Low-Tox® Guinea Pig Complement, Lyophilized from CEDARLANE

Product Specs
ItemLow-Tox® Guinea Pig Complement, Lyophilized
CompanyCEDARLANE
Price $131.00Supplier Page View Company Product Page
Catalog NumberCL4051
Quantity5x1 mL
ApplicationsCytotoxicity assays/plaque assays
FormatLyophilized
SpeciesGuinea Pig

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CEDARLANE

4410 Paletta Court

Burlington, Ontario L7L 5R2

Canada

Phone: +1 (289) 288-0001
Toll Free (North America): +1 (800) 268-5058
Fax: +1 (289) 288-0020

Email: general@cedarlanelabs.com

Company Profile

Website: http://www.cedarlanelabs.com/

(1) Breast milk antibody Fc signatures track with HIV transmission during breastfeeding in ART-naïve mothersiScienceApril 17, 2026Nadege Nziza, Wonyeong Jung, Yunjoo Lee, Jeff C. Hsiao, Tina Chen, Fan Li, Caroline Atyeo, Douglas A. Lauffenburger, Louise Kuhn, Nicole H. Tobin, et al.CaptureSelect™ IgA Affinity Matrix,Thermo Fisher,CAT # 194311005 "Low-Tox® Guinea Pig Complement, Lyophilized",Cedarlane,CAT # CL4051 EZ-Link™ Sulfo-NHS-LC-Biotin,Thermo Scientific,CAT # PIA39257 IdeZ protease,New England Biolabs,CAT

(2) HKU1 immune imprinting is associated with post-COVID symptoms after SARS-CoV-2 infectioniScienceApril 17, 2026Abdelilah Majdoubi, Christina Michalski, Allison W. Watts, Xiaoqing Dang, S. Amirhossein Golzan, Bahaa Abu-Raya, Sirui Li, Jacob Shew, Frederic Reicherz, Louise C. Mâsse, et al.then washed twice with PBS. Lyophilized guinea pig complement (Cedarlane, Burlington, ON, Canada; cat# CL4051) was reconstituted in distilled water, heat-inactivated at 56 °C for 30 min, and centrifuged at 16,000g

(3) Epstein-Barr-virus-specific functional antibody signatures in the context of nasopharyngeal carcinoma developmentMedJanuary 9, 2026Vicky Roy, Benjamin P. Kellman, Wan-Lun Hsu, Nadege Nziza, Lily Parker, Daritza Germosen, Riley Bonifer, Ruth M. Pfeiffer, Kelly J. Yu, Birgitta Michels, et al.spun down, and immune complexes were washed with PBS. Lyophilized guinea pig complement (Cedarlane, CL4051) was resuspended in cold water, diluted in Gelatin Veronal Buffer, Boston BioProducts, IBB-290X) and

(4) An influenza HA mRNA-LNP vaccine induces potent responses in newborn nonhuman primates that enhance protection from challengeNPJ VaccinesDecember 26, 2025Courtney L. Page, Beth C. Holbrook, Kali F. Crofts, Mohamad-Gabriel Alameh, Benjamin Davis, David Caudell, Drew Weissman, Martha A. Alexander-Millerdilutions, starting dilution 1:5) for 2 h at 37 °C. Lyophilized guinea pig complement (Cedarlane, #CL4051) was reconstituted in ice-cold dH20, then diluted in 1:60 veronal buffer with 0.1% gelatin (GVB + +,

(5) ALFQ adjuvanted HIV-1 envelope protein vaccination elicits durable functional antibody and cellular responses in nonhuman primatesNPJ VaccinesDecember 19, 2025Shikha Shrivastava, Joshua M. Carmen, Jiae Kim, Kristina K. Peachman, Shraddha Basu, Ryan Alving, Danielle Nettere, Gautam Kundu, Lauren Yum, Mohammad Arif Rahman, et al.Massachusetts, USA). Antibody coated beads were washed and resuspended in 200 μL of guinea pig complement (CL4051, Cedarlane, Burlington, Canada), which was prepared at a 1:50 dilution in Gelatin Veronal Buffer with

(6) Decreased Fc fucosylation aligns with enhanced RSV-specific antibody functionality in adults compared to young childrenCommunications MedicineNovember 24, 2025Anke J. Lakerveld, Wenjun Wang, Rutger M. Schepp, Jan Nouta, Steinar Gijze, Anne T. Gelderloos, Nynke Y. Rots, Robert S. van Binnendijk, Gestur Vidarsson, Manfred Wuhrer, et al.were used as negative control. After washing with PBS with 0.1% BSA, 100 μL guinea pig complement (CL4051, Cedarlane Laboratories) diluted 1:25 in HBSS was added to the beads. After 15 minutes incubation at

