Y-27632 Dihydrochloride from Selleck Chemicals

Product Specs
ItemY-27632 Dihydrochloride
CompanySelleck Chemicals
Price $197.00Supplier Page View Company Product Page
Catalog NumberS1049
Quantity5mg
Purity99.86
TargetROCK
Storage3 years-20°C powder
FormulaC14H21N3O.2HCl

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Selleck Chemicals

14408 W Sylvanfield Drive

Houston, Texas TX 77014

United States

Phone: Toll Free: (877) 796-6397 (US and Canada only)
Tel: (832) 582-8158
Fax: (832) 582-8590

Email: sales@selleckchem.com

Company Profile

Website: www.selleckchem.com

(1) A human iPSC-based perfusable and membrane-free neurovascular unit-on-chip connecting brain organoids to the blood-brain barrierLab ChipSeptember 29, 2026Henrique Nogueira Pinto, Lois Kistemaker, Mikhail Ponomarenko, Arthur A. Ermakov, Manon Karsten-van Diepen, Susanne M. A. van der Pol, R. Jeroen Pasterkamp, Stephanie D. Beekhuis-Hoekstra, Nienke M. de Wit, Emma J. van Bodegraven, et al.CHIR for 5 days, with daily media refreshments. 10 μM ROCK-inhibitor (Y-27632; Selleck Biotechnology, S1049) was added on the first day. The resulting NC cells were detached with Accutase and frozen in CryoStor

(2) TRPV4-driven ATP release activates CFTR through ADORA2B and P2RY2 receptors in the airway epitheliumiScienceSeptember 18, 2026Michele Genovese, Martina De Santis, Alessandro Giordano, Pina Marotta, Luis J.V. GaliettaC7661 DMH-1,Bio-Techne (Tocris),Cat# 4126 A 83-01,Bio-Techne (Tocris),Cat# 2939 Y-27632,SelleckChem,Cat# S1049 Amiloride hydrochloride,Sigma-Aldrich,Cat# A7410 "8-(4-Chlorophenylthio)adenosine 3′,5′-cyclic monophosphate

(3) Stroma-oriented tumor microenvironment facilitates intraosseous ameloblastoma tumor growthiScienceSeptember 18, 2026Da-Yo Yuh, Chi-Ju Yao, Chia-Yu Chen, Ching-Yi Wu, Jian-Liang Chou, Hui-Na Chou, Ling-Yu Kung, Yi-Tzu Chen, Wei-Chin Chang, Yuan-Wu Chen, et al.KBM Gold Basal Medium,Lonza,Cat#00192151 Keratinocyte SFM,Gibco,Cat#10724011 Keratinocytes Supplements,Gibco,Cat #37000-015 Y-27632,Selleckchem,Cat#S1049 Polybrene,Santa Cruz Biotechnology,Cat#sc-134220 Puromycin,Sigma,Cat#P7255 MEM α (Minimum Essential

(4) Transcriptional dynamics of the murine heart during perinatal development at single-cell resolutionBiol OpenSeptember 15, 2026Lara Feulner, Florian Wünnemann, Naimeh Rafatian, Jenna Liang, Anaïs Medouni, Philipp Hofmann, Marc-Phillip Hitz, Denis Schapiro, Severine Leclerc, Patrick Piet van Vliet, et al.plate at a concentration of 30,000 cells/cm2 in mTeSR Plus supplemented with 5 μM Y-27632 (Selleck #S1049). The next day, directed differentiation was started by replacing media with differentiation media containing

(5) PARP inhibition enhances the antitumor activity of HER3-DXd in non-small cell lung cancerCell Reports MedicineSeptember 15, 2026Linh Lin, Narges Moradi, Iris A. Lähdeniemi, Hanna K. Laitinen, Bassel Alsaed, Lilja Lahtinen, Timothy Lopez, Shadi Jansouz, Aine Knott, Kara M. Soroko, et al.Protein,PeproTech,Cat#100-26 Human FGF-7 Recombinant Protein,PeproTech,Cat#100-19 Y-27632 dihydrochloride,Selleckchem,Cat#S1049 A83-01,SigmaAldrich,Cat#SML0788-5MG SB202190,MedChemExpress,Cat#HY-10295 "NK MACS® Medium, human",Miltenyi Biotec

(6) Evaluating and comparing the signalling and functional landscape of hiPSC-CMs derived from patients with dilated cardiomyopathyNPJ Biomed InnovSeptember 11, 2026Giada Castagnola, Diego Loggia, Kyla Bourque, Karima Alim, Ida Derish, Elise Rody, Zosia Gryz, Cara Hawey, Jace Jones-Tabah, Anjali Bhardwaj, et al.(STEMCELL Technologies, 100-0276) supplemented with 10 μM Rho kinase inhibitor, Y-27632-HCl (Selleckchem, S1049). The following day, the media was removed, and 1 mL fresh mTeSRPlus media was added to the hiPSCs.

