Rapamycin (Sirolimus) from Selleck Chemicals

Product Specs
ItemRapamycin (Sirolimus)
CompanySelleck Chemicals
Price $670.00Supplier Page View Company Product Page
Catalog NumberS1039
Quantity100mg
Purity99.04
TargetmTOR
Storage2 years -80 in solvent
FormulaC51H79NO13

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Selleck Chemicals

14408 W Sylvanfield Drive

Houston, Texas TX 77014

United States

Phone: Toll Free: (877) 796-6397 (US and Canada only)
Tel: (832) 582-8158
Fax: (832) 582-8590

Email: sales@selleckchem.com

Company Profile

Website: www.selleckchem.com

(1) The titin N2A-MARP signalosome constrains muscle longitudinal hypertrophy in response to stretchElifeJuly 30, 2026Robbert van der Pijl, Jochen Gohlke, Joshua Strom, Eva Peters, Shengyi Shen, Stefan Conijn, Zaynab Hourani, Stephan Lange, Ju Chen, Paul Langlais, et al.(Mouse IgG1),Thermo Fisher,Cat#MA5-15738,WB (1:3000) "Chemical compound, drug",Rapamycin,Selleck Chem,S1039,2.5 mg/kg/day "Chemical compound, drug",Cyclosporin A,Selleck Chem,S2286,25 mg/kg/day "Software, algorithm",STAR,Dobin

(2) The Legionella pneumophila effector SidL is an adenylyltransferase that modifies the glycolytic intermediate 3-phosphoglycerateMol CellJuly 24, 2026Joshua J. Black, A. Maxwell Burroughs, Edrees H. Rashan, Charles R. Nosal, Katerina A. Romanov, Marco A. Catipovic, Catherine Valadez, L. Aravind, Kevin G. Hicks, Caren L. Freel Meyers, et al.in “Immunoblotting”. For experiments with mTOR inhibitors, 0.15% DMSO, 300 nM Torin 1, or 100 nM rapamycin (Selleckchem #S1039) was added 2 hours post-transfection and their inclusion was sustained during media exchange. For experiments

(3) SLC15A3-mediated dipeptide metabolism confers antimetabolite resistance in lymphoma via mTORC1 activationJ Clin InvestJuly 15, 2026Haojun Yang, Vincenzo Andrea Zingaro, Kevin Boardman, Ashish Noronha, Ekin Guney, Lingru Xue, Saishma Hoigebazar, Isabelle Liu, Sohit Miglani, Siyu Chen, et al.injection), mice (5 per group) were dosed by intraperitoneal injection with 4 mg/kg rapamycin (Selleckchem S1039) or vehicle 3 times per week (Monday, Wednesday, and Friday) until the survival endpoint or treated

(4) Suppression of ATM kinase signaling accelerates cellular senescenceStem Cell ReportsJuly 14, 2026Kei-ichi Ishikawa, Takahiro Shiga, Takumi Hirose, Naoko Kuzumaki, Sakura Miyoshi, Akihiro Yamaguchi, Hidetaka Tamune, Avijite Kumer Sarkar, Kento Nakai, Kazuyoshi Baba, et al.cocktail,Roche,Cat#04693132001 Puromycin,Nacalai Tesque,Cat#14861-71 Quercetin,Sigma-Aldrich,Cat#S2391 Rapamycin,Selleck Chemicals,Cat#S1039 RIPA Lysis and Extraction Buffer,Thermo Fisher Scientific,Cat#89900 RNeasy Plus Mini Kit,QIAGEN,Cat#74134 SB431542,Nacalai

(5) Rhizoma Dioscoreae Nipponicae attenuates airway remodeling and angiogenesis-related changes in asthma with altered mTOR/4EBP1/HIF-1α/VEGF pathway markersWorld Allergy Organization JournalJuly 1, 2026Xiaoqing Zhou, Zhen Wang, Suqun Zhengvarious concentrations of MHY1485 (an mTOR activator; SML0810, Selleck), rapamycin (an mTOR inhibitor; S1039, Selleck), and RDN-containing serum for 48 h. Cell viability was assessed using a CCK-8 assay to determine

(6) Potential effects of endogenous RNA/DNA hybrids on CRISPR/Cas9-mediated homology-directed repairMolecular Therapy Nucleic AcidsJune 16, 2026Francesco Puzzo, Batuhan Bayram, Claudia Macaubas, Angela Lin, Hagoon Jang, Feijie Zhang, Elizabeth Mellins, Mark A. Kayusing IGV_2.8.6. Cell-cycle experiments HEPA1-6/SpCas9 cells were treated with rapamycin (Selleck, S1039) or palbociclib (Selleck, S1116) for 24 h, fixed in 70% ethanol, stained with propidium iodide, and

