Description
FIPI is a cell-permeable, PC-PLD1/2 (PLD1/2) inhibitor (IC:50:= 1 nM and 10 nM for PLD1 and PLD2, respectively, in a CHO cell based assay, and IC:50:= 20 nM for PLD2 in a biochemical assay), that displays no activity toward MitoPLD, and is selective for PLD1 and PLD2 over other PLD superfamily enzymes. FIPI is also shown to block PLD2-dependent effects on cytoskeletal reorganization and cell trafficking in CHO cells, and diminish fMLP-directed neutrophil chemotaxis in HL60 cells at 750 nM