(7) Durable humoral immunity and long-term protection induced by a Crimean-Congo hemorrhagic fever virus replicon particle vaccine in micenpj VaccinesNovember 21, 2025Teresa E. Sorvillo, Elif Karaaslan, Katherine A. Davies, Stephen R. Welch, Florine E. M. Scholte, JoAnn D. Coleman-McCray, Virginia Aida-Ficken, Scott D. Pegan, Éric Bergeron, Joel M. Montgomery, et al.at 56 °C) NHP plasma in sodium citrate. For ADCD assays, guinea pig complement (Cedarlane; Cat. No. CL4051) diluted in gelatin veronal buffer (CompTech; Cat. No. B102) was added and incubated 15 min at 37 °C.

(8) Novel BCR-Targeting Fusion Proteins for Antigen-Specific Depletion of Alloreactive B Cells in Antibody-Mediated RejectionCellsSeptember 9, 2025Jing Zhang, Leiyan Wei, Lei Song, Xiaofang Lu, Liang Tan, Xin Li, Li Fu, Qizhi Luo, Xubiao Xie, Yizhou Zouincubated with serially diluted BCR-targeting fusion protein in fresh rabbit complement serum (Cedarlane, #CL4051, Burlington, ON, Canada) at 37 °C for 2 h. Cells were washed twice with PBS/4% FBS, then stained with

(9) Applications and insights from continuous dengue virus infection in a stable cell lineFrontiers in ImmunologyJune 24, 2025M. Jane Morwitzer, Ying Yi Zheng, Heather Friberg, Jeffrey R. CurrierBiosciences,51-2301KZ MINI26-1KT,Sigma-Aldrich,MKCQ0938 PKH26GL-1KT,Sigma-Aldrich,MKCQ6477 Aqua Live/Dead stain,ThermoScientific,L34597-A Low-Tox Guinea Pig complement,Cedarlane,CL4051 Gelatin Veronal Buffer,Sigma-Aldrich,G6514 20% Formaldehyde,Tousimis,1008B Mouse anti-CD209 (human)

(10) Systems serology-based comparison of humoral immune responses induced by liposome or aluminum hydroxide adjuvanted SARS-CoV-2 spike proteinSci RepMay 28, 2025Soo Ji Kim, Taewoo Kim, Satyanarayana Bejjani, Mi Sun Kim, Jung Hyuk Lee, Yuna Shin, Sun-Je Woo, Beom Min Cheon, Doyoung Kim, Sumin Lee, et al.163320) and incubated for 2 h at 37 °C and 5% CO2. Diluted guinea pig complement (1:50) (Cedarlane, CL4051) in RPMI containing 10% heat-inactivated FBS was added to the immune complexes and incubated for 50

(11) Acute infectious mononucleosis generates persistent, functional EBNA-1 antibodies with high cross-reactivity to alpha-crystalline betaCell ReportsMay 27, 2025Krishna Kumar Ganta, Margaret McManus, Ross Blanc, Qixin Wang, Wonyeong Jung, Robin Brody, Mary Carrington, Robert Paris, Sumana Chandramouli, Ryan P. McNamara, et al.RRID:AB_2796701" Biological samples,Biological samples,Biological samples LowTox Guinea Pig Complement,CedarLane Labs,Cat # CL4051 "Chemicals, peptides, and recombinant proteins","Chemicals, peptides, and recombinant proteins","Chemicals,

(12) Antibody function predicts viral control in newborn monkeys immunised with an influenza virus HA stem nanoparticleNat CommunApril 22, 2025Kali F. Crofts, Beth C. Holbrook, Courtney L. Page, Rebecca A. Gillespie, Ralph B. D'Agostino, Maya Sangesland, David A. Ornelles, Masaru Kanekiyo, Martha A. Alexander-Millerdilutions, starting dilution 1:5) for 2 hrs at 37 °C. Lyophilised guinea pig complement (Cedarlane, CL4051) was reconstituted in ice-cold dH20 and diluted in 1:60 veronal buffer with 0.1% gelatin (GVB + + Boston

(13) Combinatorial Fc modifications for complementary antibody functionalityMAbsFebruary 14, 2025Yannic C. Bartsch, Nicholas E. Webb, Eleanor Burgess, Jaewon Kang, Douglas A. Lauffenburger, Boris D. Julgantigen-labeled beads and incubated for 2 hours. Guinea pig complement factor (Cedarlane: Cat. No. CL4051) in GVB++ buffer was added to the immune complexes and incubated for 20 minutes at 37°C. The complement

