Rapamycin (Sirolimus) from Selleck Chemicals

Product Specs
ItemRapamycin (Sirolimus)
CompanySelleck Chemicals
Price $670.00Supplier Page View Company Product Page
Catalog NumberS1039
Quantity100mg
Purity99.04
TargetmTOR
Storage2 years -80 in solvent
FormulaC51H79NO13

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Selleck Chemicals

14408 W Sylvanfield Drive

Houston, Texas TX 77014

United States

Phone: Toll Free: (877) 796-6397 (US and Canada only)
Tel: (832) 582-8158
Fax: (832) 582-8590

Email: sales@selleckchem.com

Company Profile

Website: www.selleckchem.com

(1) Potential effects of endogenous RNA/DNA hybrids on CRISPR/Cas9-mediated homology-directed repairMolecular Therapy Nucleic AcidsJune 16, 2026Francesco Puzzo, Batuhan Bayram, Claudia Macaubas, Angela Lin, Hagoon Jang, Feijie Zhang, Elizabeth Mellins, Mark A. Kayusing IGV_2.8.6. Cell-cycle experiments HEPA1-6/SpCas9 cells were treated with rapamycin (Selleck, S1039) or palbociclib (Selleck, S1116) for 24 h, fixed in 70% ethanol, stained with propidium iodide, and

(2) CRL4AMBRA1-mediated progesterone receptor degradation drives progestin resistance and represents a therapeutic vulnerability in endometrial cancerInt J Biol SciMay 1, 2026Yaru Sheng, Ting Ni, Xiaoyi Ding, Jiaying Huang, Xueya Zhao, Xinyao Li, Qingting Li, Jing Wang, Xiaoming Yang, Lin Zhang, et al.antibodies Medroxyprogesterone acetate (S2567), MLN4924 (S7109), MG132 (S2619), BAY11-7082 (S2913), CHX (S7418), rapamycin (S1039) and CQ (S6999) were purchased from Selleck Chemicals and were dissolved in dimethylsulfoxide (DMSO,

(3) sEH inhibition attenuates mtROS-mediated NLRP3 inflammasome activation by promoting mitophagy in tubular epithelial cells in diabetic kidney diseaseFrontiers in ImmunologyApril 28, 2026Xushun Jiang, Wenge Huang, Wen Wen, Ting Liu, Wei Ren, Jia Shi, Junling He, Xiaogang DuNLRP3 inhibitor MCC950 (10 μM, MedChemExpress), the autophagy inducer rapamycin (Rapa, 10 μM, Selleck, S1039), the mitochondrial antioxidant MitoTEMPO (100 μM, MedChemExpress), or the autophagy inhibitor 3-methyladenine (3-MA

(4) TRIM7 Inhibits Rabies Virus Replication by Promoting K48-Linked Ubiquitination and Degradation of RABV-MEmerging Microbes & InfectionsApril 28, 2026Hongling He, Weiheng Liang, Wei Lin, Yang Wang, Ruikang Su, Yueming Wang, Shile Huang, Jun Luo, Xiaofeng Guo(ZVAD, MedChemExpress, Princeton, NJ, USA, #HY-164388), rapamycin (Rap, Selleckchem, Houston, TX, USA, #S1039), and MG132 (Selleckchem, #S2619). All reagents were dissolved in dimethyl sulfoxide (DMSO) and stored

(5) Cytoskeletal Imbalance and Axonal Vulnerability in Sporadic PSP-RS: Early Changes in a Human iPSC-Derived Neuronal Model with Altered mTOR SignalingCellsApril 23, 2026Raffaele Covello, Giorgia Lucia Benedetto, Stefania Scalise, Caterina Gabriele, Desirèe Valente, Clara Zannino, Barbara Puccio, Andrea Quattrone, Pietro Hiram Guzzi, Marco Gaspari, et al.treated with either 100 nM Torin-1 (Sigma-Aldrich, #475991) or 1 µM rapamycin (Selleck Chemicals, #S1039, Houston, TX, USA). Following treatment, neuronal cultures were harvested and subjected to protein extraction

(6) Prion propagation is controlled by a hierarchical network involving the nuclear Tfap2c and hnRNP K factors and the cytosolic mTORC1 complexPLoS PathogApril 20, 2026Stefano Sellitto, Davide Caredio, Matteo Bimbati, Giovanni Mariutti, Martina Cerisoli, Lukas Frick, Vangelis Bouris, Carlos Omar Oueslati Morales, Dalila Laura Vena, Sandesh Neupane, et al.Staurosporin (Abcam, ab120056); Z-VAD(Ome)-FMK (Cayman Chemical, Cay14463–1); Rapamycin (Selleckchem, S1039); Torin-1 (Sigma-Aldrich, 475991–10MG). Curve Fitting For sigmoidal curve fitting, we used GraphPad

