Trichostatin A from Cayman Chemical

Product Specs
ItemTrichostatin A
CompanyCayman Chemical
Price $104.00Supplier Page View Company Product Page
Catalog Number89730
Quantity1 mg
Research AreaEpigenetics, Transcription, & Translation, Erasers, Histone Deacetylation
FormatA crystalline solid
Molecular Weight302.4
Purity≥95%
Storage-20
FormulaC17H22N2O3
OriginCHN

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Cayman Chemical

Cayman Chemical Company 1180 East Ellsworth Road

Ann Arbor, Michigan 48108

United States

Phone: (800) 364-9897
(734) 971-3640

Company Profile

Website: http://www.caymanchem.com/

(1) Adaptation of white adipocytes to cooler temperatures: impacts on energy metabolism and protein acetylationbioRxivApril 21, 2026Hiroyuki Mori, Hadla Hariri, William Moe, Sophia Durham, Yuridia Guzman, Emma Paulsson, Rachel C. Simmermon, Parth B. Bhanderi, Sydney K. Peterson, Mia J Dickson, et al.,Cayman Chemical,10005263 3-TYP,Cayman Chemical,29660 UK 5099,Cayman Chemical,16980 Trichostatin A (TSA),Cayman Chemical,89730 sodium butyrate,Cayman Chemical,13121 EX-527,Cayman Chemical,10009798 SAHA,Cayman Chemical,10009929 ,, Kit,, NE-PER™

(2) Deep-learning-based de novo discovery and design of therapeutics that reverse disease-associated transcriptional phenotypesCellMarch 17, 2026Jing Xing, Mingdian Tan, Dmitry Leshchiner, Mengying Sun, Mohamed Abdelgied, Li Huang, Shreya Paithankar, Katie Uhl, Rama Shankar, Erika Lisabeth, et al.USA",34528 SN-38,"Cayman Chemical, Ann Arbor, MI, USA",15632 trichostatin A,"Cayman Chemical, Ann Arbor, MI, USA",89730 Alizapride (hydrochloride),"Cayman Chemical, Ann Arbor, MI, USA",15645 Panobinostat,"Cayman Chemical,

(3) Trichostatin A suppresses hearing loss by reducing oxidative stress and inflammation in an Alport syndrome modelPLoS OneFebruary 5, 2025Yoon Seok Nam, Eun-Ji Gi, Yoo-Seung Ko, Sungsu Lee, Hyong-Ho Cho(https://arriveguidelines.org). TSA treatment and cochlear tissue harvest TSA (Cayman Chemical Company, 89730) was dissolved in 10% kolliphor in each desired concentration. For the in vivo study, a TSA dose of

(4) Small molecular weight epigenetic inhibitors modulate the extracellular matrix during pancreatic acinar ductal metaplasiaBiochemical and Biophysical Research CommunicationsDecember 3, 2024Corey M. Perkins, Yating Mao, Jinmai Jiang, Diana J. Wilkie, Bo Han, Qi-Yin Chen, Hendrik Luesch, Jamel Ali, Thomas D. SchmittgenFlorida. 2.2. Chemicals, compounds and reagents Trichostatin A (TSA) was purchased from Cayman Chemicals (#89730), FK228 from Sigma-Aldrich, (#SML1175) and chaetocin from Cayman Chemicals (#11076). Largazole homodimer

(5) The H3.3 K36M oncohistone disrupts the establishment of epigenetic memory through loss of DNA methylationMolecular CellOctober 17, 2024Joydeb Sinha, Jan F. Nickels, Abby R. Thurm, Connor H. Ludwig, Bella N. Archibald, Michaela M. Hinks, Jun Wan, Dong Fang, Lacramioara Bintu,Sigma Aldrich,Cat# A3656 SETD2-IN1 TFA,Medchem Express,Cat# HY-136328 Trichostatin A (TSA),Cayman,Cat# 89730 Lipofectamine RNAiMax,Invitrogen,Cat# 13778075 Lipofectamine LTX,Invitrogen,Cat# 15338030 PEI,Polysciences,Cat#

(6) Sensitive Detection of Histones and γ-H2AX by Immunoblotting: Problems and SolutionsChemical research in toxicologySeptember 16, 2024Krawic C, Luczak MW, Zhitkovich A.Sigma-Aldrich (E1383), camptothecin from Sigma-Aldrich (C9911) and Trichostatin A from Cayman Chemical (89730). Cell Culture H460 and IMR90 human cells were obtained from the American Type Culture Collection.

