SignalSilence ® Bcl-xL siRNA I from Cell Signaling Technology

Product Specs
ItemSignalSilence ® Bcl-xL siRNA I
CompanyCell Signaling Technology
Price $369.00 Inquire
Catalog Number6362S
Quantity300 µl
TargetBCL-xL
NCBI Gene AliasesBCL-XL/S, BCL2L, BCLX, Bcl-X, PPP1R52
NCBI Full Gene NameBCL2 like 1
Research AreaApoptosis
ReactivityH
ApplicationssiRNA
TypesiRNA

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Cell Signaling Technology

3 Trask Lane

Danvers, Massachusetts 01923

United States

Phone: 877-616-CELL
Phone: 978-867-2388
Fax: 866-432-6112
Fax: 978-867-2488

Company Profile

Website: http://www.cellsignal.com/

Website: Technical Support

(1) Interaction between NF-κB and PLAC8 impairs autophagy providing a survival advantage to prostate cells transformed by cadmiumSci AdvJune 13, 2025Vaibhav Shukla, Ashish Tyagi, Balaji Chandrasekaran, Bhawna Tyagi, Balpreet Singh, Thulasidharan Nair Devanarayanan, Venkatesh Kolluru, Murali K. Ankem, Chendil DamodaranOrigene), or BCL-xL (TR320077, Origene) knockdown were generated by shRNA and antibiotic selection. BCL-xL (6362, Cell Signaling) or a control small interfering RNA was used for transient transfection. For overexpression

(2) OGDH and Bcl-xL loss causes synthetic lethality in glioblastomaJCI InsightMarch 14, 2024Trang T.T. Nguyen, Consuelo Torrini, Enyuan Shang, Chang Shu, Jeong-Yeon Mun, Qiuqiang Gao, Nelson Humala, Hasan O. Akman, Guoan Zhang, Mike-Andrew Westhoff, et al.siRNA (s10709) were purchased from Thermo Fisher Scientific. Cells were transfected with Bcl-xL-1 (CST, 6362) and Bcl-xL-2 (CST, 6363) siRNA using Lipofectamine RNAiMAX (Invitrogen, 13778075) according to the

(3) Induction of Synthetic Lethality by Activation of Mitochondrial ClpP and Inhibition of HDAC1/2 in GlioblastomaClinical cancer research : an official journal of the American Association for Cancer ResearchMay 2, 2022Nguyen TTT, Shang E, Schiffgens S, Torrini C, Shu C, Akman HO, Prabhu VV, Allen JE, Westhoff MA, Karpel-Massler G, et al.siRNA (L-003493–00–0005), HDAC2 siRNA (L-003495–02–0005), Mcl1 siRNA (J-004501–17–0005). Bcl-xL (CST, 6362) siRNA was obtained from Cell Signaling Technology. Transfections were performed with Lipofectamine

(4) Snail mediates crosstalk between TGFβ and LXRα in hepatocellular carcinomaCell death and differentiationMay 1, 2018Bellomo C, Caja L, Fabregat I, Mikulits W, Kardassis D, Heldin CH, Moustakas A.

(5) Bortezomib Alone and in Combination With Salinosporamid A Induces Apoptosis and Promotes Pheochromocytoma Cell Death In Vitro and in Female Nude MiceEndocrinologyOctober 1, 2017Petra Bullova, Antony Cougnoux, Geena Marzouca, Juraj Kopacek, Karel Pacak

(6) Lysosomotropism depends on glucose: a chloroquine resistance mechanismCell death & diseaseAugust 24, 2017Gallagher LE, Radhi OA, Abdullah MO, McCluskey AG, Boyd M, Chan EYW.

(7) Design, Synthesis and Biological Evaluation of novel Hedgehog Inhibitors for treating Pancreatic CancerScientific reportsMay 10, 2017Kumar V, Chaudhary AK, Dong Y, Zhong HA, Mondal G, Lin F, Kumar V, Mahato RI.

(8) The Rab7 effector PLEKHM1 binds Arl8b to promote cargo traffic to lysosomesThe Journal of cell biologyApril 3, 2017Marwaha R, Arya SB, Jagga D, Kaur H, Tuli A, Sharma M.

(9) JMJD3 suppresses stem cell-like characteristics in breast cancer cells by downregulation of Oct4 independently of its demethylase activityOncotargetMarch 28, 2017Xun J, Wang D, Shen L, Gong J, Gao R, Du L, Chang A, Song X, Xiang R, Tan X.

(10) Acute lymphoblastic leukemia cells are sensitive to disturbances in protein homeostasis induced by proteasome deubiquitinase inhibitionOncotargetMarch 28, 2017Magdalena Mazurkiewicz, Ellin-Kristina Hillert, Xin Wang, Paola Pellegrini, Maria Hägg Olofsson, Karthik Selvaraju, Padraig D’Arcy, Stig Linder

(11) Ibulocydine sensitizes human hepatocellular carcinoma cells to TRAIL-induced apoptosis via calpain-mediated Bax cleavageThe international journal of biochemistry & cell biologyFebruary 1, 2017Park SS, Jwa E, Shin SH, Ju EJ, Park I, Pak JH, Hwang JJ, Cho DH, Kim BM, Kim SB, et al.

(12) The proteasome deubiquitinase inhibitor VLX1570 shows selectivity for ubiquitin-specific protease-14 and induces apoptosis of multiple myeloma cellsScientific reportsJune 6, 2016Wang X, Mazurkiewicz M, Hillert EK, Olofsson MH, Pierrou S, Hillertz P, Gullbo J, Selvaraju K, Paulus A, Akhtar S, et al.

(13) BRD4-targeted therapy induces Myc-independent cytotoxicity in Gnaq/11-mutatant uveal melanoma cellsOncotargetOctober 20, 2015Ambrosini G, Sawle AD, Musi E, Schwartz GK.siRNA (sc-37007) were purchased from Santa Cruz Biotechnology. Bcl-xL siRNA was from Cell Signaling (#6362), and siRNA-2 SMARTpool from Dharmacon (L-004937-00). siRNA-2 for Rad51 (L-003530-00) and BRD4 (L-004937-00)

(14) Receptor Tyrosine Kinase Inhibitors That Block Replication of Influenza A and Other VirusesAntimicrobial Agents and ChemotherapyDecember 1, 2011Naveen Kumar, Nishi R. Sharma, Hinh Ly, Tristram G. Parslow, Yuying Liangand avirulent Pichinde viruses: a model virus to study arenavirus-induced hemorrhagic fevers. J. Virol. 83:6357–6362. 14. Le, Q. M., et al. 2005. Avian flu: isolation of drug-resistant H5N1 virus. Nature 437:1108. 15.

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