KB-R7943 mesylate from MedChemExpress | Biocompare.com

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KB-R7943 mesylate

Description

KB-R7943 mesylate is a widely used inhibitor of the reverse Na⁺/Ca²⁺ exchanger (NCX_rev) with IC₅₀ of 5.7±2.1 µM. KB-R7943 mesylate induces cancer cell death via activating the JNK pathway and blocking autophagic flux

Product Specs
ItemKB-R7943 mesylate
CompanyMedChemExpress
Price $123.00Supplier Page View Company Product Page
Catalog NumberHY-15415
Research AreaCancer
FormulaC₁₇H₂₁N₃O₆S₂
Molecular Weight427.5
TypeChemical
Purity99.16%
ApplicationsBioactivity, Structure and function analysis, ELISA, SDS-PAGE, Western blotting
Quantity10 mM * 1 mL

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(1) NCX1 reverse mode promotes calcium-dependent Neutrophil Extracellular Trap formation and lung damage in chronic obstructive pulmonary diseaseNature CommunicationsMarch 11, 2026Shi-Xia Liao, Yan-Wen Wang, Ling-Mei Shi, Lan-Ying Zhang, Jian Zhou, Peng-Peng Sun, Huai-Yu Hu, Yu-Ting Liu, Xuan An, Jing-Qing Xu, et al.injection of KB-R7943 (1.5 μL of 100 mg/mL KB-R7943 diluted in 98.5 μL 0.9% saline per mouse, MCE, HY-15415) or Vehicle (1.5 μL DMSO in 98.5 μL 0.9% saline per mouse) every 2 days for total 12 weeks. In the experiments

(2) The reverse-mode NCX1 activity inhibitor KB-R7943 promotes prostate cancer cell death by activating the JNK pathway and blocking autophagic fluxOncotargetJuly 5, 2016Long Z, Chen B, Liu Q, Zhao J, Yang Z, Dong X, Xia L, Huang S, Hu X, Song B, et al.

(3) High potency inhibition of hERG potassium channels by the sodium-calcium exchange inhibitor KB-R7943British journal of pharmacologyApril 1, 2012Cheng H, Zhang Y, Du C, Dempsey CE, Hancox JC.

(4) KB-R7943, an inhibitor of the reverse Na+ /Ca2+ exchanger, blocks N-methyl-D-aspartate receptor and inhibits mitochondrial complex IBritish journal of pharmacologyJanuary 1, 2011Brustovetsky T, Brittain MK, Sheets PL, Cummins TR, Pinelis V, Brustovetsky N.

(5) The Na+/Ca2+ exchange inhibitor 2-(2-(4-(4-nitrobenzyloxy)phenyl)ethyl)isothiourea methanesulfonate (KB-R7943) also blocks ryanodine receptors type 1 (RyR1) and type 2 (RyR2) channelsMolecular pharmacologySeptember 1, 2009Barrientos G, Bose DD, Feng W, Padilla I, Pessah IN.

(6) Recovery of anaerobic bacteria from a post-traumatic nasal septal abscess. A report of two casesThe Annals of otology, rhinology, and laryngologyNovember 1, 1998Brook I.

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