(7) Protocol for mass spectrometric profiling of lysine malonylation by lysine acetyltransferase in CRISPRi K562 cell linesSTAR ProtocolsJune 21, 2024Ran Zhang, Joanna Bons, Jacob P. Rose, Birgit Schilling, Eric Verdin,Santa Cruz Biotechnology,Cat. #sc-108071 Sodium chloride,VWR,Cat. #BDH9286 Trichostatin A,Cayman Chemical,Cat. #89730 "Triethylammonium bicarbonate (TEAB), pH8 (1 M)",Sigma-Aldrich,Cat. #7408 Trifluoroacetic acid (TFA;

(8) Regulation of urea cycle by reversible high-stoichiometry lysine succinylationNature MetabolismMarch 6, 2024Ran Zhang, Jingqi Fang, Xueshu Xie, Chris Carrico, Jesse G. Meyer, Lei Wei, Joanna Bons, Jacob Rose, Rebeccah Riley, Ryan Kwok, et al.inhibitor cocktail (Thermo Scientific, cat. no. PI78447), 5 M trichostatin A (Cayman Chem, cat. no. 89730) and 5 mM nicotinamide (Sigma-Aldrich, cat. no. 72340). IP was performed using anti-succinyl-lysine

(9) G-quadruplex is critical to Epigenetic activation of the lncRNA HOTAIR in cancer cellsiScienceDecember 15, 2023Xiaohan Qu, Zhen Lin, Janarthanan Jayawickramarajah, John S. Alsager, Emily Schmidt, Kenneth P. Nephew, Fang Fang, Shankar Balasubramanian, Bin ShanBloom ML216,Cayman Chemical,15186 Pyridostatin,Cayman Chemical,18013 Trichostatin A,Cayman Chemical,89730 5-Aza-2′-deoxycytidine,BioVision,Catalog #: 1754 TAP1,"Department of Chemistry, University of Cambridge",NA TMPyP4,Aldrich

(10) Regulatory Roles of Histone Deacetylation in Metabolic Stress-Induced Expression of Caspase Recruitment Domain-Containing Protein 9 (CARD9) in Pancreatic β-CellsInternational Journal of Molecular SciencesNovember 6, 2023Mirabela Hali, Nelson Pinto, Noah Gleason, Anjaneyulu KowluruAntibody for β-actin (catalog # A1978) was from Sigma Aldrich (St. Louis, MO, USA). TSA (catalog # 89730) and SAHA (catalog # 10009929) were obtained from Cayman Chemicals (Ann Arbor, MI, USA). 4.2. Culture

(11) Non-Psychoactive Phytocannabinoids Inhibit Inflammation-Related Changes of Human Coronary Artery Smooth Muscle and Endothelial CellsCellsSeptember 30, 2023Teichmann E, Blessing E, Hinz B.(#13067), SP600125 (#10010466), PD98059 (#10006726), BAY 11-7082 (#10010266), trichostatin A (TSA, #89730), and sirolimus (#13346) were obtained from Cayman Chemical (Ann Arbor, MI, USA). WST-1 was bought from

(12) Redox Dysregulation of Vascular Smooth Muscle Sirtuin-1 in Thoracic Aortic Aneurysm in Marfan SyndromeArterioscler Thromb Vasc BiolJune 8, 2023Budbazar Enkhjargal, Sandra Sulser Ponce De Leon, Yuko Tsukahara, Hanxiao Liu, Yuhao Huangfu, Yu Wang, Pedro Maria Seabra, Xiaoqiu Yang, Jena Goodman, Xueping Wan, et al.10% glycerol, pH=7.5) supplemented with protease inhibitors (P8340, Sigma-Aldrich), trichostatin A (89730, Cayman Chemical) and 100 mM N-ethylmaleimide (129585, Sigma-Aldrich). Samples were incubated for 1

(13) A Shared Pathogenic Mechanism for Valproic Acid and SHROOM3 Knockout in a Brain Organoid Model of Neural Tube DefectsbioRxivApril 18, 2023Taylor N. Takla, Jinghui Luo, Roksolana Sudyk, Joy Huang, J. Clayton Walker, Neeta L. Vora, Jonathan Z. Sexton, Jack M. Parent, Andrew M. Tidballantioxidants. We tested HDAC inhibitors that target different classes: Trichostatin A (TSA; Cayman Chemical, 89730), Nicotinamide (Cayman Chemical, 11127), CI-994 (Cayman Chemical, 12084). GSK3β inhibitors included

