MG132 from Selleck Chemicals

Product Specs
ItemMG132
CompanySelleck Chemicals
Price $977.00Supplier Page View Company Product Page
Catalog NumberS2619
Quantity100mg
Purity99.07
TargetProteasome
Molecular Weight228.2
Storage2 years -80 in solvent
FormulaC26H41N3O5

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Selleck Chemicals

14408 W Sylvanfield Drive

Houston, Texas TX 77014

United States

Phone: Toll Free: (877) 796-6397 (US and Canada only)
Tel: (832) 582-8158
Fax: (832) 582-8590

Email: sales@selleckchem.com

Company Profile

Website: www.selleckchem.com

(1) Oncogenic USP3 promotes hepatocellular carcinoma progression via K11/K48-specific deubiquitination and stabilization of YAPiScienceSeptember 18, 2026Yuanhao Peng, Hui Nie, Xuanxuan Li, Yongguang Tao, Yangying Zhougon,N/A Ub-WT,Youbio,N/A Ub-K6,Youbio,N/A Ub-K11,Youbio,N/A Ub-K27,Youbio,N/A Ub-K29,Youbio,N/A Ub-K33,Youbio,N/A Ub-K48,Youbio,N/A Ub-K63,Youbio,N/A MG132,Selleck,S2619 AZ1,Selleck,S8904 C527,MCE,HY-12988 B-AP15,Selleck,S4920 BAY-805,Selleck,E1633 TCID,Selleck,S7140 BAY 11-7082

(2) RNF180 loss stabilizes BCAS4 to enhance PD-L1 expression and immune evasion in hepatocellular carcinomaiScienceSeptember 18, 2026Ke Ye, Xiupeng Cai, Xuefan Dongactivator,Proteintech,Cat# KMS310 Cycloheximide (CHX),Sigma,Cat# C7698 MG132,Selleck Chemicals,Cat# S2619 BAY 11-7082,Selleck Chemicals,Cat# S2913 Lipofectamine 3000,Thermo Fisher,Cat# L3000001 Ficoll-Paque,GE Healthcare

(3) SPARC Drives Podocyte Mitochondrial Damage and Ferroptosis in Diabetic Kidney Disease Following Klotho DeficiencyAdv Sci (Weinh)August 29, 2026Qing Yang, Huimin Jiang, Chenyang Xiong, Xindi Zhou, Qinqin Tan, Han Xiao, Lan Qiu, Chun Gan, Yaxi Chen, Haiping Yang, et al.relevant proteolytic pathway, cells were co‐treated with either the proteasome inhibitor MG132 (10 µM, S2619, Selleck) or the lysosome inhibitor chloroquine (CQ, 50 µM, S6999, Selleck). CUX1 protein levels at

(4) Cloning and characterization of intermediate Homer1E of human skeletal muscleJ Muscle Res Cell MotilAugust 27, 2026Sandra Furlan, Marcello Carotti, Ahmed Samaha, Giovanni Minervini, Eylem Emek Akyurek, Emanuela Dazzo, Paola Lorenzon, Dieter Blottner, Michele Salanova, Dorianna Sandonà, et al.pathway was involved, transfected HEK293 cells were treated for either 8 h with 10 µM MG132 (Selleckchem S2619, Houston, TX, USA) or 24 h with either 50 or 100 nM Bafilomycin A1 (Selleckchem S1413, Houston, TX,

(5) Targeted degradation of Influenza a virus nucleoprotein via aptamer-based PROTACs for antiviral therapyVirulenceAugust 23, 2026Weiqiang Li, Yong Ju, Yaoyao Gao, Jinkun Peng, Nan Qiantibodies (Catalog #: SA00001-2) were acquired from Proteintech (Wuhan, China). MG132 (Catalog #: S2619), Cell Counting Kit-8 (Catalog #: C6005M) and serum-free medium for influenza A virus isolation (Catalog

(6) ZEB2 SUMOylation in Cardiac Fibroblast Drives Post-Infarction Cardiac Remodeling through CtBP1-Associated repression of Nr4a1iScienceAugust 21, 2026Yilin Wang, Shaopeng Cheng, Hongyu Chen, Zhihao Yang, Xiaoting Wu, Qiuyan Zong, Jianing Wang, Yi Jiang, Yanrong Yu, Hao Chen, et al.®647),Abcam,Cat #: ab150115 DAPI,Abcam,Cat #: ab104139 Cycloheximide,Selleck,Cat #: S7418 MG132,Selleck,Cat #: S2619 Isoproterenol,Selleck,Cat #: S2566 ,, Bacterial and virus strains,Bacterial and virus strains,Bacterial

