Purmorphamine from Cayman Chemical

Product Specs
ItemPurmorphamine
CompanyCayman Chemical
Price $39.00Supplier Page View Company Product Page
Catalog Number10009634
Quantity1 mg
Research AreaBone Growth & Remodeling, Cell Biology, Cell Signaling, Differentiation, Endocrinology & Metabolism, Hedgehog Signaling, Stem Cell Research
FormatA crystalline solid
Molecular Weight520.6
Purity≥98%
Storage-20
FormulaC31H32N6O2
OriginCHN

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Cayman Chemical

Cayman Chemical Company 1180 East Ellsworth Road

Ann Arbor, Michigan 48108

United States

Phone: (800) 364-9897
(734) 971-3640

Company Profile

Website: http://www.caymanchem.com/

(1) Single-cell RNA profiling of oligodendroglial lineage cells derived from iPSCs carrying Parkinson’s disease-relevant LRRK2-G2019S mutationiScienceJuly 17, 2026Nasser Karmali, Wiebke Kessler, Mohammad Dehestani, Wenhua Sun, Layla Drwesh, Polina Volos, Stanislav Tsitkov, Ashutosh Dhingra, Christian Thomas, Salvador Rodriguez-Nieto, et al.expansion medium (N2B27) supplemented with 3 μM CHIR (R&D System, 4423), 0.5 μM PMA (Cayman Chemical, 10009634) and 64 mg/L Ascorbic acid (AA, Sigma-Aldrich, A8960) for up to 8 passages before use in any downstream

(2) Munc13-1 restoration mitigates presynaptic pathology in spinal muscular atrophyNature communicationsSeptember 30, 2025Moradi M, Weingart J, Deng C, Nasouti M, Briese M, Jablonka S, Sauer M, Sendtner M.CHIR99021 (Cayman Chemical Company, 13122, 3 µM), and Purmorphamine (PMA) (Cayman Chemical Company, 10009634, 0.5 µM). On day 2, mTeSR Plus medium was replaced with neuronal medium (Neurobasal medium (Gibco, 21103049),

(3) Functional variants of CFAP410 affect the DNA damage response leading to motor neuron degeneration – Implications for ALSiScienceSeptember 19, 2025Ross Ferguson, Vasanta Subramanianbeads,2BScientific,Cat# 1503-1 TrypLE 1x with phenol red,Gibco,Cat# 10043382 purmorphamine,Cayman,Cat# 10009634 BDNF,Peprotech,Cat# 450-02 GDNF,Peprotech,Cat# 450-10 CNTF,Peprotech,Cat# 450-13 Sodium arsenite,Bdh,— Etoposide,MP

(4) Temporal transcriptomic profiling of human three-dimensional neuromuscular co-culturesBiology OpenSeptember 15, 2025Neha Jadhav Giridhar, Bita Hambrecht, Maren Schenke, Bettina Seeger, Thorsten Bischler, Michael Briese, Patrick LüningschrörCHIR99021 (Cayman Chemical Company, 13122), and 0.5 µM Purmorphamine (PMA) (Cayman Chemical Company, 10009634). On day 2, the medium was switched to neuronal medium supplemented with the same small molecules. The

(5) Axonal tau reduction ameliorates tau and amyloid pathology in a mouse model of Alzheimer's diseaseTransl NeurodegenerJuly 29, 2025Abdolhossein Zare, Saeede Salehi, Jakob M. Bader, Anna-Lena Wiessler, Manuela Prokesch, Vincent Albrecht, Carmen Villmann, Matthias Mann, Michael Briese, Michael SendtnerMinneapolis, MN), 3 µmol/L CHIR99021 (13122, Cayman Chemical Company) and 0.5 µmol/L purmorphamine (PMA; 10009634, Cayman Chemical Company). On day 2, medium was replaced by N2B27 medium containing Neurobasal medium,

(6) Patterning ganglionic eminences in developing human brain organoids using a morphogen-gradient-inducing deviceCell Reports MethodsJanuary 22, 2024Narciso Pavon, Karmen Diep, Feiyu Yang, Rebecca Sebastian, Beatriz Martinez-Martin, Ravi Ranjan, Yubing Sun, ChangHui Pakng/mL],PeproTech,AF-100-15-500ug FGF [20 ng/mL],PeproTech,100-18B-100UG "Purmorphamine [1 μM, 100 μM, or 100 nM]",Cayman Chemical,10009634 BDNF [20 ng/mL],PeproTech,450-02-100ug NT3 [20 ng/mL],PeproTech,450-03-100 ,, Deposited data,Deposited

