X500B QTOF System from SCIEX

Product Specs
ItemX500B QTOF System
CompanySCIEX
Price Get Pricing Get Quote for this Product
Catalog NumberX500B
QuantityEA
Mass Rangeup to 40 kDa.
Scanning SpeedUp to 100 Hz MS/MS
Mass AnalyzerQuadrupole Time-of-flight
ResolutionEqual to or greater than 42,000 (FWHM) measured on the (M+6H)6+ charge isotope cluster for bovine insulin at m/z 956

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SCIEX

500 Old Connecticut Path

Framingham, MA 01701

United States

Phone: 1 877-740-2129

Email: sales.americas@sciex.com

Company Profile

Website: www.sciex.com

Website: www.lifesciences.danaher.com/us/en/products/brands/sciex

(1) COQ8 chaperones coenzyme Q lipid intermediates through ATP-driven structural gatingSci AdvJuly 31, 2026Andrea Gottinger, Marco Malatesta, Callum R. Nicoll, Georg Ansari, Mathieu Quinodoz, Karolina Kaminska, Rachael W.C. Tang, Tien-En Tan, Beau J. Fenner, Pilar Barberán-Martínez, et al.Q1 were detected and quantitated as previously described (23). Briefly, samples were analyzed on a X500B quadrupole time-of-flight High-Resolution Mass-Spectrometry (qTOF HRMS) coupled to an ExionLC (Sciex)

(2) Cannabidiol Activates Integrated Stress Response Signaling and Immune Trafficking Programs in an A375 Melanoma–Jurkat T Cell Coculture Model: A Multi-Omics AnalysisACS OmegaJune 30, 2026Ni Deng, Huifang Li, Ang Cai, Christopher L. Hemme, Jonghae Youn, Ryan Janis, Matthew D. Stone, Hang Ma, Chang Liu54–65 min, re-equilibration at 97% A. For mass calibration, SCIEX ESI Positive Calibration Solution X500B was infused every 5 samples. Data were acquired using SCIEX OS v3.4.0. In ZenoSWATH-MS experiments,

(3) 3-Methylthiopropionic Acid Kills Carbapenem-Resistant Klebsiella pneumoniae by Disrupting Membrane Integrity and BioenergeticsJACS AuJune 22, 2026Lirui Ge, Liang Zhao, Saiwa Liu, Jingjing Du, Jian Xu, Kexin Cui, Yu Ga, Jingyu Liu, Dongmei Zhao, Shuwen Wang, et al.liquid chromatography (UHPLC) system coupled to a high-resolution mass spectrometry (HRMS) instrument (X500B, SCIEX, Framingham, MA, USA). Separation was achieved on both reversed-phase and hydrophilic interaction

(4) Integrated network pharmacology and serum metabolomics to reveal the protective mechanism of methanolic extract of BaiYangJie on cisplatin-induced acute kidney injury in miceExp Ther MedJune 4, 2026Bin Xia, Jianglong Chen, Jinhui Wang, Dalong Li, Lixia Zhang, Jing Su, Xuan Ding, Yana Lv, Shifang Liu, Xue Zhang, et al.Waters China Ltd.) on a Shimadzu LC400 system (Shimadzu Scientific Instruments) coupled with AB SCIEX X500B Q-TOF mass spectrometer (SCIEX) operating in dual electrospray ionization mode. The eluent system comprised

(5) A molecular stabiliser of an inhibitory eIF2B-eIF2(αP) complex activates the Integrated Stress ResponseNature CommunicationsMay 6, 2026Fiona Shilliday, Miguel Gancedo-Rodrigo, Ginto George, Shintaro Aibara, Santosh Adhikari, Syedah Neha Ashraf, Evelyne J. Barrey, Paolo A. Centrella, Damian Crowther, Paige Dickson, et al.liquid nitrogen. Protein identity and labelling were confirmed by intact mass spectrometry using a Sciex X500B Q-TOF with Sciex Excion LC instrument and bioZen 3.6 µm Intact XB-C8 column. All proteins were diluted