(7) Targeting the Mitochondrial Phenotype in Cockayne Syndrome Patient Cells: From Bioenergetic Fragility to Pharmacologic RescuebioRxivMay 28, 2026Melis Kose, Elizabeth M. McCormick, Kelsey Keith, Cristina Remes, Suraiya Haroon, Eiko Nakamaru-Ogiso, Marni J. Falk490–46-0; N-acetylcysteine, Sigma-Aldrich, #A9165; taurine, Sigma-Aldrich, #T8691; rapamycin, Selleckchem, #S1039). ATP-based cell viability assay and candidate compound screen. Cell viability was quantified using

(8) Low-dose EGFR inhibition unlocks ferroptosis susceptibility to sensitize chemotherapy in EGFR- high triple-negative breast cancerJournal of Biological ChemistryMay 25, 2026Xiaoxi Li, Ling Liu, Lingli Luo, Minyao Deng, Yong Jiang, Weijun Ren, Hui Qian(Erlo, S1023), Lapatinib (Lapa, S1028), Pictilisib (Pic, S1065), MK-2206 (S1078), Rapamycin (Rapa, S1039), Caffeic Acid Phenethyl Ester (CAPE, S7414), Sorafenib (Sora, S1040), Trametinib (Trame, S2673), Ulixertinib

(9) LARP7 enhances the potential of dental pulp stem cells to promote peripheral nerve repairStem CellsMay 23, 2026Zihan Yang, Guanlin Qu, Xiping Wang, Li Wang, Lu Chen, Guiqiang Fu, Wenze Chen, Zitong Yang, Wenjing Li, Yuqiong Zhou, et al.days. DPSCs were treated with LY294002 (25 μM; Selleckchem, S1105), rapamycin (200 nM; Selleckchem, S1039), AZ-5104 (10 nM, MedChemExpress, HY-B0793), EF-1 (10 μM, MedChemExpress, HY-168438), or DMSO for 72

(10) Macrophage-derived fibronectin suppresses antitumor immunity via tissue stiffening and immunosuppressive cell induction in cancer mouse modelsNature CommunicationsMay 22, 2026Aitian Li, Ying Wang, Haiqing Bai, Xin Xie, Beibei Xu, Yunhan Wang, Shengjun Luo, Lei Zhang, Qitai Zhao, Shichao Duan, et al.mice were injected with FB (5 mg/kg; Santa Cruz Biotechnology, sc-202156)/RAPA (0.75 mg/kg; Selleck, S1039)/PBS every two days. FN1fl/fl and FN1ΔLyz2 mice were injected with RAPA/PBS. Tumor growth was monitored

(11) Mapping neuro-vascular unit communications reveals distinct angiogenic programs across developing mouse brain regionsNature CommunicationsMay 22, 2026Mathilde Bizou, Elise Drapé, Gael Cagnone, Joel P. Howard, Frans Irgolitsch, Séverine Leclerc, Mei Xi Chen, Blanche Boisseau, Isabelle Robillard, Matthieu Ruiz, et al.littermates were treated with tamoxifen and used as control mice for each experiment. Rapamycin (Selleckchem, S1039; stock solution at 100 mg/mL in DMSO) was injected intraperitoneally (2 mg/kg in corn oil) at P6 and

(12) Blockade of NKp46⁻ CCR6⁻ ILC3 autophagy protects against necrotizing enterocolitis by restoring energy metabolism balance in miceNature CommunicationsMay 19, 2026Junyu He, Meiqi Chen, Laiqin Peng, Qiqiong Wang, Yizhuang Lu, Yimin Chen, Xinyao Li, Yanling Mou, Jianjun Wang, Yuxiong Guo, et al.inhibitor 3-methyladenine (30 mg/kg/day; Selleck, Cat#: S2767) or induced rapamycin (1 mg/kg/day; Selleck, S1039) was administered intraperitoneally once daily during NEC induction. Sodium lactate (1 g/kg/day; Macklin,

(13) Loss of Kmt2c/d promotes gastric cancer and confers vulnerability to mTORC1 and PD-1 inhibitionJ Clin InvestMay 12, 2026Naitao Wang, Dan Li, Tao Zhang, Mohini R. Pachai, Dana M. Schoeps, Yudi Bao, Woo Hyun Cho, Makhzuna N. Khudoynazarova, Kae Kristoff, Marion Liu, et al.PI3K/AKT, mTORC1, and mTORC2 inhibitors (BYL-719, S2814; AZD8186, S7694; ipatasertib, S2808; rapamycin, S1039; RAD001, S1120; INK-128, S2811; Selleck Chemicals), 1,000 TP and TPCD cells were seeded in a precoated,

