SIRT1 siRNA (h) from Santa Cruz Biotechnology, Inc.

Product Specs
ItemSIRT1 siRNA (h)
CompanySanta Cruz Biotechnology, Inc.
Price $293.00Supplier Page View Company Product Page
Catalog Numbersc-40986
Specieshuman
NCBI Full Gene Namesirtuin 1
NCBI Gene AliasesSIR2, SIR2L1, SIR2alpha
TypesiRNA/dsRNA
Quantity10 µM
Gene Namesirtuin 1

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Santa Cruz Biotechnology, Inc.

10410 Finnell Street

Dallas, Texas 75220

United States

Phone: 1-800-457-3801
831-457-3801

Company Profile

Website: http://www.scbt.com/

(1) Targeting TGF-β–Smad2/3–JNK1-mediated SIRT1 activity overcomes the chemoresistance of KRAS mutation lung cancerExperimental & Molecular MedicineSeptember 12, 2025Dong Hoon Shin, Minyoung Choi, Chungyong Han, Sang Soo Kimpurchased from Addgene. Small interfering RNAs (siRNAs), including siKRAS (sc-35731 and sc-43874), siSIRT1 (sc-40986) and siSmad2/3 (sc-37238) and antibodies including SIRT1 (sc-15454), KRAS (F234, sc-30), PARP (sc-8007)

(2) Acer tegmentosum Maxim and Bacillus subtilis-fermented products inhibit TNF-α-induced endothelial inflammation and vascular dysfunction of the retina: the role of tyrosol moiety in active compounds targeting Glu230 in SIRT1Frontiers in PharmacologyNovember 20, 2024Phuc Anh Nguyen, Jong Soon Won, Min Kyung Chowere purchased from Bio-Rad (Hercules, CA, United States). The Sirt1 small interfering RNA (siRNA, sc-40986) and non-targeting scrambled RNA (control siRNA, sc-37007) were obtained from Santa Cruz Biotechnology

(3) Acacetin protects against acute lung injury by upregulating SIRT1/ NF-κB pathwayHeliyonSeptember 15, 2024Gu L, Yin Y, Liu M, Yu L.Culture Collection (#CCL-185, Rockville, MD, USA). Control siRNA (#sc-37007), SIRT1 specific siRNA (#sc-40986), siRNA Transfection Reagent (#sc-29528) were purchased from Santa Cruz Biotechnology (USA). 2.2 Survival

(4) Identification of zinc finger MIZ-type containing 2 as an oncoprotein enhancing NAD-dependent protein deacetylase sirtuin-1 deacetylase activity to regulate Wnt and Hippo pathways in non-small-cell lung cancerCellular & Molecular Biology LettersSeptember 12, 2024Xueting Gan, Yuheng Feng, Yang Liu, Xuyong Lin, Xinmiao Yu, Xuezhu Rong, Qiang HanBaihao Company (Shenyang, China). Control siRNA (sc-37007), siRNA-ZMIZ2 (sc-89373), and siRNA-SIRT1 (sc-40986) were purchased from Santa Cruz Technology Inc. (CA). Lentivirus-ZMIZ2 and sgRNA-ZMIZ2 lentivirus plasmids

(5) A molecular circuit linking the BCR to the NAD biosynthetic enzyme NAMPT is an actionable target in Richter syndrome∗Blood AdvancesApril 23, 2024Vincenzo G. Messana, Amelia Fascì, Nicoletta Vitale, Matilde Micillo, Matteo Rovere, Noemi A. Pesce, Claudio Martines, Dimitar G. Efremov, Tiziana Vaisitti, Silvia DeaglioSIRT2 silencing, freshly isolated RS cells (6 × 106) were transfected with validated siRNA for SIRT1 (sc-40986), SIRT2 (sc-40988), or scramble siRNA (sc-37007), from Santa Cruz Biotechnology (DBA Italia, Milan,

(6) Sirtuin1 Mediates the Protective Effects of Echinacoside against Sepsis-Induced Acute Lung Injury via Regulating the NOX4-Nrf2 AxisAntioxidants (Basel, Switzerland)October 29, 2023Xie W, Deng L, Lin M, Huang X, Qian R, Xiong D, Liu W, Tang S.were analyzed using Flowjo 10.8.1 software. 2.16. siRNA Transfection siRNAs specific for SIRT1 (Cat# sc-40986, Santa Cruz, Dallas, TX, USA) or scrambled control (Cat# sc-37007, Santa Cruz, USA) were transfected

(7) Identification of SIRT3 as an eraser of H4K16laiScienceOctober 20, 2023Zhuming Fan, Zhiyang Liu, Nan Zhang, Wenyu Wei, Ke Cheng, Hongyan Sun, Quan HaoMG,Merk,09063001 ,, Oligonucleotides,Oligonucleotides,Oligonucleotides ,, SIRT1 siRNA,Santa Cruz,sc-40986 SIRT2 siRNA,Santa Cruz,sc-40988 SIRT3 siRNA,Santa Cruz,sc-61555 HDAC3 siRNA,Santa Cruz,sc-35538 Control

(8) NAD Supplement Alleviates Intestinal Barrier Injury Induced by Ethanol Via Protecting Epithelial Mitochondrial FunctionNutrientsDecember 30, 2022Li W, Zhou Y, Pang N, Hu Q, Li Q, Sun Y, Ding Y, Gu Y, Xiao Y, Gao M, et al.