(7) Engineered muscle tissues with enhanced maturation enable the identification of clinically relevant rAAV productsMolecular Therapy AdvancesSeptember 10, 2026Clémence Lièvre, Bérangère Robert, Giada Mainieri, Nicolas Jaulin, Marine Cotinat, Ninon Carlet, Tiphaine Girard, Christian Mandrycky, David L. Mack, Oumeya Adjali, et al.STEMCELL Technologies, #100–0276) supplemented in 10 μM ROCK inhibitor (Y-27632 ROCK inhibitor, Selleckchem, #S1049) for the first day. Fresh media without ROCK inhibitor was renewed every other day. Abnormally looking

(8) Microdystrophins partially rescue deficits of duchenne muscular dystrophy iPSC-cardiomyocytesMol Ther AdvSeptember 10, 2026Abiageal R. Keegan, Adriana Fernanda G.S. Gonzalez, Rongruo Zhang, Hung Doan, Sofía I. Torres-Bigio, Fiona Lau, Kaulen N. Ly, Elaine C. Lai, Leahlyn C. Mamuyac, Sriram Bhimaraju, et al.KnockOut Serum Replacement (KSR) (Invitrogen; 10828010), and 10 μM Y-27632 (Selleck Chemicals, Houston, TX; S1049). On days 18 and 19, iPSC-CMs were selected for resistance to zeocin 20 μg/mL (Fisher; R25001). From

(9) C9orf72-associated and sporadic FTD patient iPSC-microglia show differences in phagocytosis and gene expressionStem Cell ReportsSeptember 8, 2026Hannah Rostalski, Tomi Hietanen, Dorit Hoffmann, Sami Heikkinen, Nadine Huber, Ashutosh Dhingra, Salvador Rodriguez-Nieto, Teemu Kuulasmaa, Sohvi Ohtonen, Henna Jäntti, et al.+37°C in 0.5 mM EDTA (15575020, Invitrogen) in DPBS (17-512F; Lonza) and kept in 5 μM Y-27632 2HCl (S1049, Selleck Chemicals) containing E8 medium. iPSCs were cryopreserved in E8 medium + 10% (v/v) heat inactivated

(10) Multi-sampling allows intra-tumoral heterogeneity querying and vulnerability profiling in glioblastomaNeuro-OncologySeptember 1, 2026Diogo Moniz Garcia, Wan-Hsin Lin, Daniel P Wickland, Erik Jessen, Erik H Middlebrooks, Lauren E Haydu, Mieu Brooks, Ryan W Feathers, Lindsey Kinsella, Chris Sereduk, et al.1% penicillin-streptomycin (MT30002CI, Corning), Y-27632 (10 µM, ALX-270-333, Enzo Life Sciences or S1049, Selleckchem), human EGF (10 ng/ml; AF-100-15, PeproTech), and insulin (5 µg/ml; I1882, Sigma). An equal

(11) Establishment, biobanking, and multi-omics characterization of 41 patient-derived colorectal cancer organoids: MYC/PRC classificationTranslational OncologySeptember 1, 2026You Jin Lee, Jae Hyun Park, Hee Ju Nam, Soon-Chan Kim, Min Jung Kim, Seung-Yong Jeong, Ji Won Park, Ja-Lok KuCat#17101–015), hyaluronidase (20 µg mL⁻¹, Sigma-Aldrich, Cat#H3506), and Y-27632 (10 µM, Selleckchem, Cat#S1049). The cell suspension was filtered through a 100 µm strainer (SPL Life Sciences, Cat#93100), centrifuged

(12) Generation of two iPSC lines from ALS patients harboring C9orf72 hexanucleotide repeat expansionsStem Cell ResearchSeptember 1, 2026Dide Wu, Ana Kojic, Jay P. Ross, Dong Li, Parker Walther, Neelam Goyal, Jacinda Sampson, Joseph C. Wusingle-cell dissociation, the culture medium was supplemented with 5 μM Y-27632 (Selleck Chemicals, Cat #S1049) when passage was conducted. We changed medium 24 hours post-passage, and then every 48 hours until

