Low-Tox® Guinea Pig Complement, Lyophilized from CEDARLANE

Product Specs
ItemLow-Tox® Guinea Pig Complement, Lyophilized
CompanyCEDARLANE
Price $131.00Supplier Page View Company Product Page
Catalog NumberCL4051
Quantity5x1 mL
ApplicationsCytotoxicity assays/plaque assays
FormatLyophilized
SpeciesGuinea Pig

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CEDARLANE

4410 Paletta Court

Burlington, Ontario L7L 5R2

Canada

Phone: +1 (289) 288-0001
Toll Free (North America): +1 (800) 268-5058
Fax: +1 (289) 288-0020

Email: general@cedarlanelabs.com

Company Profile

Website: http://www.cedarlanelabs.com/

(1) Human neutralizing antibodies targeting the measles virus hemagglutinin and fusion surface proteinsCell Host & MicrobeJune 10, 2026Marissa Acciani, Dawid Zyla, Gele Niemeyer, Stephanie Harkins, Diptiben Parekh, Emily Pawlack, Davide Lacarbonara, Dhvanir Kansara, Margaret E. Ackerman, Stefan Niewiesk, et al.multiplex assay streptavidin beads prepared as previously described.97 Guinea pig complement serum (Cedarlane # CL4051) was diluted 1:60 in gelatin veronal buffer (Sigma-Aldrich, GVB++, G6514) and mixed with diluted samples

(2) Depletion and recovery of IgG following treatment with an anti-FcRn antibody and IdeS in pigtail macaquesClinical and Experimental ImmunologyMay 21, 2026Kara M. Rzasa, Joanna Zikos, Toni Penney, Faith R. Schiro, Lara A. Doyle-Meyers, Pyone P. Aye, Ronald S. Veazey, James A. Hoxie, Nicholas J. Maness, Diogo M. Magnani, et al.Subsequently, samples were incubated with 1:100 dilution of low tox guinea pig complement (Cedarlane, CL4051) for one hour at 37°C and then another hour with PE-labeled anti-complement C3b antibody (BioLegend,

(3) A dual-adjuvanted HA stem nanoparticle vaccine elicits a multifunctional antibody response that is associated with protection in newborn monkeysCell Reports MedicineMay 19, 2026Kali F. Crofts, Beth C. Holbrook, Courtney L. Page, Colby J. Hendrix, David Caudell, Rebecca A. Gillespie, Ralph B. D’Agostino, Syed M. Moin, Maya Sangesland, David A. Ornelles, et al.(2-fold dilutions, starting dilution 1:5) for 2 h at 37°C. Lyophilized guinea pig complement (Cedarlane, CL4051) was reconstituted in ice-cold dH20, then diluted in 1:60 veronal buffer with 0.1% gelatin (GVB++. Boston

(4) Breast milk antibody Fc signatures track with HIV transmission during breastfeeding in ART-naïve mothersiScienceApril 17, 2026Nadege Nziza, Wonyeong Jung, Yunjoo Lee, Jeff C. Hsiao, Tina Chen, Fan Li, Caroline Atyeo, Douglas A. Lauffenburger, Louise Kuhn, Nicole H. Tobin, et al.CaptureSelect™ IgA Affinity Matrix,Thermo Fisher,CAT # 194311005 "Low-Tox® Guinea Pig Complement, Lyophilized",Cedarlane,CAT # CL4051 EZ-Link™ Sulfo-NHS-LC-Biotin,Thermo Scientific,CAT # PIA39257 IdeZ protease,New England Biolabs,CAT

(5) HKU1 immune imprinting is associated with post-COVID symptoms after SARS-CoV-2 infectioniScienceApril 17, 2026Majdoubi A, Michalski C, Watts AW, Dang X, Golzan SA, Abu-Raya B, Li S, Shew J, Reicherz F, Mâsse LC, et al.then washed twice with PBS. Lyophilized guinea pig complement (Cedarlane, Burlington, ON, Canada; cat# CL4051) was reconstituted in distilled water, heat-inactivated at 56 °C for 30 min, and centrifuged at 16,000g

(6) Rational Design of Multiclade Coronavirus Spike Immunodominant Domain Nanoparticles to Elicit Broad Antibody ResponsesResearch SquareJanuary 17, 2026Christian K.O. Corbett-Helaire, Christian Dzuvor, Lindsay R. McManus, Lindsay McManus, Abigail E. Dzordzorme, Abigail Dzordzorme, Taewoo Joseph, Valerie Joseph, Ingelise J. Gordon, Ingelise Gordon, et al.Tecan Hydrospeed plate washer. Next, plates were incubated with lyophilized guinea pig complement (#CL4051, Cedarlane, Burlington, Canada) in gelatin veronal buffer with calcium and magnesium (#G6514, Sigma,

