MLi-2 from Tocris Bioscience, a Bio-Techne Brand

Product Specs
ItemMLi-2
CompanyTocris Bioscience, a Bio-Techne Brand
Price $328.00Supplier Page View Company Product Page
Catalog Number5756/10
Quantity10 mg (also 50 mg)
Purity98%
Molecular Weight379.46
Molecule Namerel-3-[6-[(2R,6S)-2,6-Dimethyl-4-morpholinyl]-4-pyrimidyl]-5-[(1-methylcyclopropyl)oxy]-1H-indazole
FormulaC21H25N5O2
StorageStore at -20°C

Specifications/Features

Sizes Available: 10 mg (also 50 mg)

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Tocris Bioscience, a Bio-Techne Brand

614 McKinley Place N.E.

Minneapolis, Minnesota 55413

United States

Phone: 1 (800) 343-7475
1 (612) 379-2956
Fax: 1 (612) 656-4400

Company Profile

Website: http://www.tocris.com

(1) The LRRK2 G2019S variant rewires Rab GTPase phosphorylation after lysosomal damage and promotes cell death in human macrophagesJournal of Cell ScienceJuly 15, 2026Rebecca Morrison, Simeon R. Mihaylov, Chak Hon Luk, Cyril Lemerle, Angela Rodgers, Natalia Athanasiadi, Huw R. Morris, Enrica Pellegrino, Sila K. Ultanir, Maximiliano G. Gutierrez0.3% methanol in RPMI or X-VIVO 15 was used in all control samples. Cells were pre-treated with MLi-2 (5756/10, Tocris) at 100 nM or GSK2578215A (ab254316, Abcam) at 0.1 μM for 2 h and all subsequent treatments

(2) Characterization of Lipopolysaccharide Effects on LRRK2 Signaling in RAW MacrophagesInternational journal of molecular sciencesJanuary 13, 2023Oun A, Hoeksema E, Soliman A, Brouwer F, García-Reyes F, Pots H, Trombetta-Lima M, Kortholt A, Dolga AM.

(3) DJ-1 is an essential downstream mediator in PINK1/parkin-dependent mitophagyBrain : a journal of neurologyDecember 19, 2022Imberechts D, Kinnart I, Wauters F, Terbeek J, Manders L, Wierda K, Eggermont K, Madeiro RF, Sue C, Verfaillie C, et al.

(4) Lysosomal positioning regulates Rab10 phosphorylation at LRRK2(+) lysosomesProceedings of the National Academy of Sciences of the United States of AmericaOctober 25, 2022Kluss JH, Beilina A, Williamson CD, Lewis PA, Cookson MR, Bonet-Ponce L.

(5) Directing LRRK2 to membranes of the endolysosomal pathway triggers RAB phosphorylation and JIP4 recruitmentNeurobiology of diseaseAugust 1, 2022Kluss JH, Bonet-Ponce L, Lewis PA, Cookson MR.

(6) Trafficking of the glutamate transporter is impaired in LRRK2-related Parkinson's diseaseActa neuropathologicaJuly 1, 2022Iovino L, Giusti V, Pischedda F, Giusto E, Plotegher N, Marte A, Battisti I, Di Iacovo A, Marku A, Piccoli G, et al.

(7) LRRK2 Inhibition Mitigates the Neuroinflammation Caused by TLR2-Specific α-Synuclein and Alleviates Neuroinflammation-Derived Dopaminergic Neuronal LossCellsMarch 2, 2022Ho DH, Nam D, Seo M, Park SW, Seol W, Son I.

(8) Nanobodies as allosteric modulators of Parkinson's disease-associated LRRK2Proceedings of the National Academy of Sciences of the United States of AmericaMarch 1, 2022Singh RK, Soliman A, Guaitoli G, Störmer E, von Zweydorf F, Dal Maso T, Oun A, Van Rillaer L, Schmidt SH, Chatterjee D, et al.

(9) A cell-based GEF assay reveals new substrates for DENN domains and a role for DENND2B in primary ciliogenesisScience advancesFebruary 25, 2022Kumar R, Francis V, Kulasekaran G, Khan M, Armstrong GAB, McPherson PS.

