SignalSilence ® PKA C-alpha siRNA I from Cell Signaling Technology

Product Specs
ItemSignalSilence ® PKA C-alpha siRNA I
CompanyCell Signaling Technology
Price $369.00 Inquire
Catalog Number6406S
Quantity300 µl
TargetPKA C-alpha
NCBI Gene AliasesCAFD1, PKACA, PPNAD4
NCBI Full Gene Nameprotein kinase cAMP-activated catalytic subunit alpha
Research AreaCa, cAMP and Lipid Signaling
Molecular Weight42
ReactivityH
ApplicationssiRNA
TypesiRNA

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Cell Signaling Technology

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Website: http://www.cellsignal.com/

Website: Technical Support

(1) Markers of MEK inhibitor resistance in low-grade serous ovarian cancer: EGFR is a potential therapeutic targetCancer Cell InternationalDecember 1, 2019Marta Llaurado Fernandez et al.resistant to single selumetinib and erlotinib treatments. However, when the drugs were combined, VOA-6406 and VOA-3723 cell lines demonstrated complete cell death while VOA-4627 and VOA-3993 cells were shown

(2) Differential phosphorylation signals control endocytosis of GPR15Molecular biology of the cellAugust 15, 2017Okamoto Y, Shikano S.transfected with 10 nM control siRNA (D-001206-13-05; GE Dharmacon) or siRNA against PKA catalytic subunit α (6406S; Cell Signaling Technology) using Lipofectamine RNAiMAX (ThermoFisher). After 24 h, the cells were replated

(3) Viral Replication Complexes Are Targeted by LC3-Guided Interferon-Inducible GTPasesCell host & microbeJuly 12, 2017Biering SB, Choi J, Halstrom RA, Brown HM, Beatty WL, Lee S, McCune BT, Dominici E, Williams LE, Orchard RC, et al.

(4) Intracellular ascorbate tightens the endothelial permeability barrier through Epac1 and the tubulin cytoskeletonAmerican journal of physiology. Cell physiologyOctober 1, 2016Parker WH, Rhea EM, Qu ZC, Hecker MR, May JM.small interfering RNA (siRNA) to inhibit expression of PKA␣ catalytic subunit (PKA C-␣; catalog no. 6406; Cell Signaling Technology; 10 nM) or control siRNA with fluorescein conjugate (catalog no. 6201; Cell Signaling Technology

(5) The Histone Deacetylase Inhibitor JAHA Down-Regulates pERK and Global DNA Methylation in MDA-MB231 Breast Cancer CellsMaterials (Basel)October 16, 2015Mariangela Librizzi, Roberto Chiarelli, Liana Bosco, Supojjanee Sansook, Jose M. Gascon, John Spencer, Fabio Caradonna, Claudio Luparello

(6) Dynamic mitochondrial-nuclear redistribution of the immunophilin FKBP51 is regulated by PKA signaling pathway to control gene expression in the process of adipocyte differentiationJournal of Cell ScienceDecember 1, 2013Judith Toneatto, Sergio Guber, Nancy L. CharÃ³, SebastiÃ¡n Susperreguy, Jessica Schwartz, Mario D Galigniana, Graciela Piwien-PilipukMA, USA). Rabbit polyclonal IgG against PKA-ca and C/EBPb, as well as the siRNAs for PKA-ca (cat. no. 6406) and control siRNA (cat. no. 6201) were from Cell Signaling Technology, Inc. (Beverly, MA, USA). Secondary antibodies

(7) The BCL2 antagonist of cell death pathway influences endometrial cancer cell sensitivity to cisplatinGynecologic OncologyJanuary 1, 2012Hye Sook Chon, Douglas C. Marchion, Yin Xiong, Ning Chen, Elona Bicaku, Xiaomang Ba Stickles, Nadim Bou Bou Zgheib, Patricia L. Judson, Ardeshir Hakam, Jesus Gonzalez-Bosquet, et al.by MTS assay. Two different siRNAs for each target were used in this study: protein kinase A (PKA; #6406, #6574 Cell Signaling) and PP2C (PPM1A #s10919, #s10920, Applied Biosystems). RESULTS Gene and pathway

(8) BAD phosphorylation determines ovarian cancer chemo-sensitivity and patient survivalClinical Cancer ResearchOctober 1, 2011Douglas C. Marchion et al.Transfection RNA duplexes for PP2C/PPM1A (s10909 and s10919, ABI), cAMP-dependent protein kinase (PKA; 6406 and 6574, Cell Signaling), and pFlag-600 vectors containing full-length BAD harboring serine (S) to

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