PD-0332991 (Palbociclib) Hydrochloride from Selleck Chemicals

Product Specs
ItemPD-0332991 (Palbociclib) Hydrochloride
CompanySelleck Chemicals
Price $237.00Supplier Page View Company Product Page
Catalog NumberS1116
Quantity10mg
Purity99.61
TargetCDK
Storage2 years -80 in solvent
FormulaC24H29N7O2.HCl

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Selleck Chemicals

14408 W Sylvanfield Drive

Houston, Texas TX 77014

United States

Phone: Toll Free: (877) 796-6397 (US and Canada only)
Tel: (832) 582-8158
Fax: (832) 582-8590

Email: sales@selleckchem.com

Company Profile

Website: www.selleckchem.com

(1) CDK8/19 inhibition prevents adaptive resistance to CDK4/6 inhibitors in vitro and in vivoCell Reports MedicineSeptember 15, 2026Zachary T. Mack, Margarita Yastrebova, Chang-uk Lim, Xiaokai Ding, Jing Li, Alvina Khamidullina, Amanda C. Sharko, Michael Saint-Antoine, Thomas A. Hilimire, Gary P. Schools, et al.USC COBRE Center for Targeted Therapeutics. Palbociclib isethionate was purchased from SelleckChem (#S1116, Houston, TX). Abemaciclib (KP-736-002) was provided by Kalyra Pharmaceuticals (Batch MW: 506.59 g/mol;

(2) CDC7 and APC/CCdh1 gate distinct routes to initiate DNA replicationNature CommunicationsJuly 24, 2026Samsara W. Upadhya, Nalin Ratnayeke, Katherine R. Ferrick, David L. Rosenthal, Tobias MeyerTAK-931 (MedChemExpress Cat# HY-100888), 1 μM CDK4/6 inhibitor palbociclib (Selleck Chemicals, Cat#S1116), 1 μM CDK2 inhibitor PF-07104091 (ChemieTek, Cat# CT-PF0710), 500 nM MK-1775 (WEE1i, Cayman Chemical

(3) CDK4/6 inhibition induces a senescence-associated secretory phenotype via delayed NF-κB activationLife Sci AllianceJuly 9, 2026Joanna Lan-Hing Yeung, Justin Rendleman, Lauren Anderson Westcott, Arnold Ou, Matthew Pressler, Nicole Pagane, Irene Duba, Ria Hosuru, Bat-Ider Tumenbayar, Viviana I Riscadrug treatment. For samples sent for sequencing, cells were treated with either 1 μM palbociclib (Cat# S1116; Selleck Chemicals) or 100 nM doxorubicin (Cat# S1208; Selleck Chemicals), with medium changes every

(4) Spatially defined microenvironmental niches are associated with clinical outcome and tumor ecosystem diversity in head and neck cancerMedJuly 2, 2026Jianhong An, Erqiang Hu, Qunlun Shen, Jing Zhu, Jiye Zhu, Naijia Liu, Qingxiang Lin, Leti Nunez, Shamsu Bello, Yuting Ren, et al.Center,N/A Chemicals,Chemicals,Chemicals Cisplatin,Tocris Bioscience,Cat# 2251 Palbociclib,Selleck Chemical,Cat# S1116 DMEM/F12 medium,Gibco,Cat# 11765-054 Fetal bovine serum,Life Technologies,Cat# A5669402 Penicillin/streptomycin,Corning,Cat#

(5) Targeting PFKFB3 to enhance CDK4/6 inhibitor response in ER+ breast cancerBreast Cancer ResearchJune 25, 2026Sucheta Telang, Brian F Clem, Ariamna A Herrera Miret, Leanne Price, Susan M Dougherty, Anna Schmitz, Xinmin Yin, Xipeng Ma, Xiang Zhang, Jason Chesney, et al.using cells within 15 passages after reconstitution from frozen stocks. Drug treatments Palbociclib (S1116; Selleckchem), ribociclib (S7440; Selleckchem), and PFK-158 (HY-12203; MedChem Express) were used in

(6) Multiplexed cytokine and antigen mRNA administration generates durable anti-tumor immunity against pancreatic cancerNature CommunicationsJune 19, 2026Chaitanya N. Parikh, Kelly D. DeMarco, Nikita Bhalerao, Hadiya K. Giwa, Griffin I. Kane, Ronnie W. Dinnell, Boyang Ma, Haruka Mori, Meghan L. Brassil, Katherine C. Murphy, et al.5005). All cell lines tested negative for Mycoplasma contamination. Trametinib (S2673) and palbociclib (S1116) were purchased from Selleck chemicals for in vitro studies. Drugs were dissolved in DMSO (vehicle)

