MG132 from Selleck Chemicals

Product Specs
ItemMG132
CompanySelleck Chemicals
Price $977.00Supplier Page View Company Product Page
Catalog NumberS2619
Quantity100mg
Purity99.07
TargetProteasome
Molecular Weight228.2
Storage2 years -80 in solvent
FormulaC26H41N3O5

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Selleck Chemicals

14408 W Sylvanfield Drive

Houston, Texas TX 77014

United States

Phone: Toll Free: (877) 796-6397 (US and Canada only)
Tel: (832) 582-8158
Fax: (832) 582-8590

Email: sales@selleckchem.com

Company Profile

Website: www.selleckchem.com

(1) Damage to newly synthesized proteins is a major cause of Cd(II) toxicity counteracted by proteasomes and integrated stress response in human cellsChemico-Biological InteractionsJune 1, 2026Giorgiana Madalina Ursu, Anatoly Zhitkovichubiquitination (TAK-243, MedChemExpress, cat. #HY-100487), proteasome activity (MG132, Selleckchem, cat. #S2619), protein synthesis (cycloheximide, Sigma-Aldrich, cat. #01810) and integrated stress response (ISRIB,

(2) mTORC1-signaling switches megalin function from endocytosis to cell cycle progressionCell Mol Life SciMay 23, 2026Eileen Dahlke, Madlen Kunke, Hannah Knöfler, Yaman Anan, Yuanhao Shen, Danyang Zhao, Christine von Toerne, Franziska Theiligdirect after the nocodazole treatment, cells were washed twice in PBS and treated with 25 µM MG-132 (S2619, Selleckchem, Cologne, Germany) in DMEM medium (without serum) for 70 min. Cells were washed in PBS

(3) FGF8-mediated TRIM16 regulation promotes K48-linked ubiquitination and degradation of RIG-I to facilitate Influenza a virus immune evasionVirulenceMay 22, 2026Ran Wei, Huixia Zhang, Kaihui Cheng, Song Wang, Zhen Yuan, Sisi Ma, Zhijun Yu2000. Twenty-four hours post-transfection, cells were treated with 10 µM MG132 (Selleck Chemicals, S2619) for 6 hours to block proteasomal degradation. Cells were then lysed in IP lysis buffer (Biyuntian Biotechnology)

(4) HSPA5 induces autophagy targeting VP2 through the PERK-eIF2α signaling pathway to inhibit SVA replicationJournal of VirologyMay 19, 2026Liang Li, Ruimin Bi, Jie Li, Meifang Chang, Jinting Zhao, Xuan Wang, Li Wei, Xinyue Chang, Yan Cheng, Zongjun Yin, et al.reagents were purchased commercially, including 3-MA (3-Methyladenine) (Selleck, S2767), MG132 (Selleck, S2619), Ac-DEVD-CHO (Selleck, S7901), Ceapim-A7 (Selleck, E1099), Salubrinal (Selleck, S2923), 4μ8C (Selleck,

(5) FASN Inhibition Enhances the Efficacy of Chemotherapy in Colorectal Cancer by Inhibiting the DNA Damage ResponseCancer ResMay 15, 2026Moumita Banerjee, Yekaterina Y Zaytseva, Ellen M Reusch, Dana L Napier, Sumati Hasani, Piotr Rychahou, Tadahide Izumi, Dennis A Cheek, Jing Li, Robert M Flight, et al.purchased from Tocris Bioscience (RRID:SCR_003689). Fircostat (S8893), cycloheximide (S7418) and MG132 (S2619) were purchased from Selleck Chemicals (RRID:SCR_003823) while CBM301940 (HY-125748) was from MedChemExpress

(6) NUP62 promotes breast cancer progression and inhibits ferroptosis by stabilizing NRF2 in a KEAP1-dependent wayiScienceMay 15, 2026Ziran Qiu, Yu Lin, Shanzheng Chen, Wenqing Cao, Jun Yang, Rui Li, Yuan Chen, Xiaoqing Yao, Senlin Fu, Na Jin(HY-13442) and Protein A/G Magnetic Beads (HY–K0202) from MedChemExpress; Ferrostatin-1 (S7243), MG-132 (S2619) and Cycloheximide (S7418) from Selleck. Plasmid construction and transfection All overexpression

