EM TP Automated Tissue Processor from Leica Microsystems

Product Specs
ItemEM TP Automated Tissue Processor
CompanyLeica Microsystems
Price Get Pricing Get Quote for this Product
Catalog NumberEM TP
QuantityEach
ApplicationsAutomated dehydration, infiltration, and embedding for electron microscopy sample preparation
TypeAutomated Tissue Processor

Specifications/Features

Pre-heating and pre-cooling of the reagents
Versatile: EM, EM high throughput, and LM
The sample carousel holds 24 EM or 12 LM vials

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Leica Microsystems

10 Parkway North Blvd., Suite 300

Deerfield, Illinois 60015

United States

Phone: 800 248 0123

Company Profile

Website: www.leica-microsystems.com

(1) A strategy of microglia replacement alleviates microgliopathy in a CSF1R I794T hotspot mutation mouse model of CSF1R-related disorderCell Reports MedicineMarch 17, 2026Xin Li, Banglian Hu, Chujun Wu, Ziwei Wang, Hanzheng Fan, Xiaoyan Guan, Sulan Xie, Dadian Chen, Xiaohua Huang, Hao Sun, et al.buffer at 4°C overnight, followed by ethanol dehydration and uranium-saturated solution with Leica EM TP (Leica, Germany). After being embedded with Spurr’s resin, ultra-structures of the corpus callosum and

(2) Aberrant nuclear pore complex degradation contributes to neurodegeneration in VCP diseaseNeuronMarch 4, 2026Sandeep Kumar Dubey, Divya Chaubey, Chiseko Ikenaga, Wen-Wen Lin, Hugo J. Bellen, Thomas E. Lloydsecondary fixation and subsequently dehydrated in graded ethanol and propylene oxide using a Leica EM TP Automated Tissue Processor. Embed-812 resin (Electron Microscopy Science, Hatfield, PA) was used for embedding samples. The sample

(3) Starch synthesis in Brachypodium distachyon endosperm occurs in dynamic, connected amyloplast compartmentsNew PhytologistMarch 1, 2026Lara Esch, Qi Yang Ngai, Sergio G. Lopez, J. Elaine Barclay, Inmaculada Hernández‐Pinzón, Matthew J. Moscou, David Seungdehydrated in ethanol and infiltrated with LR White resin (Agar Scientific, Stansted, UK), using an EM TP embedding machine (Leica, Milton Keynes, UK). LR White blocks were polymerised at 60°C for 16 h. For

(4) Unveiling FLNC variants: iPSC-derived myogenic cells as a model to study disease mechanismsSkeletal MuscleFebruary 12, 2026Nassam M. Daya, Anne Schänzer, Andreas Hentschel, Marie-Cecile Kienitz, Dominik Sellung, Nicolina Suedkamp, Karsten Krause, Jaqueline C. Kinold, Leon Volke, Anja Schreiner, et al.washed thrice with 0.1 M Epon-PBS and processed with a tissue processor with 1% osmium tetroxide (Leica EM TP). Samples were dehydrated by immersion in increasing ethanol concentrations (25%, 35%, 50%, 70%, 75%,

(5) Cooperative Architecture of Mitochondrial Proteome HomeostasismedRxivFebruary 11, 2026Patrick Forny, Merima Forny, Andrew J. Smith, Andrew Y. Sung, Kaixian Liu, David J. Pagliariniorbital shaker at 300 rpm. Cover slips with cells were processed through infiltration using a Leica EM TP autoprocessor. Cells were rinsed out of fixative with 1X HBSS 3 times for 10 minutes each and subjected

(6) Two lysosomal genes ATP13A2 and GBA1 interact to drive neurodegenerationMolecular NeurodegenerationJanuary 30, 2026Mingxue Gu, Jinghan Zhao, Mingxi Deng, Guang Lin, Xueyang Pan, Wenwen Lin, Mengqi Ma, Jinyong Kim, Seul Kee Byeon, Akhilesh Pandey, et al.tetroxide for 40 minutes, then dehydrated through a graded ethanol and propylene oxide series using a Leica EM TP Automated Tissue Processor. Samples were embedded in Embed-812 resin (a mixture of Embed 812, NMA, DDSA, and DMP-30; Electron Microscopy