(9) Hyperacetylation of the C-terminal domain of p53 inhibits the formation of the p53/p21 complexBiochemical and biophysical research communicationsDecember 20, 2022Kim U, Kim KS, Park JK, Um HD.

(10) "Hyperglycemic Neurovasculature-On-A-Chip to Study the Effect of SIRT1-Targeted Therapy for the Type 3 Diabetes ""Alzheimer's Disease"""Advanced science (Weinheim, Baden-Wurttemberg, Germany)December 1, 2022Jang M, Choi N, Kim HN.

(11) Elaiophylin Inhibits Tumorigenesis of Human Lung Adenocarcinoma by Inhibiting Mitophagy via Suppression of SIRT1/Nrf2 SignalingCancersNovember 25, 2022Ji J, Wang K, Meng X, Zhong H, Li X, Zhao H, Xie G, Xie Y, Wang X, Zhu X.purchased from GenePharma (Shanghai, China). The SIRT1 siRNA was purchased from Santa Cruz Biotechnology (sc-40986, Dallas, TX, USA). Cells were seeded in 96-well plates (1 × 104 cells/well) or 6-well plates (1 × 105

(12) SARS-CoV-2 virus NSP14 Impairs NRF2/HMOX1 activation by targeting Sirtuin 1Cellular & molecular immunologyAugust 1, 2022Zhang S, Wang J, Wang L, Aliyari S, Cheng G.incubated at 37 °C for 24 h. siRNA-mediated gene knockdown The pooled siRNAs against human SIRT1 (sc-40986) and PGC-1α (sc-38884) were purchased from Santa Cruz Biotechnology. For siRNA transfection. siRNA against

(13) Protein Kinase CK2 Is Upregulated by Calorie Restriction and Induces AutophagyMolecules and CellsMarch 31, 2022Jeong-Woo Park, Jihyeon Jeong, Young-Seuk BaeSigma-Aldrich (USA). We also purchased antibodies against CK2α, CK2β, β-actin, SIRT1, and siRNA for SIRT1 (sc-40986) from Santa Cruz Biotechnology (USA). We obtained antibodies against LC3, Atg5, Atg7, Atg5 (D5F5U),

(14) Dual Effects of Korean Red Ginseng on Astrocytes and Neural Stem Cells in Traumatic Brain Injury: The HO-1-Tom20 Axis as a Putative Target for Mitochondrial FunctionCellsMarch 4, 2022Kim M, Moon S, Jeon HS, Kim S, Koh SH, Chang MS, Kim YM, Choi YK.

(15) Fucoxanthin Attenuates Oxidative Damage by Activating the Sirt1/Nrf2/HO-1 Signaling Pathway to Protect the Kidney from Ischemia-Reperfusion InjuryOxidative medicine and cellular longevityJanuary 1, 2022Mao H, Wang L, Xiong Y, Jiang G, Liu X.

(16) SIRT4-Catalyzed Deacetylation of Axin1 Modulates the Wnt/β-Catenin Signaling PathwayFrontiers in oncologyJanuary 1, 2022Wang Y, Yue J, Xiao M, Lu X, Chin YE.(siRNAs) against SIRT family mRNAs were purchased from Santa Cruz Biotechnology, Inc. (SIRT1 siRNA (h), sc-40986, SIRT3 siRNA (h), sc-61555, SIRT4 siRNA (h), sc-63024, SIRT5 siRNA (h), sc-63026, SIRT6 siRNA (h), sc-63028,

(17) Protocatechualdehyde Rescues Oxygen-Glucose Deprivation/Reoxygenation-Induced Endothelial Cells Injury by Inducing Autophagy and Inhibiting Apoptosis via Regulation of SIRT1Frontiers in pharmacologyJanuary 1, 2022Cao S, Chen S, Qiao X, Guo Y, Liu F, Ding Z, Jin B.

(18) Ginsenoside Rg3 Attenuates TNF-α-Induced Damage in Chondrocytes through Regulating SIRT1-Mediated Anti-Apoptotic and Anti-Inflammatory MechanismsAntioxidants (Basel, Switzerland)December 10, 2021Ma CH, Chou WC, Wu CH, Jou IM, Tu YK, Hsieh PL, Tsai KL.

(19) Patchouli alcohol ameliorates skeletal muscle insulin resistance and NAFLD via AMPK/SIRT1-mediated suppression of inflammationMolecular and cellular endocrinologyDecember 1, 2021Pyun DH, Kim TJ, Park SY, Lee HJ, Abd El-Aty AM, Jeong JH, Jung TW.

(20) Oxymatrine attenuates oxidized low‑density lipoprotein‑induced HUVEC injury by inhibiting NLRP3 inflammasome‑mediated pyroptosis via the activation of the SIRT1/Nrf2 signaling pathwayInternational journal of molecular medicineOctober 1, 2021Jin X, Fu W, Zhou J, Shuai N, Yang Y, Wang B.cat. no. sc-45469) and control siRNA-B (siNC; cat. no. sc-44230), siRNA for SIRT1 (siSIRT1; cat. no. sc-40986) and control siRNA-A (siCon; cat. no. sc-37007) were purchased from Santa Cruz Biotechnology, Inc. HUVEC

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SIRT1 siRNA (h)

SIRT1 siRNA (h) from Santa Cruz Biotechnology, Inc.

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Santa Cruz Biotechnology, Inc.

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SIRT1 siRNA (h) from Santa Cruz Biotechnology, Inc.

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