(6) Global Proteomics Investigation of SAMT-247 Targets: An Antiviral Thioester that Acetylates Zinc Finger ProteinsbioRxivApril 30, 2026Connor P. Jewell, Andrew J. Perciaccante, Kate Brown, Tapan K. Maity, Jerry C. Dinan, Massimiliano Bissa, Mohammad Arif Rahman, Genoveffa Franchini, Daniel H. Appella, Lisa M. JenkinsTFA, 50% acetonitrile and lyophilized. Desalted peptides were then analyzed by mass spectrometry on an X500B Q-TOF (SCIEX) coupled to an Exion liquid chromatography system. Recombinant ZC3H7A440-971 was purified

(7) Selection of Functional Glycoforms in Anti-SARS-CoV-2 Human IgG1 Monoclonal Antibodies by FcγRIIIa Affinity Chromatography and Mass SpectrometryJ Med ChemApril 23, 2026Barbara Oliviero, Sunil Kumar, Daniela Conteianni, Gaia Donetti, Antonella Cerino, Antonino Samuele Iraci, Alessia La Gaipa, Sabrina Ottolini, Sara Tengattini, Gabriella Massolini, et al.temperature maintained at 60 °C. For mass spectrometric analysis, the UPLC system was directly coupled to a X500B QTOF system (Sciex) operating in the intact MS mode. The instrument parameters were set as follows: positive ionization

(8) Development and Validation of an Ion-Pair Reverse-Phase High-Performance Liquid Chromatography-Electrospray Ionization Mass Spectrometry Method for Determination of Purity of Nusinersen for Quality Control of Drug Substance or Drug ProductInt J Mol SciApril 5, 2026Mikhail Samoilov, Ekaterina Zubareva, Maksim DegterevReproducibility The reproducibility was estimated using the Agilent 1260 Infinity II Bio with the Sciex X500B system, with sample preparation carried out by two analysts on different days (Table S5). The RSDXICArea

(9) RPLC- and HILIC-based non-targeted metabolomics workflow for blood microsamplesMetabolomicsFebruary 9, 2026Pauline Couacault, Michael Wittingwater purification system (Billerica, MA, United States of America). ESI Positive Calibration Solution X500B and ESI Negative Calibration Solution X500 were purchased from Sciex (Sciex Deutschland GmbH, Darmstadt,

(10) Chemical Investigation of the Global Regulator veA-Overexpressed Mutant of an Arctic Strain Aspergillus sydowii MNP-2Marine DrugsJanuary 9, 2026Qing Gong, Wei Wang, Yujie Zhao, Xiaoying Wang, Xuelian Bai, Huawei Zhang20 min, and the supernatant was collected into a sample vial. The instrumentation used was a SCIEX X500B quadrupole time-of-flight (QTOF) high-resolution mass spectrometer (HRMS) coupled with a SCIEX ExionLC

(11) A Green Approach to Bio-Based Active Packaging: Grape Skin Extract-Synthesized AgNPs for Food PreservationMaterials (Basel)January 6, 2026Wenjia Yin, Yongzhen Lei, Jiayi Wang, Qin Lei, Wenxi Yu, Siyu Ou/MS Analysis The phytochemical composition of GSE was profiled using a UHPLC-QTOF-MS/MS system. A QTOF X500B mass spectrometer (SCIEX, Framingham, MA, USA) with an Exion AD UPLC system was used for sample analysis.

(12) Bacterial ubiquitin ligase engineered for small molecule and protein target identificationThe EMBO JournalJanuary 3, 2026James S Ye, Abir Majumdar, Brenden C Park, Miles H Black, Ting-Sung Hsieh, Adam Osinski, Kelly A Servage, Kartik Kulkarni, Jacinth Naidoo, Neal M Alto, et al.mass spectrometry analysis. Intact mass spectrometry analysis Protein samples were analyzed by LC–MS, using a Sciex X500B Q-TOF mass spectrometer coupled to an Agilent 1290 Infinity II HPLC. Samples were injected onto a POROS

(13) Integrated serum metabolomics reveal molecular mechanism of Xietu Hemu prescription on metabolic dysfunction-associated steatotic liver disease-related obesityWJHDecember 27, 2025Zhe Cheng, Yi-Fan Lu, Yi-Xian He, Wei Wei, Yi-Xuan Xie, Tian-Su Lv, Yi Wei, Yan Lou, Jiang-Yi Yu, Xi-Qiao ZhouSupplementary Table 1. Mass spectrometric analysis was executed using a SCIEX Exion LC system coupled to an X500B Q-TOF mass spectrometer (AB Sciex, Foster City, CA, United States) equipped with an electrospray ionization

