Rapamycin (Sirolimus) from Selleck Chemicals

Product Specs
ItemRapamycin (Sirolimus)
CompanySelleck Chemicals
Price $670.00Supplier Page View Company Product Page
Catalog NumberS1039
Quantity100mg
Purity99.04
TargetmTOR
Storage2 years -80 in solvent
FormulaC51H79NO13

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Selleck Chemicals

14408 W Sylvanfield Drive

Houston, Texas TX 77014

United States

Phone: Toll Free: (877) 796-6397 (US and Canada only)
Tel: (832) 582-8158
Fax: (832) 582-8590

Email: sales@selleckchem.com

Company Profile

Website: www.selleckchem.com

(1) Rhizoma Dioscoreae Nipponicae attenuates airway remodeling and angiogenesis-related changes in asthma with altered mTOR/4EBP1/HIF-1α/VEGF pathway markersWorld Allergy Organization JournalJuly 1, 2026Xiaoqing Zhou, Zhen Wang, Suqun Zhengvarious concentrations of MHY1485 (an mTOR activator; SML0810, Selleck), rapamycin (an mTOR inhibitor; S1039, Selleck), and RDN-containing serum for 48 h. Cell viability was assessed using a CCK-8 assay to determine

(2) Potential effects of endogenous RNA/DNA hybrids on CRISPR/Cas9-mediated homology-directed repairMolecular Therapy Nucleic AcidsJune 16, 2026Francesco Puzzo, Batuhan Bayram, Claudia Macaubas, Angela Lin, Hagoon Jang, Feijie Zhang, Elizabeth Mellins, Mark A. Kayusing IGV_2.8.6. Cell-cycle experiments HEPA1-6/SpCas9 cells were treated with rapamycin (Selleck, S1039) or palbociclib (Selleck, S1116) for 24 h, fixed in 70% ethanol, stained with propidium iodide, and

(3) Targeting the Mitochondrial Phenotype in Cockayne Syndrome Patient Cells: From Bioenergetic Fragility to Pharmacologic RescuebioRxivMay 28, 2026Melis Kose, Elizabeth M. McCormick, Kelsey Keith, Cristina Remes, Suraiya Haroon, Eiko Nakamaru-Ogiso, Marni J. Falk490–46-0; N-acetylcysteine, Sigma-Aldrich, #A9165; taurine, Sigma-Aldrich, #T8691; rapamycin, Selleckchem, #S1039). ATP-based cell viability assay and candidate compound screen. Cell viability was quantified using

(4) Low-dose EGFR inhibition unlocks ferroptosis susceptibility to sensitize chemotherapy in EGFR- high triple-negative breast cancerJournal of Biological ChemistryMay 25, 2026Xiaoxi Li, Ling Liu, Lingli Luo, Minyao Deng, Yong Jiang, Weijun Ren, Hui Qian(Erlo, S1023), Lapatinib (Lapa, S1028), Pictilisib (Pic, S1065), MK-2206 (S1078), Rapamycin (Rapa, S1039), Caffeic Acid Phenethyl Ester (CAPE, S7414), Sorafenib (Sora, S1040), Trametinib (Trame, S2673), Ulixertinib

(5) LARP7 enhances the potential of dental pulp stem cells to promote peripheral nerve repairStem CellsMay 23, 2026Zihan Yang, Guanlin Qu, Xiping Wang, Li Wang, Lu Chen, Guiqiang Fu, Wenze Chen, Zitong Yang, Wenjing Li, Yuqiong Zhou, et al.days. DPSCs were treated with LY294002 (25 μM; Selleckchem, S1105), rapamycin (200 nM; Selleckchem, S1039), AZ-5104 (10 nM, MedChemExpress, HY-B0793), EF-1 (10 μM, MedChemExpress, HY-168438), or DMSO for 72

(6) Hepatocyte estrogen-related receptor α modulates a gluconeogenic–epigenetic crosstalk counteracting MASLD/MASH progressionExperimental & Molecular MedicineMay 8, 2026Jun Gao, Meng Yang, Rui Duan, Tongling Huang, Pengda Li, Lu Gao, Zhaocheng Lu, Chi-Wai Wong, Chang-An Geng, Min Guanoutput assay, hepatocytes were treated with some of the following agents: 20 µM C29 (ChemPartner, #S1039), 20 µM H89 (Selleck, #S1582), 100 nM glucagon (MCE, #HY-P0082), 50 μM Bt2-cAMP (Sigma, #D0627), 5 mM

