Triptolide from MedChemExpress

Product Specs
ItemTriptolide
CompanyMedChemExpress
Price $95.00Supplier Page View Company Product Page
Catalog NumberHY-32735
Quantity10 mM * 1 mL
ApplicationsBioactivity, Structure and function analysis, ELISA, SDS-PAGE, Western blotting
Purity99.86%
TypeChemical
Molecular Weight360.4
FormulaC₂₀H₂₄O₆
Research AreaCancer

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(1) Triptolide Triggers Protective Autophagy via ROS Induction in NSCLC: Therapeutic Synergy with Autophagy InhibitionCancers (Basel)March 11, 2026Siqi Chen, Mengjia Sun, Quancheng Yang, Yi Lv, Xuejia ZhaiMaterials Small-molecule reagents were purchased from MedChemExpress (Monmouth Junction, NJ, USA), including triptolide (HY-32735), Ferrostatin-1 (HY-100579), bafilomycin A1 (HY-100558), SAR405 (HY-12481), rapamycin (HY-10219), Z-VAD-FMK

(2) DDX41 facilitates PD-L1-mediated immune escape in OSCC via the phase separation and activation STING pathwaynpj Precision OncologyFebruary 11, 2026Zhen Tian, Hao Cui, Si Sun, Zhou Lan, Peiliang Zhong, Wei Liu, Bowen Li, Hao Chen, Zhiyang Zhu, Yumiao Yang, et al.inhibitor C-176 and the p65 inhibitor triptolide were purchased from MCE (C-176 MCE HY-112906, Triptolide HY-32735). Salmon testis DNA (HTDNA) was purchased from Sigma (D6898-250MG). The anti-CD8 antibody was purchased

(3) Mitochondrial CISD1 Modulates Microglial Metabolic Reprogramming to Drive Stress Susceptibility in MiceAdvanced ScienceJanuary 1, 2026Wanting Dong, Duo Liu, Songsen Fu, Jiaming Zhang, Xi Chen, Songqiang Huangwith ice‐cold saline containing actinomycin D (5 mg mL−1; MCE, HY‐17559) and triptolide (10 mM; MCE, HY‐32735) to minimize microglial activation. The medial prefrontal cortex (mPFC) was rapidly dissected, minced,

(4) HHIPL2 positively governs Hedgehog signaling to accelerate non-small cell lung cancer progression via enhancing HNRNPC-mediated HNF1A mRNA stabilizationCell Death & DiseaseDecember 18, 2025Ning Mu, Fanrong Liu, Xiangqing Song, Biao Wang, Yilin Zhu, Lingbing Li, Lingxiao Yang, Huacong Sui, Jinfu Wang, Fengyuan Gao, et al.contamination from mycoplasma. Reagents and antibodies The chemicals used in our experiments were Triptolide (HY-32735), Cyclopamine (HY-17024), and Actinomycin D (HY-17559), which were purchased from MedChemExpress. Puromycin Dihydrochloride

(5) Triptolide ameliorates LPS-induced acute lung injury in Balb/c mice through gut-lung axis-mediated regulation of bile acid metabolism and gut microbiotaScientific ReportsNovember 25, 2025Yulong Zha, Linrui Fan, Tao Shen, Yu Zhang, Hongzheng RenPBS) to establish the ALI model first. As specified in the experimental protocol, TP (MCE, Cat. No.: HY-32735; white powder) was administered via intraperitoneal injection at 66.7 µg/kg per day for 7 consecutive

(6) PHB1 attenuates triptolide-induced cardiotoxicity by regulating mitochondrial dynamics in cultured newborn mice cardiomyocytesJournal of Cardiovascular PharmacologyOctober 20, 2025Wanlin Chen, XinGuo LiYan'an University, but an ethics approval number was not provided for this study. Reagents Triptolide (HY-32735) and Z-VAD-FMK (HY-16658B) were obtained from MedChemExpress. The stock solutions (1 mM) of triptolide

