SAHA from Cayman Chemical

Product Specs
ItemSAHA
CompanyCayman Chemical
Price $106.00Supplier Page View Company Product Page
Catalog Number10009929
Research AreaEpigenetics, Transcription, & Translation, Erasers, Histone Deacetylation
FormatA crystalline solid
Molecular Weight264.3
Purity≥98%
Storage-20
FormulaC14H20N2O3
OriginCHN
TypeInhibitors
Quantity250 mg

Specifications/Features

Ki, IC, EC, or working concentration: IC50 = 50 nM

Add to Compare List

Cayman Chemical

Cayman Chemical Company 1180 East Ellsworth Road

Ann Arbor, Michigan 48108

United States

Phone: (800) 364-9897
(734) 971-3640

Company Profile

Website: http://www.caymanchem.com/

(1) Thermal shift engagement assay for Class IIA histone deacetylase inhibitor screeningResults in ChemistryDecember 31, 2025Lauren N. Kotsull, Mary Kay H. PflumChemicals Four HDAC inhibitors were obtained commercially and used without purification: SAHA (Cayman Chemical, 10009929), TMP269 (Selleck Chem, S7324), SB939 (BPS, 27771–1), and BRD-6929 (Sigma, #SML2521). All inhibitors

(2) Reversible histone deacetylase activity catalyzes lysine acylationNature Chemical BiologySeptember 1, 2025Takeshi Tsusaka, Mohd. Altaf Najar, Benjamin Schwarz, Eric Bohrnsen, Juan A. Oses-Prieto, Helena Neudorf, Christina Lee, Jonathan P. Little, Alma L. Burlingame, Catharine M. Bosio, et al.(R)-BHB (54920, Sigma-Aldrich), sodium butyrate (B5887, Sigma-Aldrich), TSA (T8552, Sigma-Aldrich), SAHA (10009929, Cayman), Pano (13280, Cayman), MS-275 (14043, Active Motif), triacsin C (ab141888, Abcam) and A485

(3) Hyperactive PLCG1 induces cell-autonomous and bystander T cell activation and drug resistanceEMBO ReportsAugust 12, 2025Longhui Zeng, Xinyan Zhang, Yiwei Xiong, Kazuki Sato, Nicole Hajicek, Yasunori Kogure, Keisuke Kataoka, Seishi Ogawa, John Sondek, Xiaolei Suenzymes and other reagents","Chemicals, enzymes and other reagents" Vorinostat,Cayman Chemical,Cat#10009929 Belinostat,Cayman Chemical,Cat#34084 Panobinostat,Cayman Chemical,Cat#13280 LY3214996,Cayman Chemical,Cat#27936 Napabucasin,Cayman Chemical

(4) Dose-dependent dual effects of HDAC inhibitors on glial inflammatory responseSci RepApril 10, 2025Samantha Mancino, Mariaserena Boraso, Andrea Galmozzi, Melania Maria Serafini, Emma De Fabiani, Maurizio Crestani, Barbara VivianiSigma-Aldrich Co. (T8552), Suberoylanilide hydroxamic acid was purchased from Cayman (Michigan, USA) (10009929), MS275 and MC1568 were synthetized and were kind gifts by Antonello Mai (“Sapienza” Università di Roma).

(5) Enhancing transporter activity in heterologous expression systems with SAHA: a 2500‐times more potent and odorless alternative to butyrateFEBS Open BioMarch 7, 2025Svenja Flögel, Maurice Tust, Samira Boussettaoui, Dietmar Fischer, Dirk Gründemannstated otherwise, compounds were obtained from Merck (formerly Sigma‐Aldrich, Munich, Germany). SAHA (10009929, Cayman Chemical), sodium butyrate (8.17500), valproic acid sodium salt (P4543). Results The function

(6) Class I histone deacetylases catalyze lysine lactylationbioRxivMarch 1, 2025Takeshi Tsusaka, Mohd. Altaf Najar, Isha Sharma, Mariola M. Marcinkiewicz, Claudia Veronica Da Silva Da Silva Crispim, Nathaniel W. Snyder, George M. Burslem, Emily L. GoldbergSigma-Aldrich), Trichostatin A (TSA, T8552, Sigma-Aldrich), Suberoylanilide Hydroxamic Acid (SAHA, 10009929, Cayman), MS-275 (14043, Active Motif), A485 (63875, Tocris), sodium dichloroacetate (DCA, S8615, Selleckchem),

