Description
MACS® Matchmaker - With the MACS
® Matchmaker you can experience a robust platform that delivers quantitative data on binder affinity, kinetics, and specificity in complex samples. Unlock new possibilities in your research today – because every target deserves its perfect match!
The MACS
® Matchmaker is the first commercial instrument using focal molography technology, an entirely new methodology to explore protein-protein interactions directly in complex biological samples like serum, plasma or cell culture supernatant. This innovative approach provides a direct, undisturbed view of molecular dynamics in their natural state, without the need for labels, overcoming traditional research limitations like signal disturbance and non-specific binding. It's not just an instrument; it's a gateway to a new era of life sciences research, enabling real-time observation and quantification of biological processes. It is transforming biological research, paving the way for more accurate, efficient, and straightforward studies, heralding a groundbreaking future in molecular interaction research.
Key benefits of the system include:
- Interaction studies in complex samples: in vivo like measurement and saving time by eliminate the hassle of sample pre-purification
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Automated acquisition: Use the MACS® Sampler for fully unattended runs in combination with up to 2 x 384 well plates
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Multiplexed assays: Characterize 64 interactions simultaneously, significantly reducing experiment times
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Label-free analysis: Focal molography is a label-free interaction technology able to characterize a plurality of important interactions.
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Pico-molar sensitivity: Characterize even small proteins or peptides at pM sensitivity in complex biological matrices.
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Drift-free data: Experience robust and more reliable data with minimized artifacts with a drift of <0,05 pg/mm2/min. Perfect for characterizing low-off rate binders.
MACS® Sampler - Simplify your workflow and save valuable laboratory time with the fully automated MACS
® Sampler, a perfect extension for the MACS
® Matchmaker instrument, allowing you to fully integrate automatization solution for your interaction studies. Depending on your need you can combine the MACS
®Matchmaker with the MACS
® Sampler, a fully integrated automatization solution for your interaction studies.
- Sample format: 300 or 1800 µL vials, 96 or 384 well plates.
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Capacity: 2 positions for 48 vial tray or well plates.
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Throughput: Characterize up to 1536 interactions per day
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Flow path: One needle, one syringe pump
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Hands off: Up to 4 days unattended run time
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Biocompatibility: metal-free flow path for samples injection via biocompatible sample needle, valves, and tubing.
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Cooling: Sample compartment can be chilled at 4 °C for optimal storage.
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Software: Seamless integration into the MACS® Matchmaker software.
*with DNA directed immobilization chemistry in batches of 64 immobilized compounds against one target.