ARGO™ HT System from Alamar Biosciences

Product Specs
ItemARGO™ HT System
CompanyAlamar Biosciences
Price Inquire
Catalog NumberARGO HT
DetectionAlamar has turned NULISA technology into a turnkey protein analysis workstation with the ARGO™ HT System. The ARGO HT System, a fully automated, high-throughput precision proteomics platform, performs ultra-high sensitivity and multiplexed analysis to support broad biomarker profiling, validation, and translation into clinical use.
ApplicationsSingle-plex and multiplex NULISA™ assays

(1) Predicting continuous amyloid PET levels with CSF and plasma brain-derived p-tau217Alzheimers DementAugust 6, 2026Lydia Trudel, Joseph Therriault, Arthur C. Macedo, Etienne Aumont, Seyyed Ali Hosseini, Andrea L. Benedet, Lili-Naz Hazrati, Serge Gauthier, Henrik Zetterberg, Paolo Vitali, et al.release, secondary capture with streptavidin beads, and ligation, were performed on the automated Alamar ARGO HT system following the manufacturer's instructions. Reporter DNA libraries containing target‐specific molecular

(2) Plasma Proteomic Changes in GRN and C9orf72 Frontotemporal DementiaEur J NeurolJuly 12, 2026Joel Simrén, Andrea L. Benedet, Guglielmo Di Molfetta, Ilaria Pola, Kübra Tan, Valentina Cantoni, Ilenia Libri, Jasmine Rivolta, Roberta Ghidoni, Henrik Zetterberg, et al.the CNS Disease Panel (124 targets listed in Table S1; Alamar Biosciences, Fremont, CA, USA) on an ARGO HT system, and the resulting DNA reporters were subsequently sequenced, processed and normalized as described

(3) Prognostic value of plasma brain-derived pTaumedRxivJune 30, 2026Valentina Ghisays, Marisa N. Denkinger, Alpana Singh, Taina M. Marques, Michael Malek-Ahmadi, Kendall Van-Keuren Jensen, Hillary D. Protas, Javad Sohankar, Dhruman D. Goradia, Vivek Devadas, et al.were measured at Michael T. Zuendel Biomarker Laboratory at Banner Sun Health Research Institute on an ARGO HT platform (Alamar Biosciences) using the NULISAseq™ CNS Disease Panel.18–20 We use the NULISA Protein

(4) Targeting Inflammation by Pioglitazone and its R-Enantiomer Mitigates Pathological Myocardial Remodeling in Murine Hypertrophic CardiomyopathyJACC Basic Transl SciJune 13, 2026Anna-Theresa Pfaller, Claudia Veneziano, Sarala Raj Murthi, Jan B. Stöckl, Bachuki Shashikadze, Florian Flenkenthaler, Josh Gorham, Alessandra Moretti, Ana Kitanovic, Linden J. Gearing, et al.α-MHC719/+, n = 4 α-MHC719/++ R-pio, n = 5 WT+ R-pio). The NULISAseq library pool was generated using the Argo HT and the Mouse Panel 120 (version 2) (#801320, Lot 2502305, Alamar Biosciences). The final library pool

(5) Human vaccine responses regulated by parallel cytokine pathwaysNature ImmunologyJune 12, 2026Guangbo Chen, Jing Guo, John Heath, Tyler R. Prestwood, Woo Joo Kwon, Ashley R. Smith, Tran T. Nguyen, Karan R. Kathuria, Elsa Sola, AbuBakr Sangare, et al.assay targeting 250 inflammation-associated proteins. The assay was processed automatically in the ARGO HT system (Alamar BioSciences). Each sample (25 μl) of was loaded on the sample plate, along with three sample

(6) Blood-based biomarker discovery in motor neuron disease using nucleic acid-linked immuno-sandwich assayBrain CommunicationsMay 26, 2026Hatice Bozkurt, Katy R Reid, Judith Newton, Jessica Gill, Isaac Chau, Chloe Parker, Hatice Kurucu King, Johnny Tam, Dominic Ng, Maria Stavrou, et al.for 1 min, transferred into the NULISAseq sample plate (provided in kit), and analysed on an Alamar ARGO HT System. The barcoded amplicon sequences for each target were quantified by next generation sequencing (NGS).

