Dorsomorphin (Compound C), AMP-kinase inhibitor from Abcam

Product Specs
ItemDorsomorphin (Compound C), AMP-kinase inhibitor
CompanyAbcam
Price Supplier Page View Company Product Page
Catalog Numberab120843
Quantity5 mg, 10 mg, 50 mg
Purity0.99
TypeInhibitor, inhibitor
Molecule NameDorsomorphin

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(1) Lentinan Improves Sodium Arsenite-Induced Hepatic Lipid Accumulation and Ferroptosis: Role of AMPK Signaling PathwayToxicsAugust 7, 2026Shunli Luo, Yekang Deng, Yan Lu, Yuan YangDuma Biotechnology Co., Ltd., Shanghai, China) or an AMPK inhibitor compound C (CC, CAS.866405-64-3, ab120843, Abcam, Cambridge, UK), as the intervention agent, were dissolved in phosphate-buffered saline (PBS).

(2) Sotagliflozin ameliorates doxorubicin-induced cardiomyopathy by regulating inflammation and mitochondrial dysfunction through the AMPK/mTOR pathwayExp Ther MedJune 4, 2026Haifeng Liu, Danye Han, Meiling Liinhibitor experiments, cells were concomitantly administered DOX and SOTA with 10 µM Compound C (cat. no. ab120843; Abcam). Cell Counting Kit-8 (CCK-8) cell viability assay A CCK-8 assay was used to determine cell

(3) Met@MPDA rejuvenates BMSC energy metabolism to promote bone regeneration in semaglutide-treated obese periodontitisMater Today BioMay 14, 2026Ting Jiang, Tian-Hao Wan, Min-Jie Wang, Xue-Qin Zhu, Yu-Ran Jiang, Feng Yang, Zhi-Chen Ling, Xin-Yi Tan, Jun Wang, Ning-Juan Ouyang(1:5000, D16H11, Cell Signaling Tech Inc., USA). For the indicated groups, compound C (10 μm, Abcam, #ab120843) or AICAR (2.5 mM, Abcam, #ab120358) was added to the culture medium for in vitro experiments. 2.11

(4) Targeting p75NTR activity alleviates the neurotoxic effect of high glucose on iPSC-derived dopaminergic neuronsStem Cell Research & TherapyMarch 21, 2026Konstantina Chanoumidou, Ioanna Zota, Maria Anna Papadopoulou, Chrystalla Konstantinou, Alexandros Tsimpolis, Electra Tsagliotis, Maria Tziortziou, Katerina Ntarntani, Anne Grünewald, Matthieu David Lavigne, et al.in human embryonic stem cell (hESC) medium without FGF2 supplemented with 1 µM Dorsomorphin (Abcam, ab120843), 3 µM CHIR99021 (Sigma, SML1046), 10 µM SB-431542 (Stem Cell Technologies, 72232) and 0.5 µM Purmorphamine

(5) p75 neurotrophin receptor shapes the dynamics of adult hippocampal neurogenesis in Alzheimer’s diseaseAlzheimer's Research & TherapyFebruary 20, 2026Maria Anna Papadopoulou, Konstantina Chanoumidou, Maria Peteinareli, Electra Tsaglioti, Konstantina Michalaki, Matthieu D. Lavigne, Ioannis Charalampopoulos(C1764, Sigma) and resuspended in the same medium without FGF2, supplemented with 1 µM Dorsomorphin (ab120843, Abcam, Cambridge, UK), 3 µM CHIR99021 (SML1046, Sigma), 10 µM SB-431542 (72232, Stem Cell Technologies,

(6) Lysine acetyltransferase 2A-mediated succinylation of adenosine monophosphate-activated protein kinase suppresses gallstone formation by inhibiting inflammation and pyroptosisWorld Journal of GastroenterologyOctober 21, 2025Xin-Xing Wang, Ming-Ze Ma, Li-Chao Zhu, Long-Fei Dai, Chuan Qin, Shuai Shao, Xian-Wen Xu, Ru-Xin Gao, Zhen-Hai Zhangpreviously[22]. Additionally, GMECs were treated with the AMPK inhibitor dorsomorphin (DOR; purity > 99%; ab120843; 10 μmol/L; Abcam) for 24 hours to assess AMPK signaling involvement. The empty pcDNA3.1 vector, pcDNA3.1-KAT2A

