Fingolimod (hydrochloride) from Cayman Chemical

Product Specs
ItemFingolimod (hydrochloride)
CompanyCayman Chemical
Price $83.00Supplier Page View Company Product Page
Catalog Number10006292
Quantity50 mg
Research AreaAdaptive Immunity, Glycerophospholipids, Immunology & Inflammation, Innate Immunity, Lipid Biochemistry, Lipid Transport, Multiple Sclerosis, Neurodegenerative Disorders, Neuroscience, Phospholipases, Sphingolipids
FormatA crystalline solid
Molecular Weight343.936
Purity≥98%
Storage-20
FormulaC19H33NO2 • HCl
OriginCHN
TypeInhibitors

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Cayman Chemical

Cayman Chemical Company 1180 East Ellsworth Road

Ann Arbor, Michigan 48108

United States

Phone: (800) 364-9897
(734) 971-3640

Company Profile

Website: http://www.caymanchem.com/

(1) Repeatedly occurring retrograde menstruation intensifies central sensitization driven by neuroinflammation in endometriosis modelsJ Clin InvestMarch 17, 2026Madeleine E. Harvey, Mingxin Shi, Yeongseok Oh, Taylor M. Page, Debra A. Mitchell, Addie Luo, Ov D. Slayden, James A. MacLean, Anjali Sharma, Kanako Hayashiorally by placing a pipette tip containing a dose in PBS into the mouth, and (c) fingolimod (Cayman 10006292) 1 mg/kg/b.w. i.p. for 3 weeks from 3 weeks after the last induction of 1x or 6x inductions, as shown

(2) Peripheral immune-inducer dendritic cells drive early-life allergic inflammationNatureFebruary 25, 2026Yue Xing, Ilana Reznikov, Abonti Nur Ahmed, Ikjot Sidhu, Jill Wisnewski, Asma Farhat, Aleksandr Prystupa, Piotr Konieczny, Kody Mansfield, Melissa L. Cooper, et al.with diphtheria toxin (0.5 ng g−1) and treated with HDM 24 h later. Fingolimod (FTY720). FTY720 (10006292, Cayman Chemical) was dissolved in DMSO and diluted into PBS containing 2% β-hydroxypropyl-cyclodextrin

(3) Sphingosine kinase 1 is integral for elastin deficiency-induced arterial hypermuscularizationNature Cardiovascular ResearchJanuary 5, 2026Junichi Saito, Jui M. Dave, Eunate Gallardo-Vara, Nandhini Sadagopan, Inamul Kabir, George Tellides, Robert K. Riemer, Zsolt Urban, Sarah Spiegel, Timothy Hla, et al.(Cayman Chemical, 17034–25, 1 μM), Ex26 (Tocris Bioscience, 5833, 1 μM) or fingolimod (Cayman Chemical, 10006292, 1 μM), PGE2 (Sigma-Aldrich, P0409, 10−6 μM) or indomethacin (Sigma-Aldrich, I7378, 10−5 μM) for 24–48

(4) T-cell Priming by High-Avidity Neoantigens in Lymph Nodes Augments Adoptive ImmunotherapyCancer Immunol ResDecember 5, 2025Megen C. Wittling, Amalia M. Rivera-Reyes, Megan M. Wyatt, Anna C. Cole, Aubrey S. Smith, Guillermo O. Rangel Rivera, James H. Carmouche, Kailey G. Diatikar, Ayana T. Ruffin, Michael B. Ware, et al.intraperitoneal injection on days 0, 2, and 4 after ACT. FTY720 administration FTY720 (Cayman Chemicals, cat. #10006292) was added to the drinking water of mice at a concentration of 2 μg/mL, supplied ad libitum. Drug was

(5) T cell priming by high avidity neoantigens in lymph nodes augments adoptive immunotherapyCancer Immunology ResearchDecember 5, 2025Megen C. Wittling, Amalia M. Rivera Rivera Reyes, Megan M. Wyatt, Anna C. Cole, Aubrey S. Smith, Guillermo O. Rangel Rangel Rivera, James H. Carmouche, Kailey G. Diatikar, Ayana T. Ruffin, Michael B. Ware, et al.intraperitoneal injection on days 0, 2, and 4 after ACT. FTY720 administration FTY720 (Cayman Chemicals, cat. #10006292) was added to the drinking water of mice at a concentration of 2 μg/mL, supplied ad libitum. Drug was