(7) Exercise serum promotes DNA damage repair and remodels gene expression in colon cancer cellsInternational Journal of CancerMay 15, 2026Samuel T. Orange, Emily Dodd, Sharanya Nath, Hannah Bowden, Alastair R. Jordan, Hannah Tweddle, Ann Hedley, Ifeoma Chukwuma, Ian Hickson, Sweta Sharma Sahacentrifuged at 2200 g for 10 min. A 25 μL aliquot of supernatant was assayed on the automated Alamar ARGO HT system (Alamar Biosciences) at Altheome Limited laboratories (London, UK). Following immunocomplex formation

(8) CXCR6+ CD127– Tr1 cells balance immunity and persistence in Plasmodium falciparum infectionJ Clin InvestMay 5, 2026Jason Nideffer, Florian Bach, Steven Strubbe, Luis Lopez, Maato Zedi, Felistas Nankya, Jessica Briggs, Kattria van der Ploeg, Kenneth Musinguzi, Soyeon Kim, et al.platform, a high-sensitivity, multiplexed immunoassay. The assay was processed automatically in the ARGO HT system (Alamar BioSciences). 25 µL of each sample was loaded on the sample plate, along with three sample controls

(9) Pre-analytical guidelines for blood and CSF Biomarkers 2025: Recommendations from the NACC ADRC Biofluid Biomarker Best Practices WorkgroupAlzheimers DementMay 4, 2026Timothy E. Van Meter, Edward N. Wilson, Fanny Elahi, Robert A. Rissman, Argentina Lario Lago, Kelley Faber, Kathryn Gauthreaux, Ricardo Osorio, Matthew Perkins, Nora Gray, et al.HD‐X1), Fujirebio Lumipulse G 1200, and multiplex discovery platforms including Alamar Biosciences ARGO HT, Somalogic Somascan, and mass spectroscopy. Note that mass spectroscopy is often used for discovery,

(10) Distinct phases of immune system programming during ART-suppressed immunodeficiency virus infectionbioRxivMay 1, 2026Maanasa Kaza, Benjamin Varco-Merth, G W McElfresh, Sebastian Benjamin, Gregory J. Boggy, Morgan Chaunzwa, Shana Feltham, Sohita Ojha, Karina Belica, Andrea N. Selseth, et al.Inflammation Panel 250 targeting mostly inflammation and immune response-related cytokines and chemokines. The ARGO™ HT platform was used to perform the NULISA workflow, starting with immunocomplex formation with DNA-barcoded

(11) Evaluation of serum as an alternative matrix to plasma for NULISA‑based proteomic blood biomarker measurementsScientific ReportsApril 18, 2026Marissa F. Farinas, Yijun Chen, Xuemei Zeng, Michel N. Nafash, Ann D. Cohen, Oscar L. Lopez, Thomas K. Karikariparticulates. The supernatants were analyzed using the NULISAseq CNS disease panel 120 (v2) on an Alamar ARGO HT system as previously described25. Briefly, samples were incubated with a cocktail of paired capture and detection

(12) Loss of neuronal population organization links pathology to behavior in a model of Alzheimer’s diseasebioRxivMarch 23, 2026Douglas A. Ruff, Drew E.G. Sheets, Ramanujan Srinath, Giovanne B. Diniz, Devon J. Griggs, Danielle Beckman, Sean Ott, Kayla Schwartz, Carissa Erices, Scott Muller, et al.compensate for technical variability. All assay steps were executed automatically using a preprogrammed ARGO HT system (Alamar Biosciences). Pooled sequencing libraries were generated and sequenced on an AVITI benchtop

(13) Head-to-head comparison of brain-derived pTau217 and total pTau217 for brain amyloid and tau pathology classificationProc Natl Acad Sci U S AMarch 10, 2026Yuanbing Jiang, Wenyue Zheng, Zengjie Xia, Wan Wa Wong, Lily K. W. Cheng, Fanny C. Ip, Siu Man Choi, Andrew L. T. Chan, Ching Yu Lam, Ka Shing Ho, et al.Appendix, Table S4). Plasma BD-pTau217 Measurement. We measured plasma BD-pTau217 levels on an Alamar ARGO HT system using the commercially available NULISAqpcr BD-pTau217 Assay (Cat. No. 801430, Alamar Biosciences).

