PD0325901 (Mirdametinib) from Selleck Chemicals

Product Specs
ItemPD0325901 (Mirdametinib)
CompanySelleck Chemicals
Price $147.00Supplier Page View Company Product Page
Catalog NumberS1036
Quantity5mg
Purity99.17
TargetMEK
Storage2 years -80 in solvent
FormulaC16H14F3IN2O4

Specifications/Features

Ki, IC, EC, or working concentration: Ki: 1.1 nM for MEK1
Ki: 0.79 nM for MEK2

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Selleck Chemicals

14408 W Sylvanfield Drive

Houston, Texas TX 77014

United States

Phone: Toll Free: (877) 796-6397 (US and Canada only)
Tel: (832) 582-8158
Fax: (832) 582-8590

Email: sales@selleckchem.com

Company Profile

Website: www.selleckchem.com

(1) Generation of Budoids: 3D Multilineage Limb Models From Mouse Embryonic Stem CellsBio ProtocSeptember 5, 2026Kelly Hu, Can Aztekinnumber: AF-300-05-25UG) (used interchangeably) 13. PD0325901 (Mirdametinib) (Selleckchem, catalog number: S1036), product format: 10 mM (1 mL in DMSO) 14. CHIR-99021 (CT99021) (ApexBio, catalog number: A3011), product

(2) Decaying and expanding Erk gradients process memory of skeletal size during zebrafish fin regenerationNature PhysicsAugust 24, 2026Ashley Rich, Ziqi Lu, Alessandro De Simone, Lucas Garcia, Jacqueline Janssen, Kazunori Ando, Jianhong Ou, Massimo Vergassola, Kenneth D. Poss, Stefano Di Taliaexperiment. The pan-Fgfr inhibitor, BGJ398 (Selleck Chem 2183), and MEK inhibitor, PD0325901 (Selleck Chem S1036), were dissolved in DMSO and used at 10μM unless otherwise indicated. Control fish were treated with

(3) Protocol for PI3K inhibitor-free differentiation and maturation of human iPSC-derived arterial- and venous-like endothelial cellsSTAR ProtocJuly 30, 2026Oliwia N. Mruk, Alexandra J. Musk, Ralitsa R. MadsenA8960 DMH1,Sigma-Aldrich,Cat# 203646 RO4929097,SelleckChem,Cat# S1575 PD0325901,SelleckChem,Cat# S1036 EGM-2 Endothelial Cell Growth Medium-2 BulletKit,Lonza,Cat# CC-3162 Bovine Serum Albumin (BSA) 10%

(4) The antiviral role of TRIM25 in mammalian embryonic stem cellsVirologica SinicaJuly 30, 2026Jie Zou, Yuxin Lin, Chunyan Wu, Yao Ji, Xuankai Zhao, Zhan Xu, Jingfei Gong, Zhiyuan Shi, Tianyang Luo, Xiaoling Xie, et al.(354232), trypsin-EDTA (25-053-CI) were purchased from Corning (NY, USA); CHIR99021 (S1263), PD0325901 (S1036) were purchased from Selleck Chemicals (Massachusetts, USA). Cell lines and cell culture Mouse embryonic stem cells

(5) Protocol for the generation of human medullary spinal trigeminal nucleus-like organoids and trigeminothalamic assembloidsSTAR ProtocJuly 14, 2026Wei Pang, Jinkui Zhu, Siyuan Chu, Yangfei Xiangab120163 CHIR99021,Stem Cell Technologies,Cat# 72054 BMP7,Life Technologies,Cat# PHC9544 PD325901,Selleck,Cat# S1036 BDNF,novoprotein,Cat# C076 Bucladesine sodium,MCE,Cat# HY-B0764 Ascorbic acid,Sigma-Aldrich,Cat#

(6) PAR3-mediated coordination of hepatocyte proliferation, maturation, and architecture in liver development and regenerationNature CommunicationsJune 12, 2026Li Yang, Yu-Heng Zhou, Junya Hayase, Lei Wang, Weiguang Zhang, Erfei Bi, Cheng-Ran Xutreated with DMSO (Sigma-Aldrich, D2650), 0.5 µM TPPB (Calbiochem, 508158), 0.5 µM PD0325901 (Selleck, S1036), 10 µM U0126 (Sigma-Aldrich, U120), 1 µM Y27632 (Selleck, S1049), or 0.5 µM Cytochalasin D (Selleck,