(14) Dose-dependent serological profiling of AdCLD-CoV19-1 vaccine in adultsmSphereJanuary 28, 2025Jung Hyuk Lee, Yuna Shin, Kwang-Soo Shin, Ju Yeon Park, Mi Sun Kim, Young-Shin Park, Wuhyun Kim, Joon Young Song, Ji Yun Noh, Hee Jin Cheong, et al.Gibco) with 10% FBS (#16000044, Gibco) was used to reconstitute lyophilized guinea pig complement (#CL4051, Cedarlane). The reconstituted guinea pig complement (#CL4051, Cedarlane) was added to the washed immune

(15) Crimean-Congo hemorrhagic fever virus replicon particle vaccine is safe and elicits functional, non-neutralizing anti-nucleoprotein antibodies and T cell activation in rhesus macaquesAntiviral ResearchJanuary 1, 2025Alyssa Kleymann, Elif Karaaslan, Florine E.M. Scholte, Teresa E. Sorvillo, Stephen R. Welch, Éric Bergeron, Stephanie Elser, Melvyn R. Almanzar-Jordan, Eric Velazquez, Sarah C. Genzer, et al.heat-inactivated (30 min at 56 °C) NHP plasma in sodium citrate. For ADCD assays, guinea pig complement (Cedarlane CL4051) diluted in gelatin veronal buffer (CompTech B102) was added and incubated 15 min at 37 °C. Beads were

(16) A trivalent mucosal vaccine encoding phylogenetically inferred ancestral RBD sequences confers pan-Sarbecovirus protection in miceCell Host & MicrobeDecember 11, 2024James Brett Case, Shilpa Sanapala, Carly Dillen, Victoria Rhodes, Christian Zmasek, Taras M. Chicz, Charlotte E. Switzer, Suzanne M. Scheaffer, George Georgiev, Catherine Jacob-Dolan, et al.IV,Duke Protein Production Facility,Custom order "Low-Tox Guinea Pig Complement, lyophilized",Cedarlane,CL4051 Foxp3/Transcription Factor Staining Buffer Set,eBioscience,00-5523 Streptavidin fluorescent yellow

(17) Compartment-specific antibody correlates of protection to SARS-CoV-2 Omicron in macaquesiScienceSeptember 20, 2024Tong X, Wang Q, Jung W, Chicz TM, Blanc R, Parker LJ, Barouch DH, McNamara RP.samples,Biological samples,Biological samples ,, LowTox Guinea Pig Complement,CedarLane Labs,Cat # CL4051 ,, "Chemicals, peptides, and recombinant proteins","Chemicals, peptides, and recombinant proteins","Chemicals,

(18) Repeated COVID-19 mRNA vaccination results in IgG4 class switching and decreased NK cell activation by S1-specific antibodies in older adultsImmunity & ageing : I & ASeptember 14, 2024Gelderloos AT, Verheul MK, Middelhof I, de Zeeuw-Brouwer ML, van Binnendijk RS, Buisman AM, van Kasteren PB.pandemic were included as negative controls, giving similar results. Low-Tox® Guinea Pig Complement (CL4051, Cedarlane) was reconstituted in 1 ml dH2O, diluted 25 × in HBSS and 100 ul was added per well. Plates

(19) Structure-based design of a soluble human cytomegalovirus glycoprotein B antigen stabilized in a prefusion-like conformationProceedings of the National Academy of SciencesSeptember 10, 2024Madeline R. Sponholtz, Patrick O. Byrne, Alison G. Lee, Ajit R. Ramamohan, Jory A. Goldsmith, Ryan S. McCool, Ling Zhou, Nicole V. Johnson, Ching-Lin Hsieh, Megan Connors, et al.diluted (4 × 10−2 to 1.3 × 10−4). For assays including complement, guinea pig complement (Cedarlane, CL4051) was mixed with cell culture media prior to addition to virus and sera at a final concentration of 12.5%.

(20) Distinctive antibody responses to Mycobacterium tuberculosis in pulmonary and brain infectionBrainSeptember 3, 2024Marianna Spatola, Nadège Nziza, Edward B Irvine, Deniz Cizmeci, Wonyeong Jung, Le Hong Van, Le Thanh Hoang Nhat, Vu Thi Ngoc Ha, Nguyen Hoan Phu, Dang Trung Nghia Ho, et al.then washed and incubated with complement factors from guinea pig during 20 min at 37°C (Cedarlane CL4051). To stop the complement reaction, beads were washed with 15 mM EDTA. The deposition of complement was

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Low-Tox® Guinea Pig Complement, Lyophilized from CEDARLANE

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Low-Tox® Guinea Pig Complement, Lyophilized from CEDARLANE

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