SVG p12 from ATCC

Product Specs
ItemSVG p12
CompanyATCC
Price $551.00Supplier Page View Company Product Page
Catalog NumberCRL-8621
TypeCell Biology
SpeciesHomo sapiens
TissueBrain
Cell LineSVG p12
Validated Species ReactivityHuman (Hu)
Tissue (standardized)Brain
Cell Typeastroglia
Agefetus; third trimester
ApplicationsThe are susceptible to infection by JC virus, and may be useful in, detecting and cultivating other human neurotropic viruses

Specifications/Features

Post freeze viability ≥ 50%

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ATCC

10801 University Boulevard

Manassas, Virginia 20110-2209

United States

Phone: (703) 365-2700
Fax: (703) 365-2701

Company Profile

Website: http://www.atcc.org

(1) Cinobufotalin reduces glioblastoma resistance to temozolomide by inhibiting the CCL5-mediated PI3K/Akt/mTOR signaling pathwayTranslational Cancer ResearchMarch 31, 2026Jiwei Sun, Xianyuan Ma, Jian Song, Yesen Zhang, Ning Li, Yulong Li, Xiang Zhang, Yi Hananalyze the results. Cell culture and treatment GBM cells including SVGp12 (ATCC, Manassas, VA, USA; CRL-8621, RRID: CVCL_3797), U251 (Procell, Wuhan, China; CL-0237, RRID: CVCL_5H95), and U138 (ATCC, HTB-16, RRID:

(2) SHH pathway inhibition and astrocyte co-culture induce distinct responses in glioblastoma and cancer stem cellsScientific ReportsFebruary 7, 2026Duygu Calik Kocaturk, Berrin Ozdil, Yasemin Adali, Huseyin Aktug, Vildan Bozok, Ayşegul Uysallines and culture conditions Human astrocytes and GBM cell lines were represented with SVG p12 (ATCC CRL-8621) and U87 MG (ATCC HTB-14), respectively. Cells were cultured in Eagle’s Minimum Essential Medium (EMEM;

(3) Nanoplastics trigger glial–neuronal collagen signaling miscommunication to exacerbate cognitive impairment in Alzheimer's diseaseAlzheimer's & DementiaJanuary 21, 2026Yizhou Zhong, Bingchi Fan, Xiaohong Yang, Yuji Huang, Boxuan Liang, Zhiming Li, Xiaohu Ren, Hongyi Xian, Yanhong Deng, Yu Feng, et al.SVG p12 was purchased from the American Type Culture Collection (ATCC, Manassas, VA, USA, Catalog No. CRL‐8621), while human microglia line HMC3 (Catalog No. CL_0620) and neuron line SH‐SY5Y were obtained from Procell

(4) The Glycosaminoglycan‐Dependent Interactome of Neurexin‐1 in Human Fetal Glial CellsProteoglycan ResearchDecember 18, 2025Meg Critcher, Han Wu, Yajing Lu, Mia L. Huangwas performed on the resulting transformants by PlasmidSaurus. 4.2 | Cell Culture SVG p12 cells (CRL-8621) were purchased from ATCC and cultured in EMEM (ATCC, #30–2003) supplemented with 10% FBS (Omega Scientific

(5) Reversibly unlocking the blood–brain barrier: A study on microtubule dynamics modulation using gold nanoparticle-modified reduced graphene oxideActa Pharmaceutica Sinica BDecember 15, 2025Junrong Wu, Guangman Cui, Zhousheng Lin, Wanmei Lin, Yaqing Zhang, Tianhang Zhou, Ping He, Yunjiao Zhang, Guangyu Yao3 μm, Corning, USA) were used. HCMEC/D3 cells (BNCC337728, BNCC, Beijing, China) and SVG p12 cells (CRL-8621, ATCC, VA, USA) were separately seeded in the upper and lower chambers, and they were separately cultured

(6) How endosomal PIKfyve inhibition prevents viral membrane fusion and entrybioRxivNovember 28, 2025Nicholas Chow, Gustavo Scanavachi, Anand Saminathan, Tom Kirchhausenfetal bovine serum (FBS) and 1% penicillin-streptomycin (P/S) at 37°C in 5% CO2. SVG-A cells (ATCC CRL-8621) and a homozygous gene-edited derivative expressing EEA1–mScarlet and NPC1–HaloTag from both alleles11

