ROCK IMAGER® Protein Crystallization Imagers from FORMULATRIX

Product Specs
ItemROCK IMAGER^® Protein Crystallization Imagers
CompanyFORMULATRIX
Price Get Pricing
Catalog NumberROCK IMAGER
CapacityNumber of plates and compatible plate types depends on the model
QuantityEA
ApplicationsProtein crystallography
TypeProtein Crystallization Imager
Light SourceVisible, UV, Fluorescence (depends on model)

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FORMULATRIX

5 DeAngelo Drive

Bedford, MA 01730

United States

Phone: +1 781 788 0228
Fax: +1 781 207 5522

Email: info@formulatrix.com

Company Profile

Website: https://formulatrix.com/

(1) AXIS: a Lab-in-the-Loop machine learning approach for automated detection of macromolecular crystalsIUCrJMay 1, 2026Aurelien Personnaz, Sihyun Sung, Raphael Bourgeas, Sruthi Unni, Florine Dupeux, Bukunmi Adediran, Rosicler Barbosa, Anne-Sophie Humm, Euan Colaco-Osorio, José Antonio Márquezthe different classifier models with local images (Table 1 ▸). These images were generated with two Rock Imager 1000 imaging robots (Formulatrix, Bedford, MA, USA) equipped with visible and UV imaging systems. Crystallization

(2) A milestone in C4 carbon concentration mechanism evolution: structural remodeling of NADP-malic enzyme in PoaceaeMol Biol EvolApril 22, 2026Jonas M Böhm, Simone Willms, Oja Ferrao, Martin Buitrago-Arango, Meike Hüdig, Gereon Poschmann, Nazanin Fazelnia, Luitgard Nagel-Steger, Sebastián Klinke, Athina Drakonaki, et al.commercial screen solution. Plates were incubated at 4 °C and were manually imaged on a Formulatrix Rock Imager 1000 apparatus (Bedford, MA, USA). C4G200R crystals appeared with a solution consisting of 2 M (NH4)2SO4,

(3) Workflow for Crystallographic Fragment Screening by Crystal Soaking for Protein Targets: A Case Study on Thioredoxin Glutathione Reductase from Schistosoma mansoniBIO-PROTOCOLApril 20, 2026Lauro R. S. Neto, Bogar O. Montoya, José Brandão-Neto, Kelly Parker, Frank Von Delft, Nicholas Furnham, Raymond J. Owens, Floriano P. Silva-Jrsafety cabinet (Contained Air Solutions, model: BioMAT2) 6. Crystal plate imager (Formulatrix, model: RockImager 1000) 7. Incubated orbital shaker (Thermo Fisher Scientific, model: MaxQ 6000) 8. Liquid handler (Art

(4) The tRNA moieties of both aminoacyl-tRNA substrates of a cyclodipeptide synthase share a common binding site, as revealed by RNA microhelices mimicking tRNA acceptor armsNucleic Acids ResApril 7, 2026Zahra Marouf, Carine Tellier-Lebegue, Matthieu Glousieau, Nelly Morellet, Philippe Cuniasse, Alexa Bourand-Plantefol, Stéphane Plancqueel, Ikram Mahmoudi, Jessica Andreani, Pierre Legrand, et al.were performed at the I2BC crystallization platform using a Mosquito-LCP robot (TTP LabTech’s) and a RockImager 1000 (Formulatrix) for crystal visualization. Screenings with NeXtal crystallization 96-well kits (The

(5) Alzheimer’s Aβ catalyzes Tau phase separation and aggregation via early nanocluster solubilizationNature CommunicationsMarch 10, 2026Xun Sun, Yiming Tang, Xue Wang, Guadalupe Pereira Curia, Rebecca Sternke-Hoffmann, Cecilia Mörman, Juan Atilio Gerez, Roland Riek, Guanghong Wei, Jinghui Luotested in at least three replicates. The plates were sealed, incubated at 20 °C, and imaged using a Rock Imager microscope (Formulatrix). Droplet size and area were quantified using Fiji software. Fluorescence imaging