(7) mTOR-driven integrin β4-enriched extracellular vesicles from lenvatinib-resistant hepatocellular carcinoma fuel lung metastasis via fibroblast-niche formationSignal Transduct Target TherApril 16, 2026Tiantian Zou, Xufeng Wang, Haoting Sun, Beiyuan Hu, Jianhua Li, Yu Guo, Zilu Tian, Hao Xu, Yan Zheng, Yinghan Su, et al.euthanized for the collection and processing of tumor samples. The drugs lenvatinib (S1164) and rapamycin (S1039) were purchased from Selleckchem for use in this study. Proteomics analysis The label-free proteome

(8) MEK-dependent bioenergetic demand drives terminal CD8 + T cell exhaustionbioRxivApril 12, 2026Tanmana Mitra, Jahan Rahman, Madeline Hwee, Ruben Jose Jesus Faustino Ramos, Hui Liu, Travis Hartman, Justin Cross, Miguel de Jesus, Morgan Huse, Valerie Longo, et al.(SB203580),SelleckChem,Cat# S1076 Sotrastaurin (AEB071),SelleckChem,Cat# S2791 Rapamycin,SelleckChem,Cat# S1039 Trametinib (GSK1120212),SelleckChem,Cat# S2673 InVivoMAb anti-mouse CD4 (clone GK1.5),BioXCell,Cat#

(9) FGF1 orchestrates circadian hepatic triglyceride secretionNature CommunicationsMarch 19, 2026Benan Pelin Sermikli, Sihao Liu, Kyeongkyu Kim, Linnea Hases, Tim van Zutphen, Ashley Untereiner, Jocelyn Torres, Mingxiao He, Lillian Crossley, Yang Dai, et al.inhibitor Afuresertib (GSK2110183, SelleckChem, S7521), and mTOR inhibitor Rapamycin (Selleck Chem, S1039). The following IRE1-related plasmids, created by our colleagues in the Peter Walter lab (University

(10) The effects of valine, lysine and threonine and their optimal combinations on the synthesis of α-casein by MAC-T cellsFrontiers in Veterinary ScienceMarch 18, 2026Min Yang, Xinyu Zhang, Yu Ding, Lewen Xie, Yu Gao, Kangyu Yao, Wanping Ren, Liang Yang, Yankun Zhao, Wei ShaoUnited States) were purchased from Thermo Scientific. Rapamycin was purchased from Selleck (Cat No. S1039, Selleck Chemicals LLC, Houston, Texas, United States). PBS was purchased from Pricella (Cat No. Cat

(11) Hypoxia-Inducible Factor-1α Drives Cellular Senescence via Autophagy Activation to Promote Acute Kidney Injury-to-CKD TransitionAmerican Journal of NephrologyMarch 16, 2026Manzhu Zhang, Lingxu Li, Xinyue Mao, Xiaoying Yun, Meiting Wu, Chang Wang, Bing Liinhibitor bafilomycin A1 (Baf-A1) (S1413, Selleck) at 200 nm and the autophagy agonist rapamycin (RAPA) (S1039, Selleck) at 400 nm were added, respectively. For the hypoxia/reoxygenation (H/R) model, HK-2 cells

(12) Eukaryote initiation factor 6 modulates small-cell lung carcinoma plasticity via the integrin-FAK signaling axisNature CommunicationsFebruary 24, 2026Haoning Peng, Zhile Wang, Mengyao Wang, Zheyu Ding, Kaixiu Li, Yuqing Wang, Xuejiao Yu, Siyang Song, Yulan Deng, Yi Liu, et al.stock 10 mM in DMSO), Cobimetinib (Selleckchem #S8041, Stock 10 mM in DMSO), Rapamycin (Selleckchem #S1039, stock 10 mM in DMSO). The following primary antibodies were used: rabbit anti-RPL7 (Proteintech #14583-1-AP,

(13) Functional analysis of target of rapamycin in regulating mycelial growth and development in Penicillium italicumInternational MicrobiologyFebruary 23, 2026Tingting Chen, Hang Chen, Lan Ge, Jing Zheng, Xiaoke Fu, Tingting Hu, Kai Wangthe bootstrap test (1000 replicates) are shown next to the branches. Rapamycin treatment Rapamycin (S1039) was ordered from Selleck Chemicals. It was dissolved in DMSO to make the 10 mM (10 mmol/L) mother solution.

