Sivelestat from MedChemExpress

Product Specs
ItemSivelestat
CompanyMedChemExpress
Price $92.00Supplier Page View Company Product Page
Catalog NumberHY-17443
Quantity10 mM * 1 mL
ApplicationsBioactivity, Structure and function analysis, ELISA, SDS-PAGE, Western blotting
Purity99.34%
TypeChemical
Molecular Weight434.46
FormulaC₂₀H₂₂N₂O₇S
Research AreaCancer

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(1) Diabetes Mellitus Facilitates Gallstone Formation Through CXCR2‐NETs–Mediated Liver‐Bile Barrier DamageAdvanced ScienceFebruary 16, 2026Chao Shi, Shuo Feng, Tianming Liu, Ziang Meng, Yi Zheng, Zhenghao Huang, Tong Wang, Bojian Zhang, Dongbo Xue, Biao Ma, et al.with either the vehicle control (DMSO), the neutrophil elastase (NE) inhibitor sivelestat (0.05 µM; HY‐17443, MCE), the myeloperoxidase (MPO) inhibitor AZD5904 (140 nm; HY‐111341, MCE), the competitive matrix

(2) Thrombomodulin protects against acute vascular and multiorgan injury in sickle cell diseaseJCI InsightJanuary 23, 2026Guohui Ren, Dustin R. Fraidenburg, Suman Setty, Jiwang Chen, Janae Gonzales, Maria Armila Ruiz, Zalaya Ivy, Najmeh Eskandari, Richard D. Minshall, James P. Lash, et al.in hospitalized patients (24 hours). For the neutrophil elastase inhibition experiments, sivelestat (HY-17443, MedChemExpress LLC), a specific neutrophil elastase inhibitor, was utilized. Mice were treated with

(3) Neutrophils Induce P-Selectin Shedding from Activated Platelets Via Neutrophil ElastaseInflammationDecember 1, 2025Huang Y, Ling L, He S, Liu C, Huang X, Wang S, Yu Z, Zhou J.activated platelets, neutrophils were pre-treated with neutrophil elastase (NE) inhibitor Sivelestat (HY-17443, MedChemExpress, 1 mM), myeloperoxidase (MPO) inhibitor ABAH (475944-1GM, EMD Millipore, 2 mM), Latrunculin

(4) Xiao Qing Long Tang ameliorates neutrophil extracellular trap-dendritic cells-T helper 17 cell axis in Neutrophilic AsthmaPLOS OneNovember 6, 2025Xiaoying Ji, Hongda Chen, Sheng-dong He, Min Huang, Xiaoli You, Chuan Xiao, Zhifeng Chen, Jinwen Caithe mice were assigned to six groups (n = 3 per group): control (con), XQLT, Sivelestat (MCE, USA, HY-17443) (SIV), OVA (SIGMA, USA, A5503)/LPS (SIGMA, USA, L2630) (OL), OVA/LPS/Sivelestat (OLS), and OVA/LPS/XQLT

(5) TLR9/NF-κB-mediated dendritic cell activation by neutrophil extracellular traps drives pathogenesis in experimental cerebral malariaJ NeuroinflammationAugust 26, 2025Shijie Yao, Yan Zhao, Chao Yao, Qing Li, Mengna Sun, Qinghui Wang, Li Zheng, Yaming Caotreated). For NET inhibition by previous description [30], mice were administered with Sivelestat (50 mg/kg, #HY-17443 A, MedChemExpress, USA) via tail vein injections at 0, 2, and 4 dpi. Control mice received 5% DMSO in

(6) Formation of neutrophil extracellular traps in the early stages exacerbate the healing process by regulating macrophage polarization in Achilles tendon-bone injuryJ Tissue EngAugust 19, 2025Yiqin Zhou, Xiaolei Yang, Dawei Niu, Peiliang Fu, Qirong Qian, Qi ZhouLipopolysaccharide (LPS; L2630) was purchased from Sigma-Aldrich. GSK484 hydrochloride (HY-100514) and sivelestat (HY-17443) were obtained from MedChemExpress. Mice The Animal Care and Use Committee of the Navy Medical University

(7) Brd7 loss reawakens dormant metastasis initiating cells in lung by forging an immunosuppressive nicheNature communicationsFebruary 5, 2025Mondal J, Zhang J, Qing F, Li S, Kumar D, Huse JT, Giancotti FG.clone MPC-11) and the rat IgG1 isotype control (BioXcell, clone HRPN). For Sivelestat (MedChemExpress, HY17443) treatment, the mice injected with the 4T07-TGL-Brd7 KO cells (Day 0) were i.p. injected with Sivelestat

(8) Evaluation of Neutrophil Elastase Inhibitors as Potential Therapies for ELANE Associated NeutropeniaJournal of Cellular ImmunologyJanuary 27, 2025Vahagn Makaryan, Merideth Kelley, Audrey Anna Bolyard, Gobind Chugh, David C. Dalecommercially available through MedChemExpress (MCE) as DMP-777 (HY-75957). NE inhibitors: Sivelestat (HY-17443), GW311616 (HY-15891), BAY-678 (HY-111457A) with its inactive control, BAY-677 (HY-111457) and DPP1

