ML385 from MedChemExpress

Product Specs
ItemML385
CompanyMedChemExpress
Price $68.00Supplier Page View Company Product Page
Catalog NumberHY-100523
Quantity10 mM * 1 mL
ApplicationsBioactivity, Structure and function analysis, ELISA, SDS-PAGE, Western blotting
Purity99.96%
TypeChemical
Molecular Weight511.59
FormulaC₂₉H₂₅N₃O₄S
Research AreaCancer

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(1) The role of salvianolic acid B and benzoylpaeoniflorin in enhancing angiogenesis through Nrf2/HO-1/VEGFA signaling axis in ischemic stroke recoveryPharmaceutical BiologyDecember 31, 2026Chao Zhao, Xiaodan Bai, Yi Ding, Aiguo Zeng, Aidong Wen, Qiang Fu, Jingwen WangBio-Technology Co., Ltd (Suzhou, China). Ponatinib (CAS: 943319-70-8, HY-12047) and ML385 (CAS: 846557-71-9, HY-100523) were purchased from MCE (NJ, USA). Trizol was purchased from Thermo Fisher Scientific (15596018CN,

(2) Uric acid alleviates the inflammatory response in LPS-induced BV2 cells and MPTP-induced PD mice by resisting ferroptosis through the Nrf2 signalling pathwayRedox RepDecember 31, 2026Dongmei Zhou, Tian Xiong, Bing Yang, Fanjie Liu, Xianglai Mo, Ting Chen, Peipei Lu, Xinghuan Liang, Li Li, Yingfen Qin, et al.sourced from Sigma-Aldrich (Darmstadt, Germany). Probenecid (PBN, Cat. No. HY-B0545), ML385 (Cat. No. HY-100523), MPTP (Cat. No. HY-15608) and MPP+ (Cat. # HY-W008719) were purchased from MedChemExpress (New Jersey,

(3) JP1 peptide modulates oxidative stress and autophagy via Keap1-Nrf2-ARE in ALS model miceBMC MedAugust 25, 2026Yu Zhang, Yaxi Liu, Shiyu Shi, Qingyang Li, Yani Huo, Pan You, Mingzhu Shu, Xi Cheng, Jun Zhang, Dong Liang, et al.group (150 mg/kg of JP1 + 30 mg/kg of ML385, administered intraperitoneally, once daily). ML385 (MCE, HY-100523) was dissolved in DMSO (final DMSO concentration < 1%) and administered intraperitoneally 2 h before

(4) Activation of the Nrf2-ARE Signaling Pathway Mediates the Neuroprotective Effects of Exercise in a Mouse Model of Chronic Parkinson's DiseaseInt J Mol SciAugust 20, 2026Shuwei Zhang, Dong Yang, Changfa Tang, Yu Zhangprotein (CBP) to suppress the transcriptional activity of Nrf2. ML385 (MCE, Shanghai, China, Cat. No. HY-100523) was dissolved in DMSO to prepare a 50 mg/mL stock solution, which was stored at −20 °C under light

(5) Baicalein Attenuates High Glucose and Sodium Palmitate-Induced Ferroptosis in Cardiomyocytes via the Nrf2/SLC7A11/GPX4 Signaling PathwayInt J Mol SciJuly 18, 2026Huan Wang, Yuhan Xu, Lei Wang, Wanting Meng, Yanwu Xu, Haidong Guobaicalein, AC16 cells were treated with the Nrf2 inhibitor ML385 (MedChemExpress, Shanghai, China; Cat. No. HY-100523) at a final concentration of 1 μmol/L [78]. For the ML385-related cell viability assay, cells were assigned

(6) Sivelestat sodium alleviates sepsis-associated acute lung injury by inhibiting ferroptosis via the Nrf2/SLC7A11/GPX4 axisPLoS OneJuly 14, 2026Ying Wang, Xiaoling Xia, Yan Lu, ChengLiang Zhang, Yaqing Zhou, Jingjing Fanmechanistic validation experiment 2.4.1 Reagents and equipment. The Nrf2 inhibitor ML385 (Cat. No. HY-100523) was purchased from MedChemExpress (USA). The rabbit anti-Lamin B1 antibody was purchased from Wuhan