(7) Potential effects of endogenous RNA/DNA hybrids on CRISPR/Cas9-mediated homology-directed repairMolecular Therapy Nucleic AcidsJune 16, 2026Francesco Puzzo, Batuhan Bayram, Claudia Macaubas, Angela Lin, Hagoon Jang, Feijie Zhang, Elizabeth Mellins, Mark A. Kayexperiments HEPA1-6/SpCas9 cells were treated with rapamycin (Selleck, S1039) or palbociclib (Selleck, S1116) for 24 h, fixed in 70% ethanol, stained with propidium iodide, and analyzed by flow cytometry (NovoCyte Penteon

(8) Oncogenic KRAS-driven type I interferon signalling primes pancreatic cancer for necroptosisNat CommunJune 15, 2026Sofya Tishina, Alina Dahlhaus, Marta Manik, Lejla Mulalic, Janine Murr, Michael Kotliar, Hassan Rakhsh-Khorshid, Myrto Kostopoulou, Florian Hocher, Jenny Stroh, et al.(S1078, Sellekchem), Ruxolitinib (S1378, Selleckchem), STINGi (C-178, S6667, Selleckchem), Palbociclib (S1116, Sellekchem), IMT1B (HY-137067, MedChemExpress), 2′,3′-Didesoxycytidin / Zalcitabine / ddC (HY-17392,

(9) Unveiling Candidate Markers for Drug Resistance or Synthetic Lethality in Cervical Cancer: Integrative Analysis of Genetic and PharmacoprofilingCancer Rep (Hoboken)June 12, 2026Suzy Scholl, Elaine Del Nery, Pierre Gestraud, Maral Halladjian, Elodie Girard, Adèle Soria, Elodie Anthony, Leanne De Koning, Nicolas Servant, Els Berns, et al.Curie Mitomicyn C,,RT2 lab Herceptine,,BFX lab GSK650394,S7209,Selleckchem APR246,,APREA AB Palbociclib,S1116,Selleckchem : List of drugs used.

(10) Cdk1-phosphorylated Nur77 accumulates at the centrosome during mitosis to regulate the Cep192–PLK1 signaling axisCell Death & DiseaseJune 3, 2026Guobin Xie, Qiqiang Wang, Mingxuan Du, Yuqi Zhou, Ziwen Chen, Shuangzhou Peng, Hualan Zhou, Xiaoli Zhang, Qi Cai, Gulimiran Alitongbieke, et al.PYR-41(Selleck Chemicals, S7129), RO-3306 (Selleck Chemicals, S7747), Palbociclib HCL (Selleck Chemicals, S1116), Flavopiridol (Selleck Chemicals, S1230), SB203580 (Selleck Chemicals, S1076), AKTi-1/2 (Selleck Chemicals,

(11) Stage-Specific Degradation of Cyclin D3 Orchestrates Myelopoiesis and Restrains Myeloproliferative Neoplasms DevelopmentCancer ResJune 1, 2026Bartosz Mucha, Vincenzo Tarallo, Ata Abbas, Melina Hall, Shuyuan Zhang, Marganit Farago, Polly J. Phillips-Mason, Harrison Lindley, Mark Cameron, Chen Zhao, et al.MethoCult M3434 medium supplemented with a single dose of either 250 nM palbociclib (Selleckchem, Cat# S1116, CAS# 827022-32-2) or 100 nM pemrametostat (Selleckchem, Cat# S8664, CAS# 1616392-22-3) for 21 days

(12) Low-dose EGFR inhibition unlocks ferroptosis susceptibility to sensitize chemotherapy in EGFR- high triple-negative breast cancerJournal of Biological ChemistryMay 25, 2026Xiaoxi Li, Ling Liu, Lingli Luo, Minyao Deng, Yong Jiang, Weijun Ren, Hui QianSorafenib (Sora, S1040), Trametinib (Trame, S2673), Ulixertinib (Ulixer, S7854) Palbociclib (Palbo, S1116) and Dinaciclib (Dina, S2768), were purchased from Selleck. Epigenetic modulators: Decitabine (DAC,

(13) Direct Mapping of CDK2 Substrates in Embryonic Stem Cells Uncovers an AP-Site Repair Mechanism via HMCES PhosphorylationbioRxivMay 23, 2026Benjamin R. Topacio, Eli-Eelika Esvald, Jürgen Tuvikene, Lida Langroudi, Tapan K. Maity, Lisa M. Jenkins, Travis H. Stracker, Mardo Kõivomägi, S. Ali Shariatifor 1h. Unless specified, the used concentrations were: 50 μM Palbociclib (PD-0332991; Selleckchem #S1116), 10 μM INX-315 (Selleckchem, #E1854), 50 μM RO-3306 (Cayman Chemical, #15149–5), 500 nM PF-06873600