(7) CRL4AMBRA1-mediated progesterone receptor degradation drives progestin resistance and represents a therapeutic vulnerability in endometrial cancerInt J Biol SciMay 1, 2026Yaru Sheng, Ting Ni, Xiaoyi Ding, Jiaying Huang, Xueya Zhao, Xinyao Li, Qingting Li, Jing Wang, Xiaoming Yang, Lin Zhang, et al.antibodies Medroxyprogesterone acetate (S2567), MLN4924 (S7109), MG132 (S2619), BAY11-7082 (S2913), CHX (S7418), rapamycin (S1039) and CQ (S6999) were purchased from Selleck Chemicals and were dissolved in dimethylsulfoxide (DMSO,

(8) Inhibition of PTEN nuclear translocation by peptide Tat-K13 attenuates p-JUN–SESN2–AMPK-dependent autophagy and enhances neurological recovery after neonatal hypoxic-ischemic brain damageCell & BioscienceApril 29, 2026Chunfang Dai, Xiaobin Wu, Xiaohuan Li, Boqing Xu, Yayan Pang, Yunyun Huang, Xiangjun Dong, Nianrong Wang, Zhifang Dongpost-hypoxia, additional doses were administered on the second and third days [19]. 2 mg/kg Rap (Selleck, S1039) was i.p. consecutively injected to rats after HI for 5 days according to previously reported with modification

(9) TRIM7 Inhibits Rabies Virus Replication by Promoting K48-Linked Ubiquitination and Degradation of RABV-MEmerging Microbes & InfectionsApril 28, 2026Hongling He, Weiheng Liang, Wei Lin, Yang Wang, Ruikang Su, Yueming Wang, Shile Huang, Jun Luo, Xiaofeng Guo(ZVAD, MedChemExpress, Princeton, NJ, USA, #HY-164388), rapamycin (Rap, Selleckchem, Houston, TX, USA, #S1039), and MG132 (Selleckchem, #S2619). All reagents were dissolved in dimethyl sulfoxide (DMSO) and stored

(10) sEH inhibition attenuates mtROS-mediated NLRP3 inflammasome activation by promoting mitophagy in tubular epithelial cells in diabetic kidney diseaseFrontiers in ImmunologyApril 28, 2026Xushun Jiang, Wenge Huang, Wen Wen, Ting Liu, Wei Ren, Jia Shi, Junling He, Xiaogang DuNLRP3 inhibitor MCC950 (10 μM, MedChemExpress), the autophagy inducer rapamycin (Rapa, 10 μM, Selleck, S1039), the mitochondrial antioxidant MitoTEMPO (100 μM, MedChemExpress), or the autophagy inhibitor 3-methyladenine (3-MA

(11) Cytoskeletal Imbalance and Axonal Vulnerability in Sporadic PSP-RS: Early Changes in a Human iPSC-Derived Neuronal Model with Altered mTOR SignalingCellsApril 23, 2026Raffaele Covello, Giorgia Lucia Benedetto, Stefania Scalise, Caterina Gabriele, Desirèe Valente, Clara Zannino, Barbara Puccio, Andrea Quattrone, Pietro Hiram Guzzi, Marco Gaspari, et al.treated with either 100 nM Torin-1 (Sigma-Aldrich, #475991) or 1 µM rapamycin (Selleck Chemicals, #S1039, Houston, TX, USA). Following treatment, neuronal cultures were harvested and subjected to protein extraction

(12) Prion propagation is controlled by a hierarchical network involving the nuclear Tfap2c and hnRNP K factors and the cytosolic mTORC1 complexPLoS PathogApril 20, 2026Stefano Sellitto, Davide Caredio, Matteo Bimbati, Giovanni Mariutti, Martina Cerisoli, Lukas Frick, Vangelis Bouris, Carlos Omar Oueslati Morales, Dalila Laura Vena, Sandesh Neupane, et al.Staurosporin (Abcam, ab120056); Z-VAD(Ome)-FMK (Cayman Chemical, Cay14463–1); Rapamycin (Selleckchem, S1039); Torin-1 (Sigma-Aldrich, 475991–10MG). Curve Fitting For sigmoidal curve fitting, we used GraphPad

(13) mTOR-driven integrin β4-enriched extracellular vesicles from lenvatinib-resistant hepatocellular carcinoma fuel lung metastasis via fibroblast-niche formationSignal Transduct Target TherApril 16, 2026Tiantian Zou, Xufeng Wang, Haoting Sun, Beiyuan Hu, Jianhua Li, Yu Guo, Zilu Tian, Hao Xu, Yan Zheng, Yinghan Su, et al.euthanized for the collection and processing of tumor samples. The drugs lenvatinib (S1164) and rapamycin (S1039) were purchased from Selleckchem for use in this study. Proteomics analysis The label-free proteome