(14) Hepatocyte estrogen-related receptor α modulates a gluconeogenic–epigenetic crosstalk counteracting MASLD/MASH progressionExperimental & Molecular MedicineMay 8, 2026Jun Gao, Meng Yang, Rui Duan, Tongling Huang, Pengda Li, Lu Gao, Zhaocheng Lu, Chi-Wai Wong, Chang-An Geng, Min Guanoutput assay, hepatocytes were treated with some of the following agents: 20 µM C29 (ChemPartner, #S1039), 20 µM H89 (Selleck, #S1582), 100 nM glucagon (MCE, #HY-P0082), 50 μM Bt2-cAMP (Sigma, #D0627), 5 mM

(15) CRL4AMBRA1-mediated progesterone receptor degradation drives progestin resistance and represents a therapeutic vulnerability in endometrial cancerInt J Biol SciMay 1, 2026Yaru Sheng, Ting Ni, Xiaoyi Ding, Jiaying Huang, Xueya Zhao, Xinyao Li, Qingting Li, Jing Wang, Xiaoming Yang, Lin Zhang, et al.antibodies Medroxyprogesterone acetate (S2567), MLN4924 (S7109), MG132 (S2619), BAY11-7082 (S2913), CHX (S7418), rapamycin (S1039) and CQ (S6999) were purchased from Selleck Chemicals and were dissolved in dimethylsulfoxide (DMSO,

(16) Inhibition of PTEN nuclear translocation by peptide Tat-K13 attenuates p-JUN–SESN2–AMPK-dependent autophagy and enhances neurological recovery after neonatal hypoxic-ischemic brain damageCell & BioscienceApril 29, 2026Chunfang Dai, Xiaobin Wu, Xiaohuan Li, Boqing Xu, Yayan Pang, Yunyun Huang, Xiangjun Dong, Nianrong Wang, Zhifang Dongpost-hypoxia, additional doses were administered on the second and third days [19]. 2 mg/kg Rap (Selleck, S1039) was i.p. consecutively injected to rats after HI for 5 days according to previously reported with modification

(17) sEH inhibition attenuates mtROS-mediated NLRP3 inflammasome activation by promoting mitophagy in tubular epithelial cells in diabetic kidney diseaseFrontiers in ImmunologyApril 28, 2026Xushun Jiang, Wenge Huang, Wen Wen, Ting Liu, Wei Ren, Jia Shi, Junling He, Xiaogang DuNLRP3 inhibitor MCC950 (10 μM, MedChemExpress), the autophagy inducer rapamycin (Rapa, 10 μM, Selleck, S1039), the mitochondrial antioxidant MitoTEMPO (100 μM, MedChemExpress), or the autophagy inhibitor 3-methyladenine (3-MA

(18) TRIM7 Inhibits Rabies Virus Replication by Promoting K48-Linked Ubiquitination and Degradation of RABV-MEmerging Microbes & InfectionsApril 28, 2026Hongling He, Weiheng Liang, Wei Lin, Yang Wang, Ruikang Su, Yueming Wang, Shile Huang, Jun Luo, Xiaofeng Guo(ZVAD, MedChemExpress, Princeton, NJ, USA, #HY-164388), rapamycin (Rap, Selleckchem, Houston, TX, USA, #S1039), and MG132 (Selleckchem, #S2619). All reagents were dissolved in dimethyl sulfoxide (DMSO) and stored

(19) Cytoskeletal Imbalance and Axonal Vulnerability in Sporadic PSP-RS: Early Changes in a Human iPSC-Derived Neuronal Model with Altered mTOR SignalingCellsApril 23, 2026Raffaele Covello, Giorgia Lucia Benedetto, Stefania Scalise, Caterina Gabriele, Desirèe Valente, Clara Zannino, Barbara Puccio, Andrea Quattrone, Pietro Hiram Guzzi, Marco Gaspari, et al.treated with either 100 nM Torin-1 (Sigma-Aldrich, #475991) or 1 µM rapamycin (Selleck Chemicals, #S1039, Houston, TX, USA). Following treatment, neuronal cultures were harvested and subjected to protein extraction

(20) Prion propagation is controlled by a hierarchical network involving the nuclear Tfap2c and hnRNP K factors and the cytosolic mTORC1 complexPLoS PathogApril 20, 2026Stefano Sellitto, Davide Caredio, Matteo Bimbati, Giovanni Mariutti, Martina Cerisoli, Lukas Frick, Vangelis Bouris, Carlos Omar Oueslati Morales, Dalila Laura Vena, Sandesh Neupane, et al.Staurosporin (Abcam, ab120056); Z-VAD(Ome)-FMK (Cayman Chemical, Cay14463–1); Rapamycin (Selleckchem, S1039); Torin-1 (Sigma-Aldrich, 475991–10MG). Curve Fitting For sigmoidal curve fitting, we used GraphPad

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