MG132 from Selleck Chemicals

Product Specs
ItemMG132
CompanySelleck Chemicals
Price $977.00Supplier Page View Company Product Page
Catalog NumberS2619
Quantity100mg
Purity99.07
TargetProteasome
Molecular Weight228.2
Storage2 years -80 in solvent
FormulaC26H41N3O5

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Selleck Chemicals

14408 W Sylvanfield Drive

Houston, Texas TX 77014

United States

Phone: Toll Free: (877) 796-6397 (US and Canada only)
Tel: (832) 582-8158
Fax: (832) 582-8590

Email: sales@selleckchem.com

Company Profile

Website: www.selleckchem.com

(1) Glycolytic reprogramming and the EMT drive cervical cancer progression via the NQO1/HIF1α-SIX1 axisiScienceAugust 21, 2026Guang Zhu, Zhenggen Piao, Yuan Gao, Xianling Cong, Pengcheng Wei, Anna Han, Houkun Zhou, Zhenhua Lin, Toufeng JinX-100,Beyotime,ST795 RIPA buffer,CWBIO,CW2333S Protein A/G PLUS-Agarose,SantaCruz,sc-2003 MG132,Selleck Chemicals,S2619 ECL Chemiluminescence Detection Kit,Zomanbio,ZD310-2 DMSO,Solarbio,GC-MC-008 CHX,MedChemExpress,HY-12320 MTT,Solarbio,M1020 2-Deoxy-D-glucose,MedChemExpress,HY-13966 3-Bromopyruvic acid

(2) Large-scale quaternary structural transitions underlie gain of function of SPOP cancer mutationsMol CellAugust 6, 2026Matthew J. Cuneo, Ömer Güllülü, Mohamed-Raafet Ammar, Xinrui Gui, Kelly Churion, Martin Turk, Brian G. O'Flynn, Nafiseh Sabri, Tanja Mittagand recombinant proteins",, Ubiquitin,Boston Biochem,Cat# U-100H-10M MG132,Selleck Chemicals,Cat# S2619 Cycloheximide,Cell Signaling,Cat# 2112 Lipofectamine 3000,ThermoFisher,Cat# L3000008 F-BRD3 peptide:

(3) Microenvironmental arginine restriction sensitizes pancreatic cancers to polyunsaturated fatty acids by suppression of lipid synthesisElifeAugust 5, 2026Patrick B Jonker, Mumina Sadullozoda, Guillaume Cognet, Juan J Apiz Saab, Kelly H Sokol, Violet X Wu, Deepa Kumari, Colin Sheehan, Mete E Ozgurses, Darby Agovino, et al.(Roche, 11836170001)]. To detect SREBP1 protein, cells were treated with 10 µM MG132 (Selleck Chemical, S2619) 6 hr prior to harvesting where indicated. The following antibodies were used for immunoblot analysis:

(4) Duck plague virus US2 promotes p62-mediated autophagic degradation of RIG-I to suppress antiviral signalingPoultry ScienceAugust 1, 2026Yuanyuan Hao, Meiyuan Xiong, Mingshu Wang, Anchun Chengde novo protein synthesis. Cells were subsequently treated with the proteasome inhibitor MG132 (Cat# S2619), the autophagy-lysosome inhibitor bafilomycin A1 (BafA1; Cat# S1413), or the apoptosis inhibitor Z-VAD-FMK

(5) RNF187 inhibits porcine reproductive and respiratory syndrome virus replication by recruiting the autophagy receptor NDP52 to degrade nsp12Vet ResAugust 1, 2026Qiumei Wang, Guoxin Zheng, Tao Tian, Anli Chen, Guihong Zhang, Heng Wangpurchased from Abmart (Shanghai, China). The anti-Flag magnetic beads (B26102), 3-MA (S2767), MG132 (S2619), and Z-VAD-FMK (S7023) were purchased from Selleck (Shanghai, China). Anti-RNF187 antibody (NBP2-83456)

(6) An Acetylation-Primed SUMOylation Switch Controls RORβ Stability through a p300-SIRT1 Regulatory AxisResearchSquareJuly 23, 2026Patrick Griffin, Timothy O'Leary, Denis Shutin, Nadeska Montalvan, Nereida Abad-Yang, Vuong Dang, Dean Edwards, Mi Ra ChangN0636 Trichostatin A (TSA),Sigma-Aldrich,Cat# T8552 MG-132 (proteasome inhibitor),Selleckchem,Cat# S2619 SRT2104 (SIRT1 activator),Selleckchem,Cat# S7792 DSSO crosslinker,Thermo Scientific,Cat# A33545 Cycloheximide,Sigma-Aldrich,Cat#