(7) Mitochondrial stress-induced protein carboxyl-terminal alanine threonine tailing (msiCAT-tailing) facilitates glioblastoma tumorigenesis through the modulation of mitochondrial functionsbioRxivJune 19, 2025Bei Zhang, Ting Cai, Esha Reddy, Yuanna Wu, Adaeze Scholastical Gbufor, Yinglu Tang, Isha Mondal, Jerry Wang, Yawei Shen, Qing Liu, et al.Methods Cell lines and cell culture conditions The human astroglia cell line SVG p12 (ATCC, cat. CRL-8621) and the human glioma cell line SF268 were from Dr. Rongze Olivia Lu. Both cell lines were cultured

(8) CRISPR antiviral inhibits neurotrophic JC polyomavirus in 2D and 3D culture models through dual-gRNA excision by SaCas9Molecular Therapy Nucleic AcidsJune 10, 2025Angela Rocchi, Shuren Liao, Hong Liu, Chen Chen, Senem Çakır, Anna Bellizzi, Hassen S. Wollebo, Ilker K. Sariyer, Kamel Khalililines transformed by SV40 large tumor antigen were originally purchased from ATCC. SVGA cells (ATCC CRL-8621) are fetal astroglia used for infection studies and the creation of novel construct-expressing cell

(9) Dual-enzyme activated theranostic nanoparticles for image-guided glioblastoma therapySci RepApril 19, 2025Zahra Shokri Varniab, Edwin Chang, Jie Wang, Ramesh Duwa, Vidyani Suryadevara, Wei Wu, Manoj Kumar, Tie Liang, Zubeda Khatoon, Goreti Ribeiro Morais, et al.passages) for all subsequent experiments. SVG p12 cells used in this study were obtained from ATCC (CRL-8621™). This cell line was originally established by transfecting cultured human fetal glial cells with DNA

(10) Regional variation in mineral content, cytotoxicity, and antioxidant activity of Aerodramus fuciphagus nests from different districts in Kelantan, MalaysiaJournal of Advanced Veterinary and Animal ResearchMarch 24, 2025Mohd Dasuki Sul'ain, Musa Isah, Wan-Nor-Amilah Wan Abdul WahabCCL-2™), the MCF-7 breast cancer cell line (ATCC® HTB22™), and the glial regular cell line SVG p12 (ATCC® CRL-8621™). After every 24 h, the cells were carefully maintained through routine passage to ensure uninterrupted

(11) A genetically encoded fluorescent sensor enables sensitive and specific detection of IDH mutant associated oncometabolite D-2-hydroxyglutarateBMC CancerMarch 14, 2025Kristian A. Choate, Wren W. L. Konickson, Zoe L. Moreno, Olivia S. Brill, Brett C. Cromell, Bella M. Detienne, Matthew J. Jennings, Paul B. Mann, Robert J. Winn, David O. Kamson, et al.values for 30 s. Cell viability assays U87MG, IDH1-R132H mutant U87MG, and SVG (ATCC, Manassas, VA, CRL-8621) cells were plated at 10,000 cells per well in an opaque 96-well plate with complete media and incubation

(12) The effect of Polybrominated diphenyl ethers at the fetal blood-brain-barrier: evaluation using a microphysiological systemFront Cell Dev BiolMarch 12, 2025Sourabh Sharma, Manuel Vidal, Souvik Paul, Arum Han, Ramkumar Menon, Lauren S. RichardsonThe fetal brain cells used in this study were SVG p12 (astroglia) obtained from ATCC (ATCC cat. no. CRL-8621, Manassas, VA) and HMC3 (microglia) (ATCC cat. no. CRL-3304, Manassas, VA). Astroglia and microglia