(7) TRIM59 Drives Bladder Cancer Progression Through E3 Ligase-Dependent K48-Linked Degradation of PTRFCancer SciAugust 21, 2026Junlin Gan, Xuesong Bai, Aijie Zhang, Fei Lin, Hang Tong, Tinghao Li, Ning Xu, Xinyuan Li, Zhou Yu, Hubin Yina humidified atmosphere with 5% CO2. Cycloheximide (CHX; S7418) and the proteasome inhibitor MG132 (S2619) were purchased from Selleck (USA). 2.2 Collection of Clinical Specimens Primary BLCA specimens were

(8) Glycolytic reprogramming and the EMT drive cervical cancer progression via the NQO1/HIF1α-SIX1 axisiScienceAugust 21, 2026Guang Zhu, Zhenggen Piao, Yuan Gao, Xianling Cong, Pengcheng Wei, Anna Han, Houkun Zhou, Zhenhua Lin, Toufeng JinX-100,Beyotime,ST795 RIPA buffer,CWBIO,CW2333S Protein A/G PLUS-Agarose,SantaCruz,sc-2003 MG132,Selleck Chemicals,S2619 ECL Chemiluminescence Detection Kit,Zomanbio,ZD310-2 DMSO,Solarbio,GC-MC-008 CHX,MedChemExpress,HY-12320 MTT,Solarbio,M1020 2-Deoxy-D-glucose,MedChemExpress,HY-13966 3-Bromopyruvic acid

(9) c-Fos enhances influenza virus replication by stabilizing the M2 protein and promoting autophagosome accumulationJournal of VirologyAugust 18, 2026Xiaonan Chen, Junyang Yan, Mengxue Li, Hanbin Liu, Daiqiang Lu, Yang Wang, Yun Liu, Qiao Zhang, Feng Gao, Jiaojiao PengT-5224 (B4664; APExBIO), cycloheximide (CHX, HY-12320; MedChemExpress), rapamycin (9904S; CST), MG132 (S2619; Selleck), bafilomycin A1 (A8510; Solarbio), and chloroquine (C6628; Sigma). siRNA oligonucleotides

(10) ETS1-EGR2 facilitates renal cell carcinoma progression by activating NOTCH signallingClin Transl MedAugust 17, 2026Weifeng Ye, Sishun Gan, Qiang Xu, Xiaoyang Shu, Panpan Dong, Lin Li, Chao Tangantibodies were acquired from Santa Cruz Biotechnology. DAPT (S2215), cycloheximide (S7418) and MG132 (S2619) were acquired from Selleckchem. 2.3 Dual‐luciferase reporter assays NOTCH‐specific luciferase reporter

(11) CDT1 acts with the replisome to remodel replication forksSci AdvAugust 14, 2026Caitlin Hathaway, Thanh Le, Yuki Hatoyama, Masato Kanemaki, Huzefa Dungrawala(Selleck Chemicals, S8007), APH (Sigma-Aldrich A0781-5MG), CIS (Sigma-Aldrich, P4394), MG132 (Selleck Chemicals, S2619), 5-Ph-IAA (Sigma-Aldrich, SML3574), CldU (Sigma-Aldrich, C6891), EdU (Sigma-Aldrich, 61135-33-9), IdU

(12) Defective microhomology-mediated end joining in SMARCB1-deficient tumorsSci AdvAugust 14, 2026Guangli Zhu, Shuhei Asada, Huy Nguyen, Yuna Hirohashi, Lifang Sun, Avneesh Saravanapavan, Erfan Rahmani, Maryia Hrynashka, Sirisha Mukkavalli, Mona Batish, et al.#15140163). Compounds The chemical compounds used in this study were as follows: MG132 (Selleck, #S2619), Cycloheximide (Selleck, #S7418), Actinomycin D (Selleck, #S8964), Mitomycin C (Selleck, #S8146), Olaparib

(13) Macrophage polarization regulated by the βTrCP-NF-κB inflammatory signaling pathway is required for valproic acid's dual role in breast tumor radiosensitivity and normal tissue radioprotectionFront ImmunolAugust 10, 2026Beidi Jia, Guochao Liu, David Lim, Quanji Li, Songying Xie, Zhihui Fenganalysis. Alternatively, after VPA and IR treatment, cells were incubated with 20 μM MG132 (Cat. No. S2619, Selleck Chemicals, USA) for 12 h before cellular proteins were harvested for Western blot analysis. CCK8

