TRAF-6 Inhibitor Peptide Set from Novus Biologicals, a Bio-Techne Brand

Product Specs
ItemTRAF-6 Inhibitor Peptide Set
CompanyNovus Biologicals, a Bio-Techne Brand
Price $599.00Supplier Page View Company Product Page
Catalog NumberNBP2-26506
Quantity2 mg (also 5 mg)
SpeciesHuman, Mouse, Rat
ImmunogenFunctions as a TRAF6 decoy by binding to the T6DP motif of RANK, thereby preventing binding of RANK to TRAF6
ConcentrationLYOPH
ApplicationsIn vitro assay, Block/Neutralize
Research AreaImmunology, Innate Immunity, Signal Transduction, Zinc Finger
FormatWhite Solid Solubilize the peptides prior to use by making 5 mM PBS* stock solutions (please see Preparation of 5 mM Stock Solutions under Preparation Method)
Molecule NameTRAF-6
TypeInhibitor Peptide Set
StorageStore at -20C. Avoid freeze-thaw cycles
NCBI Full Gene NameTNF receptor associated factor 6
NCBI Gene AliasesMGC:3310, RNF85

Specifications/Features

Available conjugates: Specificity: The TRAF6 inhibitory peptide also contains a protein transduction (PTD) sequence (DRQIKIWFQNRRMKWKK) derived from antennapedia which renders the peptide cell permeable. The control peptide consists of only the PTD sequence.

Sizes Available: 2 mg (also 5 mg)

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Novus Biologicals, a Bio-Techne Brand

United States: 10771 E Easter Ave

Centennial, Colorado 80112

United States

Phone:
303-730-1950
888-506-6887

Email: novus@novusbio.com

Company Profile

Website: https://www.novusbio.com

(1) Virtual slide telepathology workstation of the future: lessons learned from teleradiologyHuman pathologyAugust 1, 2009Krupinski EA.

(2) Evidence that genetic deletion of the TNF receptor p60 or p80 in macrophages modulates RANKL-induced signalingBloodJanuary 1, 0001"Takada Y, Aggarwal BB."

(3) Cooperative role of NF-{kappa}B and poly(ADP-ribose) polymerase 1 (PARP-1) in the TNF-induced inhibition of PHEX expression in osteoblastsThe Journal of biological chemistryJanuary 1, 0001"Majewski PM, Thurston RD, Ramalingam R, Kiela PR, Ghishan FK."

(4) Interleukin-6 (IL-6) and IL-17 synergistically promote viral persistence by inhibiting cellular apoptosis and cytotoxic T cell functionJournal of virologyJanuary 1, 0001"Hou W, Jin YH, Kang HS, Kim BS."

(5) Lipopolysaccharide signaling without a nucleus: kinase cascades stimulate platelet shedding of proinflammatory IL-1β-rich microparticles"Journal of immunology (Baltimore, Md. : 1950)"January 1, 0001"Brown GT, McIntyre TM."

(6) Inhibition of RANKL-mediated osteoclast differentiation by selective TRAF6 decoy peptidesBiochemical and biophysical research communicationsJanuary 1, 0001"Poblenz AT, Jacoby JJ, Singh S, Darnay BG."

(7) Dynamic protein associations define two phases of IL-1beta transcriptional activation"Journal of immunology (Baltimore, Md. : 1950)"January 1, 0001"Zhang Y, Saccani S, Shin H, Nikolajczyk BS."

(8) Evidence that receptor activator of nuclear factor (NF)-kappaB ligand can suppress cell proliferation and induce apoptosis through activation of a NF-kappaB-independent and TRAF6-dependent mechanismThe Journal of biological chemistryJanuary 1, 0001"Bharti AC, Takada Y, Shishodia S, Aggarwal BB."

(9) Distinct molecular mechanism for initiating TRAF6 signallingNatureJanuary 1, 0001"Ye H, Arron JR, Lamothe B, Cirilli M, Kobayashi T, Shevde NK, Segal D, Dzivenu OK, Vologodskaia M, Yim M, et al."

(10) RIP2 Gates TRAF6 Interaction with Death Receptor p75^NTR to Regulate Cerebellar Granule Neuron SurvivalCell reportsJanuary 1, 0001"Kisiswa L, Fernández-Suárez D, Sergaki MC, Ibáñez CF."

(11) TLR2 Plays a Key Role in Platelet Hyperreactivity and Accelerated Thrombosis Associated With HyperlipidemiaCirculation researchJanuary 1, 0001"Biswas S, Zimman A, Gao D, Byzova TV, Podrez EA."

(12) The Pancreatic Cancer Microbiome Promotes Oncogenesis by Induction of Innate and Adaptive Immune SuppressionCancer discoveryJanuary 1, 0001"Pushalkar S, Hundeyin M, Daley D, Zambirinis CP, Kurz E, Mishra A, Mohan N, Aykut B, Usyk M, Torres LE, et al."

(13) Epstein-Barr virus-driven B cell lymphoma mediated by a direct LMP1-TRAF6 complexNature communicationsJanuary 1, 0001"Giehler F, Ostertag MS, Sommermann T, Weidl D, Sterz KR, Kutz H, Moosmann A, Feller SM, Geerlof A, Biesinger B, et al."

(14) Autophagy-linked FYVE containing protein WDFY3 interacts with TRAF6 and modulates RANKL-induced osteoclastogenesisJournal of autoimmunityJanuary 1, 0001"Wu DJ, Gu R, Sarin R, Zavodovskaya R, Chen CP, Christiansen BA, Zarbalis KS, Adamopoulos IE."and M-CSF ELISA (R&D Systems, DY416), RANKL ELISA (R&D Systems, DY462), and TRAF6 inhibitor (Novus, NBP2-26506) were used for in vitro experiments. CMG14-12 (CMG) media was generated as described before [24]. Collagenase

(15) "RANKL/RANK is required for cytokine-induced beta cell death; osteoprotegerin, a RANKL inhibitor, reverses rodent type 1 diabetes"Science advancesJanuary 1, 0001"Kondegowda NG, Filipowska J, Do JS, Leon-Rivera N, Li R, Hampton R, Ogyaadu S, Levister C, Penninger JM, Reijonen H, et al."

(16) TRAF6 mediates human DNA2 polyubiquitination and nuclear localization to maintain nuclear genome integrityNucleic acids researchJanuary 1, 0001"Meng Y, Liu C, Shen L, Zhou M, Liu W, Kowolik C, Campbell JL, Zheng L, Shen B."h at a final concentration of 30 μM. The TRAF6 inhibitory peptide T6PD (Novus Biologicals, Catalog #NBP2–26506) was added for 24 h at a final concentration of 100 μM. The ataxia-telangiectasia mutated (ATM) inhibitor

(17) Lipopolysaccharide stimulates platelets through an IL-1β autocrine loop"Journal of immunology (Baltimore, Md. : 1950)"January 1, 0001"Brown GT, Narayanan P, Li W, Silverstein RL, McIntyre TM."

(18) Molecular determinants of TRAF6 binding specificity suggest that native interaction partners are not optimized for affinityProtein science : a publication of the Protein SocietyJanuary 1, 0001"Halpin JC, Whitney D, Rigoldi F, Sivaraman V, Singer A, Keating AE."to promote cell entry is currently sold commercially as a TRAF6 inhibitor (e.g., Novus Biologicals NBP2‐26506). 16 The reported affinity of a RANK peptide with sequence RKIPTEDEY for TRAF6 is 78 μM, determined

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