(7) Cleavage of TOM1 by the SARS-CoV-2 main protease NSP5 prevents autophagic degradation of viral envelopeJournal of VirologyJuly 21, 2026Qingxiang Zhang, Jingguo Xin, Chunlei Wang, Xue Zhang, Yuan Gao, Wenying Gao, Wenyan Zhangincluding TNF-α (E7641), vinblastine (S4504), bafilomycin A1 (S1413), 3-methyladenine (S2767), and MG132 (S2619), were purchased from Selleck. CHX (66-81-9) was obtained from Sigma. Z-VAD-FMK (HY-16658B), rapamycin

(8) Disruption of microhomology-mediated end joining in Ewing sarcomaMol CellJuly 21, 2026Shuhei Asada, Guangli Zhu, Jithma Prasad Abeykoon, Yutaro Tanaka, Huy Nguyen, Yuna Hirohashi, Divya R. Iyer, Nicholas William Ashton, Sirisha Mukkavalli, Martha Velazquez, et al.HY-153244 Nocodazole,Sigma-Aldrich,Cat# 1404 dTAGv1,Tocris,Cat# 6914 Biotin,Sigma-Aldrich,Cat# B4501 MG-132,Selleck Chemicals,Cat# S2619 Puromycin dihydrochloride,Sigma-Aldrich,Cat# P8833 Blasticidin S HCl,Thermo Fisher Scientific,Cat#

(9) Mitochondrial SLC25A46 Rewires Fatty Acid Oxidation to Promote Cell Proliferation and Ferroptosis Evasion in Ovarian Cancer by Stabilizing CACTAdv Sci (Weinh)July 20, 2026Yunge Gao, Jiatao Hao, Xiaohong Zhang, Meiting Long, Yujing Feng, Xiaoyue Liu, Xuejian Li, Shujuan Liu, Xin Guo, Xiaohui LvEtomoxir sodium salt (catalog number #S8244), BPTES (catalog number #S7753), MG132 (catalog number #S2619), Chloroquine (catalog number #S6999), Sulfosuccinimidyl Oleate Sodium (SSO, catalog number E2988),

(10) A Practical Experimental Protocol for Identification and Validation of UFMylation Substrate in Human CellsBio ProtocJuly 20, 2026Qian Liang, Yaoyao Fang, Juexi Dong, Xingling Yi, Yu-Sheng Cong03-050-1BCS) 32. Opti-MEM (Gibco, catalog number: 31985-070) 33. MG132 (Selleck Chemicals, catalog number: S2619) 34. Anti-FLAG M2 affinity gel (Sigma-Aldrich, catalog number: A2220) Note: Storage: -20 °C. Shelf life:

(11) Repurposing primaquine diphosphate for imatinib-resistant chronic myeloid leukemia via targeting BCR-ABL and Wnt/β-catenin pathwayiScienceJuly 17, 2026Changqing Yin, Wenhao Liu, Chensheng Ma, Zhida Zhang, Zenghui Fang, Jiawei Cao, Guang Wu, Haihua Gu, Licai He(PRQ),MedChemExpress,Cat#HY-12651 CHIR-99021,Selleckchem,Cat#S2924 Cycloheximide (CHX),Selleckchem,Cat#S7418 MG132,Selleckchem,Cat#S2619 NBT,Beyotime Biotechnology,Cat#ST362 TPA,Beyotime Biotechnology,Cat#S1819 ,, Critical commercial

(12) Itgb1-Mediated Stabilization of Vimentin Alleviates Excessive Mechanical Stress-Induced Nucleus Pulposus Cell Pyroptosis and Intervertebral Disc Degeneration via PINK1-Parkin-Dependent MitophagyCell ProlifJuly 14, 2026Xuening Liu, Fengguang Yang, Yanni Duan, Hefang Xiao, Zhenyu Cao, Zhaoheng Wang, Haijun Zhang, Xuewen Kang3‐MA (5 mM; Selleck, S2767), cycloheximide (CHX, 10 μM; Selleck, S7418), or MG132 (10 μM; Selleck, S2619). 2.4 Lentiviral Transduction and In Vitro siRNA Lentiviral vectors for Vimentin or Itgb1 overexpression

(13) Turnip crinkle virus coat protein subverts DRB7-mediated compensatory RNAi through ubiquitin-proteasome-dependent degradationPlant CommunicationsJuly 13, 2026Kunxin Wu, Yan Fu, Pingjuan Zhao, Qiuxian Xie, Shuxia Li, Yadan Wu, Xueting Liu, Ping Gan, Mengbin Ruan, Xiuchun Zhangwere infiltrated with 5 mM 3-MA (Selleckchem, S2767) dissolved in water or 100 μM MG132 (Selleckchem, S2619) dissolved in DMSO at 24–48 h after agroinfiltration. Control leaves were infiltrated with equivalent