(7) MAP1LC3C repression reduces CIITA- and HLA class II expression in non-small cell lung cancerPLoS OneFebruary 10, 2025Lydie M. O. Barbeau, Nicky A. Beelen, Kim G. Savelkouls, Tom G. H. Keulers, Lotte Wieten, Kasper M. A. Rouschopdissolved in water. Tazemetostat (MedChemExpress, cat# HY-13803), Vorinostat (Cayman Chemical, cat# 10009929 and Romidepsin (Cayman Chemical, cat# 17130) were dissolved in DMSO. Vorinostat and Romidepsin used

(8) Cytotoxic mechanisms of pemetrexed and HDAC inhibition in non-small cell lung cancer cells involving ribonucleotides in DNASci RepJanuary 15, 2025Tobias Solli Iveland, Lars Hagen, Mirta Mittelstedt Leal de Sousa, Nina Beate Liabakk, Per Arne Aas, Animesh Sharma, Bodil Kavli, Geir SlupphaugHRP (Dako Chemicals), rabbit anti-goat, HRP (Dako Chemicals). Vorinostat (SAHA) (CAYMAN chemicals Cat#10009929), Entinostat (MS275) (Selleck S1053), Alimta/Pemetrexed (Active Biochem A-2002), 4-AN (Sigma A0966). Targeted

(9) NSC95397 Is a Novel HIV-1 Latency-Reversing AgentVirusesNovember 16, 2024Nichols Doyle R, Yang V, Kayode YI, Damoiseaux R, Taylor HE, Fregoso OI.PA, USA, Cat# 102515-692), prostratin (Cayman Chemistry, Cat# 10272), SAHA (Cayman Chemistry, Cat# 10009929), and sunitinib (Cayman Chemistry, Cat# 13159). 2.3. Flow Cytometry J-Lat 10.6 or 5A8, ACH-2, or U1

(10) Combined inhibition of histone methyltransferases EZH2 and DOT1L is an effective therapy for neuroblastomaCancer MedicineNovember 5, 2024Janith A. Seneviratne, Daenikka Ravindrarajah, Daniel R. Carter, Vicki Zhai, Amit Lalwani, Sukriti Krishan, Anushree Balachandran, Ernest Ng, Ruby Pandher, Matthew Wong, et al.Buffalo, USA). JQ1 (Cayman #11187), 13‐cis‐retinoic acid (13‐cis‐RA) (Sigma #R3255), SAHA (Cayman #10009929), GSK343 (Cayman #14094), SGC0946 (Cayman #13967), GSK‐LSD1 (Cayman #16439), 5‐AZA‐dC (Sigma #A3656),

(11) Distribution and diversity of classical deacylases in bacteriaNature CommunicationsNovember 3, 2024Leonie G. Graf, Carlos Moreno-Yruela, Chuan Qin, Sabrina Schulze, Gottfried J. Palm, Ole Schmöker, Nancy Wang, Dianna M. Hocking, Leila Jebeli, Britta Girbardt, et al.overnight at 4 °C with 10-fold higher concentrations of SAHA compared to protein (Cayman chemical, cat no. 10009929), concentrated on the next day and crystallized with the robotic platform CyBiTM-HTPC. RsPrpH (1b)•SAHA

(12) Lack of SMARCB1 expression characterizes a subset of human and murine peripheral T-cell lymphomasNature CommunicationsOctober 3, 2024Anja Fischer, Thomas K. Albert, Natalia Moreno, Marta Interlandi, Jana Mormann, Selina Glaser, Paurnima Patil, Flavia W. de Faria, Mathis Richter, Archana Verma, et al.condition or any of the above symptoms. For HDACi in vivo experiments, SAHA (Cayman Chemical Company, #10009929) was applied intraperitoneally three times per week for three weeks in a concentration of 50 mg/kg.

(13) The Evaluation of Drugs as Potential Modulators of the Trafficking and Maturation of ACE2, the SARS-CoV-2 ReceptorBiomoleculesJune 27, 2024Nesreen F. Alkhofash, Bassam R. Alipanobinostat",303410,Sigma-Aldrich,DMSO COVID-19investigated drugs,8,SAHA(Vorinostat in dimethyl sulfoxide form),Histone deacetylase (HDAC) inhibitor,10009929,"Cayman Chemical Company(Ann Arbor, MI, USA)",DMSO COVID-19investigated drugs,9,Celastrol,Disrupts