(14) PIAS4 inhibition induces cell cycle arrest and exhibits a synergistic effect in combination with CDK4/6 inhibitor in breast cancer treatmentOncogeneMay 1, 2026Chen H, Hu X, Feng L, Cheng X, Zhu L, Xu F, Zhu T, Gao Y, Wang J, Jin H, et al.States). The following chemicals were used: N-ethylmaleimide (NEM; E3876, Sigma-Aldrich), palbociclib (S1116, Selleck), Subasumstat/TAK-981 (S8829, Selleck), 2-D08 (S8696, Selleck), and puromycin (S7417, Selleck).

(15) Elevated Protein Tyrosine Phosphatase Kappa Expression Is Associated With Disease Progression and Poor Prognosis of Pancreatic CancerCancer Diagn PrognMay 1, 2026ZIQIAN FANG, XIANGYI LIU, XIUYUN TIAN, BILAL AL-SARIREH, CHUNYI HAO, WEN G. JIANG, LIN YEinhibitor BSJ-03-123 (Cat. No. 6921; TOCRIS, Bristol, UK), the dual CDK4/6 inhibitor Palbocicilib (Cat. No. S1116 Selleckchem, Houston, TX, USA), and the CDK4 inhibitor 3-ATA (Cat. No. sc-202414; Santa Cruz Biotechnology)

(16) THE FAM53C/DYRK1A axis regulates the G1/S transition of the cell cycleeLifeApril 30, 2026Taylar Hammond, Jong Bin Choi, Miles W Membreño, Janos Demeter, Roy Ng, Debadrita Bhattacharya, Thuyen N Nguyen, Griffin G Hartmann, Caterina I Colón, Carine Bossard, et al.Attardi. The following small molecule inhibitors were used in cells: palbociclib HCl (Selleckchem #S1116) and puromycin (Thermo Fisher #A1113803). For DYRK1A kinase inhibition, we used SM13797 from Biosplice

(17) The FAM53C/DYRK1A axis regulates the G1/S transition of the cell cycleElifeApril 30, 2026Taylar Hammond, Jong Bin Choi, Miles W Membreño, Janos Demeter, Roy Ng, Debadrita Bhattacharya, Thuyen N Nguyen, Griffin G Hartmann, Caterina I Colon, Carine Bossard, et al.Attardi. The following small molecule inhibitors were used in cells: palbociclib HCl (Selleckchem #S1116) and puromycin (Thermo Fisher #A1113803). For DYRK1A kinase inhibition, we used SM13797 from Biosplice

(18) Multi-omics analysis and functional validation reveal the oncogenic role of TRIP13Frontiers in ImmunologyApril 22, 2026Yuanqiao Zhao, Yongqi Zhao, Ruilin Liu, Jing Li, Yinhuai Wang1:2,000), and cleaved caspase 3 (#25128-1-AP Proteintech, Wuhan, China; 1:1,000). Palbociclib HCl (#S1116) was purchased from Selleck (Shanghai, China). The sources of all the other reagents are explicitly

(19) Targeting TPX2-dependent lineage plasticity by CDK4/6 inhibition reverses therapy resistance in neuroendocrine bladder carcinomaCell Reports MedicineApril 21, 2026Zehua Chen, Shengmeng Peng, Shi Fu, Shizhi Lin, Yiwen Su, Xinxin He, Yangjie Zhang, Junlin Lu, Sen Liu, Hengji Zhan, et al.Selleck, Cat#S1714], 10 μM Etoposide [Eto; Selleck, Cat#S1225], 5 μM Palbociclib [Pal, Selleck, Cat#S1116], or 10 μg/mL αPD-1 (Selleck, Cat#A3039) for a total of 72 h. At the end of treatment, SYTOX dye (KeyGEN,

(20) CSF1R inhibitors mitigate CDK4/6 inhibitor-induced immunosuppression to increase antitumor immunity in HR+/HER2− breast cancerOncogeneApril 15, 2026Siwei Li, Yajie Gong, Hui Li, Siyu Liu, Yanling Yin, Yuanyuan Yu, Yijun Chu, Jianxun Hou, Jialin Liu, Huaixi Zhang, et al.B and C [33]. Drug selection The cell and animal studies utilized several compounds: Palbociclib (S1116, Selleck), Pexidartinib (S7818, Selleck), INCB3344 (S8220, Selleck, USA), Stattic (HY-13818, MCE), Phorbol

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