(9) Ferritin-mediated neutrophil extracellular traps formation and cytokine storm via macrophage scavenger receptor in sepsis-associated lung injuryCell communication and signaling : CCSFebruary 2, 2024Zhang H, Wu D, Wang Y, Shi Y, Shao Y, Zeng F, Spencer CB, Ortoga L, Wu D, Miao C.Sigma-Aldrich, St Louis, MO, USA), DPI (1 mg/kg, D2926, Sigma-Aldrich, USA), sivelestat (50 mg/kg, HY-17443, MCE, China). Before bone marrow transplantation (BMT), 8-week-old female C57BL/6 wild-type mice were

(10) Neutrophil extracellular traps and extracellular histones potentiate IL-17 inflammation in periodontitisThe Journal of experimental medicineSeptember 4, 2023Kim TS, Silva LM, Theofilou VI, Greenwell-Wild T, Li L, Williams DW, Ikeuchi T, Brenchley L, NIDCD/NIDCR Genomics and Computational Biology Core, Bugge TH, et al.6. Sivelestat treatment For in vivo NE inhibition, mice were administered 50 mg/kg of sivelestat (HY-17443, MedChemExpress) dissolved in vehicle control (10% DMSO + 40% PEG300 + 5% Tween 80 + 45% saline) or

(11) Neutrophil extracellular traps participate in the development of cancer-associated thrombosis in patients with gastric cancerWorld journal of gastroenterologyJuly 14, 2022Li JC, Zou XM, Yang SF, Jin JQ, Zhu L, Li CJ, Yang H, Zhang AG, Zhao TQ, Chen CY.presence of DNase I (100 U/mL, Roche), APC (100 nM, HY-P1918; MedChemExpress), and sivelestat (100 nM, HY-17443; MedChemExpress) alone or together. DNase I cleaves NET DNA, whereas APC and sivelestat disrupt histones

(12) CD44/ERM/F-actin complex mediates targeted nuclear degranulation and excessive neutrophil extracellular trap formation during sepsisJournal of cellular and molecular medicineApril 1, 2022Shao Y, Li L, Liu L, Yang Y, Huang J, Ji D, Zhou Y, Chen Y, Zhu Z, Sun B.fluorescence microscopy. Wherever indicated, cells were preincubated with an NE inhibitor (NEi) at 2 μM (MCE, HY‐17443) or an MPO inhibitor (MPOi) at 1 μM (MCE, HY‐111341) for 30 min before stimulation. Wherever indicated,

(13) CXCR2 Mediates Distinct Neutrophil Behavior in Brain Metastatic Breast TumorCancersJanuary 20, 2022Safarulla S, Madan A, Xing F, Chandrasekaran A.conditioned media. To inhibit the NETs formation, neutrophils were pre-treated with 10 µM of Sivelestat (HY-17443, Medchemexpress, South Brunswick Township, NJ, USA), a Neutrophil Elastase Inhibitor, prior to the assays. Image-iT™

(14) A novel tumor-immune microenvironment (TIME)-on-Chip mimics three dimensional neutrophil-tumor dynamics and neutrophil extracellular traps (NETs)-mediated collective tumor invasionBiofabricationApril 8, 2021Surendran V, Rutledge D, Colmon R, Chandrasekaran A.the inhibition of NET formation, neutrophils were re-suspended in RPMI containing 10 µM Sivelestat (HY-17443, Medchemexpress) prior to use in the experiments. 2.4 Immunostaining For stimulated tumor migration

(15) Neutrophil elastase inhibitor (sivelestat) may be a promising therapeutic option for management of acute lung injury/acute respiratory distress syndrome or disseminated intravascular coagulation in COVID-19Journal of clinical pharmacy and therapeuticsDecember 1, 2020Sahebnasagh A, Saghafi F, Safdari M, Khataminia M, Sadremomtaz A, Talaei Z, Rezai Ghaleno H, Bagheri M, Habtemariam S, Avan R.

(16) Neutrophil elastase inhibitor, sivelestat sodium hydrate prevents ischemia-reperfusion injury in the rat bladderMolecular and cellular biochemistryApril 1, 2008Kono T, Okada S, Saito M.

(17) A neutrophil elastase inhibitor, sivelestat, ameliorates lung injury after hemorrhagic shock in ratsInternational journal of molecular medicineFebruary 1, 2007Toda Y, Takahashi T, Maeshima K, Shimizu H, Inoue K, Morimatsu H, Omori E, Takeuchi M, Akagi R, Morita K.

(18) ONO-5046, a novel inhibitor of human neutrophil elastaseBiochemical and biophysical research communicationsJune 14, 1991Kawabata K, Suzuki M, Sugitani M, Imaki K, Toda M, Miyamoto T.

(19) Histochemical and chronobiological studies on uptake of L-DOPA by granulocytes--its promotion and suppressionActa histochemicaJanuary 1, 1978Mato M, Ookawara S.

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Sivelestat from MedChemExpress

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Sivelestat from MedChemExpress

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