(7) Portal vein-enriched metabolites as intermediate regulators of the gut microbiome in insulin resistanceCell MetabolismOctober 7, 2025Vitor Rosetto Muñoz, Francois Moreau, Marion Soto, Yoshiyuki Watanabe, Loc-Duyen Pham, Jimmy Zhong, Sam Zimmerman, Bruna B. Brandao, Khyati Girdhar, Julian Avila, et al.citraconate, the HepG2 cells were treated with the transcription inhibitor triptolide (100 nM, 2h, #HY-32735, MedChemExpress), then subjected to 6h of metabolite (10 μM) treatment, after which the cells were washed

(8) Triptolide Attenuates Traumatic Heterotopic Ossification via Modulation of Inflammatory and Differentiation Pathways: Implications for Biochemical ToxicologyJournal of Biochemical and Molecular ToxicologySeptember 2, 2025Zuo‐Hua Li, Zong‐Huan Li, Zheng Wang, Xiang Jiang, Ai‐Xi Yuwith collagen type I (2–5 μg/cm²) to enhance adhesion for specific assays. Triptolide (TP; Cat. No. HY‐32735; MedChemExpress, NJ, USA) was used as the primary experimental reagent. TP is a diterpenoid triepoxide

(9) Small Molecule Screening Identifies HSP90 as a Modifier of RNA Foci in Myotonic Dystrophy Type 1Molecular and Cellular BiologyJune 3, 2025Sara J. Johnson, Hannah L. Johnson, Reid T. Powell, Clifford Stephan, Fabio Stossi, Thomas A. Coopersc-202581A) at 5mM and cells were treated at 5μM for 48 hours. Triptolide (CAS 38748–32-2 MedChemExpress HY32735/CS-0286), Flavopiridol (CAS 146426–40-6 MedChem Express HY-10005/CS-0018), SNS-032 (CAS 345627–80-7

(10) Exploring the mechanism of triptolide inhibiting the motility of fibroblast-like synoviocytes in rheumatoid arthritis via RhoA/Rho-associated kinase axis, based on network pharmacology, molecular docking and molecular dynamics simulationsFront PharmacolApril 3, 2025Jiacheng Shen, Yuxuan Fang, Nan Xu, Hongyi Chen, Miao Zhu, Dan Li, Zewen Chu, Masataka Sunagawa, Yanqing Liu, Haibo Wang, et al.Drugs and regents Triptolide (standard, HPLC ≥99.86%) was purchased from MedChemExpress LLC (Cat. No. HY-32735). Triptolide was dissolved in dimethyl sulfoxide (DMSO, Sigma, Berlin, Germany, Cat. No. D2650). The

(11) Integration and functionality of human iPSC-derived microglia in a chimeric mouse retinal modelJ NeuroinflammationFebruary 27, 2025Chun Tang, Qi-Qi Zhou, Xiu-Feng Huang, Ya-Yi Ju, Bi-Lin Rao, Zhi-Cong Liu, Yi-An Jia, Zhan-Pei Bai, Qing-Yang Lin, Lin Liu, et al.which included 5 µg/mL Actinomycin D (Cat.# HY-17559, MedChemExpress, USA), 10 µM Triptolide (Cat.# HY-32735, MedChemExpress, USA), and 27.1 µg/mL Anisomycin (Cat.# HY18982, MedChemExpress, USA). RFP-positive

(12) Role of glutaminyl-peptide cyclotransferase in breast cancer doxorubicin sensitivityCancer biology & therapyDecember 31, 2024Xu B, Yang L, Yang L, Al-Maamari A, Zhang J, Song H, Wang M, Su S, Song Z.contamination. In addition, all cell lines were authenticated by STR profiling. DOX and triptolide (Cat.No. HY-32735) were purchased from Yuanye (Shanghai, China) and MedChemExpress (Monmouth Junction, NJ, USA), respectively. Cell transfection