(7) Unconventional linkers facilitate potent stabilized coronavirus stem antibody responses following nanoparticle vaccinationbioRxivJanuary 16, 2026Christian K.O. Dzuvor, Sydney P. Moak, Lindsay R. McManus, Abigail E. Dzordzorme, Lamount R. Evanson, Taewoo Kim, Abigail Thomas, Olayimika Adeyemi, Valerie Foley, Aditi Limaye, et al.washed with 1% BSA in PBS using a magnetic Tecan Hydrospeed washer. Lyophilized guinea pig complement (#CL4051, Cedarlane), reconstituted in gelatin veronal buffer with calcium and magnesium (#G6514, Sigma), was

(8) Epstein-Barr-virus-specific functional antibody signatures in the context of nasopharyngeal carcinoma developmentMedJanuary 9, 2026Vicky Roy, Benjamin P. Kellman, Wan-Lun Hsu, Nadege Nziza, Lily Parker, Daritza Germosen, Riley Bonifer, Ruth M. Pfeiffer, Kelly J. Yu, Birgitta Michels, et al.spun down, and immune complexes were washed with PBS. Lyophilized guinea pig complement (Cedarlane, CL4051) was resuspended in cold water, diluted in Gelatin Veronal Buffer, Boston BioProducts, IBB-290X) and

(9) An influenza HA mRNA-LNP vaccine induces potent responses in newborn nonhuman primates that enhance protection from challengeNPJ VaccinesDecember 26, 2025Courtney L. Page, Beth C. Holbrook, Kali F. Crofts, Mohamad-Gabriel Alameh, Benjamin Davis, David Caudell, Drew Weissman, Martha A. Alexander-Millerdilutions, starting dilution 1:5) for 2 h at 37 °C. Lyophilized guinea pig complement (Cedarlane, #CL4051) was reconstituted in ice-cold dH20, then diluted in 1:60 veronal buffer with 0.1% gelatin (GVB + +,

(10) ALFQ adjuvanted HIV-1 envelope protein vaccination elicits durable functional antibody and cellular responses in nonhuman primatesNPJ VaccinesDecember 19, 2025Shikha Shrivastava, Joshua M. Carmen, Jiae Kim, Kristina K. Peachman, Shraddha Basu, Ryan Alving, Danielle Nettere, Gautam Kundu, Lauren Yum, Mohammad Arif Rahman, et al.Massachusetts, USA). Antibody coated beads were washed and resuspended in 200 μL of guinea pig complement (CL4051, Cedarlane, Burlington, Canada), which was prepared at a 1:50 dilution in Gelatin Veronal Buffer with

(11) Combinatorial Fc modifications for complementary antibody functionalitymAbsDecember 1, 2025Bartsch YC, Webb NE, Burgess E, Kang J, Lauffenburger DA, Julg BD.antigen-labeled beads and incubated for 2 hours. Guinea pig complement factor (Cedarlane: Cat. No. CL4051) in GVB++ buffer was added to the immune complexes and incubated for 20 minutes at 37°C. The complement

(12) Decreased Fc fucosylation aligns with enhanced RSV-specific antibody functionality in adults compared to young childrenCommunications MedicineNovember 24, 2025Anke J. Lakerveld, Wenjun Wang, Rutger M. Schepp, Jan Nouta, Steinar Gijze, Anne T. Gelderloos, Nynke Y. Rots, Robert S. van Binnendijk, Gestur Vidarsson, Manfred Wuhrer, et al.were used as negative control. After washing with PBS with 0.1% BSA, 100 μL guinea pig complement (CL4051, Cedarlane Laboratories) diluted 1:25 in HBSS was added to the beads. After 15 minutes incubation at

(13) Durable humoral immunity and long-term protection induced by a Crimean-Congo hemorrhagic fever virus replicon particle vaccine in micenpj VaccinesNovember 21, 2025Teresa E. Sorvillo, Elif Karaaslan, Katherine A. Davies, Stephen R. Welch, Florine E. M. Scholte, JoAnn D. Coleman-McCray, Virginia Aida-Ficken, Scott D. Pegan, Éric Bergeron, Joel M. Montgomery, et al.at 56 °C) NHP plasma in sodium citrate. For ADCD assays, guinea pig complement (Cedarlane; Cat. No. CL4051) diluted in gelatin veronal buffer (CompTech; Cat. No. B102) was added and incubated 15 min at 37 °C.

