TIRAP (TLR2 and TLR4) Inhibitor Peptide Set from Novus Biologicals, a Bio-Techne Brand

Product Specs
ItemTIRAP (TLR2 and TLR4) Inhibitor Peptide Set
CompanyNovus Biologicals, a Bio-Techne Brand
Price $599.00Supplier Page View Company Product Page
Catalog NumberNBP2-26245
ApplicationsFlow Cytometry, In vitro assay
Research AreaImmunology, Innate Immunity, Prostate Cancer
FormatWhite solid Solubilize the peptides prior to use by preparing 2.5 mM stock solution in sterile water
Molecule NameTIRAP (TLR2 and TLR4)
TypeInhibitor Peptide Set
NCBI Full Gene NameTIR domain containing adaptor protein
NCBI Gene AliasesBACTS1, Mal, MyD88-2, wyatt
StorageAliquot and store at -20C or -80C. Avoid freeze-thaw cycles
SpeciesHuman, Mouse
Quantity1 mg (also 5 mg)

Specifications/Features

Available conjugates: Specificity: TLR2 and TLR4 Inhibitor Peptide: COBRA TLR2 and TLR4 Inhibitor interferes with interaction between TIRAP/Mal and TIR domain of TLR2 or TLR4.

Sizes Available: 1 mg (also 5 mg)

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Novus Biologicals, a Bio-Techne Brand

United States: 10771 E Easter Ave

Centennial, Colorado 80112

United States

Phone:
303-730-1950
888-506-6887

Email: novus@novusbio.com

Company Profile

Website: https://www.novusbio.com

(1) SAA restricts T cell mediated anti-tumor immunity by limiting antigen presentation in lung cancerFrontiers in immunologyJanuary 1, 2025Huang M, Shi R, Xu C, Zhang Y, Du X, Wen S, Wang C, Jiang F, Zhou G, Wang X, et al.(924903, R&D), rec. SAA1 (300-53, PeproTech), SMS121/CD36 inhibitor (HY-163541, MCE) and TLR2/4 inhibitor (NBP2-26245, Novus). Fresh medium with cytokines was replenished every 2 days. For the following co-culture experiments

(2) Streptococcus pneumoniae Evades Host Cell Phagocytosis and Limits Host Mortality Through Its Cell Wall Anchoring Protein PfbAFrontiers in cellular and infection microbiologyJanuary 1, 0001"Yamaguchi M, Hirose Y, Takemura M, Ono M, Sumitomo T, Nakata M, Terao Y, Kawabata S."

(3) Toll-like receptor 2/4 inhibitors can reduce preterm birth in miceThe Journal of international medical researchJanuary 1, 0001"Jing X, Min C, Qi Yun L, Shun Qin H, Li Rui L, Jia L, Run Mei M."

(4) Targeting Toll-like receptor (TLR) signaling by Toll/interleukin-1 receptor (TIR) domain-containing adapter protein/MyD88 adapter-like (TIRAP/Mal)-derived decoy peptidesThe Journal of biological chemistryJanuary 1, 0001"Couture LA, Piao W, Ru LW, Vogel SN, Toshchakov VY."

(5) Monocyte-lymphocyte fusion induced by the HIV-1 envelope generates functional heterokaryons with an activated monocyte-like phenotypeExperimental cell researchJanuary 1, 0001"Martínez-Méndez D, Rivera-Toledo E, Ortega E, Licona-Limón I, Huerta L."

(6) Toll-like receptors 2 and 4 mediate hyperglycemia induced macrovascular aortic endothelial cell inflammation and perturbation of the endothelial glycocalyxJournal of diabetes and its complicationsJanuary 1, 0001"Pahwa R, Nallasamy P, Jialal I."

(7) Toll-like receptors (TLR2 and TLR4) antagonist mitigates the onset of cerebral small vessel disease through PI3K/Akt/GSK3β pathway in stroke-prone renovascular hypertensive ratsBiotechnology & genetic engineering reviewsJanuary 1, 0001"Wang N, Guo W, Liu T, Chen X, Lin M."

(8) Hypoxia/reoxygenation-induced HMGB1 translocation and release promotes islet proinflammatory cytokine production and early islet graft failure through TLRs signalingBiochimica et biophysica acta. Molecular basis of diseaseJanuary 1, 0001"Cheng Y, Xiong J, Chen Q, Xia J, Zhang Y, Yang X, Tao K, Zhang S, He S."

(9) Attenuative Effects of Platelet-Rich Plasma on 30 kDa Fibronectin Fragment-Induced MMP-13 Expression Associated with TLR2 Signaling in Osteoarthritic Chondrocytes and Synovial FibroblastsJournal of clinical medicineJanuary 1, 0001"Lu HT, Lu JW, Lee CH, Peng YJ, Lee HS, Chu YH, Ho YJ, Liu FC, Shen PH, Wang CC."for 2 h, co-incubated with 10 times concentration (10×) TIRAP (TLR2 and TLR4) inhibitor peptide set (NBP2-26245, Novus Biologicals, Littleton, CO, USA) and PRP for 2 h, and then co-incubated with 30 kDa fibronectin

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