(7) SREBP2-activated CNPY3 Phase Separation Promotes Colorectal Cancer by Enhancing MDM2-mediated p53 DegradationInt J Biol SciMay 15, 2026Xue Li, Min-Yue Yin, Yan-Fei Wei, Jie Xing, Qian Zhang, Ye Zong, Shu-Tian Zhang, Si-An Xielevels of CNPY3 overexpressing HCT116 (E) and RKO cells (F) with or without MG132 treatment (Selleck, S2619; 20 μM, 5 h), using β-tubulin as a control. (G-H) The p53 protein levels of CNPY3 knockdown HCT116 (G)

(8) Inhibiting MDM2 enhances RIPK3-mediated necroptosis and synergizes with immune checkpoint blockade therapyiScienceMay 15, 2026Yingxin Wu, Hanyang Yu, Zongxu Zhang, Weihang Xiong, Zexian Zeng, Weili Liu, Hailin Tu, Xin Lin,Enzo life science,Cat# ALX-522-008 BV-6,Selleck,Cat# S7597 GSK’872,Selleck,Cat# S8465 MG132,Selleck,Cat# S2619 Chloroquine,Selleck,Cat# S6999 Nutlin-3a,Selleck,Cat# S1061 Necrostatin-1,Beyotime,Cat# N9037 zVAD.fmk,Beyotime,Cat#

(9) Microenvironmental arginine restriction sensitizes pancreatic cancers to polyunsaturated fatty acids by suppression of lipid synthesisbioRxivMay 4, 2026Patrick B. Jonker, Mumina Sadullozoda, Guillaume Cognet, Juan J. Apiz Saab, Kelly H. Sokol, Violet X. Wu, Deepa Kumari, Colin Sheehan, Mete E. Ozgurses, Darby Agovino, et al.(Roche, 11836170001)]. To detect SREBP1 protein, cells were treated with 10 μM MG132 (Selleck Chemical, S2619) 6 hours prior to harvesting where indicated. The following antibodies were used for immunoblot analysis:

(10) Ixazomib triggers autophagic degradation of MUC5AC/integrin-β4 and inhibits non-small cell lung cancer progressionCancer LettersMay 1, 2026Muthamil Iniyan Appadurai, Zahraa Wajih Alsafwani, Sanjib Chaudhary, Ashu Shah, Pranay Somavarapu, Sriman N. Dooshety, Ben S. Kubicek, Surinder K. Batra, Imayavaramban Lakshmanan, Apar Kishor Gantipenicillin–streptomycin under 5% CO2 at 37° C. IXZ (Cat# S2180), carboplatin (CBP) (Cat# S1215), MG132 (Cat# S2619), 3-Methyladenine (3-MA) (Cat# S2767), and Hydroxychloroquine (HCQ) (Cat# S4430) were purchased from

(11) CRL4AMBRA1-mediated progesterone receptor degradation drives progestin resistance and represents a therapeutic vulnerability in endometrial cancerInt J Biol SciMay 1, 2026Yaru Sheng, Ting Ni, Xiaoyi Ding, Jiaying Huang, Xueya Zhao, Xinyao Li, Qingting Li, Jing Wang, Xiaoming Yang, Lin Zhang, et al.Mycoplasma infection. Reagents and antibodies Medroxyprogesterone acetate (S2567), MLN4924 (S7109), MG132 (S2619), BAY11-7082 (S2913), CHX (S7418), rapamycin (S1039) and CQ (S6999) were purchased from Selleck Chemicals

(12) TRIM7 Inhibits Rabies Virus Replication by Promoting K48-Linked Ubiquitination and Degradation of RABV-MEmerging Microbes & InfectionsApril 28, 2026Hongling He, Weiheng Liang, Wei Lin, Yang Wang, Ruikang Su, Yueming Wang, Shile Huang, Jun Luo, Xiaofeng GuoUSA, #HY-164388), rapamycin (Rap, Selleckchem, Houston, TX, USA, #S1039), and MG132 (Selleckchem, #S2619). All reagents were dissolved in dimethyl sulfoxide (DMSO) and stored at −80°C. Primary antibodies employed

(13) Isoform-specific cofactor recruitment through the intrinsically disordered N-terminus of p63 underlies differential transcriptional activitiesbioRxivApril 26, 2026Marina F. Nogueira, Michael J. Moore, Aparna R. Biswas, Michael P. Meers, Sidharth V. Puramwater. GSK-699 PROTAC (InvivoChem, 2260944-68-9) and MG132 proteasome inhibitor (Selleck Chemicals, S2619) were reconstituted in DMSO (Sigma-Aldrich, D2650). Apoptosis Assays PCI-30 and SCC9 cell lines transduced