(6) The tumor-sentinel lymph node immuno-migratome reveals CCR7⁺ dendritic cells drive response to sequenced immunoradiotherapyNat CommunJuly 17, 2025Robert Saddawi-Konefka, Riyam Al Msari, Shiqi Tang, Chad Philips, Sayed Sadat, Lauren M. Clubb, Sarah Luna, Santiago Fassardi, Riley Jones, Ida Franiak Pietryga, et al.antibodies were purchased from BD Biosciences (San Jose, CA) and BioLegend (San Diego, CA). FTY720 (Cayman 10006292). All other chemicals and reagents were from Sigma-Aldrich (St. Louis, MO) unless indicated. Cell lines

(7) An Acrolein-Based Drug Delivery System Enables Tumor-Specific Sphingosine-1-Phosphate Targeting in Breast Cancer without LymphocytopeniaCancer Res CommunJune 1, 2025Masayuki Nagahashi, Miki Komatsu, Sayaka Urano, Mamiko Kuroiwa, Yuria Takahashi, Koji Morimoto, Ambara R. Pradipta, Katsunori Tanaka, Yasuo Miyoshipaclitaxel (Tokyo Chemical Industry, catalog number P1632), FTY720 (Cayman Chemical, catalog number 10006292), or pro-FTY was added to each well. After incubation for 96 hours, culture supernatants were collected

(8) An Acrolein-Based Drug Delivery System Enables Tumor-Specific Sphingosine-1-Phosphate Targeting in Breast Cancer without LymphocytopeniaCancer Res CommunJune 1, 2025Masayuki Nagahashi, Miki Komatsu, Sayaka Urano, Mamiko Kuroiwa, Yuria Takahashi, Koji Morimoto, Ambara R. Pradipta, Katsunori Tanaka, Yasuo Miyoshipaclitaxel (Tokyo Chemical Industry, catalog number P1632), FTY720 (Cayman Chemical, catalog number 10006292), or pro-FTY was added to each well. After incubation for 96 hours, culture supernatants were collected

(9) Thin Layer Chromatography Goes Ultrasmall to Assay Sphingosine Kinase Activation in Single Primary Leukemic CellsAnalytical ChemistryFebruary 11, 2025Ming Yao, Yuli Wang, Lucas Cornwell, Christopher E. Sims, Nancy L. Allbrittoncalcium and magnesium salts, # 14025092) were from Gibco (Grand Island, NY). K145 (#11691), FTY720 (#10006292), SKI2 (#10009222), PF-543 (#17034) were procured from Cayman Chemical Company (Ann Arbor, MI). Extracellular

(10) Dendritic cells type 1 control the formation, maintenance, and function of tertiary lymphoid structures in cancerbioRxivDecember 29, 2024Raphaël Mattiuz, Jesse Boumelha, Pauline Hamon, Jessica Le Berichel, Abishek Vaidya, Brian Y. Soong, Laszlo Halasz, Emir Radkevich, Hye Mi Kim, Matthew D. Park, et al.egress from peripheral lymphoid organs, mice were administered 20 μg of FTY720 (Cayman Chemical, Cat # 10006292) daily over the indicated time periods. To increase DC numbers, mice received 75 μg of FLT3-L-Fc (Gilead)

(11) Interruption of the intratumor CD8+ T cell:Treg crosstalk improves the efficacy of PD-1 immunotherapyCancer CellJune 10, 2024Shannon N. Geels, Alexander Moshensky, Rachel S. Sousa, Claire Murat, Matias A. Bustos, Benjamin L. Walker, Rima Singh, Stacey N. Harbour, Giselle Gutierrez, Michael Hwang, et al.LS004189 Diphtheria Toxin,Calbiochem,Cat# 322326 DNAse I,Roche,Cat# 04536282001 FTY720,Cayman Chemical,Cat# 10006292 Lambda phosphatase,NEB,Cat#: P0753S Mouse IL-2,BioLegend,Cat# 575404 Tamoxifen,Sigma,Cat# T5648 Critical

(12) CXCL9/10-engineered dendritic cells promote T cell activation and enhance immune checkpoint blockade for lung cancerCell reports. MedicineApril 16, 2024Lim RJ, Salehi-Rad R, Tran LM, Oh MS, Dumitras C, Crosson WP, Li R, Patel TS, Man S, Yean CE, et al.μg/injection. Prevention of T cell LN egress was performed with fingolimod hydrochloride (FTY720; Cayman, 10006292) administered i.p. every other day at 2 mg/kg. All antibody experiments utilized isotype controls (BioXcell,