(14) Tuberous sclerosis complex is associated with a novel human tauopathyActa neuropathologicaJanuary 1, 2023Hwang JL, Perloff OS, Gaus SE, Benitez C, Alquezar C, Cosme CQ, Nana AL, Vatsavayai SC, Ramos EM, Geschwind DH, et al.(MilliporeSigma, #4906837001), and deacetylase inhibitors 3μM trichostatin A (Cayman Chemical Company, #89730) and 10 mM niacinamide (MilliporeSigma, #N5535) and homogenizing using Kimble Pellet Pestle Cordless

(15) Histone deacetylase inhibitors suppress ACE2 and ABO simultaneously, suggesting a preventive potential against COVID-19Scientific ReportsDecember 1, 2021Yoichiro Takahashi, Akira Hayakawa, Rie Sano, Haruki Fukuda, Megumi Harada, Rieko Kubo, Takafumi Okawa, Yoshihiko Kominato(#13033; Cayman Chemical Company), vorinostat (#10009929; Cayman Chemical Company) and trichostatin A (#89730; Cayman Chemical Company). The solvent used for sodium butyrate and sodium valproate was deionized-distilled

(16) TSC1 loss increases risk for tauopathy by inducing tau acetylation and preventing tau clearance via chaperone-mediated autophagyScience advancesNovember 5, 2021Alquezar C, Schoch KM, Geier EG, Ramos EM, Scrivo A, Li KH, Argouarch AR, Mlynarski EE, Dombroski B, DeTure M, et al.(MilliporeSigma, #4906837001), and deacetylase inhibitors 3 μM trichostatin A (Cayman Chemical Company, #89730) and 10 mM niacinamide (MilliporeSigma, #N5535). Then, lysates were centrifuged at 15,000 rpm for 15

(17) PI3K/ NF-κB-dependent TNF-α and HDAC activities facilitate LPS-induced RGS10 suppression in pulmonary macrophagesCellular signallingOctober 1, 2021Almutairi F, Tucker SL, Sarr D, Rada B.(cat#: 10006726), SB 239063 (cat#: 19142), SP 600125 (cat#: 10010466), Trichostatin A (TSA) (cat#: 89730), JSH-23 (cat#: 15036), wortmannin (cat#: 10010591), and 5-Azacytidine (5-Aza) (cat#: 11164) were obtained

(18) Dynamics and competition of CRISPR-Cas9 ribonucleoproteins and AAV donor-mediated NHEJ, MMEJ and HDR editingNucleic acids researchJanuary 25, 2021Fu YW, Dai XY, Wang WT, Yang ZX, Zhao JJ, Zhang JP, Wen W, Zhang F, Oberg KC, Zhang L, et al.(Calbiochem; 553510), NU7026 (Cayman; 13308), NU7441 (Tocris; 3712), Trichostatin A (TSA) (Cayman; 89730), Pevonedistat (MLN4924) (Selleckchem; S7109), and M3814 (MedKoo; 206478). As a control, this study

(19) Lactate production by Staphylococcus aureus biofilm inhibits HDAC11 to reprogramme the host immune response during persistent infectionNature microbiologyOctober 1, 2020Heim CE, Bosch ME, Yamada KJ, Aldrich AL, Chaudhari SS, Klinkebiel D, Gries CM, Alqarzaee AA, Li Y, Thomas VC, et al.experiments, mice received daily i.p. injections of the pan-HDACi trichostatin A (0.5 mg/kg; Cat. #89730; Cayman Chemical) or the HDAC6i tubastatin A (0.5 mg/kg; Cat. #15785; Cayman Chemical Company) beginning

(20) Context dependent effects of ascorbic acid treatment in TET2 mutant myeloid neoplasiaCommunications biologySeptember 7, 2020Guan Y, Greenberg EF, Hasipek M, Chen S, Liu X, Kerr CM, Gackowski D, Zarakowska E, Radivoyevitch T, Gu X, et al.was harvested and 5hmC/5mC was determined by dot blot analysis. TSA: Trichostatin A (Cayman, Item No. 89730). c CMK cells were treated with increasing concentrations of SRT1720 (Sirtuins activator, Cayman, Catalog

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Trichostatin A

Trichostatin A

Trichostatin A from Cayman Chemical

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Cayman Chemical

Citations (26)

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Trichostatin A from Cayman Chemical

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