(7) EZH2 Regulates the Pluripotency of Mouse Embryonic Stem Cells by Modulating Nanog Expression Under PKC InhibitionBiology (Basel)June 2, 2026Fangfang Wu, Zhihui Liu, Yuan Gao, Jinshan Li, Xiao Chen, Xiyue Wang, Lanjun Liu, Fuliang Duβ-mercaptoethanol, 2 mM GlutaMax, 103 IU/mL murine LIF (ESG1107, Millipore, Burlington, MA, USA), 1 μM PD0325901 (S1036, Selleck, Houston, TX, USA), and 3 μM CHIR99021 (CT99021, Selleck). 2.3. RNA Extraction, cDNA Synthesis,

(8) MEK inhibitor Mirdametinib promotes fracture healing in osteofibrous dysplasia RASopathyJournal of Clinical InvestigationMay 1, 2026Aysha B. Khalid, Kristin Denton, Nandina Paria, Ila Oxendine, Meghan Wassell, Reuel Cornelia, Sasidhar Uppuganti, Jeffry S. Nyman, G. Jayashree Jagadeesh, Carlos R. Ferreira, et al.capmatinib (10 μM, catalog no. S2788, Selleck Chemicals), the MEK inhibitor mirdametinib (1 μM, catalog no. S1036, Selleck Chemicals), or the MEK inhibitor selumetinib (5 μM, catalog no. S1008, Selleck Chemicals).

(9) Deciphering tRNA repertoires and translation coordination during mouse early embryogenesis by ORACLE-tRNAseqNature CommunicationsApril 30, 2026Yun Li, Xin Wang, Ruofan Huang, Haoquan Yu, You Wu, Ze Shu, Wenlin Jiang, Zheng Cao, Zongyu Yu, Hongyan Li, et al.Thermo Fisher Scientific), 0.1% mouse leukemia inhibitory factor (Sigma-Aldrich, ESG1106), 1 μM PD0325901 (Selleck, S1036), and 3 μM CHIR99021 (Selleck, S2924) on gelatin-coated adherent cell culture dishes at 37 °C with 5%

(10) CORO1C (coronin 1C) promotes autophagosome formation by coordinating branched actin network dynamicsAutophagyApril 20, 2026Guozhong Zhang, Ningqing Yu, Yi Sun, Xiaowen Li, Lihong Sun, Guang Liu, Yue HuangESG1107), 3 μM CHIR99021 (Selleck Chemicals LLC, S2924) and 1 μM PD0325901 (Selleck Chemicals LLC, S1036). H4 and 293 FT cell lines were obtained from the Cell Resource Center, Peking Union Medical College

(11) KDM3A catalyses the oxidation of acetyl-lysine to hydroxyacetyl-lysine on histone H3K9Nature ChemistryApril 15, 2026Roman Belle, John-Paul Bukowski, Rachel Schiller, Ronald Cutler, Eidarus Salah, Robert S. Dawber, Anthony Tumber, Joanna Bonnici, Jessica D. Kindrick, Loane Serrano, et al.(ThermoFisher, 35050061), 3 μM GSK-3 inhibitor (Selleckchem, S2924), 2 μM MEK inhibitor (Selleckchem, S1036) and ESGRO recombinant mouse LIF (Millipore, ESG1106). ES-E14TG2a cells were split into fresh medium

(12) MEK-dependent bioenergetic demand drives terminal CD8 + T cell exhaustionbioRxivApril 12, 2026Tanmana Mitra, Jahan Rahman, Madeline Hwee, Ruben Jose Jesus Faustino Ramos, Hui Liu, Travis Hartman, Justin Cross, Miguel de Jesus, Morgan Huse, Valerie Longo, et al.Tacrolimus (FK506),SelleckChem,Cat# S5003 Pictilisib (GDC-0941),SelleckChem,Cat# S1065 Mirdametinib (PD0325901),SelleckChem,Cat# S1036 Adezmapimod (SB203580),SelleckChem,Cat# S1076 Sotrastaurin (AEB071),SelleckChem,Cat# S2791 Rapamycin,SelleckChem,Cat#

(13) Decaying and expanding Erk gradients process memory of skeletal size during zebrafish fin regenerationbioRxivApril 11, 2026Ashley Rich, Ziqi Lu, Alessandro De Simone, Lucas Garcia, Jacqueline Janssen, Kazunori Ando, Jianhong Ou, Massimo Vergassola, Kenneth D. Poss, Stefano Di Taliaexperiment. The pan-FgfR inhibitor, BGJ398 (Selleck Chem 2183), and MEK inhibitor, PD0325901 (Selleck Chem S1036), were dissolved in DMSO and used at 10 μm unless otherwise indicated. Control fish were treated with