(14) Large-scale quaternary structural transitions underlie gain of function of SPOP cancer mutationsMol CellAugust 6, 2026Matthew J. Cuneo, Ömer Güllülü, Mohamed-Raafet Ammar, Xinrui Gui, Kelly Churion, Martin Turk, Brian G. O'Flynn, Nafiseh Sabri, Tanja Mittagand recombinant proteins",, Ubiquitin,Boston Biochem,Cat# U-100H-10M MG132,Selleck Chemicals,Cat# S2619 Cycloheximide,Cell Signaling,Cat# 2112 Lipofectamine 3000,ThermoFisher,Cat# L3000008 F-BRD3 peptide:

(15) Microenvironmental arginine restriction sensitizes pancreatic cancers to polyunsaturated fatty acids by suppression of lipid synthesisElifeAugust 5, 2026Patrick B Jonker, Mumina Sadullozoda, Guillaume Cognet, Juan J Apiz Saab, Kelly H Sokol, Violet X Wu, Deepa Kumari, Colin Sheehan, Mete E Ozgurses, Darby Agovino, et al.(Roche, 11836170001)]. To detect SREBP1 protein, cells were treated with 10 µM MG132 (Selleck Chemical, S2619) 6 hr prior to harvesting where indicated. The following antibodies were used for immunoblot analysis:

(16) FBXW7 suppresses gastric cancer development and progression via ubiquitination-mediated degradation of MMP2Front ImmunolAugust 4, 2026Changjiang Hao, Shengping Jiang, Songpu Wu, Weiwei Li, Jilv Peng, Bo Qin, Jinlan Li, Yong Tan, Kun Qian, Hongsheng Jiang, et al.anti-FBXW7 (1 µg/ml, ab109617, abcam), and anti-HA-Ub (1:500, 3724S, CST). Proteasome inhibitor MG132 (S2619, Selleck Chemicals, experimental concentration:20µM) and protein synthesis inhibitor cycloheximide (CHX;

(17) Duck plague virus US2 promotes p62-mediated autophagic degradation of RIG-I to suppress antiviral signalingPoultry ScienceAugust 1, 2026Yuanyuan Hao, Meiyuan Xiong, Mingshu Wang, Anchun Chengde novo protein synthesis. Cells were subsequently treated with the proteasome inhibitor MG132 (Cat# S2619), the autophagy-lysosome inhibitor bafilomycin A1 (BafA1; Cat# S1413), or the apoptosis inhibitor Z-VAD-FMK

(18) RNF187 inhibits porcine reproductive and respiratory syndrome virus replication by recruiting the autophagy receptor NDP52 to degrade nsp12Vet ResAugust 1, 2026Qiumei Wang, Guoxin Zheng, Tao Tian, Anli Chen, Guihong Zhang, Heng Wangpurchased from Abmart (Shanghai, China). The anti-Flag magnetic beads (B26102), 3-MA (S2767), MG132 (S2619), and Z-VAD-FMK (S7023) were purchased from Selleck (Shanghai, China). Anti-RNF187 antibody (NBP2-83456)

(19) EVA1A responds to endoplasmic reticulum stress to regulate renal fibrosis by promoting TGF-β signaling pathwayJournal of Advanced ResearchAugust 1, 2026Qiongdan Gao, Zhenkun Wang, Yuting Fu, Shuyi Lin, Haiping Liu, Yuanyuan Zhou, Yifei Wei, Zhenyu Ju, Lili Zhou, Bo Liu(R&D Systems, Cat#7666-MB) for 24 h. Where indicated, 2 μM MG132 proteasome inhibitor (Selleck, Cat# S2619) was administered for 16 h. Immunohistochemistry Mouse kidneys were fixed in 4% PFA for 24 h, dehydrated

(20) Enzymatic activity-independent NANS stabilizes LATS2 to drive growth and therapeutic resistance in HR+/HER2- breast cancerNature CommunicationsJuly 24, 2026Jia-Yang Cai, Min-Ying Huang, Shao-Ying Yang, Fang-Lin Zhang, Yin-Ling Zhang, Lisa Andriani, Qian Zhao, A-Yong Cao, Da-Qiang Li, Zhi-Ming Shaothe indicated plasmids for 48 h, followed by treatment with the proteasome inhibitor MG132 (10 μM; #S2619, Selleck) for 6 h. Cells were then lysed using denaturing buffer and subjected to IP assays. For the

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MG132

MG132 from Selleck Chemicals

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MG132 from Selleck Chemicals

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