INVITROCYP M-CLASS 50-Donor Pooled Human Liver Liver Microsomes from BioIVT

Product Specs
ItemINVITROCYP M-CLASS 50-Donor Pooled Human Liver Liver Microsomes
CompanyBioIVT
Price Supplier Page View Company Product Page
Catalog NumberX008067
SpeciesHuman
Quantity10 mg
TissueLiver
TypeMicrosome
Source50-Donor Pooled
Source/Expression System50-Donor Pooled
GenderMixed Gender
Breed / StrainHuman
Research AreaADME-Tox, Drug Discovery, DMPK

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BioIVT

PO Box 770

Hicksville, New York 11802

United States

Phone: 516-483-1196

Email: customerservice@bioivt.com

Company Profile

Website: www.bioivt.com

(1) NAD(P)+-dependent alcohol oxidoreductases oxidize 7-hydroxycannabidiol to a reactive formyl metaboliteArchives of ToxicologyNovember 1, 2025Qiangen Wu, Jia-Long Fang, Suresh K. Nagumalli, Xiaoqing Guo, Frederick A. Belandwere obtained from Cerilliant (Round Rock, TX). Pooled human liver microsomes (Mixed sexes, Product # X008067, Lot # WKO) and pooled human liver S9 fractions (Mixed sexes, Product # X008023, Lot # YOC) were obtained

(2) Human cytochrome P450 enzymes catalyze oxidative metabolism of pectolinarigenin to generate a more active Nrf2 agonistChinese Herbal MedicinesOctober 1, 2025Peiqi Liu, Yanyan Deng, Dongzhu Tu, Jiahao Gong, Feng Zhang, Huixin Liu, Qian Li, Jing Hu, Guangbo Geall purchased from Sigma-Aldrich (Missouri, USA). Human liver microsome (HLM, from 50 donors, Lot No. X008067) was ordered from Bioreclamation IVT (Baltimore, MD, USA). Human P450 enzymes (including CYP1A1, -1A2,

(3) Discovery of a novel AhR–CYP1A1 axis activator for mitigating inflammatory diseases using an in situ functional imaging assayActa Pharmaceutica Sinica BJanuary 1, 2025Feng Zhang, Bei Zhao, Yufan Fan, Lanhui Qin, Jinhui Shi, Lin Chen, Leizhi Xu, Xudong Jin, Mengru Sun, Hongping Deng, et al.from TCI (Shanghai) Development Co., Ltd. Pooled human liver microsomes from 50 donors (HLMs, lot No. X008067) were obtained from Bioreclamation IVT (Baltimore, MD, USA). Ketoconazole, DMEM medium, RPMI 1640 medium,

(4) Identification and cross-species comparison of in vitro phase I brevetoxin (BTX-2) metabolites in northern Gulf of Mexico fish and human liver microsomes by UHPLC-HRMS(/MS)Toxicon: XSeptember 1, 2023Jessica Kay Gwinn, Alison Robertson, Lada Ivanova, Christiane Kruse Fæste, Fedor Kryuchkov, Silvio Uhliga mixed gender pool of 50 donors and were obtained from Bioreclamation IVT (Westbury, NY, USA; No. X008067, Lots SBM, YAO, and IHG). The total protein concentrations, total CYP contents, and specific CYP enzyme

(5) Discovery of triterpenoids as potent dual inhibitors of pancreatic lipase and human carboxylesterase 1Journal of enzyme inhibition and medicinal chemistryDecember 1, 2022Zhang J, Pan QS, Qian XK, Zhou XL, Wang YJ, He RJ, Wang LT, Li YR, Huo H, Sun CG, et al.from Promega Biotech (Madison, WI). The pooled human liver microsomes from 50 donors (HLM, lot No. X008067) were purchased from Bioreclamation IVT (Baltimore, MD). 0.1 M McIlvane buffer (0.1 M citrate-Na2HPO4,