(7) Lysine acetyltransferase 2A-mediated succinylation of adenosine monophosphate-activated protein kinase suppresses gallstone formation by inhibiting inflammation and pyroptosisWorld J GastroenterolOctober 21, 2025Xin-Xing Wang, Ming-Ze Ma, Li-Chao Zhu, Long-Fei Dai, Chuan Qin, Shuai Shao, Xian-Wen Xu, Ru-Xin Gao, Zhen-Hai Zhangpreviously[22]. Additionally, GMECs were treated with the AMPK inhibitor dorsomorphin (DOR; purity > 99%; ab120843; 10 μmol/L; Abcam) for 24 hours to assess AMPK signaling involvement. The empty pcDNA3.1 vector, pcDNA3.1-KAT2A

(8) Astragaloside IV improves the survival rates of retinal ganglion cells in traumatic optic neuropathy by regulating autophagy mediated by the AMPK-MTOR-ULK signaling pathwayMol VisMarch 28, 2025Wu Sun, Guojun Chao, Qiong Wu, Yanting Xia, Mengqiu Shang, Qiping Wei, Jian Zhou, Liang LiaoCo., Ltd., Shanghai, China), rapamycin (ab146591; Abcam, Cambridge, UK), compound C (dorsomorphin, ab120843; Abcam), LC3B (E5Q2K) mouse mAb (83506S; CST, Boston, MA), AMPKα (D63G4) rabbit mAb (40308ES20; CST),

(9) EXPRESS: AMPK Activation Mitigates Inflammatory Pain by Modulating STAT3 Phosphorylation in Inflamed Tissue Macrophages of Adult Male MiceMol PainFebruary 21, 2025Hongchun Xiang, Yuye Lan, Liang Hu, Renjie Qin, Hongping Li, Tao Weng, Yan Zou, Yongmin Liu, Xuefei Hu, Wenqiang Ge, et al.AMPK to decrease iNOS expression, NR8383 cells were treated with AICAR(0.5 mM) and Compound C (Abcam, #ab120843, 20 μM) before N.S.(Control) or CFA (100 μg/ml) treatment. NR8383 cells were exposed to CFA or vehicle

(10) Identification of a novel neutralization epitope in rhesus AAVsMolecular Therapy - Methods & Clinical DevelopmentDecember 12, 2024Gabriel Dagotto, Jana L. Fisher, David Li, Zhenyu Li, Simon Jenni, Zongli Li, Lawrence J. Tartaglia, Peter Abbink, Dan H. Barouch37°C for 1 h. During this incubation, cells were incubated with 20 μM dorsomorphin (Abcam, catalog no. ab120843) at 37°C for 1 h. After incubation, 10 μL AAV vector and serum mixture was added to the cells (still

(11) Decreased AMPK/SIRT1/PDK4 induced by androgen excess inhibits human endometrial stromal cell decidualization in PCOSCellular and Molecular Life SciencesDecember 1, 2024Ling Hong, Shan Xiao, Lianghui Diao, Ruochun Lian, Cong Chen, Yong Zeng, Su Liu(DCA) (Selleck, USA, S8615), A-769662 (Abcam, UK, ab120335), Dorsomorphin (Compound C) (Abcam, UK, ab120843), SRT1720 (Abcam, UK, ab273598), EX527 (Abcam, UK, ab141506), and ARV-110 (Selleck, USA, S6965). It

(12) Tensin-2 interactomics reveals interaction with GAPDH and a phosphorylation-mediated regulatory role in glycolysisScientific reportsAugust 27, 2024Turkki P, Chowdhury I, Öhman T, Azizi L, Varjosalo M, Hytönen VP.3 µM (Abcam, ab141409) and FAK14 5 µM (Abcam ab144503) or 24 h prior as with compound C 5 µM (Abcam ab120843), Y27632 5 µM (Abcam, ab120129) and wortmannin 3 µM (Abcam, ab120148). mRNA sequencing mRNA was isolated

(13) Nesfatin-1 and nesfatin-1-like peptide attenuate hepatocyte lipid accumulation and nucleobindin-1 disruption modulates lipid metabolic pathwaysCommunications BiologyMay 27, 2024Atefeh Nasri, Mateh Kowaluk, Scott B. Widenmaier, Suraj Unniappanmode. Mechanism of action of NLP and NESF-1 on HepG2 cells A specific AMPK inhibitor, compound C (cat no. ab120843, ABCAM, UK) was used to block AMPK-mediated pathway in HepG2/C3A cells. Briefly, OA-induced cells at