(7) Isopropyl 3-(3,4-Dihydroxyphenyl)-2-Hydroxypropanoate Attenuates Experimental Renal Ischemia-Reperfusion Injury by Limiting Sterile Inflammation and Preserving Mitochondrial Function: Involvement of an Nrf2-Associated Cytoprotective ResponseJ Inflamm ResJuly 10, 2026Xiaofei Yan, Yuli Miao, Ying Zhang, Yixuan Li, Ziyi Wang, Zhaoqi Pu, Xiaohui Zheng, Jin Zheng(GB23303), and the bicinchoninic acid protein assay kit were obtained from Servicebio (Wuhan, China). ML385 (HY-100523) was purchased from MedChemExpress (Monmouth Junction, NJ, USA). IDHP (purity >98% by high-performance liquid chromatography

(8) Oxidative stress-driven m5C methylation by NSUN5 confers cisplatin resistance in lung adenocarcinoma through promoting glycolysisRedox BiologyJuly 1, 2026Xin Wang, Jinfeng Ning, Mengru Cao, Wei Liu, Siyi Sun, Man Dou, Li Cai, Ying Xingin Supplemetary Table S1. The ROS scavenger Tempol (Cat# HY-100561) and Nrf2 inhibitor ML385 (Cat# HY-100523) were purchased from MedChemExpress (Shanghai, China). 5.3 RNA extraction and quantitative real-time PCR

(9) Salvianic Acid A Regulates Ferroptosis by Activating the Nrf2-GPX4 Pathway Through EGFR to Protect Myocardial Ischemia-Reperfusion InjuryJ Inflamm ResJune 19, 2026Lin Tu, Yuming Lu, Xingde Liu, Xiangchun Shen+ Salvianic acid A-high (300 μM), and H/R + Salvianic acid A-high + Nrf2 inhibitor ML385 (5 μM, no. HY-100523, MCE, USA) groups. The fourth part included control, H/R, H/R + Salvianic acid A-high (300 μM), H/R

(10) miR-941 in extracellular vesicles confers anlotinib resistance via Keap1/Nrf2 axis and represents a therapeutic target in non-small cell lung cancerClin Transl MedJune 15, 2026Aimi Huang, Xiaoqi Li, Erpeng Wu, Menglan Hao, Weimin Wang, Jinjing Xiain vitro treatments, the following reagents were used: anlotinib (MCE, Cat#HY‐101416), ML385 (MCE, Cat#HY‐100523; specific Nrf2 inhibitor), the TNF‐α neutralizing antibody infliximab (MCE, Cat#HY‐P9970), and the pan‐caspase

(11) SERPINE2-mediated activation of JAK2/STAT3 facilitates NRF2 nuclear translocation and GCLC transcription to confer ferroptosis resistance and lenvatinib resistance in hepatocellular carcinomaJournal of Experimental & Clinical Cancer ResearchJune 6, 2026Kan Liu, Shenglan Huang, Yongkang Xu, Ye Mao, Ning Chen, Yixin Yuan, Qinwen Xiao, Shumin Fu, Jianbing WuShanghai, China; HY-15763), ferrostatin-1 (MCE, Shanghai, China; HY-100579), ML385 (MCE, Shanghai, China; HY-100523), ruxolitinib (MCE, Shanghai, China; HY-50856), sulfobutylether-β-cyclodextrin (SBE-β-CD; MCE, Shanghai,

(12) Forsythiaside A Alleviates LPS-Induced Mastitis by Inhibiting Ferroptosis and Oxidative StressAnimals (Basel)June 5, 2026Zhonghua Hao, Kai Shi, Jiang Tong, Ruya Zhang, Xinyue Li, Li Wang, Xinhui Yao, Yi Fan, Xu Yang, Xiao Li, et al.Wuhan, Hubei, China; small-molecule reagents Fer-1 (Cat#HY-100579), RSL3 (Cat#HY-100218A), ML385 (Cat#HY-100523) were purchased from MedChemExpress, Monmouth Junction, NJ, USA; BCA assay kit (Cat#ZJ102) was purchased

(13) DL-3-n-Butylphthalide Protects Against PrP106 -126-Induced Neurotoxicity Through NRF2 Signaling and OPA1/DRP1-Mediated Mitochondrial DynamicsCNS Neurosci TherJune 2, 2026Wei Wu, Xixi Zhang, Mingyue Jiang, Ning MaCells underwent a 24 h pretreatment with NBP (10 mM) before PrP106‐126 exposure. ML385 (MedChemExpress, HY‐100523, USA) was prepared in DMSO (5 mM). N2a cells underwent a 12 h pretreatment with ML385 (5 mM) before