(14) Blood-based proteomic signatures of spontaneous menopause: Implications for later-life brain aging and Alzheimer’s disease riskmedRxivFebruary 14, 2026Madeline Wood Alexander, Jennifer S. Rabin, Michelle Caunca, Allesandra Iadipaolo, Louisa Cornelis, Nina Miolane, Albert Pham, Julia Borger, Valentina Diaz, Emily W. Paolillo, et al.cohorts, see below) was analyzed on the NULISAseq CNS panel (~120 proteins) using the automated Alamar Argo HT workflow (Extended Data). Aging cohorts To evaluate the relevance of menopause-related biological

(15) Blood-based proteomic signatures of spontaneous menopause: Implications for later-life brain aging and Alzheimer’s disease riskResearch SquareFebruary 12, 2026Madeline Wood Casaletto, Madeline Wood Alexander, Jennifer Caunca, Allesandra Iadipaolo, Allesandra Iadipaolo, Louisa Cornelis, Albert Miolane, Albert Borger, Valentina Borger, Valentina Paolillo, et al.cohorts, see below) was analyzed on the NULISAseq CNS panel (~120 proteins) using the automated Alamar Argo HT workflow (Extended Data). Aging cohorts To evaluate the relevance of menopause-related biological

(16) Plasma vs. serum: which is better for proteomic blood biomarker analysis? Evaluation of the novel NULISA platformmedRxivJanuary 16, 2026Marissa F. Farinas, Yijun Chen, Xuemei Zeng, Michel N. Nafash, Ann D. Cohen, Oscar I. Lopez, Thomas K. Karikariparticulates. The supernatants were analyzed using the NULISAseq CNS disease panel 120 (v2) on an Alamar ARGO™ HT system as previously described [25]. Briefly, samples were incubated with a cocktail of paired capture and

(17) The National Centralized Repository for Alzheimer's Disease and Related Dementia's Biomarker Assay Laboratory: A Resource for the Alzheimer's Disease Research CommunityAlzheimer's & DementiaNovember 6, 2025Kristen A. Russ, Kaci Lacy, Jeffrey L. Dage, Tatiana Foroud1080 automated liquid handlers, two Quanterix Simoa HD‐X, a Fujirebio Lumipulse G1200, and an Alamar ARGO HT for use with NULISAseq technology. The lab is currently equipped and staffed to analyze approximately

(18) Characterizing the physiology of circulatory arrest in humansNat MedOctober 16, 2025Jordan D. Bird, Laura Hornby, Veronica Hirsch-Reinshagen, Chloe P. Allen, George Isac, Peter A. Gooderham, Sam D. Shemie, Sonny Dhanani, Sonny Thiara, Sophie Stukas, et al.analysis of plasma samples was performed using the NULISAseq CNS Disease Panel 120 (800104) on the ARGO HT platform (Alamar Biosciences). Biospecimens were thawed and centrifuged at 10,000g for 10 min to remove

(19) Identifying a Biological Signature of Trauma-Related Neurodegeneration Following Repeated Traumatic Brain Injuries Compared with Healthy ControlsNeurotrauma ReportsJuly 9, 2025Shawn R. Eagle, Ava Puccio, Sarah Svirsky, James Mountz, Charles Laymon, Allison Borasso, Luke Henry, David O. Okonkwophosphorylated transactive response DNA-binding protein 43 (pTDP-43) were measured using the automated Alamar Argo HT workflow. Sample controls, internal controls, inter-plate controls, and negative controls were all included

(20) Targeted proteomic biomarker profiling using NULISA in a cohort enriched with risk for Alzheimer's disease and related dementiasAlzheimer's & DementiaMay 2, 2025Ramiro Eduardo Rea Reyes, Rachael E. Wilson, Rebecca E. Langhough, Rachel L. Studer, Erin M. Jonaitis, Julie E. Oomens, Elizabeth M. Planalp, Barbara B. Bendlin, Nathaniel A. Chin, Sanjay Asthana, et al.reagent kit. The plate was sealed and spun for 1 min at 1000 × g and 4°C. Utilizing the automated Alamar Argo HT workflow, target analytes within each sample were bound through multiple capture, wash, and release

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ARGO™ HT System from Alamar Biosciences

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ARGO™ HT System from Alamar Biosciences

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