(10) WHOPPA Enables Parallel Assessment of Leucine-Rich Repeat Kinase 2 and Glucocerebrosidase Enzymatic Activity in Parkinson's Disease MonocytesFrontiers in cellular neuroscienceJanuary 1, 2022Wallings RL, Hughes LP, Staley HA, Simon ZD, McFarland NR, Alcalay RN, Garrido A, Martí MJ, Sarró ET, Dzamko N, et al.

(11) Endosomal traffic and glutamate synapse activity are increased in VPS35 D620N mutant knock-in mouse neurons, and resistant to LRRK2 kinase inhibitionMolecular brainSeptember 16, 2021Kadgien CA, Kamesh A, Milnerwood AJ.

(12) Increased LRRK2 kinase activity alters neuronal autophagy by disrupting the axonal transport of autophagosomesCurrent biology : CBMay 24, 2021Boecker CA, Goldsmith J, Dou D, Cajka GG, Holzbaur ELF.

(13) Pathogenic LRRK2 regulates ciliation probability upstream of tau tubulin kinase 2 via Rab10 and RILPL1 proteinsProceedings of the National Academy of Sciences of the United States of AmericaMarch 9, 2021Sobu Y, Wawro PS, Dhekne HS, Yeshaw WM, Pfeffer SR.

(14) LRRK2 Kinase Activity Does Not Alter Cell-Autonomous Tau Pathology Development in Primary NeuronsJournal of Parkinson's diseaseJanuary 1, 2021Henderson MX, Changolkar L, Trojanowski JQ, Lee VMY.

(15) LRRK2 mediates tubulation and vesicle sorting from lysosomesScience advancesNovember 1, 2020Bonet-Ponce L, Beilina A, Williamson CD, Lindberg E, Kluss JH, Saez-Atienzar S, Landeck N, Kumaran R, Mamais A, Bleck CKE, et al.

(16) Protein synthesis is suppressed in sporadic and familial Parkinson's disease by LRRK2FASEB journal : official publication of the Federation of American Societies for Experimental BiologyNovember 1, 2020Deshpande P, Flinkman D, Hong Y, Goltseva E, Siino V, Sun L, Peltonen S, Elo LL, Kaasinen V, James P, et al.

(17) LRRK2 activation controls the repair of damaged endomembranes in macrophagesThe EMBO journalSeptember 15, 2020Herbst S, Campbell P, Harvey J, Bernard EM, Papayannopoulos V, Wood NW, Morris HR, Gutierrez MG.inhibitors Macrophages were treated with GSK2578215A inhibitor (Cat# 4629, Tocris) at 1 μM or MLi‐2 (Cat# 5756/10, Tocris) at 0.1 μM for 1 h before infection or treatment. The inhibitors were present during infection

(18) Accurate MS-based Rab10 Phosphorylation Stoichiometry Determination as Readout for LRRK2 Activity in Parkinson's DiseaseMolecular & cellular proteomics : MCPSeptember 1, 2020Karayel Ö, Tonelli F, Virreira Winter S, Geyer PE, Fan Y, Sammler EM, Alessi DR, Steger M, Mann M.

(19) Parkinson's disease-related Leucine-rich repeat kinase 2 modulates nuclear morphology and genomic stability in striatal projection neurons during agingMolecular neurodegenerationFebruary 19, 2020Chen X, Xie C, Tian W, Sun L, Zheng W, Hawes S, Chang L, Kung J, Ding J, Chen S, et al.

(20) LRRK2 mutations impair depolarization-induced mitophagy through inhibition of mitochondrial accumulation of RAB10AutophagyFebruary 1, 2020Wauters F, Cornelissen T, Imberechts D, Martin S, Koentjoro B, Sue C, Vangheluwe P, Vandenberghe W.

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MLi-2

MLi-2 from Tocris Bioscience, a Bio-Techne Brand

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Specifications/Features

Tocris Bioscience, a Bio-Techne Brand

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MLi-2 from Tocris Bioscience, a Bio-Techne Brand

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