(6) CSL305: A Dual Functional Therapeutic Antibody Targeting Complement C2 and FcRnInt J Mol SciMarch 4, 2026Sandra Wymann, Rodrigo A. V. Morales, Wei Hong Toh, Jana Remlinger, Kirsten Guse, Rajesh Ghai, Sabine Pestel, Georgina Sansome, Chao-Guang Chen, Veronika Rayzman, et al.μL reservoir solution were incubated at 4 °C or 20 °C and imaged under visible and UV light using a RockImager 1000 (Formulatrix, Bedford, MA, USA). Initial hits were scaled up in hanging drops in Linbro plates

(7) Structural and mechanistic analysis of covalent ligands targeting the RNA-binding protein NONOCell Chemical BiologyFebruary 19, 2026Garrett L. Lindsey, Thomas K. Hockley, Alejandro Villa Gomez, Andrew C. Marshall, William R. Brothers, Colin T. Finney, Jacob Gross, Archa H. Fox, Gene W. Yeo, Bruno Melillo, et al.(reservoir 80 μL, protein:reservoir ratios 1:1, 2:1, 1:2), incubated at 20°C and observed using Formulatrix RockImager. Diffraction quality crystals were obtained from conditions optimized to 0.1 M HEPES, 28% PEG 2000 monomethyl

(8) Enzymatic Production of Prebiotic Xylooligosaccharides Using a Bacillus pumilus GH30_8 Glucuronoxylanase: Structural Basis of Glucuronoxylan Recognition and HydrolysisJournal of Agricultural and Food ChemistryFebruary 18, 2026Milena Moreira Vacilotto, Vanessa de Oliveira Arnoldi Pellegrini, Evandro Aresde de de Araujo, Marcelo V. Liberato, Igor Polikarpovcrystallization kits in the sitting-drop vapor diffusion settings. Crystallization plates were stored in Rock Imager 1000 (Formulatrix, Bedford, MA, USA) equipment. Initial needle-shaped crystals were observed under conditions

(9) The SETD2 L1609P mutation found in leukemia disrupts methyltransferase activity and reduces histone H3K36 trimethylationJournal of Biological ChemistryFebruary 5, 2026Christina Michail, Jérémy Berthelet, Ariel E. Mechaly, Linh-Chi Bui, Haopeng Yang, Duo Cai, Amira Al Mahi, Aowei Xie, Valeria Bisio, Valentina Sirri, et al.volume of the reservoir solution from the multiwell plates. The plates were stored at 18 °C in the RockImager system (Formulatrix) and crystal growth was monitored using the automated imaging system. Crystals of

(10) A 3.3-Å cryo-EM structure of an engineered high-affinity human prothrombinase complex∗BloodJanuary 29, 2026Fatma Işık Üstok, Alexandre Faille, James A. Huntington(TTP Labtech) by mixing 100nL of protein and 100nL of reservoir solutions. Plates were monitored using a Rock Imager 182 (Formulatrix). Initial crystals were obtained after 4 days in 0.1M imidazole at pH 7.0 and 50% MPD

(11) Unraveling the prevalence and multifaceted roles of accessory peptide deformylases in bacterial adaptation and resistanceMolecular Biology and EvolutionNovember 29, 2025Morgan Lambérioux, Magaly Ducos-Galand, Pierre-Alexandre Kaminski, Eloi Littner, Jean-Michel Betton, Ariel Mechaly, Ahmed Haouz, Didier Mazelnanoliter dispensing system (TTP Labtech, Melbourn, UK). The plates were then stored at 18 °C in a RockImager automated imaging system (Formulatrix, Bedford, USA) to monitor crystal growth. Initial crystallization

(12) Spermine modulation of Alzheimer’s Tau and Parkinson’s α-synuclein: implications for biomolecular condensation and neurodegenerationNature CommunicationsNovember 21, 2025Xun Sun, Debasis Saha, Xue Wang, Cecilia Mörman, Rebecca Sternke-Hoffmann, Juan Atilio Gerez, Fátima Herranz-Trillo, Roland Riek, Wenwei Zheng, Jinghui Luocondition were tested. The plates were sealed and kept at 20 °C and imaged at a certain time point using a Rock Imager microscope (Formulatrix). The droplet size was calculated using the Fiji image analysis platform62. Fluorescence imaging