(14) MK8722 alleviates osteoarthritis by activating Sesn2 and transcriptionally upregulating BNIP3 to promote mitophagy and inhibit chondrocyte ferroptosisJournal of Advanced ResearchJune 1, 2026Haochen Wang, Ze Zhao, Jianbang Su, Wenzheng Chen, Haoyan Shi, Tianqi Gao, Minghao Yu, Lunhao Bai, Peng Dong, Qian Zhang, et al.mRNA expression was evaluated after 24 h, and protein expression was assessed at 48 h. 10 μm ML385 (HY-100523, MedChemExpress) was used to establish an Nrf2 inhibition cell model, and 10 μm MK8722 (HY-111363, MedChemExpress)

(15) Asperosaponin VI Ameliorates Spontaneous Abortion by Inhibiting Trophoblast Ferroptosis via the KEAP1/NRF2/GPX4 AxisAntioxidants (Basel)May 31, 2026Yangyang Duan, Xinyu Xiao, Jiahong Chen, Xianglun Ji, Jinghang Yang, Zhangrui Nie, Hairuo Chen, Yingxi Wei, Yuhan Wu, Zhonglin Chen, et al.B20204-20 mg) was purchased from Yuanye Bio-Technology (Shanghai, China); the NRF2 inhibitor ML385 (HY-100523) and ferroptosis inducer Erastin (HY-15763) were obtained from MedChemExpress (Monmouth Junction, NJ,

(16) USP33 alleviates FIS1-dependent mitochondrial fission and cardiac microvascular injury in diabetic cardiomyopathy via deubiquitinating and stabilizing ATG7Cell Death & DiseaseMay 30, 2026Yuqiong Chen, Xiangyu Sun, Xinyan Li, Bo Guan, Xiaopei Yan, Chao Huang, Nannan Zhang, Wenjun Mao, Yuan Tian, Chao Chen, et al.(HY-10219), Tenilsetam (HY-131528), JSH-23 (HY-13982), Go 6983 (HY-13689), Tempol (HY-100561) and ML385 (HY-100523 were purchased from MedChemExpress (USA). Anti-USP33 antibody (20445-1-AP), anti-FIS1 antibody (66635-1-Ig),

(17) Sulforaphane Alleviates Zearalenone-Induced Oxidative Stress in Bovine Mammary Epithelial CellsAnimals (Basel)May 25, 2026Yurong Fu, Tingting Liu, Peng Peng, Xi Chen, Siwei Wang, Shuang Liang, Shaoqing Shi, Chuanqi Wang, Kun Wang(S5676, Houston, TX, USA). Sulforaphane (HY-13755, purity ≥ 98%) and the Nrf2 inhibitor ML385 (Cat. No. HY-100523) was obtained from MedChemExpress (South Brunswick Township, NJ, USA). DMEM basal medium (6124323),

(18) Sauchinone attenuates UVB-induced photoaging by suppressing oxidative stress and ferroptosis through activation of the Keap1-Nrf2 pathway in dermal fibroblastsPharm BiolMay 21, 2026Xinyi Zhang, Jing Wang, Ying Zhou, Chenye Shen, Minjia Yuan, Qi Li, Wei Liconcentration of 20 μg/mL), MG132 (HY-13259, at a final concentration of 5 μM), and the Nrf2 inhibitor ML385 (HY-100523, at a final concentration of 5 μM) were obtained from MedChemExpress (MCE, USA) and prepared as DMSO

(19) Formononetin alleviated cisplatin-induced acute kidney injury by orchestrating renal tubular cell ferroptosis via PI3K/AKT/NRF2 pathwayFrontiers in PharmacologyMay 18, 2026Xiang Li, Jiayi Yan, Yao Xu, Zicheng Ling, Tianyi Zhang, Xinghua Shao, Jia Xia, Lumin Tang, Shan Mou(HY-17394), formononetin (HY-N0183), LY294002 (HY-10108), Deferoxamine (DFO) (HY-B0988) and ML385 (HY-100523) were purchased from MedChemExpress. Anti-GPX4 (67763-1-Ig; 1:1000) antibody was purchased from Proteintech.

(20) Machine learning-based integration of transcriptome and digital pathology for predicting chemoresistance in muscle-invasive bladder cancerExperimental & Molecular MedicineMay 8, 2026Jinahn Jeong, Gowun Jeong, YongHwan Kim, Hyein Ju, Hyun Jun Im, Hyun Ji Kim, Ja-Min Park, Se Un Jeong, Seungun Lee, Min Gi Jang, et al.reported1,2,14. Cells were treated with cisplatin (Sigma-Aldrich) or KEAP1–NRF2 inhibitors including ML385 (HY-100523, MedChemExpress) and R16 (HY-149508) for 24 h at the indicated concentrations. For overexpression of

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ML385 from MedChemExpress

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