EM VCT500 Vacuum Cryo Transfer System from Leica Microsystems

Product Specs
ItemEM VCT500 Vacuum Cryo Transfer System
CompanyLeica Microsystems
Price Get Pricing Get Quote for this Product
Catalog NumberEM VCT500
QuantityEA
TypeVacuum Cryo Transfer System
ApplicationsCryo-transfer of vitrified samples for cryo-electron microscopy imaging

Specifications/Features

Workflow specimen monitoring
Links workflow from preparation to analysis
Connects to more than one SEM
Various specimen holders for SEM, FIB-SEM, freeze-fracture and more

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Leica Microsystems

10 Parkway North Blvd., Suite 300

Deerfield, Illinois 60015

United States

Phone: 800 248 0123

Company Profile

Website: www.leica-microsystems.com

(1) BaTiO3 Nanoparticle-Induced Interfacial Electric Field Optimization in Chloride Solid Electrolytes for 4.8 V All-Solid-State Lithium BatteriesNano-Micro LettersDecember 1, 2026Qingmei Xiao, Shiming Huang, Donghao Liang, Cheng Liu, Ruonan Zhang, Wenjin Li, Guangliang Gary Liuadhesive tape. Sample transfer to the instrument was achieved under an inert atmosphere using a Leica EM VCT500 transfer system (Leica Microsystems). All measurements were performed in negative ion mode with Bi3+

(2) Photoresponsive Polycations Bearing an Arylazopyrazolium DyeACS OmegaMarch 31, 2026René Steinbrecher, Martin Reifarth, Jiayin Yuan, Christine M. Papadakis, Peter Müller-Buschbaum, Andreas Taubert, André Laschewsky(Leica) mounting chamber, where the specimen was fixed on a cryo-EM stage and then collected with the EM VCT500 (Leica) shuttle. The final step of the preparation was performed in the EM ACE600 (Leica) preparation

(3) Breeding Chlorophyll-Deficient Mutants of Chlorella vulgaris to Enhance Consumer AcceptanceBioengineering (Basel)March 10, 2026Malene Lihme Olsen, Daniel Poveda-Huertes, Duygu Ozcelik, Emil Gundersen, Jens Frederik Bang Thøfner, Maryna Kobylynska, Stefania Marcotti, Roland A. Fleck, Damien McGrouther, Johan Andersen-Ranberg, et al.using a JEOL JIB-4700F Z FIB-SEM (JEOL, Akishima, Tokyo, Japan), equipped with a Leica microsystems EM VCT500 cryo stage and cryo transfer system (Leica Microsystems, Wein, Austria). Images were collected as a

(4) Hyperelastic Starch Hydrogel Configures Edible and Biodegradable All‐Components for Soft RobotsAdvanced ScienceMarch 1, 2026Siyu Yao, Haohao Hu, Mengfan Zhang, Qingqing Zhu, Donghong Liu, Shaoxing Qu, Guoyong Mao, Enbo XuCharacterizations—Cryo‐Electron Microscopy (Cryo‐EM) The micro‐morphology of the starch hydrogel was characterized by Cyro‐EM (EM VCT500, Leica, Germany). The hydrogel sample was applied to the grids (Quantifoil 1.2/1.3). Grids were then

(5) Single-cell structural biology with intracellular electron crystallographyNature CommunicationsFebruary 27, 2026Štěpánka Bílá, Dominik Pinkas, Krishna Khakurel, Juliane Boger, Tomáš Bílý, Janos Hajdu, Zdeněk Franta, Iñaki de Diego Martinez, Roman Tuma, Lars Redecke, et al.retained cells in our hands. The frozen samples were transferred, under cryogenic conditions, using a VCM/VCT500 cryo-transfer system (samples were kept below -170 °C, Leica Microsystems), into an ACE600 cryo-coater

(6) Molecular Biointerface Characterization for an Implanted Medical Device Using Cryogenic Orbitrap Secondary Ion Mass Spectrometry (Cryo-OrbiSIMS)ACS Applied Materials & InterfacesFebruary 18, 2026Akmal H. Bin Sabri, Kei F. C. Wong, Anna M. Kotowska, Leanne E Fisher, Jeni Luckett, Jimiama M. Mase, Lisa Kämmerling, Grazziela Figueredo, David J. Scurr, Amir M. Ghaemmaghami, et al.(Leica, Germany), from where they were transferred to the cryo-OrbiSIMS using a shuttle chamber Leica EM VCT500 (Leica, Germany). The cryo-OrbiSIMS is equipped with a fully proportional–integral–derivative (PID)