(13) Impact of 2′-deoxyribo-purine substrates on nonenzymatic RNA template-directed primer extensionNucleic Acids ResearchNovember 20, 2025Ziyuan Fang, Orhan Acikgoz, Xiwen Jia, Jahmyl Essex, Ruby Wen, Jack W Szostakcrystallization conditions at 20°C using the sitting-drop vapor diffusion method. An NT8 robotic system and Rock Imager (Formulatrix, Waltham, MA) were used for crystallization screening and for monitoring the crystal growth

(14) Increasing the Chemical Space of L-SIGN Specific GlycomimeticsJournal of Medicinal ChemistryNovember 13, 2025Gianluca Cavazzoli, Clara Delaunay, Sara Pollastri, Andrea Panzeri, Sara Sattin, Michel Thépaut, Laura Belvisi, Franck Fieschi, Anna BernardiμL reservoir solution at 20 °C in 96-well CrystalDirect plates (MiTeGen) and automatically imaged in RockImager robot (Formulatrix). Best crystals grew in condition 1–13 of JCSG-plus screen (molecular dimensions;

(15) IL-17A complexes with therapeutic antibodies exhibit distinct size distributions, potentially contributing to clinically observed immunogenicityMAbsOctober 19, 2025Dennis Ungan, Céline Be, Paulina Baczyk, Simon Mittermeier, Sylvie Lehmann, Christian Wiesmann, Thomas Huber, Frank Kolbinger, Jean-Michel RondeauThe experiments were set up with a Phoenix robotic system (Art Robbins Instruments) and stored in a RockImager hotel (Formulatrix) at 19°C. CJM112 Fv complex with IL-17A Initial crystals were optimized in 24-well

(16) Crystal structures of agonist-bound human cannabinoid receptor CB1NatureOctober 16, 2025Tian Hua, Kiran Vemuri, Spyros P. Nikas, Yiran Wu, Lu Qu, Mengchen Pu, Anisha Korde, Shan Jiang, Jo-Hao Ho, Gye Won Han, et al.96-well glass sandwich plates were incubated and imaged at 20 °C using an automatic incubator/imager (RockImager 1000, Formulatrix). For the CB1–AM11542 complex, the crystals grew in conditions of 0.1 M sodium cacodylate

(17) Binding Differences of the Peptide‐Substrate–Binding Domain of Collagen Prolyl 4‐Hydroxylases I and II for Proline‐ and Hydroxyproline‐Rich PeptidesProteins: Structure, Function, and BioinformaticsOctober 1, 2025M. Mubinur Rahman, Ramita Sulu, Bukunmi Adediran, Hongmin Tu, Antti M. Salo, Sudarshan Murthy, Johanna Myllyharju, Rik K. Wierenga, M. Kristian Koskimake the crystallization drops. The crystallization plates were incubated at 4°C, and the Formulatrix Rock Imager RI54 was used for imaging the crystallization drops, and the in‐house developed IceBear software was

(18) A third type of PETase from the marine Halopseudomonas lineageProtein ScienceOctober 1, 2025Onur Turak, Andreas Gagsteiger, Ashank Upadhyay, Mark Kriegel, Peter Salein, Stefanie Böhnke‐Brandt, Seema Agarwal, Erik Borchert, Birte Höckerfor screening crystallization conditions in 96 well Intelli plates (Art Robbins) stored at 20°C in Rock Imager RI 182 (Formulatrix). Volume ratios of 2:1, 1:1, and 1:2 were prepared using a Phoenix robot dispenser

(19) Impact of 2′-deoxyribo-purine substrates on nonenzymatic RNA template-directed primer extensionbioRxivSeptember 11, 2025Ziyuan Fang, Orhan Acikgoz, Xiwen Jia, Jahmyl Essex, Ruby Wen, Jack W. Szostakcrystallization conditions at 20 °C using the sitting-drop vapor diffusion method. An NT8 robotic system and Rock Imager (Formulatrix, Waltham, MA) were used for crystallization screening and for monitoring the crystal growth

(20) Evolution of macromolecular crystallography beamlines at the Swiss Light Source and SwissFELJournal of Synchrotron RadiationSeptember 1, 2025Meitian Wangin situ diffraction from the GUI within 2 min and select crystallization plates from the Formulatrix Rock Imager 1000 or from a supplemental plate holder. A SCARA robot picked up the plate, transferred it to a Stäubli

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