(13) Glycosylated Delphinidins Decrease Chemoresistance to Temozolomide by Regulating NF-κB/MGMT Signaling in GlioblastomaCellsJanuary 24, 2025Diego Carrillo-Beltrán, Yessica Nahuelpan, Constanza Cuevas, Karen Fabres, Pamela Silva, Jimena Zubieta, Giovanna Navarro, Juan P. Muñoz, María A. Gleisner, Flavio Salazar-Onfray, et al.Cells Lines and Delphinidin Stock Preparation U87-MG (HTB-14) cell line (Glioblastoma) and the SVGp12 (CRL-8621) cell line (Glial cells from the brain) were obtained directly from ATCC. Primary GBM38 tumor culture

(14) Identification of Stable Reference miRNAs for miRNA Expression Analysis in Adult Neurogenesis Across Mouse and Human TissuesCellsDecember 13, 2024Daniella Liana Levitis, Julia Si, Kushal Ravishankar, Michal Toborek, Minseon Parkwith HIV (NL 4-3) for 24 h,, SVG p12,Human,Human Fetal Glial cells,"ATCC (Manassas, VA, USA. Cat# CRL-8621)" "ATCC (Manassas, VA, USA. Cat# CRL-8621)",SVG p12- CON,, "ATCC (Manassas, VA, USA. Cat# CRL-8621)",SVG p12

(15) OTUB1 Promotes Glioblastoma Growth by Inhibiting the JAK2/STAT1 Signaling PathwayJournal of CancerJune 24, 2024Jun Yang, Na Zhang, Zesong He, Junyi Xiong, Wei Meng, Chengcheng Xue, Li Ying, Meihua Li, Mei Liu, Taohui Ouyangclinical parameters of the included patients are shown in Table S2. Cell cultures Normal glial SVG p12 (CRL-8621) and GBM U87 (HTB-14) cells were purchased from ATCC. The T98G, U251, and U118MG cells were provided

(16) Reduction of spermine synthase enhances autophagy to suppress Tau accumulationCell death & diseaseMay 13, 2024Tao X, Liu J, Diaz-Perez Z, Foley JR, Nwafor A, Stewart TM, Casero RA Jr, Zhai RG.and transformed into cells as reported [43]. Control or SMS siRNA are transfected into SVG p12 cells (CRL-8621, ATCC) on coverslips in 12-well plates as mentioned above. Three days after transfection, the sonicated

(17) KRAS is a molecular determinant of platinum responsiveness in glioblastomaBMC CancerJanuary 15, 2024Candida Zuchegna, Stefano Leone, Antonella Romano, Antonio Porcellini, Samantha Messinaand 10% Fetal Bovine Serum (FBS; South America origin, Brazil). SVGp12 Human Fetal Glial Cells (ATCC-CRL-8621 # 4282167) and NHA cells (purchased from Cambrex Corporation, East Rutherford, NJ) were grown according

(18) Novel SOX10 indel mutations drive schwannomas through impaired transactivation of myelination gene programsNeuro-OncologyDecember 8, 2023Erik A Williams, Ajay Ravindranathan, Rohit Gupta, Nicholas O Stevers, Abigail K Suwala, Chibo Hong, Somang Kim, Jimmy Bo Yuan, Jasper Wu, Jairo Barreto, et al.from brain material dissected from 8 to 12-week old human embryos were obtained directly from ATCC (CRL-8621). See Supplementary Methods for further details. Primary Human Schwannoma Cell Culture Schwannoma

(19) Simple design for membrane-free microphysiological systems to model the blood-tissue barriersOrgans-on-a-ChipDecember 6, 2023By Ashlyn T. Young, Halston Deal, Gabrielle Rusch, Vladimir A. Pozdin, Ashley C. Brown, Michael Danielewith 10% FBS (Genesee) and 1X penicillin/gentamicin. SVGP12 cells were purchased from ATCC (Catalog #CRL-8621) and cultured in DMEM supplemented with 10% FBS and 1X penicillin/gentamicin. Standard aseptic techniques

(20) Adipose‑derived stem cell‑mediated alphastatin targeting delivery system inhibits angiogenesis and tumor growth in gliomaMolecular medicine reportsNovember 1, 2023Liang C, Wei T, Zhang T, Niu C.purchased from Procell Life Science & Technology Co., Ltd. The SVG p12 human astroglia cell line (cat no. CRL-8621) was purchased from the ATCC. The HUVECs used in the present study were not primary cells. Suppliers

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