(14) Novel BCR-Targeting Fusion Proteins for Antigen-Specific Depletion of Alloreactive B Cells in Antibody-Mediated RejectionCellsSeptember 9, 2025Jing Zhang, Leiyan Wei, Lei Song, Xiaofang Lu, Liang Tan, Xin Li, Li Fu, Qizhi Luo, Xubiao Xie, Yizhou Zouincubated with serially diluted BCR-targeting fusion protein in fresh rabbit complement serum (Cedarlane, #CL4051, Burlington, ON, Canada) at 37 °C for 2 h. Cells were washed twice with PBS/4% FBS, then stained with

(15) Applications and insights from continuous dengue virus infection in a stable cell lineFrontiers in ImmunologyJune 24, 2025M. Jane Morwitzer, Ying Yi Zheng, Heather Friberg, Jeffrey R. CurrierBiosciences,51-2301KZ MINI26-1KT,Sigma-Aldrich,MKCQ0938 PKH26GL-1KT,Sigma-Aldrich,MKCQ6477 Aqua Live/Dead stain,ThermoScientific,L34597-A Low-Tox Guinea Pig complement,Cedarlane,CL4051 Gelatin Veronal Buffer,Sigma-Aldrich,G6514 20% Formaldehyde,Tousimis,1008B Mouse anti-CD209 (human)

(16) Systems serology-based comparison of humoral immune responses induced by liposome or aluminum hydroxide adjuvanted SARS-CoV-2 spike proteinSci RepMay 28, 2025Soo Ji Kim, Taewoo Kim, Satyanarayana Bejjani, Mi Sun Kim, Jung Hyuk Lee, Yuna Shin, Sun-Je Woo, Beom Min Cheon, Doyoung Kim, Sumin Lee, et al.163320) and incubated for 2 h at 37 °C and 5% CO2. Diluted guinea pig complement (1:50) (Cedarlane, CL4051) in RPMI containing 10% heat-inactivated FBS was added to the immune complexes and incubated for 50

(17) Acute infectious mononucleosis generates persistent, functional EBNA-1 antibodies with high cross-reactivity to alpha-crystalline betaCell ReportsMay 27, 2025Krishna Kumar Ganta, Margaret McManus, Ross Blanc, Qixin Wang, Wonyeong Jung, Robin Brody, Mary Carrington, Robert Paris, Sumana Chandramouli, Ryan P. McNamara, et al.RRID:AB_2796701" Biological samples,Biological samples,Biological samples LowTox Guinea Pig Complement,CedarLane Labs,Cat # CL4051 "Chemicals, peptides, and recombinant proteins","Chemicals, peptides, and recombinant proteins","Chemicals,

(18) Antibody function predicts viral control in newborn monkeys immunised with an influenza virus HA stem nanoparticleNat CommunApril 22, 2025Kali F. Crofts, Beth C. Holbrook, Courtney L. Page, Rebecca A. Gillespie, Ralph B. D'Agostino, Maya Sangesland, David A. Ornelles, Masaru Kanekiyo, Martha A. Alexander-Millerdilutions, starting dilution 1:5) for 2 hrs at 37 °C. Lyophilised guinea pig complement (Cedarlane, CL4051) was reconstituted in ice-cold dH20 and diluted in 1:60 veronal buffer with 0.1% gelatin (GVB + + Boston

(19) Dose-dependent serological profiling of AdCLD-CoV19-1 vaccine in adultsmSphereJanuary 28, 2025Jung Hyuk Lee, Yuna Shin, Kwang-Soo Shin, Ju Yeon Park, Mi Sun Kim, Young-Shin Park, Wuhyun Kim, Joon Young Song, Ji Yun Noh, Hee Jin Cheong, et al.Gibco) with 10% FBS (#16000044, Gibco) was used to reconstitute lyophilized guinea pig complement (#CL4051, Cedarlane). The reconstituted guinea pig complement (#CL4051, Cedarlane) was added to the washed immune

(20) Crimean-Congo hemorrhagic fever virus replicon particle vaccine is safe and elicits functional, non-neutralizing anti-nucleoprotein antibodies and T cell activation in rhesus macaquesAntiviral ResearchJanuary 1, 2025Alyssa Kleymann, Elif Karaaslan, Florine E.M. Scholte, Teresa E. Sorvillo, Stephen R. Welch, Éric Bergeron, Stephanie Elser, Melvyn R. Almanzar-Jordan, Eric Velazquez, Sarah C. Genzer, et al.heat-inactivated (30 min at 56 °C) NHP plasma in sodium citrate. For ADCD assays, guinea pig complement (Cedarlane CL4051) diluted in gelatin veronal buffer (CompTech B102) was added and incubated 15 min at 37 °C. Beads were

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Low-Tox® Guinea Pig Complement, Lyophilized from CEDARLANE

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Low-Tox® Guinea Pig Complement, Lyophilized from CEDARLANE

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