(7) Tmbim5 and Slc8b1 cooperate in tissue-specific mitochondrial calcium regulation in zebrafishCommunications BiologyJanuary 8, 2026Iga Wasilewska, Łukasz Majewski, Dobrochna Adamek-Urbańska, Sofiia Baranykova, Paulina Castañeda-Tamez, Ilka Wittig, Matylda Macias, Aleksandra Szybińska, Axel Methnerthen polymerized at 60 °C for 48 h. Polymerized blocks were trimmed with a tissue processor (Leica EM TP) and cut with an ultramicrotome (EM UC7, Leica) to obtain ultrathin sections (70 nm thick), which were

(8) Morphology of Vavilovia formosa (Steven) Fed. Nodules Induced by Different Rhizobia StrainsPlants (Basel)December 10, 2025Anna V. Tsyganova, Artemii P. Gorshkov, Anastasiia K. Kimeklis, Olga P. Onishchuk, Maxim G. Vorobiev, Evgeny E. Andronov, Viktor E. Tsyganovembedded in the EMbed-812 epoxy resin (EMS, Hatfield, PA, USA). All these procedures were performed in an EM TP tissue processor (Leica Microsystems). The samples were polymerized in an IN55 incubator (Memmert, Schwabach,

(9) Development of Long-Term Human Adipocyte Organoids Manifesting Aging in Response to Intermittent HypoxiabioRxivDecember 1, 2025Yunzhou Dong, Jingjing Wang, Feifei Feng, Isra H. Ali, Shahid Karim, Joshua Bock, Virend K. Somersglutaraldehyde, 4% formaldehyde in 0.1 M phosphate buffer, pH 7.2). Samples were processed using a Leica EM TP microwave processor, rinsed in phosphate buffer, and post-fixed in 1% osmium tetroxide. After washes

(10) Nondestructive X-ray tomography of brain tissue ultrastructureNature MethodsNovember 27, 2025Carles Bosch, Tomas Aidukas, Mirko Holler, Alexandra Pacureanu, Elisabeth Müller, Christopher J. Peddie, Yuxin Zhang, Phil Cook, Lucy Collinson, Oliver Bunk, et al.stained with heavy metals using an established ROTO protocol42 using an automated tissue processor (Leica EMTP). Briefly, they were first stained with reduced osmium (2% OsO4, 3% potassium ferrocyanide and 2 mM

(11) Germacrone Ameliorates Diabetic Kidney Disease by Activating TFEB to Promote Autophagy and Inhibit InflammationACS OmegaNovember 25, 2025Zhishen Xie, Mengmeng Wang, Qingqing Song, Xuan Su, Jenny Jie Chen, Jiangyan Xu, Zhenqiang Zhang, Tongxiang Liu, Xiaowei Zhang, Gai Gaoprocess involved repetitive use of different ethanol concentrations. Automated resin processing (Leica, EMTP) was employed for embedding polymerization, while the Leica automatic ultrathin slicer (Leica, EMUC7)

(12) The short isoform of Tango1 is dispensable for zebrafish survival but is required for skeletal patterning and integrityBiology OpenNovember 15, 2025Elizabeth A. Lawrence, Maria Esther Prada-Sanchez, Qiao Tong, Bianca Fernandes, Rebecca M. Chatwin, Michael Donohue, Brian Link, David J. Stephens, Chrissy L. Hammondagarose before being osmium/uranyl acetate stained, dehydrated and infiltrated with EPON in a Leica EM TP tissue processor using the standard protocol outlined in Lawrence (2021). Ultra-thin sections were cut