(13) Fingolimod improves diffuse brain injury by promoting AQP4 polarization and functional recovery of the glymphatic systemCNS Neurosci TherMarch 8, 2024Dongyi Feng, Tao Liu, Xinjie Zhang, Tangtang Xiang, Wanqiang Su, Wei Quan, Rongcai Jianginjected with 0.5 mg/kg body weight fingolimod (dissolved in 0.9% sodium chloride; Cayman Chemical, 10006292) daily for 3 consecutive days beginning 30 min after the DBI procedure according to prior research and

(14) Analogs of FTY720 inhibit TRPM7 but not S1PRs and exert multimodal anti-inflammatory effectsJournal of General PhysiologyJanuary 1, 2024Gregory W. Busey, Mohan C. Manjegowda, Tao Huang, Wesley H. Iobst, Shardul S. Naphade, Joel A. Kennedy, Catherine A. Doyle, Philip V. Seegren, Kevin R. Lynch, Bimal N. DesaiVirginia). FTY720 (fingolimod), L-threo-sphingosine, and NS8593 were purchased from Cayman Chemical (item #10006292, #10010541, and #29774, respectively). AAL-149 was solubilized in 100% ethanol, and all other compounds

(15) Expansion of circulating stem-like CD8(+) T cells by adding CD122-directed IL-2 complexes to radiation and anti-PD1 therapies in miceNature communicationsApril 12, 2023Onyshchenko K, Luo R, Guffart E, Gaedicke S, Grosu AL, Firat E, Niedermann G.injected. To block T cell egress from lymph nodes, FTY720 (25 μg per mouse Fingolimod, Cayman Chemical, 10006292) was i.p. injected 1 day before treatment start and then every other day to maintain the blockade. CD8+

(16) Crosstalk between pro-survival sphingolipid metabolism and complement signaling induces inflammasome-mediated tumor metastasisCell reportsDecember 6, 2022Janneh AH, Kassir MF, Atilgan FC, Lee HG, Sheridan M, Oleinik N, Szulc Z, Voelkel-Johnson C, Nguyen H, Li H, et al.Chemicals,Cat# 10009458 PF-543,Cayman Chemicals,Cat# 17034 Fingolimod (hydrochloride),Cayman Chemicals,Cat# 10006292 ABC294640,Cayman Chemicals,Cat# 10587 "Corning® Fibronectin, Human, 1 mg",Corning Inc.,Cat# 354008 Cathepsin-L

(17) Pharmacological Targeting of Sphingosine Kinases Impedes HIV-1 Infection of CD4 T Cells through SAMHD1 ModulationJournal of VirologyMay 11, 2022Rachel S. Resop, Alberto Bosque(fingolimod/gilenya), DMS, SKI II, and ABC294640 were obtained from Cayman Chemical (FTY720, number 10006292, CAS number 162359-56-0; DMS, number 62575, CAS number 119567-63-4; SKI II, number 10009222, CAS number

(18) Clonotypic analysis of protective influenza M2e-specific lung resident Th17 memory cells reveals extensive functional diversityMucosal immunologyApril 1, 2022Omokanye A, Ong LC, Lebrero-Fernandez C, Bernasconi V, Schön K, Strömberg A, Bemark M, Saelens X, Czarnewski P, Lycke N.block lymphocyte egress from secondary lymphnodes and spleen mice were given 100 µg FTY720 (Cayman 10006292-50) i.p. in 200 μL sterile PBS every 48 h during the experiment. For testing of Trm status of the M2e-tetramer

(19) Interferon gamma constrains type 2 lymphocyte niche boundaries during mixed inflammationImmunityFebruary 8, 2022Cautivo KM, Matatia PR, Lizama CO, Mroz NM, Dahlgren MW, Yu X, Sbierski-Kind J, Taruselli MT, Brooks JF, Wade-Vallance A, et al.,R&D systems,Cat#3626-ML-010/CF Recombinant mouse IFNg,R&D systems,Cat#485-MI-100/CF FTY720,Cayman Chemicals,Cat#10006292 W146,TOCRIS,Cat#3602 Batch N.2 CYM50358 hydroxichloride,TOCRIS,Cat#4679 "1X Hanks’ Balanced Salt

(20) Characterization of CD41(+) cells in the lymph nodeFrontiers in immunologyJanuary 1, 2022Dai L, Uehara M, Li X, LaBarre BA, Banouni N, Ichimura T, Lee-Sundlov MM, Kasinath V, Sullivan JA, Ni H, et al.to assess their differentiation and function. Methods Reagents FTY720 (Cayman Chemical Company, 10006292) was purchased from Cayman, Ann Arbor, Michigan, USA. Methylcellulose-based medium (STEMCELL, MethoCult™ GF M3434

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