(7) Thermophilic bacteria employ a contractile injection system in hot spring microbial matsThe ISME JournalFebruary 10, 2026Vasil A Gaisin, Corina Hadjicharalambous, Izabela Mujakić, Cristian Villena-Alemany, Jiangning Li, Michal Koblížek, Martin Pilhoferequipped with a copper-band cooled mechanical cryo-stage (Leica Microsystems GmbH) and an integrated VCT500 vacuum transfer system (Leica Microsystems). In short, frozen EM grids were loaded onto a pre-tilted

(8) A targeted cell lysis mechanism facilitates toxin release in Clostridioides difficilebioRxivJanuary 16, 2026Shannon L. Kordus, Kateryna Nabukhotna, Rubén Cano Rodríguez, Evan Krystofiak, Kevin Childress, Anna J. Smith, Natalie Loveridge, William Ball, Grace Moore, M. Kay Washington, et al.a CLEM pre-tilted scanning electron microscopy holder (Leica). Grids were transferred using a Leica VCT500 cryo-transfer system and were sputter-coated with platinum using a Leica ACE600 cryo-sputter coater.

(9) Correlating Molecular and Textural Properties of Raw Soy‐Based and Beef Burgers Using TD‐NMR and TPAJournal of Food ScienceJanuary 9, 2026Moshe Hai Azachi, Zeev Wiesmanworkflow: Transferred under liquid nitrogen to the EM VCM station, then cryogenically transferred via EM VCT500 to the EM ACE900 freeze‐fracture device → Fractured at −140°C with a cooled knife to expose internal

(10) Electron Microscopy Transfer System to Protect Atmosphere‐Sensitive Materials for Scanning Electron Microscopy CharacterizationMicroscopy Research and TechniqueDecember 31, 2025Louis G. Corcoran, Ellen M. Monzo, Chinomso E. Onuoha, Shivasheesh Varshney, Han Seung Lee, Chris Frethem, Bharat Jalan, Alon V. McCormick, R. Lee PennEM ACE600 high vacuum sputter coater (Figure 2‐4) using a Leica vacuum cryo transfer system (Leica EM VCT500; Figure 2‐5) via the exchange ports on the VCM and ACE600 (Figure 2‐6 and Figure 2‐7, respectively).

(11) In situ structure of a gap junction–stomatin complexScience AdvancesNovember 7, 2025Nils Rosenkranz, Alexandra N. Birtasu, Konstantin Wieland, Lisa Rehm, Rachita Sharma, Atal Vats, Sina Manger, Aayush Srivastava, Abhishek Bhattacharya, Gerhard Hummer, et al.pretilted EM grid holder with shutter and additional cold trap (Leica) under liquid nitrogen using an EM VCT500 loading station (Leica). Then, the sample holder was taken up by the EM VCT500 manual transfer shuttle

(12) Mucus-derived glycans are inhibitory signals for Salmonella Typhimurium SPI-1-mediated invasionCell ReportsOctober 28, 2025Kelsey M. Wheeler, Michaela A. Gold, Corey A. Stevens, Karsten Tedin, Amanda M. Wood, Deniz Uzun, Gerardo Cárcamo-Oyarce, Bradley S. Turner, Marcus Fulde, Jeongmin Song, et al.nitrogen until further processing. For fracturing and coating, the samples were transferred into a Leica EM VCT500 vacuum transfer system and moved to a Leica ACE9000 freeze fracture system. Each sample was fractured

(13) CPOP1 is a key enzyme required for nodule microenvironment control and successful symbiotic nitrogen fixation in Lotus japonicusJournal of Integrative Plant BiologyOctober 15, 2025Yu‐Fang Tian, Yu Luo, Qi‐Min Li, Zhi‐Qin Zhang, Ya‐Long Guo, Wei‐Cai Yangnodules were then immediately frozen in liquid nitrogen and loaded into the vacuum cryotransfer system (EM VCT500; Leica; Austria). The frozen nodules were transferred to a high vacuum coater (EM ACE600; Leica; Austria)