(7) Elevated parkinsonism pathological markers in dopaminergic neurons with developmental exposure to atrazineThe Science of the total environmentJanuary 15, 2024Zhao H, Xie J, Wu S, Zhao X, Sánchez OF, Min S, Rochet JC, Freeman JL, Yuan C.dual-SMAD inhibition, 100 ng/mL SHH C25II (PeproTech, Cat # 100–45), 2 μM purmorphamine (Cayman, Cat # 10009634), and 100 ng/mL FGF8 (PeproTech, Cat # 100–25) were added to the culture medium for 6 days to activate

(8) Optogenetic induction of alpha-synuclein aggregation in human dopaminergic neurons to model Parkinson's disease pathologySTAR protocolsDecember 15, 2023Ra EA, Kim MS, Lee G.72148 SB431542 (SB),Cayman Chemical,Cat# 13031 Shh,R&D,Cat# 464-SH Purmorphamine (PMP),Cayman Chemical,Cat# 10009634-5 FGF8,PEPROTECH,Cat# 100-25 CHIR99021 (CHIR),Tocris,Cat# 4423 Brain-derived neurotrophic factor

(9) Corrosion Products from Metallic Implants Induce ROS and Cell Death in Human Motoneurons In VitroJournal of Functional BiomaterialsJuly 25, 2023Hannes Glaß, Anika Jonitz-Heincke, Janine Petters, Jan Lukas, Rainer Bader, Andreas Hermannascorbic acid (AA; A-4544; Sigma-Aldrich Chemie GmbH, Munich, Germany), and 0.5 μM purmorphamine (PMA; 10009634; Cayman Chemical; Ann Arbor, MI, USA). For differentiation, 1 million cells were seeded into 1 well

(10) Advanced human iPSC-based preclinical model for Parkinson's disease with optogenetic alpha-synuclein aggregationCell stem cellJuly 6, 2023Kim MS, Ra EA, Kweon SH, Seo BA, Ko HS, Oh Y, Lee G.72148 SB431542 (SB),Cayman Chemical,Cat# 13031 Shh,R&D,Cat# 464-SH Purmorphamine (PMP),Cayman Chemical,Cat# 10009634-5 FGF8,PEPROTECH,Cat# 100-25 CHIR99021 (CHIR),Tocris,Cat# 4423 brain-derivedneurotrophicfactor (BDNF),PeproTech,Cat#

(11) A 3D cell culture system for bioengineering human neuromuscular junctions to model ALSFrontiers in Cell and Developmental BiologyFebruary 14, 2023Bita Massih, Alexander Veh, Maren Schenke, Simon Mungwa, Bettina Seeger, Bhuvaneish T. Selvaraj, Siddharthan Chandran, Peter Reinhardt, Jared Sterneckert, Andreas Hermann, et al.CHIR99021 (Cayman Chemical Company, #13122), and 0.5 µM Purmorphamine (PMA) (Cayman Chemical Company, #10009634). On day 2, the medium was changed to neuronal medium supplemented with the same small molecule supplements.

(12) The Highly Potent AhR Agonist Picoberin Modulates Hh-Dependent Osteoblast DifferentiationJournal of medicinal chemistryDecember 22, 2022Flegel J, Shaaban S, Jia ZJ, Schulte B, Lian Y, Krzyzanowski A, Metz M, Schneidewind T, Wesseler F, Flegel A, et al.4′,6-diamidino-2-phenylindol (DAPI): Cat# D9542, CAS: 28718-90-3 (Sigma-Aldrich); purmorphamine: Cat# 10009634, CAS: 483367-10-8 (Cayman Chemical); 6-formylindolo[3,2-b]carbazole (FICZ): Cat# SML1489-1MG, CAS: 172922-91-7

(13) Generation of human pluripotent stem cell-derived fused organoids with oligodendroglia and myelinSTAR protocolsJune 18, 2021Kim H, Jiang P.,Thermo Fisher,Cat#21103-049 P/S antibiotic,HyClone,Cat#SV30010 PDGF-AA,PeproTech,Cat#100-13A Purmorphamine,Cayman Chem,Cat#10009634 SB431542,Stemgent,Cat#04-0010-05 SHH,HyClone,Cat#100-45 SM1 Neuronal Supplement,STEMCELL Technologies,Cat#05711 T3,Cayman

