Cyclopamine from Tocris Bioscience, a Bio-Techne Brand

Product Specs
ItemCyclopamine
CompanyTocris Bioscience, a Bio-Techne Brand
Price $286.00Supplier Page View Company Product Page
Catalog Number1623/1
Quantity1 mg
Purity97%
Molecular Weight411.63
Molecule Name(2'R,3S,3'R,3'aS,6'S,6aS,6bS,7'aR,11aS,11bR)-1,2,3,3'a,4,4',5',6,6',6a,6b,7,7',7'a,8,11,11a,11b-Octadecahydro-3',6',10,11b-tetramethylspiro[9H-benzo[a]fluorene-9,2'(3'H)-furo[3,2-b]pyridin]-3-ol
FormulaC27H41NO2
StorageDesiccate at -20°C

Specifications/Features

Sizes Available: 1 mg

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Tocris Bioscience, a Bio-Techne Brand

614 McKinley Place N.E.

Minneapolis, Minnesota 55413

United States

Phone: 1 (800) 343-7475
1 (612) 379-2956
Fax: 1 (612) 656-4400

Company Profile

Website: http://www.tocris.com

(1) Variant-to-gene mapping identifies ARHGEF12 as a primary open-angle glaucoma effector gene operating within retinal ganglion cellsbioRxivMarch 30, 2026Vrathasha Vrathasha, Matthew C. Pahl, James A. Pippin, Sergei Nikonov, Jie He, Mina Halimitabrizi, Laxmi Moksha, Rebecca Salowe, Amy-Ann Edziah, Yuki Bradford, et al.(R&D Systems, catalog #: 669-FO, Minneapolis, MN, USA), 0.5 μM Cyclopamine (R&D Systems, catalog #: 1623/1, Minneapolis, MN, USA), 3 μM DAPT (Stemgent, catalog #: 04-0041, Cambridge, MA, USA), and 4.2 μM Y-27632

(2) A multi-cohort genome-wide association study in African ancestry individuals reveals risk loci for primary open-angle glaucomaCellJanuary 18, 2024Shefali S. Verma, Harini V. Gudiseva, Venkata R.M. Chavali, Rebecca J. Salowe, Yuki Bradford, Lindsay Guare, Anastasia Lucas, David W. Collins, Vrathasha Vrathasha, Rohini M. Nair, et al.N0636 IGF1,R&D Systems,Cat#: 291-G1 Follistatin 300,R&D Systems,Cat#: 669-FO Cyclopamine,R&D Systems,Cat#: 1623/1 DAPT,Stemgent,Cat#: 04-0041 Y-27632 dihydrochloride (ROCK inhibitor),R&D Systems,Cat#: 1254/1 Forskolin,Selleckchem,Cat#:

(3) Transplanted human induced pluripotent stem cells- derived retinal ganglion cells embed within mouse retinas and are electrophysiologically functionaliScienceNovember 18, 2022Vrathasha V, Nikonov S, Bell BA, He J, Bungatavula Y, Uyhazi KE, Murthy Chavali VR.(R&D Systems, catalog #: 669-FO, Minneapolis, MN, USA), 0.5 μM Cyclopamine (R&D Systems, catalog #: 1623/1, Minneapolis, MN, USA), 3 μM DAPT (Stemgent, catalog #: 04–0041, Cambridge, MA, USA), and 4.2 μM Y-27632 dihydrochloride

(4) Drug Screening Identifies Sigma-1-Receptor as a Target for the Therapy of VWM LeukodystrophyFrontiers in molecular neuroscienceJanuary 1, 2018Atzmon A, Herrero M, Sharet-Eshed R, Gilad Y, Senderowitz H, Elroy-Stein O.

(5) Differentiation of Human Pluripotent Stem Cells into Colonic Organoids via Transient Activation of BMP SignalingCell stem cellJuly 6, 2017Múnera JO, Sundaram N, Rankin SA, Hill D, Watson C, Mahe M, Vallance JE, Shroyer NF, Sinagoga KL, Zarzoso-Lacoste A, et al.

(6) Chemical inhibition reveals differential requirements of signaling pathways in kras^V12- and Myc-induced liver tumors in transgenic zebrafishScientific reportsApril 5, 2017Yan C, Yang Q, Huo X, Li H, Zhou L, Gong Z.

(7) Integration of Shh and Fgf signaling in controlling Hox gene expression in cultured limb cellsProceedings of the National Academy of Sciences of the United States of AmericaMarch 21, 2017Rodrigues AR, Yakushiji-Kaminatsui N, Atsuta Y, Andrey G, Schorderet P, Duboule D, Tabin CJ.

(8) Ciliary IFT80 balances canonical versus non-canonical hedgehog signalling for osteoblast differentiationNature communicationsMarch 21, 2016Yuan X, Cao J, He X, Serra R, Qu J, Cao X, Yang S.

(9) Generation of an expandable intermediate mesoderm restricted progenitor cell line from human pluripotent stem cellseLifeNovember 10, 2015Kumar N, Richter J, Cutts J, Bush KT, Trujillo C, Nigam SK, Gaasterland T, Brafman D, Willert K.

(10) Endogenously produced Indian Hedgehog regulates TGFβ-driven chondrogenesis of human bone marrow stromal/stem cellsStem cells and developmentApril 15, 2015Handorf AM, Chamberlain CS, Li WJ.

(11) White-to-brown metabolic conversion of human adipocytes by JAK inhibitionNature cell biologyJanuary 1, 2015Moisan A, Lee YK, Zhang JD, Hudak CS, Meyer CA, Prummer M, Zoffmann S, Truong HH, Ebeling M, Kiialainen A, et al.

(12) Sonic hedgehog produced by bone marrow-derived mesenchymal stromal cells supports cell survival in myelodysplastic syndromeStem cells internationalJanuary 1, 2015Zou J, Hong Y, Tong Y, Wei J, Qin Y, Shao S, Wang C, Zhou K.

(13) Regulation and function of immunosuppressive molecule human leukocyte antigen G5 in human bone tissueFASEB journal : official publication of the Federation of American Societies for Experimental BiologyAugust 1, 2013Deschaseaux F, Gaillard J, Langonné A, Chauveau C, Naji A, Bouacida A, Rosset P, Heymann D, De Pinieux G, Rouas-Freiss N, et al.

(14) Regulation of endodermal differentiation of human embryonic stem cells through integrin-ECM interactionsCell death and differentiationMarch 1, 2013Brafman DA, Phung C, Kumar N, Willert K.

(15) GLI activation by atypical protein kinase C ι/λ regulates the growth of basal cell carcinomasNatureFebruary 28, 2013Atwood SX, Li M, Lee A, Tang JY, Oro AE.

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Cyclopamine

Cyclopamine from Tocris Bioscience, a Bio-Techne Brand

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Tocris Bioscience, a Bio-Techne Brand

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Cyclopamine from Tocris Bioscience, a Bio-Techne Brand

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