(14) Structure and assembly of the A-C linker connecting microtubule triplets in centriolesSci AdvOctober 10, 2025Bin Cai, Jingwei Xu, Erik H. Collet, Ellen Aarts, Leo Luo, Alexander Leitner, Takashi Ishikawa, Pedro Beltrao, Chad G. Pearson, Martin Pilhofer, et al.detector, a copper band–cooled mechanical cryo-stage (Zeiss), and an integrated vacuum transfer system (VCT500 from Leica). The general cryo-FIB milling workflow was performed as previously reported (61). Briefly,

(15) Tailoring Composite Microstructure Through Milling for Dry‐Processed Sulfide‐Based Solid‐State Battery CathodesSmallSeptember 5, 2025Finn Frankenberg, Carina A. Heck, Maximilian Kissel, Martin A. Lange, Vasiliki Faka, Alexander Diener, Philipp Haase, Peter Michalowski, Wolfgang G. Zeier, Jürgen Janek, et al.sample transfers were conducted under vacuum or inert Ar‐atmosphere using the transfer system Leica EM VCT500 (Leica Microsystems GmbH, Germany). X‐ray measurements were carried out to obtain 3D information on

(16) Interface Evolution and Long-Term Performance of Negative Carbon Fiber Structural ElectrodesACS OmegaJuly 15, 2025Lynn Maria Schneider, Benedikt Sochor, Marcus Johansen, Fang Liu, Göran Lindbergh, Dan Zenkert, Stephan Roth, Sarathlal Koyiloth Vayalil, Louise Lebretsamples were freeze-cut or freeze-fractured and transferred to the cryo-stage in SEM using a Leica EM VCT500. Secondary electron images were recorded under cryo-condition with the sample stage at −100 °C and an

(17) Revealing the Hidden Polysulfides in Solid-State Na–S Batteries: How Pressure and Electrical Transport Control Kinetic PathwaysJournal of the American Chemical SocietyJuly 9, 2025Hung Quoc Nguyen, Mikael Dahl Kanedal, Juraj Todt, Feng Jin, Quyen Do, Dora Zalka, Alexey Maximenko, Dragos Stoian, Norbert Schell, Wouter van Beek, et al.oxygen-free transport from the glovebox, the samples were transferred to the high-resolution SEM in the Leica EM VCT500 transfer system. The Raman microscope used is a WITec RISE, which is fully integrated in the vacuum

(18) Purity of lithium metal electrode and its impact on lithium stripping in solid-state batteriesNat CommunJune 25, 2025Juri Becker, Timo Weintraut, Sebastian L. Benz, Till Fuchs, Christian Lerch, Pascal Becker, Janis K. Eckhardt, Anja Henß, Felix H. Richter, Jürgen Janektransfer steps from glove boxes to any device were carried out using an inert transfer system (Leica VCT500, Leica Microsystems, Germany). Cryogenic ion-milling Cross-sections of electrodeposited lithium at

(19) High‐Throughput Encapsulation of Stem Cells: Characterizing Dynamic Culture Variability With a Millifluidic ApproachAdvanced Healthcare MaterialsJune 8, 2025Oscar Fabian García‐Aponte, Marta Serra, Simon Kahlenberg, Guruprakash Subbiahdoss, Erik Reimhult, Dominik Egger, Cornelia Kaspercarbon at −120 °C. Finally, the samples were transferred to the SEM using a cryo‐transfer system (Leica EM VCT500). High‐vacuum backscattered and secondary electrons were detected using two in‐lens detectors, T1 and

(20) Tin–Carbon Dual Buffer Layer to Suppress Lithium Dendrite Growth in All-Solid-State BatteriesACS NanoMay 13, 2025Venkata Sai Avvaru, Tofunmi Ogunfunmi, Seonghun Jeong, Mouhamad Said Diallo, John Watt, Mary C. Scott, Haegyeom Kimand discharged buffer layers. The samples were transferred to the microscope using an air-free Leica EM VCT500 cryo-transfer system. The cryo-SEM and cryo-FIB experiments were performed on a Scios 2 Dual Beam SEM/FIB

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Leica EM VCT500

EM VCT500 Vacuum Cryo Transfer System from Leica Microsystems

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Specifications/Features

Leica Microsystems

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EM VCT500 Vacuum Cryo Transfer System from Leica Microsystems

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