(13) Tubulin Cytoskeleton Organization in Cells of Determinate Nodules in Vigna radiata, Vigna unguiculata, and Lotus corniculatusPlants (Basel)September 26, 2025Anna B. Kitaeva, Pyotr G. Kusakin, Artemii P. Gorshkov, Anna V. Tsyganova, Viktor E. Tsyganovincreasing concentration mixed with 90% acetone (Table S1). All these procedures were performed in an EM TP tissue processor (Leica Microsystems, Vienna, Austria). The following medium-hardness EMbed-812 epoxy

(14) The Impact of GAGs, Cross-Link Maturity and Telopeptides on the Formation of a Porcine Collagen-Based HydrogelGelsSeptember 1, 2025Monika Šupová, Šárka Rýglová, Tomáš Suchý, Margit Žaloudková, Martin Braunmultiple washing in a phosphate buffer and graded ethanol and acetone dehydration series in a Leica EM TP tissue processor (Specion s.r.o., Prague, Czech Republic), and dried in a Leica EM CPD300 (Specion s.r.o.,

(15) Biological activities and application of Rosmarinus officinalis extract to improve the preservation and microbial qualities of some local meat productsSci RepAugust 21, 2025Basma T. Abd-Elhalim, Esmat S. Mohamed, Gamar Mahamat Gamar, Hanan Moawadrespectively, and the cultures are then incubated for a full day73. An automated tissue processor (Leica EM TP) was used to fixate the treated and untreated bacteria (as a control) with 2.5% glutaraldehyde and dehydrate

(16) Characterisation of lmx1b paralogues in zebrafish reveals divergent roles in skeletal, kidney and muscle developmentBiology OpenAugust 15, 2025Joanna J. Moss, Chris R. Neal, Erika Kague, Jon D. Lane, Chrissy L. Hammondwashing, larvae were placed into tissue processor for transmission electron microscopy (TEM; Leica EMTP, Leica Microsytems UK Ltd) using a standard Epon resin protocol. Briefly, larvae were stained with uranyl

(17) Lessons learned from a muscle study in nail-patella syndromeOrphanet J Rare DisJuly 28, 2025Luisa Paul, Anne Schänzer, Christel Depienne, Andreas Hentschel, Nicolai Kohlschmidt, Ulrike Schara-Schmidt, Christopher Jannik Nelke, Andreas Roos, Heike Kölbelwashed 5 times in 0.1 M Epon-PBS and processed with a tissue processor with 1% osmium tetroxide (Leica EM TP). Samples were dehydrated by immersion in increasing ethanol concentrations (25%, 35%, 50%, 70%, 75%,

(18) Microglia and CD8+ T cell activation precede neuronal loss in a murine model of spastic paraplegia 15J Exp MedJuly 7, 2025Aleksej Frolov, Hao Huang, Dagmar Schütz, Maren Köhne, Nelli Blank-Stein, Collins Osei-Sarpong, Maren Büttner, Tarek Elmzzahi, Mukhran Khundadze, Marina Zahid, et al.PBS) and incubated for a month at 4°C. The following steps were performed using a tissue processor EM TP (Leica): rinse 6× for 15 min each in 0.1 M cacodylate buffer. Secondary fixation was performed using

(19) Elevated NGF provokes decidual lipid peroxidation and promotes preterm birth in miceJ Transl MedApril 28, 2025Yuhang Ge, Ruxin Teng, Zhaoyu Jia, Yongyue Li, Yafang Lu, Jia Yuanthen soaked and embedded in epoxy resin, and polymerized using an automatic tissue processor (Leica, EM TP). The tissue was subsequently cut into semi-thin sections of 5 μm thickness using an ultramicrotome

(20) Genomic and genetic insights into Mendel’s pea genesNatureApril 23, 2025Cong Feng, Baizhi Chen, Julie Hofer, Yan Shi, Mei Jiang, Bo Song, Hong Cheng, Lu Lu, Luyao Wang, Alex Howard, et al.for fixation. Samples were left overnight at room temperature and then processed for embedding (Leica EM TP embedding machine) by washing out the fixative with three successive 15-min washes in 0.05 M sodium

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