(13) Generation of three induced pluripotent stem cell lines from an immune checkpoint inhibitor-induced myocarditis patient and controlsStem Cell ResearchSeptember 1, 2026Yin Sun, Maria Rosaria Vitale, Anna P. Hnatiuk, Noah S. Wagner, Shuai Sun, Xiaochun Yang, Lu Liu, Shaheen Khatua, Hiranya Amritavalli Sundar, Harrison Chou, et al.(Invitrogen #15575-038) and reseeded in medium containing 10 μM ROCK inhibitor (Y-27632, Selleck Chemicals #S1049) for the first 24 h. All assays were performed using iPSCs between passages 25 and 30, unless otherwise

(14) Characterization of induced pluripotent stem cell lines from patients of African American ancestryStem Cell ResearchSeptember 1, 2026Matthew A. Wu, Catherine A. Wu, Shane R. Zhao, Junyi Sun, Amira G. Flores-Banuelos, Parker Walther, Matthew Wheeler, Nazish SayedStemMACS™ iPS-Brew XF medium. During passaging, 10 μM ROCK inhibitor Y-27632 (Selleck Chemicals, Cat #S1049) was added to enhance cell survival. Cells were passaged using 0.5 mM EDTA (Invitrogen, Cat #15575-038)

(15) Generation of two induced pluripotent stem cell lines from Fabry disease patients carrying GLA mutationsStem Cell ResearchSeptember 1, 2026Debarun Patra, David G.T. Cabrera, Xiaochun Yang, Parker Walther, Souhrid Mukherjee, Jacinda Sampson, Joseph C WuMatrigel-coated culture dishes. After passaging, 10 μM ROCK inhibitor (Y-27632; Selleck Chemicals, #S1049) was added to the culture medium for 24 h to promote survival (Jimenez-Tellez et al., 2023). Media were

(16) Niche-Mediated Neural Priming Enables Robust and Scalable Generation of Human Choroid Plexus OrganoidsAdv Sci (Weinh)August 31, 2026Zhongliang Chen, Liangxia Jiang, Xianbin Wang, Lili Zhong, Rongcan Luo, Min Su, Liangzhao Chu, Peng LuoMatrigel‐coated or vitronectin‐coated surfaces in mTeSR1 or E8 supplemented with 10 µm Y‐27632 (SELLECK, S1049). Twenty‐four hours after passaging, the medium was replenished with fresh mTeSR1 or E8 medium without

(17) Leveraging long read RNA-seq to decipher neuronal regulation of alternative polyadenylationNature CommunicationsAugust 25, 2026Zhiping Zhang, Heather Glatt-Deeley, Lehan Zou, Dongyuan Song, Pedro Miura30 nM sodium selenite (MilliporeSigma #S5261)] with 10 μM Y-27632 ROCK inhibitor (RI, Selleckchem #S1049). An aliquot was diluted and counted in a Countess Cell Counter (ThermoFisher Scientific). For each

(18) Human organoids reveal PTEN-driven mesendoderm specification via retinoic acid signaling suppressionResearch (Wash D C)August 14, 2026Wuming Wang, Qiqi He, Hong Zhang, See-Wing Chan, Zhiqiang Xiong, Haite Tang, Yue Lv, Xianwei Su, Ya Guo, Yong Fan, et al.seeded at a density of 250,000 cells per well in 12-well plate in mTeSR1+ROCKi (Y-27632, Selleckchem, S1049). After 48 h of culture, MES differentiation was initiated by replacing the medium with RPMI 1640 medium

(19) Programmable ZBTB7A RNA N6-methyladenosine site-specific demethylation suppresses colorectal cancer liver metastasisMol CancerAugust 14, 2026Xuena Chen, Shuo Zhao, Bochen Liu, Yujia Fan, Huanlu Qiu, Lingtong Ren, Xinrui Zhang, Shurui Yan, Yachun An, Shirong Li, et al.mg/mL hyaluronidase (H8030, Solarbio), 0.1 mg/mL dispase type II (D4693, Sigma-Aldrich), 10 μM Y27632 (S1049, Selleck Chemicals) at 37 °C for 30~60 min. Tumor cells were filtered by 70 μm cell strainers and centrifuging

(20) Label-free biochemical imaging and time point analysis of neural organoids via deep learning-enhanced Raman microspectroscopySci AdvAugust 14, 2026Dimitar Georgiev, Ruoxiao Xie, Daniel Reumann, Xiaoyu Zhao, Álvaro Fernández-Galiana, Mauricio Barahona, Molly M. Stevenscells using Accutase (STEMCELL Technologies), resuspended in mTeSR1 supplemented with 50 μm of Y-27632 (S1049, Selleck Chemicals) and 1% (v/v) penicillin-streptomycin (15140122, Thermo Fisher Scientific), and then

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