(6) Discovery and Characterization of the Key Constituents in Ginkgo biloba Leaf Extract With Potent Inhibitory Effects on Human UDP-Glucuronosyltransferase 1A1Frontiers in PharmacologyFebruary 21, 2022Hui-Lin Pang, Guang-Hao Zhu, Qi-Hang Zhou, Chun-Zhi Ai, Ya-Di Zhu, Ping Wang, Tong-Yi Dou, Yang-Liu Xia, Hong Ma, Guang-Bo Ge(Chengdu, Sichuan, China), with the purities ≥96%. Human liver microsomes (HLMs) (from 50 donors, lot no. X008067) were obtained from Bioreclamation IVT (Baltimore, MD, United States). Recombinant UGT1A1 enzymes were

(7) A Novel System for Evaluating the Inhibition Effect of Drugs on Cytochrome P450 Enzymes in vitro Based on Human-Induced Hepatocytes (hiHeps)Frontiers in PharmacologyOctober 28, 2021Yan Li, Ying-Yuan Lu, Jun Jia, Meng Fang, Lin Zhao, Yong Jiang, Yan Shi, Peng-Fei Tu, Xiao-Yu Guowere purchased from Celsis In Vitro Technologies Inc (Maryland, United States). HLM (batch number: X008067) and human hepatocytes (batch number: X008000) were purchased from Research Institute for Liver disease

(8) In Vitro Glucuronidation of Caribbean Ciguatoxins in Fish: First Report of Conjugative Ciguatoxin MetabolitesChemical Research in ToxicologyAugust 16, 2021Jessica Kay Gwinn, Silvio Uhlig, Lada Ivanova, Christiane Kruse Fæste, Fedor Kryuchkov, Alison Robertsonsupplier (Bioreclamation IVT, Westbury, NY, U.S.A.) and consisted of a mixed gender pool of 50 donors (No. X008067, Lots SBM, YAO, and IHG). Male Wistar rat liver microsomes (RLM) were obtained from Celsis In Vitro Technologies

(9) Reversible and Irreversible Inhibition of Cytochrome P450 Enzymes by Methylophiopogonanone ADrug Metabolism and DispositionJune 1, 2021Dong-Zhu Tu, Xu Mao, Feng Zhang, Rong-Jing He, Jing-Jing Wu, Yue Wu, Xiao-Hua Zhao, Jiang Zheng, Guang-Bo Gestudy were greater than 98%. The recombinant human P450s and pooled human liver microsomes (HLMs, Lot No. X008067) were all purchased from Bioreclamation IVT (Baltimore, 7 Downloaded from dmd.aspetjournals.org at

(10) Systems pharmacological study illustrates the immune regulation, anti-infection, anti-inflammation, and multi-organ protection mechanism of Qing-Fei-Pai-Du decoction in the treatment of COVID-19PhytomedicineMay 1, 2021Jing Zhao et al.China). Recombinant human CYP1A1 and the pooled human liver microsomes (HLMs, from 50 donors, lot no. X008067) were obtained from Bioreclamation IVT (Baltimore, MD, USA). LC grade acetonitrile was ordered from

(11) Pharmacokinetics of Panaxynol in MiceJournal of Cancer Science and Clinical TherapeuticsSeptember 9, 2020Hossam Tashkandi, Anusha Chaparala, Sean Peng, Mitzi Nagarkatti, Prakash Nagarkatti, Alexander ,, A. Chumanevich, Lorne J. Hofsethpreviously described in 1994 [15]. Liver microsomes are obtained from BioIVT for both human and mouse (Cat# X008067, InVitroCYP M-Class 50-D Human Liver Microsomes [Mixed Gender]; Cat# M00501, Male ICR/CD-1 Mouse Liver Microsomes

(12) Investigation of In Vitro Endocrine Activities of Microcystis and Planktothrix Cyanobacterial StrainsToxins (Basel)April 4, 2020Vittoria Mallia, Lada Ivanova, Gunnar S. Eriksen, Emma Harper, Lisa Connolly, Silvio Uhligvitro metabolism trials were performed using commercially available human liver microsomes (HLM; No. X008067, Lot YAO; Celsis In Vitro Technologies, Baltimore, MD, USA). Estradiol (5 µM assay concentration) was