(13) Quantitative proteomic analysis of circulating exosomes reveals the mechanism by which Triptolide protects against collagen‐induced arthritisImmunity, Inflammation and DiseaseJune 18, 2024Xiuchan Liu, Xu Liu, Hui Wang, Ming Chen, Geng Zhang, Dongyun Ren, Na Zhang, Wei Weiadministered at a dose of 45 μg/kg as previously described 13 , 14 ; therefore, this dosage of TP (MCE, HY‐32735; Purity: 99.86%) was chosen for our experiment. The TP group was treated with 45 μg/kg/day of TP by

(14) CD8 T Cell-Derived Exosomal miR-186-5p Elicits Renal Inflammation via Activating Tubular TLR7/8 Signal AxisAdvanced science (Weinheim, Baden-Wurttemberg, Germany)September 1, 2023Xu X, Qu S, Zhang C, Zhang M, Qin W, Ren G, Bao H, Li L, Zen K, Liu Z.inflammatory cytokines, HK2 cells were treated with NF‐κB inhibitor triptolide (30 nM; MedChemExpress, HY‐32735) or TLR8 inhibitor enpatoran (100 nM; MedChemExpress, HY‐134581) alone or plus 10 µg mL−1 miR‐186‐5p.

(15) S100A4 Promotes BCG-Induced Pyroptosis of Macrophages by Activating the NF-κB/NLRP3 Inflammasome Signaling PathwayInternational journal of molecular sciencesAugust 11, 2023Li M, Liu Y, Nie X, Ma B, Ma Y, Hou Y, Yang Y, Xu J, Wang Y.Chemicals and Inhibitors Treatment NF-κB inhibitor Triptolide (TPL) was purchased from MedChemExpress (HY-32735, Monmouth Junction, NJ, USA), and NLRP3 inhibitor MCC950 was purchased from MedChemExpress (HY-12815,

(16) Triptolide promotes ferroptosis by suppressing Nrf2 to overcome leukemia cell resistance to doxorubicinMolecular Medicine ReportsNovember 30, 2022Xia Wu, Shangqing Chen, Kechu Huang, Gongping Linfor 24 h, 2 µM erastin (cat. no. HY-B0627; MedChemExpress) for 48 h and 40 nM triptolide (cat. no. HY-32735; MedChemExpress) for 24 or 48 h at 37°C. Plasmid transfection and lentiviral infection Recombinant

(17) Natural product triptolide induces GSDME-mediated pyroptosis in head and neck cancer through suppressing mitochondrial hexokinase-ΙΙJournal of experimental & clinical cancer research : CRJune 9, 2021Cai J, Yi M, Tan Y, Li X, Li G, Zeng Z, Xiong W, Xiang B.

(18) Triptolide Induces Leydig Cell Apoptosis by Disrupting Mitochondrial Dynamics in RatsFrontiers in pharmacologyJanuary 1, 2021Lv L, Chang Y, Li Y, Chen H, Yao J, Xie Y, Liang X, Yang X, Zhang M, Liu G.cytometry (FACS Canto II; Becton, Dickinson and Company). Chemical Agents Triptolide (TP; cat. no. HY-32735) and mitochondrial division inhibitor 1 (Mdivi-1; cat. no. HY-15886) were purchased from MedChemExpress.

(19) TriTag: an integrative tool to correlate chromatin dynamics and gene expression in living cellsNucleic Acids ResearchDecember 16, 2020Haiyue Xu, Junyan Wang, Ying Liang, Yujuan Fu, Sihui Li, Jinghan Huang, Heng Xu, Wei Zou, Baohui Chenlabeling of nascent RNAs To validate the labeling of nascent RNAs, we took advantage of triptolide (MCE, HY-32735) which inhibits transcription activity of RNA Pol II polymerase (34), and isoginkgetin (MCE, HY-N2117)

(20) Nuclear Localization of Huntingtin mRNA Is Specific to Cells of Neuronal OriginCell ReportsSeptember 4, 2018Marie-Cécile Didiot et al.Primary cortical neurons were treated with a final concentration of 25 μM triptolide (MedChemExpress #HY-32735) for indicated amount of time. Cells were fixed directly after treatment and processed for FISH experiment. Cell Viability Assay

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Triptolide from MedChemExpress

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Triptolide from MedChemExpress

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