(14) KNSTRN knockdown impairs autophagy flux to inhibit bladder cancer progressioniScienceFebruary 20, 2026Xianbin Huang, Yanqiu Meng, Jielong Song, Yizi Zhu, Jian Li, Yan Xi, Xiaodong Peng, Yaoyi XiongBeyotime, Shanghai, China), Mito-Tracker Green(C1996S, Beyotime, Shanghai, China), Rapamycin(Rapa)(S1039, Selleck, TX, USA), Chloroquine(CQ)(HY-17589, MCE, NJ, USA), Clioquinol(ClioQ)(HY-14603, MCE, NJ, USA),

(15) METTL3-mediated m6A modification regulates CDKN1A to attenuate chronic sleep deprivation-induced cognitive impairment and neuronal apoptosis in ratsTranslational PsychiatryFebruary 9, 2026Fei Xing, Xiao-Shan Shi, Han-Wen Gu, Pan-Miao Liu, Lei Lei, Min Jia, Xing-Ming Wang, Mu-Huo Ji, Jian-Jun Yangguidelines. Cells were harvested for subsequent experimentation after 48 h of transfection. Rapamycin (Rap, S1039, Selleck, Houston, USA) was dissolved in dimethyl sulfoxide (DMSO) to generate a 10 mM stock solution.

(16) Indole‐3‐Propionic Acid Improves Alveolar Development Impairment via Targeting VAMP8‐mediated SNAREs Complex Formation in Bronchopulmonary DysplasiaAdvanced ScienceFebruary 6, 2026Beibei Wang, Xu Chen, Haowei Xu, Zhiqi Zeng, Keyu Lu, Yu Mao, Qianru Lv, Hui Shi, Song Liu, Xian Shen, et al.required, with 50 µm IPA (Yuanye, B27264), 10 µm CQ (Selleck, S6999), or 5 µm rapamycin (RAPA, Selleck, S1039). 2.10 Western Blotting Analysis Lung tissues or MLE‐12 cells were lysed in RIPA buffer added with

(17) Histone H4K8 lactylation promotes glioblastoma progression by inducing NUPR1-mediated autophagosome‒lysosome fusionTheranosticsFebruary 4, 2026Jiangli Zhao, Xuchen Liu, Yanya He, Qingyuan Sun, Zhiwei Xue, Ziyi Tang, Junzhi Liu, Jiwei Wang, Chao Li, Xinyu Wang, et al.molecule compounds utilized in this study include: BafA1 (SigmaAldrich, B1793), Rapamycin (Selleck, S1039), Sodium Oxamate (Target Mol, T19831), 3-MA (Selleck, S2767), ZZW-115 (Selleck, E1037), and Sodium lactate

(18) MSMP promotes an aberrant phenotype of fibroblast-like synoviocytes in rheumatoid arthritis by blocking autophagy via the RUNX1/GPR137B axisArthritis Research & TherapyFebruary 3, 2026Cuicui Wang, Yanting Zeng, Peiyao Tan, Shiwen Yuan, Weinian Li, Jinghua Ye, Ming Chen, Minxi Lao, Youjun Xiao, Liuqin Liang, et al.confluence, and then treated with 3-methyladenine (3-MA) (Selleck, USA, S2767) or rapamycin (Selleck, USA, S1039) at different concentrations and durations. The cells were subsequently incubated with CCK-8 (NCM Biotech,

(19) DNA-PKcs controls the cytotoxic T cell response to cancer and transplant allograft through regulating LAT-dependent signalingCell ReportsJanuary 27, 2026Randall R. Rainwater, Ana C. Azevedo-Pouly, Zachary J. Waldrip, Belle H. Hicks, Nicholas A. Callais, Brian Koss, Aaron J. Storey, Lyle Burdine, Marie Schluterman Burdine"Phorbol 12-myristate 13-acetate (PMA), PKC activator",Abcam,Cat#120297 "Ionomycin, Calcium ionophore",Stemcell,Cat#73724 "RAPAMYCIN, mTOR inhibitor",Selleck-Chem,Cat#S1039 "Puromycin dihydrochloride, 98%",Invitrogen,Cat#J61278 "WORTMANNIN, PI3K inhibitor",Selleck-Chem,Cat#S2758 "CellTrace™ Violet Cell Proliferation Kit, for flow cytometry

(20) Hyperactivation of mTORC1 blocks stem cell fate transitions through TFE3-NuRD associationEMBO ReportsJanuary 20, 2026Peizhi Li, Shuhui Xu, Xinyu Wu, Yin Gao, Tanveer Ahmed, Yinghua Huang, Dajiang Qin, Baoming Qin, Lulu Wang, Xueting XuNeurobasal medium,Gibco,21103049 DMEM/F12,Hyclone,SH30023.01 B27,Gibco,17504044 N2,Gibco,17502048 PD0325901,StemRD,391210-10-9 CHIR99021,StemRD,252917-06-9 Polyethylenimine,Sigma,764965 polybrene,Sigma,H9268 DMSO,Sigma,D1435 Rapamycin,Selleck,S1039 NaB,Sigma,B5887 Tamoxifen,Sigma,H6278 TRIzol reagent,Thermo Fisher,15596026 Reagent/resource,Reagent/resource,Reagent/resource Nuclear/Cytoplasmic

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