(14) Canagliflozin and Brusatol Synergize against LKB1-KEAP1 Co-Mutant NSCLC through AKT SuppressionInt J Biol SciApril 23, 2026Yiguan Chen, Xiang-Zheng Gao, Dade Rong, Liangliang Gao, Mingzhu Tang, Guang Lu, Zhi-Qiang Ling, Han-Ming Shen(HY-19543), Ferrostatin-1 (HY-100579), GSK-872 (HY-101872A), and hydroxychloroquine (HY-B1370). MG132 (S2619) and Bafilomycin A1 (S1413) were purchased from Selleckchem. Z-VAD (V116) and N-Acetyl-L-cysteine (A9165)

(15) SplitTurboID mapping of dimeric protein phosphatase complex interactomesiScienceApril 17, 2026Abishankari Rajkumar, Antoine Gaudreau-Lapierre, Curtis L.F. Anthony, Vincent Nguyen, Sarah Ooi, Denise Campuzano, Laura Trinkle-MulcahyScientific,Cat#1856210 Biotin,Millipore Sigma,Cat#B4639 Sodium Arsenite Solution,Millipore Sigma,Cat#1062771000 MG132,SelleckChem,Cat#S2619 ,, Deposited data,Deposited data,Deposited data ,, SILAC and label-free splitTurboID raw data files,This

(16) The E3 ligase β-TRCP1 earmarks OTUD3 for destruction to fine-tune cGAS activationJournal of Biological ChemistryApril 17, 2026Jianfeng Chen, Smaran Sivashankar, Ying Wang, Pengda Liu(SAE0201), anti-HA agarose beads (A-2095), and puromycin (P8833) were purchased from Sigma-Aldrich. MG132 (S2619) and Cycloheximide (C7698) were purchased from Selleck. Protease inhibitor cocktail (K1008) and phosphatase

(17) Poxvirus A52 protein subverts autophagy flux by blocking autophagosome-lysosome fusion to promote viral replicationPLoS PathogApril 13, 2026Kang Niu, Yongxiang Fang, Yining Deng, Ziyue Wang, Shijie Xie, Junda Zhu, Baifen Song, Wenxue Wu, Zhizhong Jing, Chen Peng(P2118) were purchased from Beyotime. Rapamycin (Rapa.) (S1842) was purchased from Beyotime. MG132 (S2619), Epoxomicin (S7038), Bafilomycin A1 (baf. A1) (S1413) and 3-MA (3-Methyladenine) (S2767) were purchased

(18) Ipriflavone From Aquilaria malaccensis Lam. Exosome-Like Nanoparticles Targets Prolyl Hydroxylase Domain Protein 2 (PHD2) to Enhance Hypoxia-Inducible Factor-α (HIF-α) Hydroxylation Thereby Alleviating Hypoxia-Induced Gastrointestinal Mucosal FerroptosisMedComm (2020)April 9, 2026Dezhi Wang, Xingchen Liao, Yilin Wang, Xuexin Wang, Heng Zhang, Jie Zeng, Mingjie Zhang, Xin Wang, Fangli Ren, Yinyin Wang, et al.Shanghai, China), zileuton (an ALOX5 inhibitor; 10 µM; HY‐14164; MedChemExpress), or MG132 (10 µM; S2619; Selleck). The cells were then collected for crystal violet staining, CCK‐8 assays, Western blot analysis,

(19) Targeting ANXA1/TRKA axis enhances immunotherapy sensitivity in neural invasion-positive gastric cancerMol BiomedApril 9, 2026Tianlu Jiang, Peng Zhou, Yikai Shen, Jie Lin, Ying Li, Xusheng Shen, Lang Fang, Penghui Xu, Zekuan Xu, Linjun Wang, et al.STEMCELL, Cycloheximide (HY-12320), Larotrectinib (HY-12866) were purchased from MedChemExpress, MG132 (S2619) was purchased from Selleck, Apoptosis Detection Kit (C1065M) was purchased from Beyotime. Antibodies

(20) Targeting KIF23 inhibits cell proliferation and primary chemoresistance in cervical cancer by inactivating the MYH9/MCM2/PCNA pathwayClin Transl MedApril 6, 2026Ying Zhu, Qian Wang, Yilin Zhang, Yahui Liu, Haini Fu, Zike Yang, Xiaojie Deng, Suiqun Guoprotein degradation was examined by WB. For proteasome inhibition, cells were treated with 20 µM MG132 (S2619; Selleck). Protein lysates were prepared using RIPA lysis buffer supplemented with SDS loading buffer,

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MG132

MG132 from Selleck Chemicals

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MG132 from Selleck Chemicals

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