(14) Non-invasive and high-throughput interrogation of exon-specific isoform expressionNature cell biologyJune 1, 2021Truong DJ, Phlairaharn T, Eßwein B, Gruber C, Tümen D, Baligács E, Armbrust N, Vaccaro FL, Lederer EM, Beck EM, et al.SB431542 (S1067, Selleck Chemicals), 3 µM CHIR99021 (4953, Tocris Bioscience), 0.5 µM purmorphamine (10009634, Cayman Chemicals) and 2 µM thiazovivin (420220, Merck Millipore). The next day, the embryoid bodies

(15) Patterning Neuroepithelial Cell Sheet via a Sustained Chemical Gradient Generated by Localized Passive Diffusion DevicesACS Biomaterials Science & EngineeringApril 12, 2021Ningwei Li, Feiyu Yang, Subiksha Parthasarathy, Sarah St. St. Pierre, Kelly Hong, Narciso Pavon, ChangHui Pak, Yubing Sunadded to each well. To induce the Shh chemical gradient, 0.3 ml of 100 μM purmorphamine (a Shh agonist, 10009634, Cayman Chemical) solution prepared using the same differentiation media was added to the chemical chamber27.

(16) Alpha-synuclein dynamics in induced pluripotent stem cell-derived dopaminergic neurons from a Parkinson's disease patient (PARK4) with SNCA triplicationFEBS open bioFebruary 1, 2021Fukusumi H, Togo K, Sumida M, Nakamori M, Obika S, Baba K, Shofuda T, Ito D, Okano H, Mochizuki H, et al.130‐095‐727; Miltenyi Biotec, Bergisch Gladbach, Germany), 8 µm purmorphamine (PM; final 4 µm; cat. 10009634; Cayman Chemical, Ann Arbor, MI, USA), and 200 ng·mL−1 recombinant human FGF‐8b (FGF8; final 100 ng·mL−1;

(17) OLIG2 Drives Abnormal Neurodevelopmental Phenotypes in Human iPSC-Based Organoid and Chimeric Mouse Models of Down SyndromeCell stem cellJune 6, 2019Xu R, Brawner AT, Li S, Liu JJ, Kim H, Xue H, Pang ZP, Kim WY, Hart RP, Liu Y, et al.,Thermo Fisher Scientific,Cat# 12605028 sonic hedgehog (SHH),Peprotech,Cat# 100-45 purmorphamine,Cayman Chem,Cat# 10009634 BDNF,Peprotech,Cat# 450-02 GDNF,Peprotech,Cat# 450-10 dibutyryl-cyclic AMP,Sigma,Cat# D0260 ascorbic

(18) Dynarrestin, a Novel Inhibitor of Cytoplasmic DyneinCell chemical biologyApril 19, 2018Höing S, Yeh TY, Baumann M, Martinez NE, Habenberger P, Kremer L, Drexler HCA, Küchler P, Reinhardt P, Choidas A, et al.Proteins",, Dynarrestin,This paper,N/A Vismodegib,Selleckchem,Cat#S1082 Purmorphamine,Cayman Chemical,Cat#10009634 CDP-Star,Roche,Cat#12041677001 Smoothened agonist,Cayman Chemical,Cat#11914 Rhodamine-labeled tubulin,Cytoskeleton,Cat#TL590M Human

(19) Gelatin device for the delivery of growth factors involved in endochondral ossificationPloS oneJanuary 1, 2017Ahrens LA, Vonwil D, Christensen J, Shastri VP.electron microscopy) was procured from AppliChem. WNT agonist (#681665) was purchased from Calbiochem. Purmorphamine (#10009634) was procured from Cayman Chemical. Recombinant human FGF2 (#233-FB), rhBMP4 (314-BP), rhVEGF 165 (#293-VE),

(20) Small Molecules Efficiently Reprogram Human Astroglial Cells into Functional NeuronsCell stem cellDecember 3, 2015Zhang L, Yin JC, Yeh H, Ma NX, Lee G, Chen XA, Wang Y, Lin L, Chen L, Jin P, et al.7, medium was replaced containing SAG (0.1 μM, Cayman #11914), purmophamine (Purmo, 0.1 μM, Cayman #10009634) and Thiazovivin (0.5 μM). At day 9, medium was completely replaced with neuronal differentiation medium

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Purmorphamine

Purmorphamine

Purmorphamine from Cayman Chemical

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Cayman Chemical

Citations (21)

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Purmorphamine from Cayman Chemical

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