Go 6983 from Tocris Bioscience, a Bio-Techne Brand

Product Specs
ItemGo 6983
CompanyTocris Bioscience, a Bio-Techne Brand
Price $162.00Supplier Page View Company Product Page
Catalog Number2285/1
Purity98%
Molecular Weight442.51
Molecule Name3-[1-[3-(Dimethylamino)propyl]-5-methoxy-1H-indol-3-yl]-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione
FormulaC26H26N4O3
StorageStore at -20°C
Quantity1 mg (also 10 mg)

Specifications/Features

Sizes Available: 1 mg (also 10 mg)

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Tocris Bioscience, a Bio-Techne Brand

614 McKinley Place N.E.

Minneapolis, Minnesota 55413

United States

Phone: 1 (800) 343-7475
1 (612) 379-2956
Fax: 1 (612) 656-4400

Company Profile

Website: http://www.tocris.com

(1) Suppression of ERK signalling promotes pluripotent epiblast in the human blastocystNat CommunJuly 28, 2025Claire S. Simon, Afshan McCarthy, Laura Woods, Desislava Staneva, Martin Proks, Nazmus Salehin, Georgia Lea, Qiulin Huang, Madeleine Linneberg-Agerholm, Alex Faulkner, et al.Bioscience; 13034-1 mg-CAY), 2uM XAV939 (Cambridge bioscience, CAY13596-1mg), 2 µM Gö6983 (Bio-Techne; 2285/1), 10 ng/ml hLIF (PeproTech; 300-05), and Pen/Strep (Gibco), on MEF feeder layer (~1 × 105 cells / cm2)

(2) A2B adenosine receptor activation and modulation by protein kinase CiScienceJuly 21, 2023Zhan-Guo Gao, Ian M. Levitan, Asuka Inoue, Qiang Wei, Kenneth A. JacobsonRESOURCE,SOURCE,IDENTIFIER Chemicals,Chemicals,Chemicals ,, isoproterenol,Tocris,Cat. No. 1747/100 formoterol,Tocris,Cat. No. 1448/10 GO6983,Tocris,Cat. No. 2285/1 GO6976,Tocris,Cat. No. 2253/500U RO32-0432,Tocris,Cat. No. 1587/1 GF109203X,Tocris,Cat. No. 0741/1 H89,Tocris,Cat.

(3) FARP1, ARHGEF39, and TIAM2 are essential receptor tyrosine kinase effectors for Rac1-dependent cell motility in human lung adenocarcinomaCell ReportsNovember 2, 2021Mariana Cooke, Gabriel Kreider-Letterman, Martin J. Baker, Suli Zhang, Neil T. Sullivan, Evgeniy Eruslanov, Martin C. Abba, Silvia M. Goicoechea, Rafael García-Mata, Marcelo G. KazanietzCorporation,3000/10 LY294002,Tocris Bio-Techne Corporation,1130/5 Gö6983,Tocris Bio-Techne Corporation,2285/1 R428,VWR,1037624-75-1 SU11274,Selleckchem,S1080 PMA,LC Laboratories,P-1680 "4’,6-Diamidino-2-phenylindole

(4) Human naive epiblast cells possess unrestricted lineage potentialCell stem cellJune 3, 2021Guo G, Stirparo GG, Strawbridge SE, Spindlow D, Yang J, Clarke J, Dattani A, Yanagida A, Li MA, Myers S, et al.

(5) Existence and functions of a kisspeptin neuropeptide signaling system in a non-chordate deuterostome specieseLifeJune 9, 2020Tianming Wang et al.,Tocris Bioscience,Cat #2807/1G,Extracellular calcium chelator "Chemical compound, drug",Gö6983,Tocris Bioscience,Cat #2285/1,Broad spectrum PKC inhibitor "Chemical compound, drug",FR900359,"Kindly provided by Dr Shihua Wu, Zhejiang

(6) Cancer associated fibroblast FAK regulates malignant cell metabolismNature communicationsMarch 10, 2020Demircioglu F, Wang J, Candido J, Costa ASH, Casado P, de Luxan Delgado B, Reynolds LE, Gomez-Escudero J, Newport E, Rajeeve V, et al.medium from CAFs with 10 µM PKA inhibitor (KT 5720; Tocris, #1288), 10 µM PKC inhibitor (Go6983; Tocris, 2285/1#) for 3 h. Alternatively, cancer cells were incubated in CAF CM with 1 µM CCR1i (Chemocentryx) and 1

(7) Calcium Influx Caused by ER Stress Inducers Enhances Oncolytic Adenovirus Enadenotucirev Replication and Killing through PKCα ActivationMolecular therapy oncolyticsDecember 20, 2019Taverner WK, Jacobus EJ, Christianson J, Champion B, Paton AW, Paton JC, Su W, Cawood R, Seymour LW, Lei-Rossmann J.Santa Cruz Biotechnology (UK). BAPTA was from Life Technologies (UK, #B1205). Gö 6976 (#2253/1), Gö 6983 (#2285/1), Enzastaurin (#5994/10), and GF 109203X (#0741/1) were purchased from Bio-Techne R&D Systems (UK). xCELLigence

(8) Multiple sources of signal amplification within the B-cell Ras/MAPK pathwayMolecular biology of the cellJune 15, 2019Mclaurin JD, Weiner OD.