(14) Physalia physalis—A Source of Bioactive Collagen for the Cosmetic IndustryInternational Journal of Molecular SciencesDecember 19, 2025Raquel Fernandes, Cristiana Oliveira, Diana Ferreira-Sousa, Augusto Costa-Barbosa, Paula Sampaio, Luis Reis, Javier Fidalgo, Ana N. Barros, José A. Teixeira, Claudia Botelho1%. 3.5.2. Bioinformatics Analysis The peptides identified as collagen from the Mass Spectrometry (X500B positive Q-TOF MS, twin-spray ion source (Sciex, Framingham, MA, USA)) study were selected from the

(15) Multispecific antibodies: Bioanalytics for early-stage screening and characterization of mispairing profilesPLOS OneNovember 20, 2025Catarina Melo, Sofia B. Carvalho, Maria J. Sebastião, Ricardo A. Gomes, Pedro M. F. Sousa, Patrícia Gomes-AlvesMass Spectrometry Unit, iBET/ITQB-NOVA, Oeiras, Portugal. Samples were analyzed by LC-MS using the X500B Q-TOF (Sciex) coupled to the ExionLC (Sciex). Size-exclusion LC separation was performed using a UPLC

(16) Site-directed tyrosinase conjugation on engineered ferritin retains immune recognitionScientific ReportsNovember 19, 2025Margarida Q. Rodrigues, Mónica Thomaz, Ricardo A. Gomes, Paula M. Alves, António Roldãowith water and 0.1% formic acid (FA). MS was performed in positive TOF–MS intact protein mode using a X500B Q-TOF mass spectrometer (Sciex) equipped with a twin-spray electrospray ionization (ESI) source. Data

(17) Mode of action of a DCAF16-recruiting targeted glue that can selectively degrade BRD9Nat CommunOctober 27, 2025Scott J. Hughes, Wojciech J. Stec, Colin T. R. Davies, David McGarry, Alicia Williams, Marta Carrara, Ivan Del Barco Barrantes, Rebecca Harris, Anna Tasegian, Dominic D. G. Owens, et al.bioZen 3.6 µm, XB-C8, 50 × 2.1 mm column was used. The flow from the column was passed into the Sciex X500B mass spectrometer, collecting data in positive ion mode. To enable ionisation of the eluate, the source

(18) GCI‐Based Affinity Screening of Synthetic Oligomannosides toward Concanavalin AChemistry – A European JournalOctober 22, 2025Davide Rubes, Sara Tengattini, Massimo Serra, Teodora Bavaro, Caterina Temporini, He Wang, Yongmin Zhang, Francesca Rinaldi, Marco Terreni, Enrica Callerispectrometer (Bruker Corporation, Billerica, MA, USA). High resolution mass spectra were acquired by a X500B QTOF System (SCIEX, Framingham, MA 0 1701, USA) equipped with a Twin Sprayer ESI probe and coupled to an ExionLC

(19) A real-time imaging approach to quantify dendritic cell internalization for immunogenicity risk assessment of biotherapeuticsFrontiers in ImmunologySeptember 12, 2025Zhaojun Yin, Peter Tran, Joyce Guerrero, Justin Low, Qing Xie, Kun Peng(2.1 x 50mm, 8 μm particle size, 1000 Å pore size) column on a Sciex ExionLC™ UHPLC system coupled to X500B™ Q-TOF mass spectrometer. The separation gradient was employed from 25% to 90% mobile phase B (0.1%

(20) Discovering Uncharted Binding Pockets on E3 Ligases Leads to the Identification of FBW7 Allosteric ModulatorsAdvanced ScienceAugust 20, 2025Míriam Martínez‐Cartró, Álvaro Serrano‐Morrás, Andrea Bertran‐Mostazo, Roger Castaño‐Muñiz, Salvatore Scaffidi, Varbina Ivanova, Noémi Csorba, József Simon, Péter Ábrányi‐Balogh, Yunfeng Li, et al.series liquid chromatography with Phenomenex SecurityGuard Widepore C4 4x3 mm cartridge with Sciex x500b QTOF system with electrospray ionization, positive mode, Data S1, Supporting Information). The deconvoluted spectra

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