(14) Single-cell morphodynamical trajectories enable prediction of gene expression accompanying cell state changeCell SystApril 2, 2026Jeremy Copperman, Ian C. Mclean, Sean M. Gross, Jalim Singh, Vaibhav Murthy, Young Hwan Chang, Alexander E. Davies, Daniel M. Zuckerman, Laura M. Heiser100-11-500UG), HGF (100ng/mL, Peprotech Cat# 100-39H-25UG), MEKi/PD0325901 (500nM, Selleckchem Cat# S1036), AKTi/MK2206 (1μM, Selleckchem Cat# S1078). Cytoplasmic and nuclear regions were segmented using cellpose

(15) RBFOX1 Dysfunction Unlocks APOE4-Associated Microglial Genesis and Exacerbates Alzheimer's Pathology in Human Cerebral OrganoidsExploration (Beijing)April 2, 2026Bowen Zhang, Changjie Shi, Jiayi Zhao, Qiuhong Hua, Houchun Zhang, Hailin Gao, Yuanyuan Qian, Jiaxue Cha, Jing Li, Jiayao Chen, et al.Day 5, E6 with LDN193189∙2HCl (50 nM), SB431542 (5 µM), XAV‐939 (1 µM), PD0325901 (0.4 µM) (Selleck, S1036), SU5402 (2 µM) (Selleck, S7667), and DAPT (5 µM) (Selleck, S2215) (LSB + X + P/S/D) were added into

(16) Chromatin dynamics of the Klf4 locus in mouse pluripotent cellsScientific ReportsMarch 27, 2026Jente van Staalduinen, Hélène Kabbech, Selçuk Yavuz, Ridvan Cetin, Agnese Loda, Wiggert van Cappellen, Adriaan Houtsmuller, Kerstin Wendt, Ihor Smal, Frank GrosveldµM CHIR 99,021 (Tocris Bioscience, Catalog no: 4423/50), 1 µM PD0325901 (Selleck chem, Catalog no: S1036) and 1,000 units/mL Leukemia Inhibitory Factor (LIF) (ESGRO, Catalog no: ESG1107). When culturing the

(17) FGF4 initiates X-chromosome inactivation via activating YY1 and prompting loss of pluripotency factorsThe EMBO JournalMarch 25, 2026Lizhu Ma, Wei Fu, Lei An, Qianying Yang, Ruiqi Hai, Guangyin Xi, Yinjuan Wang, Juan Liu, Chao Zhang, Yao Fu, et al.(BGJ398),Selleck,Cat# S2183 GSK-3i (CHIR-99021),Selleck,Cat# S2924 MEKi (PD0325901),Selleck,Cat# S1036 Fludarabine,Selleck,Cat# S1491 SH-4-54,Selleck,Cat# S7337 U73122,Selleck,Cat# S7791 Phorbol 12-myristate

(18) Generation of tetraploid organs in miceZoological ResearchMarch 18, 2026Wei Shu, 中国科学院昆明动物研究所遗传进化与动物模型国家重点实验室, 云南昆明 650223, 中国, State Key Laboratory of Genetic Evolution & Animal Models, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan 650223, China, Zou Guo-Wei, Zhang Yan-Yan, Li Shuai-Peng, Hu Mei, Du Juan, Liu Jia-Wen, Ran Lin, et al.(Millipore, USA, Cat#: ESG1107, ), 1 μmol/L PD0325901, and 3 μmol/L CHIR99021 (Selleck, USA, Cat#: S1036, Cat#: S2924; hereafter referred to as 2i). After 5 days in culture, embryo-derived outgrowths were

(19) Mitigating xenogeneic barriers to chimerism through Cas13-induced host attenuationDevelopmental CellMarch 11, 2026Bingbing He, Shijian Lv, Leijie Li, Lin Zhang, Yingying Hu, Daiji Okamura, Jia Huang, Jun Wu35050-061 β-mercaptoethanol,Millipore,Cat # ES-007-E CHIR99021,Selleck,Cat # S1263 PD035901,Selleck,Cat # S1036 Mouse LIF,Millipore,Cat # ESG1107 Acid Tyrodes solution,Sigma,Cat # T1788-100ML N-2 Supplement,Gibco,Cat

(20) PD0325901 alleviates thrombin-inhibited osteogenic differentiation through an IL-1β-activated feedback loop between MEK-Erk1/2 and NF-κB signal pathways: insights from bioinformatics and experimental verificationFront ImmunolMarch 9, 2026Yang-Shuo Ge, Chun-Meng Huang, Jun Shen, Ting-Ting Meng, Min-Jun Zhao, Jian-Li Yin, Xin-Hui Huang, Liao-Lin Chen, Jia-Hui Luo, Yu-Qing Zhai, et al.serum-free DMEM supplemented with 20U/mL thrombin (ST1699, Beyotime, China), thrombin + 0.1 μM PD03 (21–23) (S1036, Selleck, China) were administered for 5, 15, and 30 minutes to detect the expression levels of p-Stat3

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