(13) Intracellular and in vivo evaluation of imidazo[2,1-b]thiazole-5-carboxamide anti-tuberculosis compoundsPLOS ONEJanuary 6, 2020Garrett C. Moraski, Nathalie Deboosère, Kate L. Marshall, Heath A. Weaver, Alexandre Vandeputte, Courtney Hastings, Lisa Woolhiser, Anne J. Lenaerts, Priscille Brodin, Marvin J. Millerexpressed as a function of time. Human liver microsomes were purchased from Celsis (catalog number X008068). Animal welfare and procedures All animal studies were performed at Colorado State University in

(14) Inhibition of human carboxylesterases by ginsenosides: structure–activity relationships and inhibitory mechanismChinese MedicineDecember 16, 2019Zhao-Hui Sun, Jing Chen, Yun-Qing Song, Tong-Yi Dou, Li-Wei Zou, Da-Cheng Hao, Hai-Bin Liu, Guang-Bo Ge, Ling Yangstudy reaches more than 98% by LC-UV. The pooled human liver microsomes (HLMs, from 50 donors, lot no. X008067) obtained from Bioreclamation IVT Sun et al. Chin Med (2019) 14:56 Page 3 of 15 Fig. 1 The chemical

(15) Discovery of dihydrooxazolo[2,3-a]isoquinoliniums as highly specific inhibitors of hCE2RSC AdvancesOctober 31, 2019Lixia Ding et al.Preferred Biotech Co., Ltd. (Chengdu, China). Pooled human liver microsomes (HLMs, from 50 donors, lot no. X008067) were obtained from Bioreclamation IVT (Baltimore, MD, USA) and stored at −80 °C until use. DMSO was

(16) Inhibition of human carboxylesterases by magnolol: Kinetic analyses and mechanismChemico-Biological InteractionsAugust 1, 2019Yun-Qing Song et al.USA) to prepare stock 124 solutions. Pooled human liver microsomes (HLMs, from 50 donors, lot no. X008067) were 125 obtained from Bioreclamation IVT (Baltimore, MD, USA). Cell culture medium and fetal 126 bovine

(17) Interspecies Variation in NCMN-O-Demethylation in Liver Microsomes from Various SpeciesMoleculesJuly 30, 2019Ziru Dai, Guibo Sun, Jiada Yang, Jie Hou, Ping Zhou, Weijie Xie, Guangbo Ge, Xiaobo Sun, Ling Yangreagents were reagent grade or better. Pooled human liver microsomes (HLMs, from 50 donors, lot no. X008067) were obtained from Bioreclamation IVT (Baltimore, MD, USA). Liver microsomes form male ICR/CD-1 mouse

(18) Inhibition of UGT1A1 by natural and synthetic flavonoidsInternational Journal of Biological MacromoleculesApril 1, 2019Xin-Yu Liu, Xia Lv, Ping Wang, Chun-Zhi Ai, Qi-Hang Zhou, Moshe Finel, Bin Fan, Yun-Feng Cao, Hui Tang, Guang-Bo Gereagents BioreclamationIVT (Baltimore, PT E from D Pooled human liver microsomes (HLMs, from 50 donors, lot no. X008067) were obtained MD, USA). Tris-HCl, 7-hydroxycoumarin, uridine-5'-diphosphoglucuronic acid (UDPGA)

(19) Cytochrome P450 3A Enzymes Are Key Contributors for Hepatic Metabolism of Bufotalin, a Natural Constitute in Chinese Medicine ChansuFrontiers in PharmacologyFebruary 4, 2019Zi-Ru Dai et al.purchased from Jianglai Biotechnology Co., Ltd. (Shanghai, China). The pooled HLMs (from 50 donors, lot no. X008067) were obtained from BioreclamationIVT (Baltimore, MD, United States). A panel of baculovirus expressed human

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INVITROCYP M-CLASS 50-Donor Pooled Human Liver Liver Microsomes from BioIVT

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INVITROCYP M-CLASS 50-Donor Pooled Human Liver Liver Microsomes from BioIVT

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