(14) Non-canonical function of transferrin receptor-1 promotes breast cancer metastasis by activating HCK‒STAT3‒MMP9 signallingClin Transl MedJuly 12, 2026Qing Zhao, Yafang Wang, Pengfei Wang, Yaqi Ding, Rong Wang, Yanyan Shen, Biyu Yang, Yanfen Fang, Jian Ding, Yi Chenwere obtained from MedChemExpress. BP‐1‐102 (#S7769), Sulphorhodamine B (SRB) (#S5976) and MG132 (#S2619) were purchased from Selleck. Tris‒HCl (#ST774), NaCl (#ST1840), MgCl2 (#Y001529), dithiothreitol (DTT)

(15) RNF31 restricts EV-A71 replication through innate immune activation and VP4 degradation, and is antagonized by viral 3C proteasesPLoS PathogJuly 2, 2026Qingxiang Zhang, Yuan Gao, Wenying Gao, Xue Zhang, Shengyuan Xu, Wenyan Zhangour laboratory. The chemical reagents used in this study are as follows: MG132 (Selleck, catalog no. S2619), Bortezomib (Selleck, catalog no. S1013), Bafilomycin A1 (Selleck, catalog no. S1413), TNF-α (Selleck,

(16) Targeted degradation of MDM2 overcomes feedback regulation of p53 signaling in Merkel cell carcinoma modelsJ Clin InvestJuly 1, 2026Varsha Ananthapadmanabhan, Simone Bruno, Leonard Vonk, Yu-Chen Cheng, Abeba Teshager, Benjamin K. Eschle, Charles L. Howarth, Joana S. Rodrigues, Julia Schnabel, Ananya Kodali, et al.obtained from VWR (75837-714) and dissolved in DMSO. MG132 and Bortezomib were obtained from SelleckChem (S2619 and S1013) and dissolved in DMSO. Viability assays. Viable trypan blue cell counts were determined

(17) A viral ORFeome library for systems-level genetic dissection of host-pathogen interactionsCellJune 30, 2026Eric Fujimura, Colin N. O'Leary, Mamie Z. Li, Rachel A. Roberts, Caleb R. Glassman, Joao A. Paulo, Hanjie Jiang, Nouran S. Abdelfattah, Eric C. Wooten, Zachary Mirman, et al.MC162R, cells were pretreated with bafilomycin A1 (100 nM) (CST, #54645S), MG-132 (2 μM) (Selleck, S2619), TAK-243 (2 μM) (Selleck, S8341) for 2 h and then induced with doxycycline (200 ng/mL) in the presence

(18) The YTHDC1/HECW1/SMAD7 axis drives cisplatin resistance in bladder cancerTranslational Andrology and UrologyJune 30, 2026Weigang Ren, Jiaxiang Yi, Mingqiang Zeng, Hongtao ChengAB_2881699) or anti-HA (1:5,000; 51064-2-AP, RRID: AB_2910459) antibodies. Cisplatin (#S1166), MG132 (#S2619), CAY10683 (#S7595), and curcumin (#S1848) were obtained from Selleck (Shanghai, China). Western blot analysis

(19) Acetylation-Primed SUMOylation Drives RORβ Turnover via a p300-SIRT1 Regulatory AxisbioRxivJune 30, 2026Timothy R. O'Leary, Denis Shutin, Nadeska I. Montalvan, Nereida M. Abad-Yang, Vuong Dang, Dean P. Edwards, Patrick R. Griffin, Mi Ra ChangN0636 Trichostatin A (TSA),Sigma-Aldrich,Cat# T8552 MG-132 (proteasome inhibitor),Selleckchem,Cat# S2619 SRT2104 (SIRT1 activator),Selleckchem,Cat# S7792 DSSO crosslinker,Thermo Scientific,Cat# A33545 Cycloheximide,Sigma-Aldrich,Cat#

(20) DHODH Drives Sunitinib Resistance Via a Non‐Enzymatic Mechanism by Inhibiting TRIM28 Ubiquitination and Consequent VEGFA Activation in RCCAdvanced ScienceJune 23, 2026Shijie Qian, Shihang Pu, Zhipeng Xu, Yiheng Ding, Ling Jin, Baochao Li, Qi Li, Xiaohai Xi, Zengjun Wang, Jiajun Xing, et al.Plasmids, and Lentivirus The chemicals used in this study: Sunitinib (S7781), Chloroquine (S6999), MG132 (S2619), Cycloheximide (S7418), and Lisaftoclax (S9970) were purchased from Selleck. Lipofectamine 3000 (L3000075)

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MG132

MG132 from Selleck Chemicals

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MG132 from Selleck Chemicals

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