR, Chen XM, Cai GY, Lin LR, He YN.

(15) Phosphoinositide 3-Kinases Upregulate System x_c⁻ via Eukaryotic Initiation Factor 2α and Activating Transcription Factor 4 – A Pathway Active in Glioblastomas and EpilepsyAntioxidants & Redox SignalingJune 20, 2014Jan Lewerenz et al.transfection, HT22 cells were plated in 60 mm dishes at 5 · 105 cells/dish and 20 pmol ATF4 siRNA (#sc-35113), GSK-3b siRNA (#sc-35525), or control siRNA (#sc-37007), all from Santa Cruz Biotechnology, were used

(16) Involvement of the osteoinductive factors, Tmem119 and BMP-2, and the ER stress response PERK-eIF2α-ATF4 pathway in the commitment of myoblastic into osteoblastic cellsCalcified tissue internationalApril 1, 2014Tanaka K, Kaji H, Yamaguchi T, Kanazawa I, Canaff L, Hendy GN, Sugimoto T.

(17) Concurrent regulation of the transcription factors Nrf2 and ATF4 mediates the enhancement of glutathione levels by the flavonoid fisetinBiochemical pharmacologyJune 15, 2013Ehren JL, Maher P.

(18) Mutation of ATF4 mediates resistance of neuronal cell lines against oxidative stress by inducing xCT expressionCell death and differentiationMay 1, 2012Lewerenz J, Sato H, Albrecht P, Henke N, Noack R, Methner A, Maher P.and cells were transfected with 4 mg pcDNA3pciNeo or pcDNA3pciNeo-xCT vector,9 80 pmol ATF4 siRNA (#sc-35113) or control siRNA (#sc-37007), both from Santa Cruz Biotechnology and 5 ml lipofectamine 2000 (Invitrogen)

(19) Basal levels of eIF2alpha phosphorylation determine cellular antioxidant status by regulating ATF4 and xCT expressionThe Journal of biological chemistryJanuary 9, 2009Lewerenz J, Maher P.

(20) Oxytocin Suppresses Inflammatory Responses Induced by Lipopolysaccharide through Inhibition of the eIF-2-ATF4 Pathway in Mouse MicrogliaCellsJanuary 1, 0001"Inoue T, Yamakage H, Tanaka M, Kusakabe T, Shimatsu A, Satoh-Asahara N."with 15 pmol of PTP1B siRNA (sc-36329; Santa Cruz Biotechnology, Santa Cruz, CA, USA), ATF4 siRNA (sc-35113; Santa Cruz Biotechnology), or control scramble siRNA (sc-37007; Santa Cruz Biotechnology) using a Lipofectamine

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ATF-4 siRNA (m)

ATF-4 siRNA (m) from Santa Cruz Biotechnology, Inc.

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Santa Cruz Biotechnology, Inc.

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ATF-4 siRNA (m) from Santa Cruz Biotechnology, Inc.

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