(9) Capacitation of human naïve pluripotent stem cells for multi-lineage differentiationDevelopment (Cambridge, England)April 3, 2019Rostovskaya M, Stirparo GG, Smith A.

(10) Transcriptional Heterogeneity in Naive and Primed Human Pluripotent Stem Cells at Single-Cell ResolutionCell reportsJanuary 22, 2019Messmer T, von Meyenn F, Savino A, Santos F, Mohammed H, Lun ATL, Marioni JC, Reik W.

(11) PKCε Inhibits Neuronal Dendritic Spine Development through Dual Phosphorylation of Ephexin5Cell reportsNovember 27, 2018Schaffer TB, Smith JE, Cook EK, Phan T, Margolis SS.

(12) Developmental protein kinase C hyper-activation results in microcephaly and behavioral abnormalities in zebrafishTranslational psychiatryOctober 23, 2018Liu T, Shi Y, Chan MTV, Peng G, Zhang Q, Sun X, Zhu Z, Xie Y, Sham KWY, Li J, et al.

(13) A distinct isoform of ZNF207 controls self-renewal and pluripotency of human embryonic stem cellsNature communicationsOctober 22, 2018Fang F, Xia N, Angulo B, Carey J, Cady Z, Durruthy-Durruthy J, Bennett T, Sebastiano V, Reijo Pera RA.

(14) CD40 is a major regulator of dendrite growth from developing excitatory and inhibitory neuronseLifeNovember 7, 2017Carriba P, Davies AM.

(15) BNGR-A25L and -A27 are two functional G protein-coupled receptors for CAPA periviscerokinin neuropeptides in the silkworm Bombyx moriThe Journal of biological chemistryOctober 6, 2017Shen Z, Chen Y, Hong L, Cui Z, Yang H, He X, Shi Y, Shi L, Han F, Zhou N.

(16) Protein kinase D at the Golgi controls NLRP3 inflammasome activationThe Journal of experimental medicineSeptember 4, 2017Zhang Z, Meszaros G, He WT, Xu Y, de Fatima Magliarelli H, Mailly L, Mihlan M, Liu Y, Puig Gámez M, Goginashvili A, et al.

(17) Reduced insulin signaling maintains electrical transmission in a neural circuit in aging fliesPLoS biologySeptember 1, 2017Augustin H, McGourty K, Allen MJ, Madem SK, Adcott J, Kerr F, Wong CT, Vincent A, Godenschwege T, Boucrot E, et al.

(18) Protein kinase D1 (PKD1) phosphorylation on Ser²⁰³ by type I p21-activated kinase (PAK) regulates PKD1 localizationThe Journal of biological chemistryJune 9, 2017Chang JK, Ni Y, Han L, Sinnett-Smith J, Jacamo R, Rey O, Young SH, Rozengurt E.

(19) AP-1 Transcription Factors Mediate BDNF-Positive Feedback Loop in Cortical NeuronsThe Journal of neuroscience : the official journal of the Society for NeuroscienceJanuary 27, 2016Tuvikene J, Pruunsild P, Orav E, Esvald EE, Timmusk T.

(20) Progesterone receptor membrane component-1 regulates hepcidin biosynthesisThe Journal of clinical investigationJanuary 1, 2016Li X, Rhee DK, Malhotra R, Mayeur C, Hurst LA, Ager E, Shelton G, Kramer Y, McCulloh D, Keefe D, et al.

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(1)

7/18/2019Go 6983 Blocks LPA-Mediated COX-2 Expression Peter Frankl.Go 6983 can be used to investigate PKC signaling.
(1)

4/30/2019Go 6983 Blocks LPA-Mediated COX-2 Expression Chintan KoyaniGo 6983 abolished LPA-induced COX-2 expression

Go 6983

Go 6983 from Tocris Bioscience, a Bio-Techne Brand

Description

Specifications/Features

Tocris Bioscience, a Bio-Techne Brand

Citations (38)

Reviews

Go 6983 from Tocris Bioscience, a Bio-Techne Brand

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