Description
A pyranone with antifungal and insecticidal activities; active against a laboratory strain and clinical isolates of C. albicans (MICs = 49 and 12-97 µg/ml, respectively); reduces fungal load in the vagina in a mouse model of fluconazole-resistant vulvovaginal candidiasis at 1, 2, and 4 mg/kg per day topically or 20, 40, and 80 mg/kg per day orally; toxic to S. exigua and S. litura larvae with LC50 values of 545.61 and 986.88 mg/L for dietary administration and 519.48 and 1,041.42 mg/L for contact application