(14) DNA methylation landscapes in DIPG reveal methylome variability that can be modified pharmacologicallyNeuro-Oncology AdvancesMarch 12, 2024Ashley R Tetens, Allison M Martin, Antje Arnold, Orlandi V Novak, Adrian Idrizi, Rakel Tryggvadottir, Jordyn Craig-Schwartz, Athanasia Liapodimitri, Kayleigh Lunsford, Michael I Barbato, et al.Supplementary Methods. Decitabine (DAC) and vorinostat (SAHA) were purchased from Cayman Chemical (#11166, #10009929). Cells were treated with 100 nm DAC or DMSO for 5 days, with media and drug change every 24 h. For

(15) Efficacy of HDAC Inhibitors in Driving Peroxisomal β-Oxidation and Immune Responses in Human Macrophages: Implications for Neuroinflammatory DisordersBiomoleculesNovember 23, 2023Andrea Villoria-González, Bettina Zierfuss, Patricia Parzer, Elisabeth Heuböck, Violetta Zujovic, Petra Waidhofer-Söllner, Markus Ponleitner, Paulus Rommer, Jens Göpfert, Sonja Forss-Petter, et al.Sorrento Pkwy, CA, USA) as described by Fransson and colleagues [44]. The HDACis vorinostat (SAHA, Cat.No.10009929, Cayman Chemicals, Ann Arbor, MI, USA), entinostat (MS-275, Cat.No.T6233, Target Mol, Boston, MA, USA),

(16) Regulatory Roles of Histone Deacetylation in Metabolic Stress-Induced Expression of Caspase Recruitment Domain-Containing Protein 9 (CARD9) in Pancreatic β-CellsInternational Journal of Molecular SciencesNovember 6, 2023Mirabela Hali, Nelson Pinto, Noah Gleason, Anjaneyulu Kowluru(catalog # A1978) was from Sigma Aldrich (St. Louis, MO, USA). TSA (catalog # 89730) and SAHA (catalog # 10009929) were obtained from Cayman Chemicals (Ann Arbor, MI, USA). 4.2. Culture of Insulin-Secreting INS-1

(17) NSC95397 is a Novel HIV Latency Reversing AgentbioRxiv : the preprint server for biologyMay 25, 2023Nichols Doyle R, Yang V, Damoiseaux R, Fregoso OI.Chemistry 21431), PMA (VWR 102515-692), prostratin (Cayman Chemistry 10272), SAHA (Cayman Chemistry 10009929), and Sunitinib (Cayman Chemistry 13159). Flow cytometry J-Lat 10.6 or 5A8 cells were plated in U-bottom

(18) Inhibition of mitochondrial translocase SLC25A5 and histone deacetylation is an effective combination therapy in neuroblastomaInternational Journal of CancerApril 1, 2023Janith A. Seneviratne, Daniel R. Carter, Rituparna Mittra, Andrew Gifford, Patrick Y. Kim, Jie‐Si Luo, Chelsea Mayoh, Alice Salib, Aldwin S. Rahmanto, Jayne Murray, et al.Perkins Centre, USYD, NSW, Australia) and were constituted in saline (NaCl 0.9%). Vorinostat (SAHA) (#10009929, Cayman Chemical, MI) and Panobinostat (LBH589) (#13280, Cayman Chemical) were constituted in DMSO (Sigma‐Aldrich,

(19) ARID1A loss in pancreas leads to islet developmental defect and metabolic disturbanceiScienceJanuary 20, 2023Kuo TL, Cheng KH, Chen LT, Hung WC.peptides, and recombinant proteins","Chemicals, peptides, and recombinant proteins" ,, SAHA,Cayman,Cat# 10009929 Lipofectamine™ 3000 Transfection Reagent,Thermo Fisher Scientific,Cat# L3000008 "cOmplete™, Mini Protease

(20) Molecular mechanisms of bifunctional vitamin D receptor agonist-histone deacetylase inhibitor hybrid molecules in triple-negative breast cancerScientific ReportsDecember 1, 2022Camille Barbier, Ali Mansour, Aiten Ismailova, Fatemeh Sarmadi, David A. Scarlata, Manuella Bouttier, Camille Zeitouni, Catherine Wang, James L. Gleason, John H. WhiteEnzo Life Sciences and was used at a final concentration of 100 nM. Suberoylanilide hydroxamic acid (SAHA, #10009929)) was purchased from Cayman Chemical and was used at a final concentration of 100 nM. Cell culture Mouse

Be the First to Write a Review!

SAHA

SAHA

Description

Specifications/Features

Cayman Chemical

Citations (54)

Reviews

SAHA from Cayman Chemical

About Biocompare

Advertise with Us

Specialized Search Tools

Site Map