Description
Pep-1 is a synthetic cell-penetrating peptide (CPP) that has been successfully used to deliver a variety of proteins and other biopharmaceutical macromolecules into cells in a non-disruptive manner. It is a CPP with primary amphipathicity that comprises a tryptophan-rich so-called "hydrophobic" domain, a hydrophilic domain derived from an NLS (nuclear localization signal) of SV40 (simian virus 40) large T-antigen, and a spacer between them. The C-terminal cysteamine group appears to play a crucial role in the delivery efficiency of cargoes into cells