(14) AMPK activation attenuates central sensitization in a recurrent nitroglycerin-induced chronic migraine mouse model by promoting microglial M2-type polarizationJ Headache PainMarch 8, 2024Guangshuang Lu, Shaobo Xiao, Fanchao Meng, Leyi Zhang, Yan Chang, Jinjing Zhao, Nan Gao, Wenjie Su, Xinghao Guo, Yingyuan Liu, et al.5-aminoimidazole-4-carboxamide-1-β-D-ribofuranoside (AICAR, ab120358, Abcam) and the AMPK inhibitor compound C (Abcam, ab120843). AICAR has been extensively studied as an AMPK activator in various cell types. It mimics the function

(15) Overcoming BCR::ABL1 dependent and independent survival mechanisms in chronic myeloid leukaemia using a multi-kinase targeting approachCell Communication and SignalingNovember 29, 2023Caroline Busch, Theresa Mulholland, Michele Zagnoni, Matthew Dalby, Catherine Berry, Helen Wheadonwell. Inhibitors 100 mM imatinib (IM) (S2475, Selleckchem) stock in water was stored at 4˚C; Dorsomorphin (DOR) (ab120843, Abcam) and saracatinib (SC) (S1006, Selleckchem) 10 mM stocks in DMSO stored at -80˚C. Inhibitors were

(16) Salicylate induces AMPK and inhibits c-MYC to activate a NRF2/ARE/miR-34a/b/c cascade resulting in suppression of colorectal cancer metastasisCell Death & DiseaseOctober 28, 2023Chunfeng Liu, Matjaz Rokavec, Zekai Huang, Heiko HermekingH2O to a 600 mM stock solution and applied at 5 mM working concentration. Dorsomorphin (Compound C, ab120843, Abcam) was dissolved in DMSO with a concentration of 10 mM. siGENOME Human NRF2 SMARTPOOL (Horizon

(17) Advanced glycation end products impair coronary artery BK channels via AMPK/Akt/FBXO32 signaling pathwayDiabetes and Vascular Disease ResearchAugust 18, 2023Xiao-Yan Li, Ling-Ling Qian, Ying Wu, Yu-Min Zhang, Shi-Peng Dang, Xiao-Yu Liu, Xu Tang, Cun-yu Lu, Ru-Xing Wangthe mechanisms involved in the AMPK/Akt signaling pathway in human coronary SMCs, Compound C (Abcam, #ab120843), an inhibitor of AMPK, and MK2206 (Beyotime, #SF2712), an inhibitor of Akt, were used to modulate the

(18) Inhibition of the LRRC8A channel promotes microglia/macrophage phagocytosis and improves outcomes after intracerebral hemorrhagic strokeiScienceDecember 22, 2022Liu J, Shen D, Wei C, Wu W, Luo Z, Hu L, Xiao Z, Hu T, Sun Q, Wang X, et al.macrophages and microglia for 6 h. We treated cells with 5 μM ML385 (S8790, Selleck, USA), 10 μM Compound C (ab120843, Abcam, USA), anti-IgA (1:500, ab37322, Abcam), or anti-CD36 (1:500, ab23680, Abcam) 2 h before hemin

(19) Protective effects of metformin against myocardial ischemia‑reperfusion injury via AMPK‑dependent suppression of NOX4Molecular medicine reportsOctober 1, 2021Shi Y, Hou SA.compound-C (HR + met + compound-C), at the onset of reoxygenation, metformin and compound-C (10 nM; cat. no. ab120843; Abcam) were added into the medium simultaneously (the dose of compound-C used in the present study

(20) An AMP-activated protein kinase complex with two distinctive alpha subunits is involved in nutritional stress responses in Trypanosoma cruziPLOS Neglected Tropical DiseasesMay 24, 2021Tamara Sternlieb, Alejandra C. Schoijet, Patricio D. Genta, Salomé C. Vilchez Larrea, Guillermo D. Alonsoprotein extract samples. For Dorsomorphin (CC) (#P5499, Sigma Aldrich, St. Louis, Missouri, United States or ab120843, Abcam, Cambridge, United Kingdom) treatment protein extracts were incubated in an ice bath with the 1

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Dorsomorphin (Compound C), AMP-kinase inhibitor from Abcam

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Dorsomorphin (Compound C), AMP-kinase inhibitor from Abcam

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