(14) MEK-dependent bioenergetic demand drives terminal CD8 + T cell exhaustionbioRxivApril 12, 2026Tanmana Mitra, Jahan Rahman, Madeline Hwee, Ruben Jose Jesus Faustino Ramos, Hui Liu, Travis Hartman, Justin Cross, Miguel de Jesus, Morgan Huse, Valerie Longo, et al.(SB203580),SelleckChem,Cat# S1076 Sotrastaurin (AEB071),SelleckChem,Cat# S2791 Rapamycin,SelleckChem,Cat# S1039 Trametinib (GSK1120212),SelleckChem,Cat# S2673 InVivoMAb anti-mouse CD4 (clone GK1.5),BioXCell,Cat#

(15) FGF1 orchestrates circadian hepatic triglyceride secretionNature CommunicationsMarch 19, 2026Benan Pelin Sermikli, Sihao Liu, Kyeongkyu Kim, Linnea Hases, Tim van Zutphen, Ashley Untereiner, Jocelyn Torres, Mingxiao He, Lillian Crossley, Yang Dai, et al.inhibitor Afuresertib (GSK2110183, SelleckChem, S7521), and mTOR inhibitor Rapamycin (Selleck Chem, S1039). The following IRE1-related plasmids, created by our colleagues in the Peter Walter lab (University

(16) The effects of valine, lysine and threonine and their optimal combinations on the synthesis of α-casein by MAC-T cellsFrontiers in Veterinary ScienceMarch 18, 2026Min Yang, Xinyu Zhang, Yu Ding, Lewen Xie, Yu Gao, Kangyu Yao, Wanping Ren, Liang Yang, Yankun Zhao, Wei ShaoUnited States) were purchased from Thermo Scientific. Rapamycin was purchased from Selleck (Cat No. S1039, Selleck Chemicals LLC, Houston, Texas, United States). PBS was purchased from Pricella (Cat No. Cat

(17) Hypoxia-Inducible Factor-1α Drives Cellular Senescence via Autophagy Activation to Promote Acute Kidney Injury-to-CKD TransitionAmerican Journal of NephrologyMarch 16, 2026Manzhu Zhang, Lingxu Li, Xinyue Mao, Xiaoying Yun, Meiting Wu, Chang Wang, Bing Liinhibitor bafilomycin A1 (Baf-A1) (S1413, Selleck) at 200 nm and the autophagy agonist rapamycin (RAPA) (S1039, Selleck) at 400 nm were added, respectively. For the hypoxia/reoxygenation (H/R) model, HK-2 cells

(18) Eukaryote initiation factor 6 modulates small-cell lung carcinoma plasticity via the integrin-FAK signaling axisNature CommunicationsFebruary 24, 2026Haoning Peng, Zhile Wang, Mengyao Wang, Zheyu Ding, Kaixiu Li, Yuqing Wang, Xuejiao Yu, Siyang Song, Yulan Deng, Yi Liu, et al.stock 10 mM in DMSO), Cobimetinib (Selleckchem #S8041, Stock 10 mM in DMSO), Rapamycin (Selleckchem #S1039, stock 10 mM in DMSO). The following primary antibodies were used: rabbit anti-RPL7 (Proteintech #14583-1-AP,

(19) Functional analysis of target of rapamycin in regulating mycelial growth and development in Penicillium italicumInternational MicrobiologyFebruary 23, 2026Tingting Chen, Hang Chen, Lan Ge, Jing Zheng, Xiaoke Fu, Tingting Hu, Kai Wangthe bootstrap test (1000 replicates) are shown next to the branches. Rapamycin treatment Rapamycin (S1039) was ordered from Selleck Chemicals. It was dissolved in DMSO to make the 10 mM (10 mmol/L) mother solution.

(20) KNSTRN knockdown impairs autophagy flux to inhibit bladder cancer progressioniScienceFebruary 20, 2026Xianbin Huang, Yanqiu Meng, Jielong Song, Yizi Zhu, Jian Li, Yan Xi, Xiaodong Peng, Yaoyi XiongBeyotime, Shanghai, China), Mito-Tracker Green(C1996S, Beyotime, Shanghai, China), Rapamycin(Rapa)(S1039, Selleck, TX, USA), Chloroquine(CQ)(HY-17589, MCE, NJ, USA), Clioquinol(ClioQ)(HY-14603, MCE, NJ, USA),

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